Linde A. Miles, PhD

SanMiguel, Jennifer M; Eudy, Elizabeth; Loberg, Matthew A; Miles, Linde A; Stearns, Tim; Mistry, Jayna J; Rauh, Michael J; Levine, Ross L; Trowbridge, Jennifer J 2022. Cell origin-dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy. Blood advances, 6 12, 3666-3677

Hoffmann, H-Heinrich; Schneider, William M; Rozen-Gagnon, Kathryn; Miles, Linde A; Schuster, Felix; Razooky, Brandon; Jacobson, Eliana; Wu, Xianfang; Yi, Soon; Rudin, Charles M; MacDonald, Margaret R; McMullan, Laura K; Poirier, John T; Rice, Charles M 2021. TMEM41B Is a Pan-flavivirus Host Factor. Cell, 184 1, 133-148.e20

Jayawardena, Nadishka; Miles, Linde A; Burga, Laura N; Rudin, Charles; Wolf, Matthias; Poirier, John T; Bostina, Mihnea 2021. N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection. Viruses, 13 5,

Luu, Anh Phuong; Yao, Zhenlan; Ramachandran, Sangeetha; Azzopardi, Stephanie A; Miles, Linde A; Schneider, William M; Hoffmann, H-Heinrich; Bozzacco, Leonia; Garcia, Gustavo; Gong, Danyang; Damoiseaux, Robert; Tang, Hengli; Morizono, Kouki; Rudin, Charles M; Sun, Ren; Arumugaswami, Vaithilingaraja; Poirier, John T; MacDonald, Margaret R; Rice, Charles M; Li, Melody M H 2021. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses, 13 11,

Hoffmann, H-Heinrich; Schneider, William M; Rozen-Gagnon, Kathryn; Miles, Linde A; Schuster, Felix; Razooky, Brandon; Jacobson, Eliana; Wu, Xianfang; Yi, Soon; Rudin, Charles M; MacDonald, Margaret R; McMullan, Laura K; Poirier, John T; Rice, Charles M 2020. TMEM41B is a pan-flavivirus host factor. bioRxiv : the preprint server for biology, ,

Miles, Linde A; Bowman, Robert L; Merlinsky, Tiffany R; Csete, Isabelle S; Ooi, Aik T; Durruthy-Durruthy, Robert; Bowman, Michael; Famulare, Christopher; Patel, Minal A; Mendez, Pedro; Ainali, Chrysanthi; Demaree, Benjamin; Delley, Cyrille L; Abate, Adam R; Manivannan, Manimozhi; Sahu, Sombeet; Goldberg, Aaron D; Bolton, Kelly L; Zehir, Ahmet; Rampal, Raajit; Carroll, Martin P; Meyer, Sara E; Viny, Aaron D; Levine, Ross L 2020. Single-cell mutation analysis of clonal evolution in myeloid malignancies. Nature, 587 7834, 477-482

Xiao, Wenbin; Miles, Linde A; Bowman, Robert L; Durani, Vidushi; Tian, Helen S; DelGaudio, Nicole L; Mishra, Tanmay; Zhu, Menglei; Zhang, Yanming; Stump, Sarah E; Tallman, Martin S; Levine, Ross L; Cai, Sheng F 2020. A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN. Blood advances, 4 23, 6034-6038

Loberg, Matthew A; Bell, Rebecca K; Goodwin, Leslie O; Eudy, Elizabeth; Miles, Linde A; SanMiguel, Jennifer M; Young, Kira; Bergstrom, David E; Levine, Ross L; Schneider, Rebekka K; Trowbridge, Jennifer J 2019. Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis. Leukemia, 33 7, 1635-1649

Gardner, Eric E; Lok, Benjamin H; Schneeberger, Valentina E; Desmeules, Patrice; Miles, Linde A; Arnold, Paige K; Ni, Andy; Khodos, Inna; de Stanchina, Elisa; Nguyen, Thuyen; Sage, Julien; Campbell, John E; Ribich, Scott; Rekhtman, Natasha; Dowlati, Afshin; Massion, Pierre P; Rudin, Charles M; Poirier, John T 2017. Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis. Cancer cell, 31 2, 286-299

Miles, Linde A; Burga, Laura N; Gardner, Eric E; Bostina, Mihnea; Poirier, John T; Rudin, Charles M 2017. Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. The Journal of clinical investigation, 127 8, 2957-2967

Yao, Zhan; Yaeger, Rona; Rodrik-Outmezguine, Vanessa S; Tao, Anthony; Torres, Neilawattie M; Chang, Matthew T; Drosten, Matthias; Zhao, Huiyong; Cecchi, Fabiola; Hembrough, Todd; Michels, Judith; Baumert, Hervé; Miles, Linde; Campbell, Naomi M; de Stanchina, Elisa; Solit, David B; Barbacid, Mariano; Taylor, Barry S; Rosen, Neal 2017. Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Nature, 548 7666, 234-238

Miles, Linde A; Garippa, Ralph J; Poirier, John T 2016. Design, execution, and analysis of pooled in vitro CRISPR/Cas9 screens. The FEBS journal, 283 17, 3170-80

Weiskopf, Kipp; Jahchan, Nadine S; Schnorr, Peter J; Cristea, Sandra; Ring, Aaron M; Maute, Roy L; Volkmer, Anne K; Volkmer, Jens-Peter; Liu, Jie; Lim, Jing Shan; Yang, Dian; Seitz, Garrett; Nguyen, Thuyen; Wu, Di; Jude, Kevin; Guerston, Heather; Barkal, Amira; Trapani, Francesca; George, Julie; Poirier, John T; Gardner, Eric E; Miles, Linde A; de Stanchina, Elisa; Lofgren, Shane M; Vogel, Hannes; Winslow, Monte M; Dive, Caroline; Thomas, Roman K; Rudin, Charles M; van de Rijn, Matt; Majeti, Ravindra; Garcia, K Christopher; Weissman, Irving L; Sage, Julien 2016. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of clinical investigation, 126 7, 2610-20

Miles, Linde A; Brennen, W Nathaniel; Rudin, Charles M; Poirier, John T 2015. Correction: Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for use in Peptide-Prodrug Therapy. PloS one, 10 8, e0136480

Miles, Linde A; Brennen, W Nathaniel; Rudin, Charles M; Poirier, John T 2015. Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy. PloS one, 10 6, e0129103

Matthews, Megan L; Chang, Wei-chen; Layne, Andrew P; Miles, Linde A; Krebs, Carsten; Bollinger, J Martin 2014. Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Nature chemical biology, 10 3, 209-15

Matthews, Megan L; Neumann, Christopher S; Miles, Linde A; Grove, Tyler L; Booker, Squire J; Krebs, Carsten; Walsh, Christopher T; Bollinger, J Martin 2009. Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Proceedings of the National Academy of Sciences of the United States of America, 106 42, 17723-8