Past projects

A list of projects that have used Fernald Community Cohort Data and Biospecimens

Medical Heritage Project

Copeland

Analysis of Laboratory Data

Pesce

Lung Cancer Family Registry

Anderson

Standardized Prevalence Ratio Analysis of Chronic Conditions, and Analysis of Selected Laboratory Tests, in Participants of the Fernald Medical Monitoring Program

Pinney

Develop Yearly and Cumulative Radon Exposure Estimates to Former Fernald Workers, as well as Obtaining Their Smoking History.

Pinney

Kidney Function of Persons with Contaminated Wells

Pinney

Spatial Relationship Between 22 Urinary System Cancers and Likely Sources of Environmental Exposure in the Fernald Exposure Domain.

Pinney

Breast Cancer Risk Factors and Mammogram Findings

Pinney

Birth Weight and Sex Ratio in Offspring of FMMP Participants

Pinney

Comparison of Women Who Do & Do not adhere to Healthcare recommendations

Deets

Develop new Statistical Techniques to Derive Reference Intervals

Horn

Cytogenetic Studies of Participants of the Fernald Medical Monitoring Program

Wones

Computer Modeling of Exposure Plumes and Linkage of Exposure Level Estimates with Geographical Points of Residence. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)

Cho

Patterns and Practices of Using a Cistern as a Drinking Water Source to Develop Exposure Metrics. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)

Fennel

Incident Cancer of the Lung, Female Breast, Prostate, Urinary System and Malignant Melanoma

Pinney

How 3 Age Groups Perceive the Effect the Program has had on the Overall Health and Well-Being of Their Lives and Their Community.

Gerhardstein

Effect of Uranium on DNA Replication

Bissler

Role of Uranium in Mutagenesis of the PDK1 Gene in Autosomal Dominate Polycystic Kidney Disease

Bissler

Fernald Area Cisterns and Wells:What is Known and What Do We Need to Know?

Brown

Incidence of Leukemia and Lymphoma in Participants in the Fernald Medical Monitoring Program. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)

Allard

Predictors of Screening Mammography Outcomes

Mahoney

Characteristics of Patients with Colorectal Cancer Among Participants of Fernald Medical Monitoring Program

Pinney

Perceived Health Status of FMMP Participants Before and One Year Following the Initial Examination.

Wones

Genetic Epidemiology of Lung Cancer Consortium (Genotyping of controls)

Anderson

Effect of Change in Body Weight on Prostatic Specific Antigen Level

Barrett

Head-and-Neck Cancer and Search for Genetic Polymorphisms (genotyping of cases and controls)

Nebert

Cellular Markers of Uranium Stress

Ho

Association Between Serum Bilirubin and Cancer

Zucker

Beta-2-microglobulin and Body Mass Index in Residents Living Near a Uranium Plant in Fernald, Ohio

Pinney

Metabolic Syndrome and Chronic Disease Morbidity and Mortality in the FMMP Population

Chakraborty

Natural History of Obesity without Surgical Intervention

Schauer

In Search of Earlier Diabetic Signs in "Under-Threshold Ranges"

Chung

Methods Study of Breast Density Assessment from Digitalization of Old Mammographic Films and that from FMMP Mammorgaphy Codes

Pinney

Analysis of Urine Albumin and Urinary Beta2 Microglobulin Data

Pesce

The Association of CD 14 levels with the Development of Abdominal Aortic Aneurysm

Blomkalns

The Cancerous Effects of Ingesting Uranium Contaminated Water as a Child

Pinney

Development of children in the Fernald Medical Monitoring Program (FMMP)

Chen

Collection conditions and reference intervals for using Beta-2-microglobulin (B 2M) as a biomarker of renal function

Pesce

Mammographic breast density as a risk factor for Breast Cancer: Environmental and Genetic Determinants

Pinney

Oxidative stress and prostate cancer, a prospective analysis

Wu

Kidney Function and Damage in Fernald Medical Monitoring Program Participants Exposed to Uranium

Succop

The Influence of Perceived Uranium Exposure on Health Perception

Dietrich

Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio River Valley

Pinney

Pre-Existing Maternal Constitutional Factors, The Missing Link Between Adverse Pregnancy Outcomes and Cartiovascular Disease

Habli

Reproductive History Data Analysis

Pinney

Uranium Exposures in a Community near the Fernald, Ohio Weapons Production Facility: Relationship with Hypertension and Hematologic Markers

Burch

Investigation of the association between lifetime sun exposure and benign neoplasms of the bowel and other health concerns

Freedman

Allelic variants and DNA damage response in the Fernald Study Group

Stambrook

A longitudinal analysis of thyroid stimulating hormone levels and weight in the Fernald Medical Monitoring Program (FMMP)

Meinhold

A longitudinal analysis of thyroid stimulating hormone levels and intake of dietary and drinking water nitrate in the Fernald Medical Monitoring Program (FMMP) cohort

Ward

Comparison calculated BMI's and Stunkard Figures of self and parents

Pinney

Spirituality Data

Chakraborty

Assessment of Archived blood specimens for nucleic acid quality and quantity

Walker

Verification of serum sPLA2-lla as a biomarker for lung cancer

Lu

Investigating the Comorbid Medical Illnesses associated with Migraine, Tension type and Other Headached Disorders.

Martin

Outline Various Types of Statistical Analyses That Could be Performed and the Required Resources

Wones

Clinical Study, M-Vu Mammography CAD Algorithm Engine

Pisano

VuComp-M-Vu Clinical Study

Wehnes

Placental latogen in breast cancer

Ben-Jonathan

Autoimmunity and Rheumatologic Disease in Community Residents Near a Uranium Plant at Fernald

Harley

Clinical, Environmental and Genetic Factors related to Variable Response to Oral Anti-Diabetic Medication

Smith

Verification of serum sPLA2-lla as a biomarker for prostate cancer

Lu

OPNc, a marker for cancer progression

Weber

Tobacco Smoke Exposure Health Effects

Smith

Secretory Phospholipase A2-llA Levels in Patients with Newly Diagnosed Breast Cancer

Huth

Mechanism behind multiparity-induced obesity

Woollett

Frequency of Diagnoses in the FMMP Database

Pinney

Hypothyroidism and cancer risk

Martin

Uranium Exposure and Autoimmune Thyroid Disease Near the Fernald Processing Plant

Choi

Autoimmune disease and /or autoimmune-related biomarkers in a cohort occupationally exposed to Libby Amphibole

Lockey

Exposure to Radon and Sunlight and the Riskof Melanoma

Yaghjan

Probing for Endometriosis Associated Serum Diagnostic Markers in the Fernald Community Cohort

Burns

Uranium Exposure and Pregnancy Outcomes in the Fernald cohort

Chen

Adult health effects associated with perfluorooctanoic acid (PFOA) exposure

Fenton

The role of fibrinogen in abdominal aortic aneurysm

Owens

Exposure to BPA and Cardiac electrical alterations in the FMMP population

Wang

Identifying environmental exposures associated with inflammation and breast density using targeted and non-targeted metabolomics

Bessonneau

Incidence and Prevalence of Breast Neoplasm Amoung Women Chronically Exposed to Low-Level Ionizing Radiation

Pinney

Urine biomarkers for urological diseases

Ho

Perfluoroalkyl substance exposure to children living in the Mid-Ohio Valley in 1991-2008, body size and cholesteroal fractions

Pinney

Project Title

Last Name

Does Exposure to Environmental Radiation Affect the Frequency of a Pregnancy Ending in Fetal Loss, Spontaneous Abortion, Still Birth or Ectopic Pregnancy?

Pinney

Archived Biospecimens

~~As of September 30, 2016, we have 159,645 banked biospecimens in six -80 C freezers.
Number of 1.0 ml aliquots (in 1.5 ml polypropylene cyrovial) banked per person at different times and total number of aliquots.
Examination/Year Blood Serum Plasma Urine (unbuffered) Urine (buffered)
Initial exam (mostly 1991-1994) 15 15 15 15 15
Second exam  2 2  
2006 (just those with cancer diagnoses) 3    
2007-2008 exam (urine only on a portion of the cohort) 3 3  3 3
     
Total aliquots remaining in freezer1 (not distributed) 32,990 48,139 36,179 21,017 20,940
1 An additional 380 DNA aliquots are banked in the freezers

Aliquots are stored in six -80 C freezers, with polypropylene boxes stored within metal racks, which improves temperature stability when the freezer is opened. 

1. Copeland BE, Pesce AJ. The Medical Heritage Concept: A Model for Assuring Comparable Laboratory Results in Long-Term Longitudinal Studies. Ann Clin Lab Sci 1992; 22(2):110-124. PMID: 1562165 https://www.ncbi.nlm.nih.gov/pubmed/1562165

2. Wones R, Radack K, Martin V, Mandell K, Pinney S, Buncher R. Do persons living near a uranium processing site have cytogenetic damage? Mutation Research 1995; 335:171-184. PMID: 7477048. http://www.sciencedirect.com/science/article/pii/0165116195900535

3. Radack KL, Pinney SM, Livingston GK. Sources of variability in the human lymphocyte micronucleus assay: A population-based study, Environmental and Molecular Mutagenesis 1995; 26:26-36. PMID: 7641705 https://www.ncbi.nlm.nih.gov/pubmed/7641705

4. Radack K, Martin V, Wones R, Buncher R, Pinney S, Mandell K. Intercorrelations and sources of variability in three mutagenicity assays of somatic mutations: A population-based study. Mutation Research 1996; 350:295-306. PMID: 8600359 http://www.sciencedirect.com/science/article/pii/002751079500162X

5. De BK, Karr BA, Ghosn S, Copeland BE. Problems and Practical Considerations in Assessing Accuracy with NIST SRM 909a; Report of Defective Vials. Clinical Chemistry 1996; 42(11):1832-1837. PMID:8906084 http://clinchem.aaccjnls.org/content/42/11/1832.long

6. Woo JG, Pinney SM. Retrospective Smoking History Data Collection for Deceased Workers: Completeness and Accuracy of Surrogate Reports. JOEM 2002; 44(10):915-923. PMID: 12921382 http://journals.lww.com/joem/pages/articleviewer.aspx?year=2002&issue=10000&article=00010&type=abstract

7. Pinney SM, Freyberg RW, Levine GH, Brannen DE, Mark LS, Nasuta JM, Tebbe CD, Buckholz JM, Wones R. Health Effects in Community Residents Near a Uranium Plant at Fernald, Ohio, USA. International Journal of Occupational Medicine and Environmental Health 2003; 16(2):139-153. PMID: 12921382 https://www.ncbi.nlm.nih.gov/pubmed/?term=Health+Effects+in+Community+Residents+Near+a+Uranium+Plant+at+Fernald%2C+Ohio%2C+USA

8. Bailey-Wilson JE*, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson M. A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics 2004; 75:460-474. Epub 2004 Jul 21.PMID: 15272417 http://www.sciencedirect.com/science/article/pii/S0002929707633175

9. Gerhardstein BG, Brown P. The Benefits of Community Medical Monitoring at Nuclear Weapons Production Sites: Lessons From Fernald. Environmental Law Review News & Analysis 2005; 35:10531-10538. No PMID http://eh.uc.edu/assets/uploads/2015/02/35.10530.pdf

10. Brown MK, Verkamp S, Yocum E, Schrorr C. Fernald Area Cisterns and Wells: What is Known and What Do We Need To Know? The findings of the MTA project are provided in their entirety on CD (publication 2006), in bound Manual (publication 2008) and at the following websites: www.fernalkdfchec.com, www.mtafund.org. http://fernaldfchec.com/Project.html

11. Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Jinna J, Gaba C, Rothchild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson W, You M. Identification of a Novel Tumor Suppressor Gene p34 on Human Chromosome 6q25.1. Cancer Research 2007; 67(1): 93-99. PMID: 17210687 http://cancerres.aacrjournals.org/content/67/1/93.long

12. Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Research 2007; 67(10): 4665-70. PMID: 17510392 http://cancerres.aacrjournals.org/content/67/10/4665.long

13. Hornung RW, Pinney SM, Lodwick J, Killough G, Brewer DE, Nasuta J. Estimation of Radon Exposures to Workers at the Fernald Feed Materials Production Center, 1952-1988. Journal of Exposure Science and Environmental Epidemiology 2008; 18(5):512-523. Epub 2008 Jan 9. PMID: 18183043 http://www.nature.com/jes/journal/v18/n5/full/7500645a.html

14. Liu P, Vikis HG Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Peterson GM, Weist JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee, J, Kupert E, Seminara D, Minna J, Bailey- Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M. Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer. Journal of the National Cancer Institute 2008; 100(18):1326-1330. PMID: 18780872 http://jnci.oxfordjournals.org/content/100/18/1326.long

15. You M*, Wang D*, Liu P*, Vikis H*, James M*, Lu Y, Wang Y, Wang M, Jia D, Liu Y, Yang P, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW . Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clinical Cancer Research 2009; 15(8); 2666-73. Epub 2009 Apr 7. PMID: 19351763 http://clincancerres.aacrjournals.org/content/15/8/2666.long

16. Christiani DC. Lung Cancer Genetics: A Family Affair. Clin Cancer Res 2009; 15(8):2581-2582. PMID: 19351746 http://clincancerres.aacrjournals.org/content/15/8/2581.long

17. Wones R, Pinney SM, Buckholz JM, Deck-Tebbe C, Freyberg R, Pesce A. Medical Monitoring: A Beneficial Remedy for Residents Living Near an Environmental Hazard Site. J Occup Environ Med. 2009; 51:1374–1383. PMID: 19952785 doi: 10.1097/JOM.0b013e3181c558f1 http://journals.lww.com/joem/pages/articleviewer.aspx?year=2009&issue=12000&article=00007&type=abstract

18. Liu Y, Liu P, Wen W, James MA, Wnag Y, Bailey-Wilson JE, Amos CI, PInney SM, Yang P, de Andrade M, Peterson GM, Wiest JS, Pain PR, Schwartz AG, Gazdar A, Gaba C, Pothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M. Haplotype cell proliferation analyses of candidate lung cancer susceptibility genes on chromosomes 15q24-25.1. Cancer Research 2009; 69(19): 7844-7850. PMID: 1978933 http://cancerres.aacrjournals.org/content/69/19/7844.long

19. Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest J, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW. A susceptibility locus on chromosome 6q greatly increases risk lung cancer risk among light and never smokers. Cancer Research 2010; 70(6):2359-2367. Epub 2010 Mar 9. PMID: 20215501 http://cancerres.aacrjournals.org/content/70/6/2359.long

20. Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M. A Second Genetic Variant on Chromosome 15q24-25.1 Associates with Lung Cancer. Cancer Research 2010; 70(8): 3128-35. PMID: 20395203 http://cancerres.aacrjournals.org/content/70/8/3128.long

21. Fang S, Pinney SM, Bailey-Wilson J, de Andrade M, Li Yafang, Kupert E, You M, Schwartz A, Yang P, Anderson M, Amos CI. Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q. Cancer Epidemiol Biomarkers Prev 2010; 19(12):3157-66. Epub 2010 Oct 28. PMID: 21030603 http://cebp.aacrjournals.org/content/19/12/3157.long

22. Wagner SE, Burch JB, Bottai M, Puett R, Porter D, Pinney SM, Vena JE, J.R. Hypertension and hematologic parameters in a community near a uranium processing facility. Environmental Research 2010; 110(8):786-797. PMID: 20889151 http://www.sciencedirect.com/science/article/pii/S0013935110001465

23. Yaghjyan L, Pinney SM, Mahoney MC, Morton AR, Buckholz J, Samaratunga R. Mammographic Breast Density Assessment: A Methods Study. Atlas Journal of Medical & Biological Sciences 2011; 1(1): 8-14. No PMID http://www.atlas-publishing.org/wp-content/uploads/2013/07/2-AJMBS-Yaghiyan_et_al_2011.pdf

24. Kupert E, Anderson M, Liu Y, Succop P, Levin L, Wang J, Wikenheiser-brokamp K, Chen P, Pinney SM, Macdonald T, Dong Z, Starnes S, Lu S. Plasma secretory phospholipase A2-lll as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BCM Cancer 2011; 11:513. PMID: 22151235 https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-513

25. Yaghjyan L, Mahoney MC, Succop P, Wones R, Buckholz J, Pinney SM. Relationship between breast cancer risk factors and mammographic breast density in Fernald Community Cohort. British Journal of Cancer 2012; 106(5): 996-1003. Epub 2012 Jan 26. PMID: 22281662 http://www.nature.com/bjc/journal/v106/n5/full/bjc20121a.html

26. Blomkalns AL, Gavrila D, Thomas M, Nelter BS, Blanco VM, Benjamin SB, McCormick ML, Stoll LL, Denning GM, Collins SP, Qin Z, Daugherty A, Cassis LA, Thompson RW, Weiss RM, Linkower PD, Pinney SM, Chatterjee T, Weintraub NL. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc 2013; 8(2):2. PMID: 23537804 http://jaha.ahajournals.org/content/2/2/e000065.long

27. Lu PY, Kottyan LC, James JA, Xie C, Buckholz JM, Pinney SM, Harley JB. Systemic Lupus Erythematosus is Associated with Uranium Exposure in a Community Living Near a Uranium Processing Plant: A Nested Case-Control Study. Arthritis and Rheumatology 2014; 66(11):3105-3112. PMID: 25103365 http://onlinelibrary.wiley.com/doi/10.1002/art.38786/abstract;jsessionid=ADA04BD338DC7990D56CBD8DB52A513C.f04t04

28. Xiong D, Wang Y, Kupert E, Simpson C, Pinney SM, Gaba CR, Mandal D, Schwartz AG, Yang P, de Andrade M, Pikielny C, Byun J, Li Y, Stambolian D, Spitz MR, Amos CI, Bailey-Wilson JE, Anderson MW, You M. A recurrent mutation in PARK2 in familial lung cancer. Am J Hum Genet 2015; 96(2):301-308. Epub 2015 Jan 29. PMID:25640678 http://www.sciencedirect.com/science/article/pii/S0002929714005229

29. Yang S, Pinney SM, Mallick P, Ho SM, Bracken B, Wu T. Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study. Clin Genitourin Cancer. 2015 Apr 18. pii: S1558-7673(15)00076-2. doi: 10.1016/j.clgc.2015.04.004. [Epub ahead of print]. PMID:25972296. http://www.sciencedirect.com/science/article/pii/S1558767315000762

30. Xie, C., Ghulam, E., Chen, A., Wang, K., Pinney, S., & Lindsell, C. (2015). Weighted Multiple Testing Correction for Correlated Endpoints in Survival Data. In D. Chen, J. Wilson (Eds), Innovative Statistical Methods for Public Health Data (pp315-323) Switzerland: Springer International Publishing. http://link.springer.com/chapter/10.1007/978-3-319-18536-1_14/fulltext.html

31. Pinney SM, Biro FM. Letter to the editor re Morollo-Frosh “Communicating Results in Post-Belmont Era Biomonitoring Studies”. Environ Res. 2015; June 12. [Epub ahead of print]. 26076818. http://www.sciencedirect.com/science/article/pii/S001393511500170X

32. Liu Y, Kheradmand F, Davi CF1, Scheurer ME, Wheeler D, Tsavachidis S, Armstrong G, Simpson C, Mandal D, Kupert E, Anderson M, You M, Xiong D, Pikielny C, Schwartz AG, Bailey-Wilson JE, Gaba C, De Andrade M, Yang P, Pinney SM, The Genetic Epidemiology of Lung Cancer Consortium, Amos CI, Spitz MR. Focused Analysis of Exome Sequencing Data for Rare Mutations in Familial and Sporadic Lung Cancer. In press, Journal of Thoracic Oncology. 2016 Jan;11(1):52-61. doi: 10.1016/j.jtho.2015.09.015. http://www.sciencedirect.com/science/article/pii/S1556086415000246

33. Jorge-Nebert LF, Zhang G, Wilson KM, Jiang Z, Butler R, Gluckman JL, Pinney SM, Nebert DW. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype. Hum Genomics 2016; 10(1): 39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127090/

34. Martin AT, Pinney SM, Xie C, Herrick RL, Bai Y, Buckholz J, Martin VT. Headache Disorders are a Risk Factor for the Development of New Onset Hypothyroidism. Headache 2017; 57:21-30. doi: 10.1111/head.12943. Epub 2016 Sep 27. PMID: 27676320. http://onlinelibrary.wiley.com/doi/10.1111/head.12943/abstract

35. Herrick RL, Buckholz JM, Biro FM, Calafat AM, Ye X, Xie C, Pinney SM. Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012. Environmental Pollution 2017; 228: 50-60. http://www.sciencedirect.com/science/article/pii/S0269749117301264

36. Giannini CM, Herrick RL, Buckholz JM, Daniels AR, Biro FM, Pinney SM. Comprehension and Perceptions of Study Participants Upon Receiving Perfluoroalkyl Substance Exposure Biomarker Results. Submitted to the International Journal of Hygiene and Environmental Health, March 12th, 2018.