Education/CredentialsDoctoral Degree: Kanazawa University (Physiology)Master Degree: China Medical University (Pharmacology)Bachelor's Degree: China Medical University (Medicine) Contact Information Vontz Center 2318 Office 513-558-0490 Email duwa@ucmail.uc.edu Research InterestsThe main focuses of my research are 1) endothelial cell and immune cell communication in the tumor microenvironment; 2) the protective role of endothelial TFEB in chemotherapy; and 3) endothelial dysfunction in cardiovascular disease. Peer Reviewed Publications Xiaohong Wang, Wa Du, Yutian Li, Hui-Hui Yang, Yu Zhang, Rubab Akbar, Hannah Morgan, Tianqing Peng, Jing Chen, Sakthivel Sadayappan, Yueh-Chiang Hu, Yanbo Fan, Wei Huang, and Guo-Chang Fan 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury JCI Insights, 9 5, Hongyan Zhao, Peng Wang, Xiaohong Wang, Wa Du, Hui-Hui Yang, Yueying Liu, Shu-Nan Cui, Wei Huang, Tianqing Peng, Jing Chen, Chen Gao, Yigang Wang, Sakthivel Sadayappan, Chengen Ma, Yanbo Fan, Chunting Wang, Guo-Chang Fan 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway Cardiovascular Research, 119 10, 1981Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi, H Daniel Lacorazza 2022. Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia Stem Cells, 40 8, 736Lu Ren, Wa Du, Dan Song, Haocheng Lu, Milton H Hamblin, Chenran Wang, Chunying Du, Guo-Chang Fan, Richard C Becker, Yanbo Fan 2022. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice iScience, 26 1, 105769Shi, Zhongcheng; Mori-Akiyama, Yuko; Du, Wa; Fultz, Robert; Zhao, Yanling; Ruan, Wenly; Venable, Susan; Engevik, Melinda A; Versalovic, James 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice. Cellular and molecular gastroenterology and hepatology, 13 3, 717-737Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A Engevik, James Versalovic 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice Cellular and Molecular Gastroenterology and Hepatology, 13 3, 717Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2, Haocheng Lu, Wa Du, Lu Ren, Milton H Hamblin, Richard C Becker, Y Eugene Chen, Yanbo Fan 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms Journal of the American Heart Association, 10 24, e023601Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, 10 24, e023601Taylor J Chen, Wa Du, Jacob J Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R Rabin, H Daniel Lacorazza 2021. Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Oncotarget, 12 18, 1787Wa Du, Lu Ren, Milton H Hamblin, Yanbo Fan 2021. Endothelial Cell Glucose Metabolism and Angiogenesis Biomedicines, 9 2, 147Thuy L Phung, Wa Du, Qi Xue, Sriram Ayyaswamy, Damien Gerald, Zeus Antonello, Sokha Nhek, Carole A Perruzzi, Isabel Acevedo, Rajesh Ramanna-Valmiki, Paul Rodriguez-Waitkus, Ladan Enayati, Marcelo L Hochman, Dina Lev, Sandaruwan Geeganage, Laura E Benjamin 2015. Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth Cancer Research, 75 1, 40Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa 2013. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice Journal of Allergy and Clinical Immunology, 132 5, 1205Wa Du, Damien Gerald, Carole A Perruzzi, Paul Rodriguez-Waitkus, Ladan Enayati, Bhuvaneswari Krishnan, Joseph Edmonds, Marcelo L Hochman, Dina C Lev, Thuy L Phung 2013. Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin Lab Investigation, 93 10, 1115Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa 2012. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function Nature Medicine, 18 10, 1560Noriko Takuwa, Wa Du, Erika Kaneko, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa 2011. Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde American Journal of Cancer Research, 1 4, 460Noriko Takuwa, Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Tamotsu Tanaka, Kaoru Hirano, Soichiro Usui, Fei Wang, Wa Du, Kazuaki Yoshioka, Yoshiko Banno, Motoko Sasaki, Ikuyo Ichi, Miwa Okamura, Naotoshi Sugimoto, Kiyomi Mizugishi, Yasuni Nakanuma, Isao Ishii, Masayuki Takamura, Shuichi Kaneko, Shosuke Kojo, Kiyoshi Satouchi, Kunitoshi Mitumori, Jerold Chun, Yoh Takuwa 2010. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovascular Research, 85 3, 484Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Koichi Gonda, Kazushi Sugihara, Akiyoshi Fukamizu, Masahide Asano, Yoh Takuwa 2010. S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice Cancer Research, 70 2, 772Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa 2010. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice European Journal of Pharmacology, 634 1-3, 121Yoh Takuwa, Wa Du, Xun Qi, Yasuo Okamoto, Noriko Takuwa, Kazuaki Yoshioka 2010. Roles of sphingosine-1-phosphate signaling in angiogenesis World Journal of Biological Chemistry, 1 10, 298
Research InterestsThe main focuses of my research are 1) endothelial cell and immune cell communication in the tumor microenvironment; 2) the protective role of endothelial TFEB in chemotherapy; and 3) endothelial dysfunction in cardiovascular disease.
Peer Reviewed Publications Xiaohong Wang, Wa Du, Yutian Li, Hui-Hui Yang, Yu Zhang, Rubab Akbar, Hannah Morgan, Tianqing Peng, Jing Chen, Sakthivel Sadayappan, Yueh-Chiang Hu, Yanbo Fan, Wei Huang, and Guo-Chang Fan 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury JCI Insights, 9 5, Hongyan Zhao, Peng Wang, Xiaohong Wang, Wa Du, Hui-Hui Yang, Yueying Liu, Shu-Nan Cui, Wei Huang, Tianqing Peng, Jing Chen, Chen Gao, Yigang Wang, Sakthivel Sadayappan, Chengen Ma, Yanbo Fan, Chunting Wang, Guo-Chang Fan 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway Cardiovascular Research, 119 10, 1981Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi, H Daniel Lacorazza 2022. Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia Stem Cells, 40 8, 736Lu Ren, Wa Du, Dan Song, Haocheng Lu, Milton H Hamblin, Chenran Wang, Chunying Du, Guo-Chang Fan, Richard C Becker, Yanbo Fan 2022. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice iScience, 26 1, 105769Shi, Zhongcheng; Mori-Akiyama, Yuko; Du, Wa; Fultz, Robert; Zhao, Yanling; Ruan, Wenly; Venable, Susan; Engevik, Melinda A; Versalovic, James 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice. Cellular and molecular gastroenterology and hepatology, 13 3, 717-737Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A Engevik, James Versalovic 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice Cellular and Molecular Gastroenterology and Hepatology, 13 3, 717Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2, Haocheng Lu, Wa Du, Lu Ren, Milton H Hamblin, Richard C Becker, Y Eugene Chen, Yanbo Fan 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms Journal of the American Heart Association, 10 24, e023601Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, 10 24, e023601Taylor J Chen, Wa Du, Jacob J Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R Rabin, H Daniel Lacorazza 2021. Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Oncotarget, 12 18, 1787Wa Du, Lu Ren, Milton H Hamblin, Yanbo Fan 2021. Endothelial Cell Glucose Metabolism and Angiogenesis Biomedicines, 9 2, 147Thuy L Phung, Wa Du, Qi Xue, Sriram Ayyaswamy, Damien Gerald, Zeus Antonello, Sokha Nhek, Carole A Perruzzi, Isabel Acevedo, Rajesh Ramanna-Valmiki, Paul Rodriguez-Waitkus, Ladan Enayati, Marcelo L Hochman, Dina Lev, Sandaruwan Geeganage, Laura E Benjamin 2015. Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth Cancer Research, 75 1, 40Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa 2013. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice Journal of Allergy and Clinical Immunology, 132 5, 1205Wa Du, Damien Gerald, Carole A Perruzzi, Paul Rodriguez-Waitkus, Ladan Enayati, Bhuvaneswari Krishnan, Joseph Edmonds, Marcelo L Hochman, Dina C Lev, Thuy L Phung 2013. Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin Lab Investigation, 93 10, 1115Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa 2012. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function Nature Medicine, 18 10, 1560Noriko Takuwa, Wa Du, Erika Kaneko, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa 2011. Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde American Journal of Cancer Research, 1 4, 460Noriko Takuwa, Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Tamotsu Tanaka, Kaoru Hirano, Soichiro Usui, Fei Wang, Wa Du, Kazuaki Yoshioka, Yoshiko Banno, Motoko Sasaki, Ikuyo Ichi, Miwa Okamura, Naotoshi Sugimoto, Kiyomi Mizugishi, Yasuni Nakanuma, Isao Ishii, Masayuki Takamura, Shuichi Kaneko, Shosuke Kojo, Kiyoshi Satouchi, Kunitoshi Mitumori, Jerold Chun, Yoh Takuwa 2010. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovascular Research, 85 3, 484Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Koichi Gonda, Kazushi Sugihara, Akiyoshi Fukamizu, Masahide Asano, Yoh Takuwa 2010. S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice Cancer Research, 70 2, 772Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa 2010. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice European Journal of Pharmacology, 634 1-3, 121Yoh Takuwa, Wa Du, Xun Qi, Yasuo Okamoto, Noriko Takuwa, Kazuaki Yoshioka 2010. Roles of sphingosine-1-phosphate signaling in angiogenesis World Journal of Biological Chemistry, 1 10, 298
Xiaohong Wang, Wa Du, Yutian Li, Hui-Hui Yang, Yu Zhang, Rubab Akbar, Hannah Morgan, Tianqing Peng, Jing Chen, Sakthivel Sadayappan, Yueh-Chiang Hu, Yanbo Fan, Wei Huang, and Guo-Chang Fan 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury JCI Insights, 9 5, Hongyan Zhao, Peng Wang, Xiaohong Wang, Wa Du, Hui-Hui Yang, Yueying Liu, Shu-Nan Cui, Wei Huang, Tianqing Peng, Jing Chen, Chen Gao, Yigang Wang, Sakthivel Sadayappan, Chengen Ma, Yanbo Fan, Chunting Wang, Guo-Chang Fan 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway Cardiovascular Research, 119 10, 1981Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi, H Daniel Lacorazza 2022. Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia Stem Cells, 40 8, 736Lu Ren, Wa Du, Dan Song, Haocheng Lu, Milton H Hamblin, Chenran Wang, Chunying Du, Guo-Chang Fan, Richard C Becker, Yanbo Fan 2022. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice iScience, 26 1, 105769Shi, Zhongcheng; Mori-Akiyama, Yuko; Du, Wa; Fultz, Robert; Zhao, Yanling; Ruan, Wenly; Venable, Susan; Engevik, Melinda A; Versalovic, James 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice. Cellular and molecular gastroenterology and hepatology, 13 3, 717-737Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A Engevik, James Versalovic 2022. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice Cellular and Molecular Gastroenterology and Hepatology, 13 3, 717Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2, Haocheng Lu, Wa Du, Lu Ren, Milton H Hamblin, Richard C Becker, Y Eugene Chen, Yanbo Fan 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms Journal of the American Heart Association, 10 24, e023601Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, 10 24, e023601Taylor J Chen, Wa Du, Jacob J Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R Rabin, H Daniel Lacorazza 2021. Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Oncotarget, 12 18, 1787Wa Du, Lu Ren, Milton H Hamblin, Yanbo Fan 2021. Endothelial Cell Glucose Metabolism and Angiogenesis Biomedicines, 9 2, 147Thuy L Phung, Wa Du, Qi Xue, Sriram Ayyaswamy, Damien Gerald, Zeus Antonello, Sokha Nhek, Carole A Perruzzi, Isabel Acevedo, Rajesh Ramanna-Valmiki, Paul Rodriguez-Waitkus, Ladan Enayati, Marcelo L Hochman, Dina Lev, Sandaruwan Geeganage, Laura E Benjamin 2015. Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth Cancer Research, 75 1, 40Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa 2013. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice Journal of Allergy and Clinical Immunology, 132 5, 1205Wa Du, Damien Gerald, Carole A Perruzzi, Paul Rodriguez-Waitkus, Ladan Enayati, Bhuvaneswari Krishnan, Joseph Edmonds, Marcelo L Hochman, Dina C Lev, Thuy L Phung 2013. Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin Lab Investigation, 93 10, 1115Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa 2012. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function Nature Medicine, 18 10, 1560Noriko Takuwa, Wa Du, Erika Kaneko, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa 2011. Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde American Journal of Cancer Research, 1 4, 460Noriko Takuwa, Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Tamotsu Tanaka, Kaoru Hirano, Soichiro Usui, Fei Wang, Wa Du, Kazuaki Yoshioka, Yoshiko Banno, Motoko Sasaki, Ikuyo Ichi, Miwa Okamura, Naotoshi Sugimoto, Kiyomi Mizugishi, Yasuni Nakanuma, Isao Ishii, Masayuki Takamura, Shuichi Kaneko, Shosuke Kojo, Kiyoshi Satouchi, Kunitoshi Mitumori, Jerold Chun, Yoh Takuwa 2010. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovascular Research, 85 3, 484Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Koichi Gonda, Kazushi Sugihara, Akiyoshi Fukamizu, Masahide Asano, Yoh Takuwa 2010. S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice Cancer Research, 70 2, 772Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa 2010. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice European Journal of Pharmacology, 634 1-3, 121Yoh Takuwa, Wa Du, Xun Qi, Yasuo Okamoto, Noriko Takuwa, Kazuaki Yoshioka 2010. Roles of sphingosine-1-phosphate signaling in angiogenesis World Journal of Biological Chemistry, 1 10, 298