Recent Publications

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2026

Assali, Essam A; Taha, Mahmoud; Salhab, Ahmad; Amer, Johnny; Krishnan, Karthickeyan Chella; Kostic, Marko; Veliova, Michaela; Brownstein, Alexandra J; Shirihai, Orian S; Safadi, Rifaat; Sekler, Israel 2026. Mitochondrial NCLX Couples Glucagon- and PDE2A-Dependent Signals to Regulate Hepatic Lipid Metabolism. Molecular metabolism, , 102433

Igel, Emily; Jaeschke, Anja; Haller, April; Asman, Melissa; Mattam, Ushodaya; Alagarsamy, Jeyashree; Chella Krishnan, Karthickeyan; Hui, David Y 2026. Cell type-specific control of cardiometabolic disease by the dileucine motif of the LDL receptor-related protein LRP1. The Journal of biological chemistry, 302 5, 111421

Porteymour, Shirin; Sajib, Saikat Das; von Hofsten, Susannah; Doncheva, Atanaska I; Bjørnvall, Christina D; Hegge, Beate; Gautier, Mélina; Grujic, Mirjana; Kolan, Pratibha; Krishnan, Karthickeyan Chella; Matthews, Jason; Dalen, Knut T; Pejler, Gunnar; Kolset, Svein O; Knutsen, Erik; Norheim, Frode A 2026. Serglycin modulates inflammation and metabolism in macrophages. iScience, 29 4, 115235

2025

Mattam, Ushodaya; Talari, Noble Kumar; Rao Sathyanarayana, Ashish; Mia, Sobuj; Frazier, James; Alagarsamy, Jeyashree; Slone, Sam; Drosatos, Konstantinos; Chella Krishnan, Karthickeyan 2025. Isolated mouse adult cardiomyocytes display minimal mitochondrial ATP demand and maximal reliance on glycolysis. Journal of molecular and cellular cardiology, 204 , 1-4

Talari, Noble Kumar; Mattam, Ushodaya; Rahman, Afra P; Hemmelgarn, Brook K; Wyder, Michael A; Sylvestre, Pamela B; Greis, Kenneth D; Chella Krishnan, Karthickeyan 2025. Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression. Communications biology, 8 1, 258

2024

He, Xingyu; Good, Angela; Kalou, Wael; Ahmad, Waqas; Dutta, Suchandrima; Chen, Sophie; Lin, Charles Noah; Chella Krishnan, Karthickeyan; Fan, Yanbo; Huang, Wei; Liang, Jialiang; Wang, Yigang 2024. Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of Cardiovascular Diseases. Cells, 13 24,

Mattam, Ushodaya; Talari, Noble Kumar; Sathyanarayana, Ashish Rao; Mia, Sobuj; Frazier, James; Slone, Sam; Drosatos, Konstantinos; Chella Krishnan, Karthickeyan 2024. Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis. bioRxiv : the preprint server for biology, ,

Talari, Noble Kumar; Mattam, Ushodaya; Kaminska, Dorota; Sotomayor-Rodriguez, Irene; Rahman, Afra P; Péterfy, Miklós; Pajukanta, Päivi; Pihlajamäki, Jussi; Chella Krishnan, Karthickeyan 2024. Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis. iScience, 27 5, 109709

2023

Chella Krishnan, Karthickeyan 2023. When diet meets genetics. eLife, 12 ,

Patel, Sanil; Sparman, Njeri Z R; Arneson, Douglas; Alvarsson, Alexandra; Santos, Luís C; Duesman, Samuel J; Centonze, Alessia; Hathaway, Ephraim; Ahn, In Sook; Diamante, Graciel; Cely, Ingrid; Cho, Chung Hwan; Talari, Noble Kumar; Rajbhandari, Abha K; Goedeke, Leigh; Wang, Peng; Butte, Atul J; Blanpain, Cédric; Chella Krishnan, Karthickeyan; Lusis, Aldons J; Stanley, Sarah A; Yang, Xia; Rajbhandari, Prashant 2023. Mammary duct luminal epithelium controls adipocyte thermogenic programme. Nature, 620 7972, 192-199

Chella Krishnan, Karthickeyan; El Hachem, Elie-Julien; Keller, Mark P; Patel, Sanjeet G; Carroll, Luke; Vegas, Alexis Diaz; Gerdes Gyuricza, Isabela; Light, Christine; Cao, Yang; Pan, Calvin; Kaczor-Urbanowicz, Karolina Elżbieta; Shravah, Varun; Anum, Diana; Pellegrini, Matteo; Lee, Chi Fung; Seldin, Marcus M; Rosenthal, Nadia A; Churchill, Gary A; Attie, Alan D; Parker, Benjamin; James, David E; Lusis, Aldons J 2023. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. eLife, 12 ,

2022

Cao, Yang; Vergnes, Laurent; Wang, Yu-Chen; Pan, Calvin; Chella Krishnan, Karthickeyan; Moore, Timothy M; Rosa-Garrido, Manuel; Kimball, Todd H; Zhou, Zhiqiang; Charugundla, Sarada; Rau, Christoph D; Seldin, Marcus M; Wang, Jessica; Wang, Yibin; Vondriska, Thomas M; Reue, Karen; Lusis, Aldons J 2022. Sex differences in heart mitochondria regulate diastolic dysfunction. Nature communications, 13 1, 3850