Contact Information Office 513-558-3898 Email jaeschaa@ucmail.uc.edu Research Interests The overall aim of Dr. Jaeschke's laboratory is to investigate the role of stress-activated protein kinases in metabolic signal transduction. Metabolic syndrome, which is associated with obesity, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD), is a major health problem world-wide. The cJun-NH2-stress-activated kinase (JNK) pathway is emerging as important player in the development of obesity-induced insulin resistance and NAFLD. ... Peer Reviewed Publications Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja 2014. Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells. Arteriosclerosis, thrombosis, and vascular biology, 34 7, 1429-36Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Ibrahim, Samar H; Gores, Gregory J; Hirsova, Petra; Kirby, Michelle; Miles, Lili; Jaeschke, Anja; Kohli, Rohit 2013. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver international : official journal of the International Association for the Study of the Liver, , Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2012. Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. The Journal of biological chemistry, 287 33, 27876-84Rebholz, Sandra L; Jones, Thomas; Burke, Katie T; Jaeschke, Anja; Tso, Patrick; D'Alessio, David A; Woollett, Laura A 2012. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. American journal of physiology. Endocrinology and metabolism, 302 4, E449-57Sharma, Manju; Gadang, Vidya; Jaeschke, Anja 2012. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Molecular pharmacology, 82 5, 1001-7Sharma, Manju; Urano, Fumihiko; Jaeschke, Anja 2012. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. Journal of hepatology, 56 1, 192-8Lu, Jing; Borthwick, Faye; Hassanali, Zahra; Wang, Ye; Mangat, Rabban; Ruth, Megan; Shi, Danni; Jaeschke, Anja; Russell, James C; Field, Catherine J; Proctor, Spencer D; Vine, Donna F 2011. Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA- cp rat model of the metabolic syndrome The British journal of nutrition, , 1-11Jaeschke, Anja; Davis, Roger J 2007. Metabolic stress signaling mediated by mixed-lineage kinases Molecular cell, 27 3, 498-508Hübner, Anette; Jaeschke, Anja; Davis, Roger J 2006. Oncogene addiction: role of signal attenuation Developmental cell, 11 6, 752-4Jaeschke, Anja; Davis, Roger J 2006. Chemical genetic analysis of signal transduction pathways Expert opinion on therapeutic targets, 10 4, 485-8Jaeschke, Anja; Karasarides, Maria; Ventura, Juan-Jose; Ehrhardt, Anka; Zhang, Chao; Flavell, Richard A; Shokat, Kevan M; Davis, Roger J 2006. JNK2 is a positive regulator of the cJun transcription factor Molecular cell, 23 6, 899-911Brancho, Deborah; Ventura, Juan-Jose; Jaeschke, Anja; Doran, Beth; Flavell, Richard A; Davis, Roger J 2005. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades Molecular and cellular biology, 25 9, 3670-81Jaeschke, Anja; Rincón, Mercedes; Doran, Beth; Reilly, Judith; Neuberg, Donna; Greiner, Dale L; Shultz, Leonard D; Rossini, Aldo A; Flavell, Richard A; Davis, Roger J 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes Proceedings of the National Academy of Sciences of the United States of America, 102 19, 6931-5Jaeschke, Anja; Czech, Michael P; Davis, Roger J 2004. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue Genes & development, 18 16, 1976-80Brancho, Deborah; Tanaka, Nobuyuki; Jaeschke, Anja; Ventura, Juan-Jose; Kelkar, Nyaya; Tanaka, Yoshinori; Kyuuma, Masanao; Takeshita, Toshikazu; Flavell, Richard A; Davis, Roger J 2003. Mechanism of p38 MAP kinase activation in vivo Genes & development, 17 16, 1969-78Jaeschke, Anja; Hartkamp, Joerg; Saitoh, Masao; Roworth, Wendy; Nobukuni, Takahiro; Hodges, Angela; Sampson, Julian; Thomas, George; Lamb, Richard 2002. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent The Journal of cell biology, 159 2, 217-24
Research Interests The overall aim of Dr. Jaeschke's laboratory is to investigate the role of stress-activated protein kinases in metabolic signal transduction. Metabolic syndrome, which is associated with obesity, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD), is a major health problem world-wide. The cJun-NH2-stress-activated kinase (JNK) pathway is emerging as important player in the development of obesity-induced insulin resistance and NAFLD. ...
Peer Reviewed Publications Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja 2014. Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells. Arteriosclerosis, thrombosis, and vascular biology, 34 7, 1429-36Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Ibrahim, Samar H; Gores, Gregory J; Hirsova, Petra; Kirby, Michelle; Miles, Lili; Jaeschke, Anja; Kohli, Rohit 2013. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver international : official journal of the International Association for the Study of the Liver, , Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2012. Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. The Journal of biological chemistry, 287 33, 27876-84Rebholz, Sandra L; Jones, Thomas; Burke, Katie T; Jaeschke, Anja; Tso, Patrick; D'Alessio, David A; Woollett, Laura A 2012. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. American journal of physiology. Endocrinology and metabolism, 302 4, E449-57Sharma, Manju; Gadang, Vidya; Jaeschke, Anja 2012. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Molecular pharmacology, 82 5, 1001-7Sharma, Manju; Urano, Fumihiko; Jaeschke, Anja 2012. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. Journal of hepatology, 56 1, 192-8Lu, Jing; Borthwick, Faye; Hassanali, Zahra; Wang, Ye; Mangat, Rabban; Ruth, Megan; Shi, Danni; Jaeschke, Anja; Russell, James C; Field, Catherine J; Proctor, Spencer D; Vine, Donna F 2011. Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA- cp rat model of the metabolic syndrome The British journal of nutrition, , 1-11Jaeschke, Anja; Davis, Roger J 2007. Metabolic stress signaling mediated by mixed-lineage kinases Molecular cell, 27 3, 498-508Hübner, Anette; Jaeschke, Anja; Davis, Roger J 2006. Oncogene addiction: role of signal attenuation Developmental cell, 11 6, 752-4Jaeschke, Anja; Davis, Roger J 2006. Chemical genetic analysis of signal transduction pathways Expert opinion on therapeutic targets, 10 4, 485-8Jaeschke, Anja; Karasarides, Maria; Ventura, Juan-Jose; Ehrhardt, Anka; Zhang, Chao; Flavell, Richard A; Shokat, Kevan M; Davis, Roger J 2006. JNK2 is a positive regulator of the cJun transcription factor Molecular cell, 23 6, 899-911Brancho, Deborah; Ventura, Juan-Jose; Jaeschke, Anja; Doran, Beth; Flavell, Richard A; Davis, Roger J 2005. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades Molecular and cellular biology, 25 9, 3670-81Jaeschke, Anja; Rincón, Mercedes; Doran, Beth; Reilly, Judith; Neuberg, Donna; Greiner, Dale L; Shultz, Leonard D; Rossini, Aldo A; Flavell, Richard A; Davis, Roger J 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes Proceedings of the National Academy of Sciences of the United States of America, 102 19, 6931-5Jaeschke, Anja; Czech, Michael P; Davis, Roger J 2004. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue Genes & development, 18 16, 1976-80Brancho, Deborah; Tanaka, Nobuyuki; Jaeschke, Anja; Ventura, Juan-Jose; Kelkar, Nyaya; Tanaka, Yoshinori; Kyuuma, Masanao; Takeshita, Toshikazu; Flavell, Richard A; Davis, Roger J 2003. Mechanism of p38 MAP kinase activation in vivo Genes & development, 17 16, 1969-78Jaeschke, Anja; Hartkamp, Joerg; Saitoh, Masao; Roworth, Wendy; Nobukuni, Takahiro; Hodges, Angela; Sampson, Julian; Thomas, George; Lamb, Richard 2002. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent The Journal of cell biology, 159 2, 217-24
Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja 2014. Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells. Arteriosclerosis, thrombosis, and vascular biology, 34 7, 1429-36Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Ibrahim, Samar H; Gores, Gregory J; Hirsova, Petra; Kirby, Michelle; Miles, Lili; Jaeschke, Anja; Kohli, Rohit 2013. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver international : official journal of the International Association for the Study of the Liver, , Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2012. Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. The Journal of biological chemistry, 287 33, 27876-84Rebholz, Sandra L; Jones, Thomas; Burke, Katie T; Jaeschke, Anja; Tso, Patrick; D'Alessio, David A; Woollett, Laura A 2012. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. American journal of physiology. Endocrinology and metabolism, 302 4, E449-57Sharma, Manju; Gadang, Vidya; Jaeschke, Anja 2012. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Molecular pharmacology, 82 5, 1001-7Sharma, Manju; Urano, Fumihiko; Jaeschke, Anja 2012. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. Journal of hepatology, 56 1, 192-8Lu, Jing; Borthwick, Faye; Hassanali, Zahra; Wang, Ye; Mangat, Rabban; Ruth, Megan; Shi, Danni; Jaeschke, Anja; Russell, James C; Field, Catherine J; Proctor, Spencer D; Vine, Donna F 2011. Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA- cp rat model of the metabolic syndrome The British journal of nutrition, , 1-11Jaeschke, Anja; Davis, Roger J 2007. Metabolic stress signaling mediated by mixed-lineage kinases Molecular cell, 27 3, 498-508Hübner, Anette; Jaeschke, Anja; Davis, Roger J 2006. Oncogene addiction: role of signal attenuation Developmental cell, 11 6, 752-4Jaeschke, Anja; Davis, Roger J 2006. Chemical genetic analysis of signal transduction pathways Expert opinion on therapeutic targets, 10 4, 485-8Jaeschke, Anja; Karasarides, Maria; Ventura, Juan-Jose; Ehrhardt, Anka; Zhang, Chao; Flavell, Richard A; Shokat, Kevan M; Davis, Roger J 2006. JNK2 is a positive regulator of the cJun transcription factor Molecular cell, 23 6, 899-911Brancho, Deborah; Ventura, Juan-Jose; Jaeschke, Anja; Doran, Beth; Flavell, Richard A; Davis, Roger J 2005. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades Molecular and cellular biology, 25 9, 3670-81Jaeschke, Anja; Rincón, Mercedes; Doran, Beth; Reilly, Judith; Neuberg, Donna; Greiner, Dale L; Shultz, Leonard D; Rossini, Aldo A; Flavell, Richard A; Davis, Roger J 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes Proceedings of the National Academy of Sciences of the United States of America, 102 19, 6931-5Jaeschke, Anja; Czech, Michael P; Davis, Roger J 2004. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue Genes & development, 18 16, 1976-80Brancho, Deborah; Tanaka, Nobuyuki; Jaeschke, Anja; Ventura, Juan-Jose; Kelkar, Nyaya; Tanaka, Yoshinori; Kyuuma, Masanao; Takeshita, Toshikazu; Flavell, Richard A; Davis, Roger J 2003. Mechanism of p38 MAP kinase activation in vivo Genes & development, 17 16, 1969-78Jaeschke, Anja; Hartkamp, Joerg; Saitoh, Masao; Roworth, Wendy; Nobukuni, Takahiro; Hodges, Angela; Sampson, Julian; Thomas, George; Lamb, Richard 2002. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent The Journal of cell biology, 159 2, 217-24