Selected Peer Reviewed Publications

2020

Chowdhury SA, Warren CM, Simon JN, Ryba DM, Batra A, Varga P, Kranias EG, Tardiff JC, Solaro RJ, Wolska BM. Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere Linked Hypertrophic Cardiomyopathy Despite Persistent Increases in Myofilament Ca-Response. Front Physiol. 2020 Mar 10;11:107. PMID: 32210830

Alogaili F, Chinnarasu S, Jaeschke A, Kranias EG, Hui DY. Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export. J Biol Chem. 2020 Apr 3;295(14):4631-4646. PMID: 32079675

Onusko E, McDermott M, Robbins N, Liu G, Kranias EG, Rubinstein J, Koch, SE. Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. PLoS One. 2020 Mar 27; PMID: 32218573

2019

Ren X, Roessler A, Lynch T, Haar, L, Mallick F, Lui Y, Tranter M, Ren MH, Xie WR, Fan G,  Zhang JM, Kranias EG, Anjak A, Koch S, Jiang M, Miao, Q, Wang, Y, Cohen A, Rubinstein J, Weintraub NL, Jones, WK. Cardioprotection via the skin; Nociceptor-Induced Conditioning, in the NIC of time. Am J Physiol Heart Circ Physiol. 2019 H543-H553. Epub 2018 Dec 21. PMID:30575436.

Hof IE, van der Heijden JF, Kranias EG, Sanoudou D, de Boer RA, van Tintelen JP, van der Zwaag PA, Doevendans PA. Prevalence and cardiac phenotype of patients with a phospholamban mutation. Neth Heart J. 2019 Feb; 27(2):64-69. PMID: 300547415

Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ines Ragone M, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Ablation of PLN rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 Mar 1 [Epub ahead of print]. PMID: 30169578

Gardner GT, Travers JG, Qian J, Liu G-S, Haghighi K, Robbins NJ, Jiang M, Li Y,  Fan G-C, Rubinstein J, Blaxall BC, Kranias EG: Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC Basic Transl Sci. 2019 Apr 29;4(2):188-199. PMID: 31061921

Essandoh K, Wang X, Huang W, Deng S, Gardner G, Mu X, Li Y, Kranias EG, Wang Y, Fan GC. Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy. J. Biol. Chem. 2019; 294:18057-18068. PMID:31619520

2018

Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC, Kranias EG. Regulation of BECN1-Mediated Autophagy by HSPB6: Insights from A Human HSPB6S10F Mutant.  2018 14(1):80-97. PMID:29157081

Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki, E, Sanoudou, D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG. HAX-1 regulates SERCA2a oxidation and degradation. J Mol Cell Cardiol. 2018 Jan;114:220-233. Epub 2017 Nov 21. PMID: 29169992

Bidwell PA, Haghighi K, Kranias EG. The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart.J Biol Chem. 2018 Jan 5;293(1):359-367. Epub 2017 Nov 17. PMID:29150445

Liu G-S, Gardner G, Adly G, Jiang M, Cai W-F, Lam CK, Alogaili F, Rubinstein J, Kranias EG: A Novel Human S10F-Hsp20 Mutation Induces Peripartum Cardiomyopathy. J Cell and Mol Med 2018 May 15 [Epub ahead of print]. PMID: 29761889

Arvanitis DA, Vafiadaki E, Johnson DM, Kranias EG, Sanoudou D. The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity. Front Physiol. 2018 Sep 27; 9:1379. PMID:30319456

Chen M, Xu D, Wu AZ, Kranias EG, Lin SF, Chen PS, Chen Z. Phospholamban Regulates Nuclear Ca2+ Stores and  Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca2+ Cycling in Cardiomyocytes. J Mol Cell Cardiol. 2018 Oct;123:185-197. Epub 2018 Sep 24. PMID: 30261161

2017

Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Impaired Calcium Homeostasis is Associated with Sudden Cardiac Death and Arrhythmias in a Genetic Equivalent Mouse Model of the Human HRC-Ser96Ala Variant. Cardiovasc Res 2017 Sep 1;113(11):1403-1417. PMID:28859293

Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez  DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias, EG. Phosphorylation of Ser96 of Histidine-Rich Calcium-Binding Protein by the Fam20C Kinase Functions to Prevent Cardiac Arrhythmia. Proc Natl Acad Sci U S A 2017 Aug 22;114(34):9098-9103. PMID:28784772

Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias EG, Weber T, Akar FG, Hajjar RJ. Protein Phosphatase Inhibitor 1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. J Am Coll Cardiol. 2017 Oct 3;70(14):1744-1756. PMID:28958332

2016

Mazzocchi G, Sommese L, Palomeque J, Felice JI, Di Carlo MN, Fainstein D, Gonzalez P, Contreras P, Skapura D, McCauley MD, Lascano EC, Negroni JA, Kranias EG, Wehrens X, Valverde CA, Mattiazzi A. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016.  Jun 1;594(11):3005-30.  PMID: 26695843

Stillitano F, Turnbull IC, Karakikes I, Nonnenmacher M, Backeris P, Hulot JS, Kranias EG, Hajjar RJ, Costa KD. Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. Eur Heart J. 2016 Nov 14;37(43):3282-3284. PMID: 27450564

2015

Tzimas C, Terrovitis J, Lehnart SE, Kranias EG, Sanoudou D: Calcium/calmodulin-dependent protin kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junction ablation under stress conditions. Heart Rhythm. 12(7):1599-610, 2015. PMID:25814413

Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis E, Papapetropoulos A: Cardioprotection by H2S engages a cGMP-dependent protein kinase/ phospholamban pathway. Cardiovasc Res. 106(3):432-42, 2015. PMID:25870184

Liu GS, Morales A, Vafiadaki E, Lam CK, Cai WF, Haghighi K, Hershberger RE, Kranias EG: A novel human R25C-phospholamban mutation is associated with superinhibition of calcium cycling and ventricular arrhythmia. Cardiovasc Res. 107(1):164-74, 2015. PMID:25852082

Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JM, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ: Correction of the human phospholamban R14del mutation associated with dilated cardiomyopathy using targeted nucleases and combination therapy. Nat Commun. 6:6955, 2015. PMID:25923014

*Cai WF, *Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Hahighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG: Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur J Heart Fail. 17:782-793, 2015. PMID:26177627 *Both authors contributed equally

Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ishiropoulos H, Kranias E, Bloch KD, Stamler JS, Ichinose F: S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res. 117:793-803, 2015. PMID: 26259881

Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Gyorke S: Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT. Cardiov Res. 108(2):299-311, 2015. PMID: 26410369

*Haghighi K, *Pritchard TJ, Liu GS, Singh VP, Bidwell P, Lam CK, Vafiadaki E, Das P, Ma J, Kunduri S, Sanoudou D, Florea S, Vanderbilt E, Wang HS, Rubinstein J, Hajjar RJ, Kranias EG. Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. J Mol Cell Cardiol. 89:349-59, 2015. PMID: 26455482 Full Text  *Both authors contributed equally

*Lam CK, *Zhao W, Liu GS, Cai WF, Gardner G, Adly G, Kranias EG. HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart. Proc Natl Acad Sci U S A. 112(47):E6466-75, 2015. PMID: 26553996 Full Text *Both authors contributed equally

Cai W-F, Liu G-S, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan G-C, Hajjar RJ, Kranias EG. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur J Heart Fail. 2015;17 (8):782-793. PMID: 26177627