Research

Investigators in the Division of Endocrinology, Diabetes and Metabolism conduct basic and clinical research in the areas of diabetes, integrated mechanisms causing obesity, metabolic signaling, lung and brain development and rare genetic lipid disorders. 

Our faculty have many collaborative research efforts with other disciplines including adult and pediatric hematology, pediatric gastroenterology, hepatology and nutrition, pediatric human genetics and the Department of Pathology and Laboratory Medicine. Our overall goal is to build a robust, multi-disciplinary program that supports both laboratory-based and patient-based research in our clinical care, research and education programs for endocrinology disorders. 

The core of our basic science research takes place at the UC Reading campus. 

Clinical Research & Clinical Trials

Clinical research trials are studies involving human subjects. Before a drug or treatment protocol is tested widely, it goes through years of testing in cells, tissue culture and pre-clinical animal models. The process is closely regulated by the government and monitored by institution’s Institutional Review Board (IRB).

There are numerous types of clinical trials, each with a different purpose: prevention, screening, diagnostics or treatment. Patients who participate in clinical trials are followed for an extended period of time (sometimes over their lifetime) after the trial is closed.

Government-funded clinical trials at the UC Academic Health Center can be found at the Clinical Trials Webpage. Please note this is not an all-inclusive list.

Clinical trials in the division focus on new treatments for diabetes and provide opportunities for physicians and patients to have access to the latest medications and treatments. 

Facilities:

The UC Division of Endocrinology, Diabetes & Metabolism occupies space in the Medical Sciences Building, and at the University of Cincinnati Reading campus.

This includes laboratory facilities equipped to perform state-of-the art experiments in molecular and cellular biology, as well as facilities for the development of transgenic mouse models, tissue culture, data analysis and high performance liquid chromatography.

Maintenance facilities and operating rooms for large and small animals are supervised by the UC Department of Laboratory Animal Medicine.

Facilities for clinical research are available at the NIH-funded Center for Clinical and Translational Science and Training centers located at Cincinnati Children's Hospital Medical Center and Cincinnati Department of Veterans Affairs Medical Center.

Fellows Research & Scholarly Activities:

Publications

Shah S, Manzoor S, Rothman Y, Hagen M, Pater L, Golnik K, Mahammedi A, Lin AL, Bhabhra R, Forbes JA, Sengupta S. Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report. Neurosurgery. 2022 May 13. doi: 10.1227/neu.0000000000002024. Epub ahead of print. PMID: 35544035.

Genco MT, Yaqub A, Jana S. Challenges in the evaluation and management of radioactive iodine-refractory differentiated thyroid cancer. Nucl Med Commun. 2022 Apr 19. doi: 10.1097/MNM.0000000000001568. Epub ahead of print. PMID: 35438680.

Awasty S S, Jafri S, Manzoor S, Yaqub, A. (September 21, 2021) Hypercalcemia Secondary to Immune Reconstitution Inflammatory Syndrome in an HIV-Infected Individual With Mycobacterium avium Complex. Cureus 13(9): e18174. doi:10.7759/cureus.18174

Rehman A, Obici S, Yaqub A. Radioiodine Therapy-Induced Conversion of Toxic Adenoma to Graves' Disease. Cureus. 2020 Jun 18;12(6):e8683. doi: 10.7759/cureus.8683. PMID: 32699683; PMCID: PMC7370676.

Ewa Gniado, Colin P Carracher, Sona Sharma, Simultaneous Occurrence of Germline Mutations of SDHB and TP53 in a Patient with Metastatic Pheochromocytoma, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 4, April 2020, Pages 991–995.

Kamal, Palwasha and Bhabhra R. (August 2019). Glipizide Induced Hepatotoxicity: A Case Report and Review of Literature. Diabetes & Metabolic Disorders. 6. 1-4. 10.24966/DMD-201X/100028. 

Dai Y, Hagen M, Andaluz N, Bhabhra R. Aggressive granular cell tumor of the neurohypophysis with optic tract edema and invasion into third ventricle. Surg Neurol Int. 2019 Nov 15;10:217. doi: 10.25259/SNI_356_2019. PMID: 31819811; PMCID: PMC6884947.

Hala Mualla, Su Ah Bae and Abid Yaqub. Autosomal Dominant Hypophosphatemic Rickets Presenting in a Phenotypically Normal Adult Female. Case Reports in Endocrinology Volume 2019, Article ID 8917519, March 4, 2019.

Book Chapters

Patel R and Yaqub A. Hypothyroidism (Book Chapter) In: Yadlapalli, G (Ed). Treatment Strategies for Common Medical Problems For Global Health (2nd ed.). SAI Trust and Publishers, Telangana, India 2017.

Patel R and Yaqub A. Myxedema Coma (Book Chapter) In: Yadlapalli, G (Ed). Treatment Strategies for Common Medical Problems For Global Health (2nd ed.). SAI Trust and Publishers, Telangana, India 2017.

Chatha S and Obici S. Hypercalcemia (Book Chapter) In: Yadlapalli, G (Ed). Treatment Strategies for Common Medical Problems For Global Health (2nd ed.). SAI Trust and Publishers, Telangana, India 2017.

Abstracts Presented

May 2020 (Meeting cancelled due to Covid-19) Matthew Tam, MD, Ruchi Bhabhra, MD, PhD, MON-338 Severe Hypophosphatemia Induced by Intravenous Ferric Carboxymaltose Therapy for Iron Deficiency Anemia, Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020, MON–338, https://doi.org/10.1210/jendso/bvaa046.1266

May 2020 (Meeting cancelled due to Covid-19) Matthew Tam, MD, Sona Sharma, MD, SUN-160 Development of Adrenocortical Carcinoma in an Adrenal Nodule After Nine Years of Size Stability on Imaging: A Case for Critical Review of Efficacy of Radiographic Size Criteria, Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020, SUN–160, https://doi.org/10.1210/jendso/bvaa046.624

May 2018, A Case of Reversible Adrenal Suppression Induced by Fluconazole in an HIV-Infected Patient. Hala Mualla, MD, Shailendra Patel, BM, ChB, DPhil, FRCP.  Poster presented at The American Association of Clinical Endocrinologists’ 27th Annual Scientific & Clinical Congress, Boston, MA – Published in Endocrine Practice 2018; Suppl. 

May 2018, Empagiflozin Effect on Weight Reduction and Glycemic Control in a Patient with Prader-Willi Syndrome. Hala Mualla, MD, Michael Canos, MD, MPH, MS, Mercedes Falciglia, MD.  Poster presented at The American Association of Clinical Endocrinologists’ 27th Annual Scientific & Clinical Congress, Boston, MA – Published in Endocrine Practice 2018; Suppl. 

May 2018, Worsening Glycemic Control Leads to Diagnosis of Pancreatic Adenocarcinoma in a Patient with Type 2 Diabetes Mellitus. Anis Rehman, MD, Abid Yaqub, MD,FACE,FACP.  Poster presented at The American Association of Clinical Endocrinologists’ 27th Annual Scientific & Clinical Congress, Boston, MA – Published in Endocrine Practice 2018; Suppl. 

May 2018, Metastatic Classical Papillary Thyroid Cancer with Undetectable Basal Thyroglobulin Level and Lack of Metastatic Uptake on Radio-Iodine Scan. Anis Rehman, MD, Abid Yaqub, MD,FACE,FACP. Poster presented at The American Association of Clinical Endocrinologists’ 27th Annual Scientific & Clinical Congress, Boston, MA. Published in Endocrine Practice 2018; Suppl.

March 2018, Recurrent Hypoglycemia Occurring Years After Removal of a Well-Differentiated Metastatic Pancreatic Neuroendocrine Tumor. Ewa Gniad, MD, Nadia Yaqub, MD. Poster presented at the 100th Annual Meeting of the Endocrine Society, Chicago, IL. Abstract published in Endocrine Rev 2018; 39(2) Suppl.

March 2018, Pan-Hypopituitarism and SIADH Associated with Right Internal carotid Artery Aneurysm. Anis Rehman, MD, Nadia Yaqub, MD. Poster presented at the 100th Annual Meeting of the Endocrine Society, Chicago, IL. Abstract published in Endocrine Rev 2018; 39(2) Suppl.

March 2018, Definitive Treatment of a Complicated Case of Amiodarone Induced Thyrotoxicosis. Anis Rehman, MD, Timothy Reed, MD, Mercedes Falciglia, MD. Poster presented at the 100th Annual Meeting of the Endocrine Society, Chicago, IL. Abstract published in Endocr Rev 2018; 39(2) Suppl.

March 2018, Doege-Potter Syndrome: Liver Solitary Fibrous Tumor with Insulin-like Growth Factor 2 mediated Non-Islet Cell Tumor Hypoglycemia with incidental findings of Adrenal Insufficiency and Differentiated Papillary Thyroid Cancer. Anis Rehman, MD, Colin Carracher, MD. Poster presented at the 100th Annual Meeting of the Endocrine Society, Chicago, IL. Abstract published in Endocr Rev 2018; 39(2) Suppl.

March 2017, ACTH dependent Cushing’s disease in Li-Fraumeni Syndrome. Anis Rehman, MD, Ruchi Bhabhra, MD, PhD. Co-author Poster Presentation. Fifteen International Pituitary Congress, Orlando, FL.

March 2017, Octreotide Therapy for Chronic, Severe Hypoglycemia Following Bilateral Nephrectomy and Roux-en-y Gastric Bypass. Jagjit Padda, MD, Elyse Harris, MD, Michael Canos, MD, MPH, MSc. Poster presented at The American Association of Clinical Endocrinologists’ 26th Annual Scientific & Clinical Congress, Austin, TX – Published in Endocr Practic 2017; Suppl.

March 2017, A Lethal Consequence of Radiotherapy: Radiation-Induced Sarcoma in a Patient with Giant Prolactinoma. Sheena Chatha, MD, Richa Patel, MD, Lindsay Lowder, MD, M Roesch, MD, Ady Kendler, MD, PhD, Colin Carracher, MD, Dima Diab, MD, Sona Sharma, MD. Poster presented at The American Association of Clinical Endocrinologists’ 26th Annual Scientific & Clinical Congress, Austin, TX – Published in Endocr Practic 2017; Suppl.

March 2017, Mimic of an Endocrine Tumour: Spindle Cell Oncocytoma of the Adenohypophysis. Sheena Chatha, MD, Lindsay Lowder, MD, Ady Kendler, MD, PhD, Sona Sharma, MD. Poster presented at The American Association of Clinical Endocrinologists’ 26th Annual Scientific & Clinical Congress, Austin, TX – Published in Endocr Practic 2017; Suppl.

American College of Physicians, Residents and Fellows Abstracts Competition 2017 Ohio Poster Finalist - Jagjit K Padda, MD - Severe Rhabdomyolysis in Infleunza.