Publications

• KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy
  Ioannis D Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J Koch, Ira J Goldberg, Vincent W Yang, Agnieszka B Bialkowska, Georgios Kararigas, Konstantinos Drosatos. ​Circ Res 2021 Feb 5;128(3):335-357
  
• B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension.
  Hoffman M, Kyriazis ID, Dimitriou A, Mishra SK, Koch WJ, Drosatos K. JCI Insight. 2020 Apr 23;5(8)
• Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.
  Hoffman M, Kyriazis ID, Lucchese AM, de Lucia C, Piedepalumbo M, Bauer M, Schulze PC, Bonios MJ, Koch WJ, Drosatos K.  J Am Heart Assoc. 2019 May 21;8(10):e012260
• Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM,
  Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K.  J Mol Cell Cardiol. 2019 Feb;127:232-245.
  
• Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM,
  Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K.  J Mol Cell Cardiol. 2019 Feb;127:232-245.
  
• Circulation Research. 2016 Jan 22;118(2):241-53
  Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.
  Drosatos K, Pollak NM, Pol CJ, Ntziachristos P, Willecke F, Valenti MC, Trent CM, Hu Y, Guo S, Aifantis I, Goldberg IJ
  Our study was selected for the Editorial
  The Relationship Between KLF5 and PPARα in the Heart: It’s Complicated
• PPARs: Protectors or Opponents of Myocardial Function?
  Pol CJ, Lieu M, Drosatos K.
  PPAR Res. 2015;2015:835985
• Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?
  Drosatos K, Lymperopoulos A, Kennel PJ, Pollak N, Schulze PC, Goldberg IJ.
  Curr Heart Fail Rep. 2015 Apr;12(2):130-40. d
  
• Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity.
  Bosma M, Dapito DH, Drosatos-Tampakaki Z, Huiping-Son N, Huang LS, Kersten S, Drosatos K, Goldberg IJ.
  Biochim Biophys Acta. 2014 Dec;1841(12):1648-55
• Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice
  Drosatos K, Khan RS, Trent CM, Jiang H, Son NH, Blaner WS, Homma S, Schulze PC, Goldberg IJ
  Circ Heart Fail. 2013, May;6(3):550-62
• Palmitic Acid and DGAT1 Deficiency Enhance Osteoclastogenesis while Oleic Acid-Induced Triglyceride Formation Prevents it.
  Drosatos-Tampakaki Z, Drosatos K, Siegelin Y, Gong S, Khan S, Van Dyke T, Goldberg IJ, Schulze PC, Schulze-Späte U.  
  J Bone Miner Res. 2013 Nov 23
• Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biologyGarcia-Arcos I, Hiyama Y, Drosatos K, Bharadwaj KG, Hu Y, Son NH, O'Byrne SM, Chang CL, Deckelbaum RJ, Takahashi M, Westerterp M, Obunike JC, Jiang H, Yagyu H, Blaner WS, Goldberg IJJ Biol Chem. 2013 May 17;288(20):14046-58

• Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy
  ​Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang, Thomas D Bannister, Agnieszka B Bialkowska, Craig H Selzman, Stavros G Drakos, Konstantinos Drosatos  
  Circulation. 2021 Mar 16;143(11):1139-1156
• Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
  Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. JCI Insight. 2019
• Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.
  Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 26. pii:S0925-4439(19)30121-8
• Krüppel-like factors: Crippling and un-crippling metabolic pathways.
  ​Pollak NM, Hoffman M, Goldberg IJ, Drosatos K
  JACC Basic Transl Sci. 2018 Feb;3(1):132-156
• Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function. Joseph LC, Kokkinaki D, Valenti MC, Kim GJ, Barca E, Tomar D, Hoffman NE, Subramanyam P, Colecraft HM, Hirano M, Ratner AJ, Madesh M, Drosatos K, Morrow JP. 
  JCI Insight. 2017 Sep 7;2(17)
• Editorial
  Savings precede spending: fatty acid utilization relies on triglyceride formation for cardiac energetics.
  Drosatos K, Schulze PC.
  Circulation. 2014 Nov 11;130(20):1775-7
• Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. 
  Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, Kato T, Khan R, Takayama H, Knöll R, Milting H, Chung CS, Jorde U, Naka Y, Mancini DM, Goldberg IJ, Schulze PC. 
  Circulation. 2012 Jun 12;125(23):2844-53
  
• Cardiac lipotoxicity: molecular pathways and therapeutic implications
  Drosatos K, Schulze PC. 
  Curr Heart Fail Rep. 2013 Jun;10(2):109-21
• Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction
  Drosatos K, Drosatos-Tampakaki Z, Khan R, Homma S, Schulze PC, Zannis VI, Goldberg IJ. J Biol Chem. 2011 Oct 21;286(42):36331-9
  
• MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
  Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI. 
  J Lipid Res. 2010 Jun;51(6):1513-23
  Selected for the cover of the journal
  
• Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activationDrosatos K, Bharadwaj KG, Lymperopoulos A, Ikeda S, Khan R, Hu Y, Agarwal R, Yu S, Jiang H, Steinberg SF, Blaner WS, Koch WJ, Goldberg IJ.Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E489-99Editor's choices