Contact Information Childrens Hospital Bldg R 2325 Office 513-636-9469 Email ratnern@ucmail.uc.edu Research InterestsNeurofibromatosis type 1, NF-1, is a common inherited disease of humans. Patients with NF-1develop a variety of symptoms, the most common of which are peripheral nerve tumors made up largely of Schwann cells, fibroblasts, and extracellular matrix. Neurofibromas develop sporadically in NF-1 patients, suggesting that mutations in the NF-1 gene cause only a predisposition to formation of tumors, which are then triggered by additional, or ''secondary'' genetic or epigenetic events. We have defined cellul... Peer Reviewed Publications Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2018. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget, 9 22, 15860-15875Fisher, Michael J; Belzberg, Allan J; de Blank, Peter; De Raedt, Thomas; Elefteriou, Florent; Ferner, Rosalie E; Giovannini, Marco; Harris, Gordon J; Kalamarides, Michel; Karajannis, Matthias A; Kim, AeRang; Lázaro, Conxi; Le, Lu Q; Li, Wei; Listernick, Robert; Martin, Staci; Morrison, Helen; Pasmant, Eric; Ratner, Nancy; Schorry, Elisabeth; Ullrich, Nicole J; Viskochil, David; Weiss, Brian; Widemann, Brigitte C; Zhu, Yuan; Bakker, Annette; Serra, Eduard 2018. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. American journal of medical genetics. Part A, 176 5, 1258-1269Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy 2017. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports, 7 , 43315Currier, Mark A; Sprague, Les; Rizvi, Tilat A; Nartker, Brooke; Chen, Chun-Yu; Wang, Pin-Yi; Hutzen, Brian J; Franczek, Meghan R; Patel, Ami V; Chaney, Katherine E; Streby, Keri A; Ecsedy, Jeffrey A; Conner, Joe; Ratner, Nancy; Cripe, Timothy P 2017. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation. Oncotarget, 8 11, 17412-17427Haworth, Kellie B; Arnold, Michael A; Pierson, Christopher R; Choi, Kwangmin; Yeager, Nicholas D; Ratner, Nancy; Roberts, Ryan D; Finlay, Jonathan L; Cripe, Timothy P 2017. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy. Oncotarget, 8 47, 82037-82048López-Juárez, Alejandro; Titus, Haley E; Silbak, Sadiq H; Pressler, Joshua W; Rizvi, Tilat A; Bogard, Madeleine; Bennett, Michael R; Ciraolo, Georgianne; Williams, Michael T; Vorhees, Charles V; Ratner, Nancy 2017. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell reports, 19 3, 545-557Maertens, Ophélia; McCurrach, Mila E; Braun, Benjamin S; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q; Lauchle, Jennifer O; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P; Clapp, D Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen 2017. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer research, 77 21, 5706-5711Reilly, Karlyne M; Kim, AeRang; Blakely, Jaishri; Ferner, Rosalie E; Gutmann, David H; Legius, Eric; Miettinen, Markku M; Randall, R Lor; Ratner, Nancy; Jumbé, N L; Bakker, Annette; Viskochil, David; Widemann, Brigitte C; Stewart, Douglas R 2017. Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future. Journal of the National Cancer Institute, 109 8, Titus, Haley E; López-Juárez, Alejandro; Silbak, Sadiq H; Rizvi, Tilat A; Bogard, Madeleine; Ratner, Nancy 2017. Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK, nitric oxide, and notch signaling. Glia, 65 12, 1990-2002Angelika Ihle, Michaela; Merkelbach-Bruse, Sabine; Hartmann, Wolfgang; Bauer, Sebastian; Ratner, Nancy; Sonobe, Hiroshi; Nishio, Jun; Larsson, Olle; Åman, Pierre; Pedeutour, Florence; Taguchi, Takahiro; Wardelmann, Eva; Buettner, Reinhard; Schildhaus, Hans-Ulrich 2016. HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat. The journal of pathology. Clinical research, 2 2, 59-71Dombi, Eva; Baldwin, Andrea; Marcus, Leigh J; Fisher, Michael J; Weiss, Brian; Kim, AeRang; Whitcomb, Patricia; Martin, Staci; Aschbacher-Smith, Lindsey E; Rizvi, Tilat A; Wu, Jianqiang; Ershler, Rachel; Wolters, Pamela; Therrien, Janet; Glod, John; Belasco, Jean B; Schorry, Elizabeth; Brofferio, Alessandra; Starosta, Amy J; Gillespie, Andrea; Doyle, Austin L; Ratner, Nancy; Widemann, Brigitte C 2016. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. The New England journal of medicine, 375 26, 2550-2560Eiymo Mwa Mpollo, Marthe-Sandrine; Brandt, Eric B; Shanmukhappa, Shiva Kumar; Arumugam, Paritha I; Tiwari, Swati; Loberg, Anastacia; Pillis, Devin; Rizvi, Tilat; Lindsey, Mark; Jonck, Bart; Carmeliet, Peter; Kalra, Vijay K; Le Cras, Timothy D; Ratner, Nancy; Wills-Karp, Marsha; Hershey, Gurjit K Khurana; Malik, Punam 2016. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. The Journal of clinical investigation, 126 2, 571-84Kendall, Jed J; Chaney, Katherine E; Patel, Ami V; Rizvi, Tilat A; Largaespada, David A; Ratner, Nancy 2016. CK2 blockade causes MPNST cell apoptosis and promotes degradation of ?-catenin. Oncotarget, 7 33, 53191-53203Patel, Ami V; Chaney, Katherine E; Choi, Kwangmin; Largaespada, David A; Kumar, Ashish R; Ratner, Nancy 2016. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine, 9 , 110-119Ratner, Nancy; Brodeur, Garrett M; Dale, Russell C; Schor, Nina F 2016. The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder. Annals of neurology, 80 1, 13-23Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy 2016. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell reports, 14 8, 1979-90Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Janhofer, David; Dombi, Eva; Dunn, Richard S; Kim, Mi-Ok; Masters, Andrea R; Jones, David R; Cripe, Timothy P; Ratner, Nancy 2015. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatric blood & cancer, 62 10, 1709-16Patel, Ami V; Johansson, Gunnar; Colbert, Melissa C; Dasgupta, Biplab; Ratner, Nancy 2015. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-oncology, 17 12, 1599-608Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Jankowski, Michael P; Dasgupta, Biplab 2015. Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 6 , 6075Ratner, Nancy; Miller, Shyra J 2015. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature reviews. Cancer, 15 5, 290-301Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena 2015. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. American journal of medical genetics. Part A, 167A 1, 1-10Wu, Jianqiang; Huang, Gang; Ratner, Nancy 2015. Runx1: a new driver in neurofibromagenesis. Oncoscience, 2 11, 904-5Ehrman, Lisa A; Nardini, Diana; Ehrman, Sarah; Rizvi, Tilat A; Gulick, James; Krenz, Maike; Dasgupta, Biplab; Robbins, Jeffrey; Ratner, Nancy; Nakafuku, Masato; Waclaw, Ronald R 2014. The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 10, 3767-78Lee, Mary P; Ratner, Nancy; Yutzey, Katherine E 2014. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells. BMC genomics, 15 , 821Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Yutaka, Yoshida; Jankowski, Michael P; Dasgupta, Biplab 2014. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 5 , 4993Rahrmann, Eric P; Moriarity, Branden S; Otto, George M; Watson, Adrienne L; Choi, Kwangmin; Collins, Margaret H; Wallace, Margaret; Webber, Beau R; Forster, Colleen L; Rizzardi, Anthony E; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2014. Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American journal of pathology, 184 7, 2082-98Watson, Adrienne L; Anderson, Leah K; Greeley, Andrew D; Keng, Vincent W; Rahrmann, Eric P; Halfond, Amanda L; Powell, Natasha M; Collins, Margaret H; Rizvi, Tilat; Moertel, Christopher L; Ratner, Nancy; Largaespada, David A 2014. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget, 5 6, 1502-14Widemann, Brigitte C; Acosta, Maria T; Ammoun, Sylvia; Belzberg, Allan J; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D Wade; Dombi, Eva; Evans, Gareth D; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Hanemann, C Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R; Legius, Eric; Packer, Roger J; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R; Ullrich, Nicole; Bakker, Annette C; Morrison, Helen 2014. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. American journal of medical genetics. Part A, 164A 3, 563-78Guo, Li; Lee, Audrey A; Rizvi, Tilat A; Ratner, Nancy; Kirschner, Lawrence S 2013. The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 46, 17967-75Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Jessen, Walter J; Miller, Shyra J; Jousma, Edwin; Wu, Jianqiang; Rizvi, Tilat A; Brundage, Meghan E; Eaves, David; Widemann, Brigitte; Kim, Mi-Ok; Dombi, Eva; Sabo, Jessica; Hardiman Dudley, Atira; Niwa-Kawakita, Michiko; Page, Grier P; Giovannini, Marco; Aronow, Bruce J; Cripe, Timothy P; Ratner, Nancy 2013. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of clinical investigation, 123 1, 340-7Largaespada, David; Ratner, Nancy 2013. Interweaving the strands: ?-catenin, an HIV co-receptor, and Schwann cell tumors. Cancer cell, 23 3, 269-71Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2013. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell reports, 4 6, 1197-212Plotkin, Scott R; Blakeley, Jaishri O; Evans, D Gareth; Hanemann, C Oliver; Hulsebos, Theo J M; Hunter-Schaedle, Kim; Kalpana, Ganjam V; Korf, Bruce; Messiaen, Ludwine; Papi, Laura; Ratner, Nancy; Sherman, Larry S; Smith, Miriam J; Stemmer-Rachamimov, Anat O; Vitte, Jeremie; Giovannini, Marco 2013. Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. American journal of medical genetics. Part A, 161A 3, 405-16Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy 2013. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta neuropathologica, 125 1, 159-68Rahrmann, Eric P; Watson, Adrienne L; Keng, Vincent W; Choi, Kwangmin; Moriarity, Branden S; Beckmann, Dominic A; Wolf, Natalie K; Sarver, Aaron; Collins, Margaret H; Moertel, Christopher L; Wallace, Margaret R; Gel, Bernat; Serra, Eduard; Ratner, Nancy; Largaespada, David A 2013. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature genetics, 45 7, 756-66Watson, Adrienne L; Rahrmann, Eric P; Moriarity, Branden S; Choi, Kwangmin; Conboy, Caitlin B; Greeley, Andrew D; Halfond, Amanda L; Anderson, Leah K; Wahl, Brian R; Keng, Vincent W; Rizzardi, Anthony E; Forster, Colleen L; Collins, Margaret H; Sarver, Aaron L; Wallace, Margaret R; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2013. Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer discovery, 3 6, 674-89Acosta, Maria T; Bearden, Carrie E; Castellanos, F Xavier; Castellanos, Xavier F; Cutting, Laurie; Elgersma, Ype; Gioia, Gerard; Gutmann, David H; Lee, Yong-Seok; Legius, Eric; Muenke, Maximillian; North, Kathryn; Parada, Luis F; Ratner, Nancy; Hunter-Schaedle, Kim; Silva, Alcino J 2012. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American journal of medical genetics. Part A, 158A 9, 2225-32Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Gutmann, David H; Parada, Luis F; Silva, Alcino J; Ratner, Nancy 2012. Neurofibromatosis type 1: modeling CNS dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 41, 14087-93Kalamarides, Michel; Acosta, Maria T; Babovic-Vuksanovic, Dusica; Carpen, Olli; Cichowski, Karen; Evans, D Gareth; Giancotti, Filippo; Hanemann, C Oliver; Ingram, David; Lloyd, Alison C; Mayes, Debra A; Messiaen, Ludwine; Morrison, Helen; North, Kathryn; Packer, Roger; Pan, Duojia; Stemmer-Rachamimov, Anat; Upadhyaya, Meena; Viskochil, David; Wallace, Margret R; Hunter-Schaedle, Kim; Ratner, Nancy 2012. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta neuropathologica, 123 3, 369-80Keng, Vincent W; Rahrmann, Eric P; Watson, Adrienne L; Tschida, Barbara R; Moertel, Christopher L; Jessen, Walter J; Rizvi, Tilat A; Collins, Margaret H; Ratner, Nancy; Largaespada, David A 2012. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer research, 72 13, 3405-13Keng, Vincent W; Watson, Adrienne L; Rahrmann, Eric P; Li, Hua; Tschida, Barbara R; Moriarity, Branden S; Choi, Kwangmin; Rizvi, Tilat A; Collins, Margaret H; Wallace, Margaret R; Ratner, Nancy; Largaespada, David A 2012. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma, 2012 , 620834Patel, Ami V; Eaves, David; Jessen, Walter J; Rizvi, Tilat A; Ecsedy, Jeffrey A; Qian, Mark G; Aronow, Bruce J; Perentesis, John P; Serra, Eduard; Cripe, Timothy P; Miller, Shyra J; Ratner, Nancy 2012. Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target. Clinical cancer research : an official journal of the American Association for Cancer Research, 18 18, 5020-30Patmore, Deanna M; Welch, Sara; Fulkerson, Patricia C; Wu, Jianqiang; Choi, Kwangmin; Eaves, David; Kordich, Jennifer J; Collins, Margaret H; Cripe, Timothy P; Ratner, Nancy 2012. In vivo regulation of TGF-? by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer research, 72 20, 5317-27Wu, Jianqiang; Dombi, Eva; Jousma, Edwin; Scott Dunn, R; Lindquist, Diana; Schnell, Beverly M; Kim, Mi-Ok; Kim, Aerang; Widemann, Brigitte C; Cripe, Timothy P; Ratner, Nancy 2012. Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatric blood & cancer, 58 2, 173-80Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2011. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research, 71 13, 4675-85Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2011. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Molecular cancer therapeutics, 10 9, 1740-50Yang, Jilong; Ylipää, Antti; Sun, Yan; Zheng, Hong; Chen, Kexin; Nykter, Matti; Trent, Jonathan; Ratner, Nancy; Lev, Dina C; Zhang, Wei 2011. Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Clinical cancer research : an official journal of the American Association for Cancer Research, 17 24, 7563-73Hummel, Trent R; Jessen, Walter J; Miller, Shyra J; Kluwe, Lan; Mautner, Victor F; Wallace, Margaret R; Lázaro, Conxi; Page, Grier P; Worley, Paul F; Aronow, Bruce J; Schorry, Elizabeth K; Ratner, Nancy 2010. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical cancer research : an official journal of the American Association for Cancer Research, 16 20, 5048-57Kissil, Joseph L; Blakeley, Jaishri O; Ferner, Rosalie E; Huson, Susan M; Kalamarides, Michel; Mautner, Victor-Felix; McCormick, Frank; Morrison, Helen; Packer, Roger; Ramesh, Vijaya; Ratner, Nancy; Rauen, Katherine A; Stevenson, David A; Hunter-Schaedle, Kim; North, Kathryn 2010. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. American journal of medical genetics. Part A, 152A 2, 269-83Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P 2009. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PloS one, 4 1, e4235Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Li, Hua; Upadhyaya, Meena; Giovannini, Marco; Muir, David; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Nielsen, G Petur; Lazaro, Conxi; Stemmer-Rachamimov, Anat; Page, Grier; Aronow, Bruce J; Ratner, Nancy 2009. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO molecular medicine, 1 4, 236-48Carroll, Steven L; Ratner, Nancy 2008. How does the Schwann cell lineage form tumors in NF1? Glia, 56 14, 1590-605Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular cancer therapeutics, 7 5, 1237-45Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy 2008. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell, 3 6, 658-69Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy 2008. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer cell, 13 2, 105-16Mahller, Yonatan Y; Vaikunth, Sachin S; Currier, Mark A; Miller, Shyra J; Ripberger, Maria C; Hsu, Ya-Hsuan; Mehrian-Shai, Ruty; Collins, Margaret H; Crombleholme, Timothy M; Ratner, Nancy; Cripe, Timothy P 2007. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molecular therapy : the journal of the American Society of Gene Therapy, 15 2, 279-86Monk, Kelly R; Wu, Jianqiang; Williams, Jon P; Finney, Brenda A; Fitzgerald, Maureen E; Filippi, Marie-Dominique; Ratner, Nancy 2007. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron glia biology, 3 3, 233-44Mahller, Yonatan Y; Rangwala, Fatima; Ratner, Nancy; Cripe, Timothy P 2006. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric blood & cancer, 46 7, 745-54Miller, Shyra J; Rangwala, Fatima; Williams, Jon; Ackerman, Peter; Kong, Sue; Jegga, Anil G; Kaiser, Sergio; Aronow, Bruce J; Frahm, Silke; Kluwe, Lan; Mautner, Victor; Upadhyaya, Meena; Muir, David; Wallace, Margaret; Hagen, Jussara; Quelle, Dawn E; Watson, Mark A; Perry, Arie; Gutmann, David H; Ratner, Nancy 2006. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer research, 66 5, 2584-91Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Ratner, Nancy; Williams, Jon P; Kordich, Jennifer J; Kim, Haesun A 2006. Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells. Methods in enzymology, 407 , 22-33Wu, Jianqiang; Crimmins, Jason T; Monk, Kelly R; Williams, Jon P; Fitzgerald, Maureen E; Tedesco, Susan; Ratner, Nancy 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. The American journal of pathology, 168 5, 1686-96Aguirre, Adan; Rizvi, Tilat A; Ratner, Nancy; Gallo, Vittorio 2005. Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 48, 11092-106Ling, Benjamin C; Wu, Jianqiang; Miller, Shyra J; Monk, Kelly R; Shamekh, Rania; Rizvi, Tilat A; Decourten-Myers, Gabrielle; Vogel, Kristine S; DeClue, Jeffrey E; Ratner, Nancy 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer cell, 7 1, 65-75Corfas, Gabriel; Velardez, Miguel Omar; Ko, Chien-Ping; Ratner, Nancy; Peles, Elior 2004. Mechanisms and roles of axon-Schwann cell interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 42, 9250-60Huang, Yuan; Rangwala, Fatima; Fulkerson, Patricia C; Ling, Bo; Reed, Erin; Cox, Adrienne D; Kamholz, John; Ratner, Nancy 2004. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene, 23 2, 368-78Stemmer-Rachamimov, Anat O; Louis, David N; Nielsen, Gunnlaugur P; Antonescu, Cristina R; Borowsky, Alexander D; Bronson, Roderick T; Burns, Dennis K; Cervera, Pascale; McLaughlin, Margaret E; Reifenberger, Guido; Schmale, Michael C; MacCollin, Mia; Chao, Richard C; Cichowski, Karen; Kalamarides, Michel; Messerli, Shanta M; McClatchey, Andrea I; Niwa-Kawakita, Michiko; Ratner, Nancy; Reilly, Karlyne M; Zhu, Yuan; Giovannini, Marco 2004. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer research, 64 10, 3718-24Stickney, John T; Bacon, W Clark; Rojas, Meghan; Ratner, Nancy; Ip, Wallace 2004. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer research, 64 8, 2717-24Tang, Yang; Lu, Aigang; Ran, Ruiqiong; Aronow, Bruce J; Schorry, Elizabeth K; Hopkin, Robert J; Gilbert, Donald L; Glauser, Tracy A; Hershey, Andrew D; Richtand, Neil W; Privitera, Michael; Dalvi, Arif; Sahay, Alok; Szaflarski, Jerzy P; Ficker, David M; Ratner, Nancy; Sharp, Frank R 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain research. Molecular brain research, 132 2, 155-67Bennett, Michael R; Rizvi, Tilat A; Karyala, Saikumar; McKinnon, Randall D; Ratner, Nancy 2003. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 18, 7207-17Manent, Jan; Oguievetskaia, Ksenia; Bayer, Jan; Ratner, Nancy; Giovannini, Marco 2003. Magnetic cell sorting for enriching Schwann cells from adult mouse peripheral nerves. Journal of neuroscience methods, 123 2, 167-73Miller, Shyra J; Li, Hongzhen; Rizvi, Tilat A; Huang, Yuan; Johansson, Gunnar; Bowersock, Jason; Sidani, Amer; Vitullo, John; Vogel, Kristine; Parysek, Linda M; DeClue, Jeffrey E; Ratner, Nancy 2003. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Molecular and cellular biology, 23 6, 2213-24Yang, Feng-Chun; Ingram, David A; Chen, Shi; Hingtgen, Cynthia M; Ratner, Nancy; Monk, Kelly R; Clegg, Travis; White, Hilary; Mead, Laura; Wenning, Mary Jo; Williams, David A; Kapur, Reuben; Atkinson, Simon J; Clapp, D Wade 2003. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of clinical investigation, 112 12, 1851-61Bashour, Anne-Marie; Meng, J-J; Ip, Wallace; MacCollin, Mia; Ratner, Nancy 2002. The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Molecular and cellular biology, 22 4, 1150-7Morfini, Gerardo; Szebenyi, Györgyi; Elluru, Ravindhra; Ratner, Nancy; Brady, Scott T 2002. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The EMBO journal, 21 3, 281-93Rizvi, Tilat A; Huang, Yuan; Sidani, Amer; Atit, Radhika; Largaespada, David A; Boissy, Raymond E; Ratner, Nancy 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 22, 9831-40Xu, Yanfang; Chiamvimonvat, Nipavan; Vázquez, Ana E; Akunuru, Shailaja; Ratner, Nancy; Yamoah, Ebenezer N 2002. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 21, 9194-202Rosenbaum, Thorsten; Kim, Haesun A; Boissy, Ying L; Ling, B O; Ratner, Nancy 1999. Neurofibromin, the Neurofibromatosis Type 1 Ras-GAP, Is Required for Appropriate P0 Expression and Myelination. Annals of the New York Academy of Sciences, 883 1, 203-214
Research InterestsNeurofibromatosis type 1, NF-1, is a common inherited disease of humans. Patients with NF-1develop a variety of symptoms, the most common of which are peripheral nerve tumors made up largely of Schwann cells, fibroblasts, and extracellular matrix. Neurofibromas develop sporadically in NF-1 patients, suggesting that mutations in the NF-1 gene cause only a predisposition to formation of tumors, which are then triggered by additional, or ''secondary'' genetic or epigenetic events. We have defined cellul...
Peer Reviewed Publications Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2018. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget, 9 22, 15860-15875Fisher, Michael J; Belzberg, Allan J; de Blank, Peter; De Raedt, Thomas; Elefteriou, Florent; Ferner, Rosalie E; Giovannini, Marco; Harris, Gordon J; Kalamarides, Michel; Karajannis, Matthias A; Kim, AeRang; Lázaro, Conxi; Le, Lu Q; Li, Wei; Listernick, Robert; Martin, Staci; Morrison, Helen; Pasmant, Eric; Ratner, Nancy; Schorry, Elisabeth; Ullrich, Nicole J; Viskochil, David; Weiss, Brian; Widemann, Brigitte C; Zhu, Yuan; Bakker, Annette; Serra, Eduard 2018. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. American journal of medical genetics. Part A, 176 5, 1258-1269Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy 2017. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports, 7 , 43315Currier, Mark A; Sprague, Les; Rizvi, Tilat A; Nartker, Brooke; Chen, Chun-Yu; Wang, Pin-Yi; Hutzen, Brian J; Franczek, Meghan R; Patel, Ami V; Chaney, Katherine E; Streby, Keri A; Ecsedy, Jeffrey A; Conner, Joe; Ratner, Nancy; Cripe, Timothy P 2017. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation. Oncotarget, 8 11, 17412-17427Haworth, Kellie B; Arnold, Michael A; Pierson, Christopher R; Choi, Kwangmin; Yeager, Nicholas D; Ratner, Nancy; Roberts, Ryan D; Finlay, Jonathan L; Cripe, Timothy P 2017. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy. Oncotarget, 8 47, 82037-82048López-Juárez, Alejandro; Titus, Haley E; Silbak, Sadiq H; Pressler, Joshua W; Rizvi, Tilat A; Bogard, Madeleine; Bennett, Michael R; Ciraolo, Georgianne; Williams, Michael T; Vorhees, Charles V; Ratner, Nancy 2017. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell reports, 19 3, 545-557Maertens, Ophélia; McCurrach, Mila E; Braun, Benjamin S; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q; Lauchle, Jennifer O; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P; Clapp, D Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen 2017. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer research, 77 21, 5706-5711Reilly, Karlyne M; Kim, AeRang; Blakely, Jaishri; Ferner, Rosalie E; Gutmann, David H; Legius, Eric; Miettinen, Markku M; Randall, R Lor; Ratner, Nancy; Jumbé, N L; Bakker, Annette; Viskochil, David; Widemann, Brigitte C; Stewart, Douglas R 2017. Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future. Journal of the National Cancer Institute, 109 8, Titus, Haley E; López-Juárez, Alejandro; Silbak, Sadiq H; Rizvi, Tilat A; Bogard, Madeleine; Ratner, Nancy 2017. Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK, nitric oxide, and notch signaling. Glia, 65 12, 1990-2002Angelika Ihle, Michaela; Merkelbach-Bruse, Sabine; Hartmann, Wolfgang; Bauer, Sebastian; Ratner, Nancy; Sonobe, Hiroshi; Nishio, Jun; Larsson, Olle; Åman, Pierre; Pedeutour, Florence; Taguchi, Takahiro; Wardelmann, Eva; Buettner, Reinhard; Schildhaus, Hans-Ulrich 2016. HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat. The journal of pathology. Clinical research, 2 2, 59-71Dombi, Eva; Baldwin, Andrea; Marcus, Leigh J; Fisher, Michael J; Weiss, Brian; Kim, AeRang; Whitcomb, Patricia; Martin, Staci; Aschbacher-Smith, Lindsey E; Rizvi, Tilat A; Wu, Jianqiang; Ershler, Rachel; Wolters, Pamela; Therrien, Janet; Glod, John; Belasco, Jean B; Schorry, Elizabeth; Brofferio, Alessandra; Starosta, Amy J; Gillespie, Andrea; Doyle, Austin L; Ratner, Nancy; Widemann, Brigitte C 2016. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. The New England journal of medicine, 375 26, 2550-2560Eiymo Mwa Mpollo, Marthe-Sandrine; Brandt, Eric B; Shanmukhappa, Shiva Kumar; Arumugam, Paritha I; Tiwari, Swati; Loberg, Anastacia; Pillis, Devin; Rizvi, Tilat; Lindsey, Mark; Jonck, Bart; Carmeliet, Peter; Kalra, Vijay K; Le Cras, Timothy D; Ratner, Nancy; Wills-Karp, Marsha; Hershey, Gurjit K Khurana; Malik, Punam 2016. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. The Journal of clinical investigation, 126 2, 571-84Kendall, Jed J; Chaney, Katherine E; Patel, Ami V; Rizvi, Tilat A; Largaespada, David A; Ratner, Nancy 2016. CK2 blockade causes MPNST cell apoptosis and promotes degradation of ?-catenin. Oncotarget, 7 33, 53191-53203Patel, Ami V; Chaney, Katherine E; Choi, Kwangmin; Largaespada, David A; Kumar, Ashish R; Ratner, Nancy 2016. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine, 9 , 110-119Ratner, Nancy; Brodeur, Garrett M; Dale, Russell C; Schor, Nina F 2016. The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder. Annals of neurology, 80 1, 13-23Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy 2016. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell reports, 14 8, 1979-90Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Janhofer, David; Dombi, Eva; Dunn, Richard S; Kim, Mi-Ok; Masters, Andrea R; Jones, David R; Cripe, Timothy P; Ratner, Nancy 2015. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatric blood & cancer, 62 10, 1709-16Patel, Ami V; Johansson, Gunnar; Colbert, Melissa C; Dasgupta, Biplab; Ratner, Nancy 2015. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-oncology, 17 12, 1599-608Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Jankowski, Michael P; Dasgupta, Biplab 2015. Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 6 , 6075Ratner, Nancy; Miller, Shyra J 2015. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature reviews. Cancer, 15 5, 290-301Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena 2015. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. American journal of medical genetics. Part A, 167A 1, 1-10Wu, Jianqiang; Huang, Gang; Ratner, Nancy 2015. Runx1: a new driver in neurofibromagenesis. Oncoscience, 2 11, 904-5Ehrman, Lisa A; Nardini, Diana; Ehrman, Sarah; Rizvi, Tilat A; Gulick, James; Krenz, Maike; Dasgupta, Biplab; Robbins, Jeffrey; Ratner, Nancy; Nakafuku, Masato; Waclaw, Ronald R 2014. The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 10, 3767-78Lee, Mary P; Ratner, Nancy; Yutzey, Katherine E 2014. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells. BMC genomics, 15 , 821Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Yutaka, Yoshida; Jankowski, Michael P; Dasgupta, Biplab 2014. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 5 , 4993Rahrmann, Eric P; Moriarity, Branden S; Otto, George M; Watson, Adrienne L; Choi, Kwangmin; Collins, Margaret H; Wallace, Margaret; Webber, Beau R; Forster, Colleen L; Rizzardi, Anthony E; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2014. Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American journal of pathology, 184 7, 2082-98Watson, Adrienne L; Anderson, Leah K; Greeley, Andrew D; Keng, Vincent W; Rahrmann, Eric P; Halfond, Amanda L; Powell, Natasha M; Collins, Margaret H; Rizvi, Tilat; Moertel, Christopher L; Ratner, Nancy; Largaespada, David A 2014. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget, 5 6, 1502-14Widemann, Brigitte C; Acosta, Maria T; Ammoun, Sylvia; Belzberg, Allan J; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D Wade; Dombi, Eva; Evans, Gareth D; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Hanemann, C Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R; Legius, Eric; Packer, Roger J; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R; Ullrich, Nicole; Bakker, Annette C; Morrison, Helen 2014. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. American journal of medical genetics. Part A, 164A 3, 563-78Guo, Li; Lee, Audrey A; Rizvi, Tilat A; Ratner, Nancy; Kirschner, Lawrence S 2013. The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 46, 17967-75Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Jessen, Walter J; Miller, Shyra J; Jousma, Edwin; Wu, Jianqiang; Rizvi, Tilat A; Brundage, Meghan E; Eaves, David; Widemann, Brigitte; Kim, Mi-Ok; Dombi, Eva; Sabo, Jessica; Hardiman Dudley, Atira; Niwa-Kawakita, Michiko; Page, Grier P; Giovannini, Marco; Aronow, Bruce J; Cripe, Timothy P; Ratner, Nancy 2013. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of clinical investigation, 123 1, 340-7Largaespada, David; Ratner, Nancy 2013. Interweaving the strands: ?-catenin, an HIV co-receptor, and Schwann cell tumors. Cancer cell, 23 3, 269-71Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2013. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell reports, 4 6, 1197-212Plotkin, Scott R; Blakeley, Jaishri O; Evans, D Gareth; Hanemann, C Oliver; Hulsebos, Theo J M; Hunter-Schaedle, Kim; Kalpana, Ganjam V; Korf, Bruce; Messiaen, Ludwine; Papi, Laura; Ratner, Nancy; Sherman, Larry S; Smith, Miriam J; Stemmer-Rachamimov, Anat O; Vitte, Jeremie; Giovannini, Marco 2013. Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. American journal of medical genetics. Part A, 161A 3, 405-16Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy 2013. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta neuropathologica, 125 1, 159-68Rahrmann, Eric P; Watson, Adrienne L; Keng, Vincent W; Choi, Kwangmin; Moriarity, Branden S; Beckmann, Dominic A; Wolf, Natalie K; Sarver, Aaron; Collins, Margaret H; Moertel, Christopher L; Wallace, Margaret R; Gel, Bernat; Serra, Eduard; Ratner, Nancy; Largaespada, David A 2013. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature genetics, 45 7, 756-66Watson, Adrienne L; Rahrmann, Eric P; Moriarity, Branden S; Choi, Kwangmin; Conboy, Caitlin B; Greeley, Andrew D; Halfond, Amanda L; Anderson, Leah K; Wahl, Brian R; Keng, Vincent W; Rizzardi, Anthony E; Forster, Colleen L; Collins, Margaret H; Sarver, Aaron L; Wallace, Margaret R; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2013. Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer discovery, 3 6, 674-89Acosta, Maria T; Bearden, Carrie E; Castellanos, F Xavier; Castellanos, Xavier F; Cutting, Laurie; Elgersma, Ype; Gioia, Gerard; Gutmann, David H; Lee, Yong-Seok; Legius, Eric; Muenke, Maximillian; North, Kathryn; Parada, Luis F; Ratner, Nancy; Hunter-Schaedle, Kim; Silva, Alcino J 2012. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American journal of medical genetics. Part A, 158A 9, 2225-32Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Gutmann, David H; Parada, Luis F; Silva, Alcino J; Ratner, Nancy 2012. Neurofibromatosis type 1: modeling CNS dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 41, 14087-93Kalamarides, Michel; Acosta, Maria T; Babovic-Vuksanovic, Dusica; Carpen, Olli; Cichowski, Karen; Evans, D Gareth; Giancotti, Filippo; Hanemann, C Oliver; Ingram, David; Lloyd, Alison C; Mayes, Debra A; Messiaen, Ludwine; Morrison, Helen; North, Kathryn; Packer, Roger; Pan, Duojia; Stemmer-Rachamimov, Anat; Upadhyaya, Meena; Viskochil, David; Wallace, Margret R; Hunter-Schaedle, Kim; Ratner, Nancy 2012. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta neuropathologica, 123 3, 369-80Keng, Vincent W; Rahrmann, Eric P; Watson, Adrienne L; Tschida, Barbara R; Moertel, Christopher L; Jessen, Walter J; Rizvi, Tilat A; Collins, Margaret H; Ratner, Nancy; Largaespada, David A 2012. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer research, 72 13, 3405-13Keng, Vincent W; Watson, Adrienne L; Rahrmann, Eric P; Li, Hua; Tschida, Barbara R; Moriarity, Branden S; Choi, Kwangmin; Rizvi, Tilat A; Collins, Margaret H; Wallace, Margaret R; Ratner, Nancy; Largaespada, David A 2012. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma, 2012 , 620834Patel, Ami V; Eaves, David; Jessen, Walter J; Rizvi, Tilat A; Ecsedy, Jeffrey A; Qian, Mark G; Aronow, Bruce J; Perentesis, John P; Serra, Eduard; Cripe, Timothy P; Miller, Shyra J; Ratner, Nancy 2012. Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target. Clinical cancer research : an official journal of the American Association for Cancer Research, 18 18, 5020-30Patmore, Deanna M; Welch, Sara; Fulkerson, Patricia C; Wu, Jianqiang; Choi, Kwangmin; Eaves, David; Kordich, Jennifer J; Collins, Margaret H; Cripe, Timothy P; Ratner, Nancy 2012. In vivo regulation of TGF-? by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer research, 72 20, 5317-27Wu, Jianqiang; Dombi, Eva; Jousma, Edwin; Scott Dunn, R; Lindquist, Diana; Schnell, Beverly M; Kim, Mi-Ok; Kim, Aerang; Widemann, Brigitte C; Cripe, Timothy P; Ratner, Nancy 2012. Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatric blood & cancer, 58 2, 173-80Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2011. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research, 71 13, 4675-85Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2011. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Molecular cancer therapeutics, 10 9, 1740-50Yang, Jilong; Ylipää, Antti; Sun, Yan; Zheng, Hong; Chen, Kexin; Nykter, Matti; Trent, Jonathan; Ratner, Nancy; Lev, Dina C; Zhang, Wei 2011. Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Clinical cancer research : an official journal of the American Association for Cancer Research, 17 24, 7563-73Hummel, Trent R; Jessen, Walter J; Miller, Shyra J; Kluwe, Lan; Mautner, Victor F; Wallace, Margaret R; Lázaro, Conxi; Page, Grier P; Worley, Paul F; Aronow, Bruce J; Schorry, Elizabeth K; Ratner, Nancy 2010. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical cancer research : an official journal of the American Association for Cancer Research, 16 20, 5048-57Kissil, Joseph L; Blakeley, Jaishri O; Ferner, Rosalie E; Huson, Susan M; Kalamarides, Michel; Mautner, Victor-Felix; McCormick, Frank; Morrison, Helen; Packer, Roger; Ramesh, Vijaya; Ratner, Nancy; Rauen, Katherine A; Stevenson, David A; Hunter-Schaedle, Kim; North, Kathryn 2010. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. American journal of medical genetics. Part A, 152A 2, 269-83Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P 2009. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PloS one, 4 1, e4235Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Li, Hua; Upadhyaya, Meena; Giovannini, Marco; Muir, David; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Nielsen, G Petur; Lazaro, Conxi; Stemmer-Rachamimov, Anat; Page, Grier; Aronow, Bruce J; Ratner, Nancy 2009. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO molecular medicine, 1 4, 236-48Carroll, Steven L; Ratner, Nancy 2008. How does the Schwann cell lineage form tumors in NF1? Glia, 56 14, 1590-605Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular cancer therapeutics, 7 5, 1237-45Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy 2008. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell, 3 6, 658-69Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy 2008. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer cell, 13 2, 105-16Mahller, Yonatan Y; Vaikunth, Sachin S; Currier, Mark A; Miller, Shyra J; Ripberger, Maria C; Hsu, Ya-Hsuan; Mehrian-Shai, Ruty; Collins, Margaret H; Crombleholme, Timothy M; Ratner, Nancy; Cripe, Timothy P 2007. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molecular therapy : the journal of the American Society of Gene Therapy, 15 2, 279-86Monk, Kelly R; Wu, Jianqiang; Williams, Jon P; Finney, Brenda A; Fitzgerald, Maureen E; Filippi, Marie-Dominique; Ratner, Nancy 2007. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron glia biology, 3 3, 233-44Mahller, Yonatan Y; Rangwala, Fatima; Ratner, Nancy; Cripe, Timothy P 2006. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric blood & cancer, 46 7, 745-54Miller, Shyra J; Rangwala, Fatima; Williams, Jon; Ackerman, Peter; Kong, Sue; Jegga, Anil G; Kaiser, Sergio; Aronow, Bruce J; Frahm, Silke; Kluwe, Lan; Mautner, Victor; Upadhyaya, Meena; Muir, David; Wallace, Margaret; Hagen, Jussara; Quelle, Dawn E; Watson, Mark A; Perry, Arie; Gutmann, David H; Ratner, Nancy 2006. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer research, 66 5, 2584-91Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Ratner, Nancy; Williams, Jon P; Kordich, Jennifer J; Kim, Haesun A 2006. Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells. Methods in enzymology, 407 , 22-33Wu, Jianqiang; Crimmins, Jason T; Monk, Kelly R; Williams, Jon P; Fitzgerald, Maureen E; Tedesco, Susan; Ratner, Nancy 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. The American journal of pathology, 168 5, 1686-96Aguirre, Adan; Rizvi, Tilat A; Ratner, Nancy; Gallo, Vittorio 2005. Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 48, 11092-106Ling, Benjamin C; Wu, Jianqiang; Miller, Shyra J; Monk, Kelly R; Shamekh, Rania; Rizvi, Tilat A; Decourten-Myers, Gabrielle; Vogel, Kristine S; DeClue, Jeffrey E; Ratner, Nancy 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer cell, 7 1, 65-75Corfas, Gabriel; Velardez, Miguel Omar; Ko, Chien-Ping; Ratner, Nancy; Peles, Elior 2004. Mechanisms and roles of axon-Schwann cell interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 42, 9250-60Huang, Yuan; Rangwala, Fatima; Fulkerson, Patricia C; Ling, Bo; Reed, Erin; Cox, Adrienne D; Kamholz, John; Ratner, Nancy 2004. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene, 23 2, 368-78Stemmer-Rachamimov, Anat O; Louis, David N; Nielsen, Gunnlaugur P; Antonescu, Cristina R; Borowsky, Alexander D; Bronson, Roderick T; Burns, Dennis K; Cervera, Pascale; McLaughlin, Margaret E; Reifenberger, Guido; Schmale, Michael C; MacCollin, Mia; Chao, Richard C; Cichowski, Karen; Kalamarides, Michel; Messerli, Shanta M; McClatchey, Andrea I; Niwa-Kawakita, Michiko; Ratner, Nancy; Reilly, Karlyne M; Zhu, Yuan; Giovannini, Marco 2004. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer research, 64 10, 3718-24Stickney, John T; Bacon, W Clark; Rojas, Meghan; Ratner, Nancy; Ip, Wallace 2004. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer research, 64 8, 2717-24Tang, Yang; Lu, Aigang; Ran, Ruiqiong; Aronow, Bruce J; Schorry, Elizabeth K; Hopkin, Robert J; Gilbert, Donald L; Glauser, Tracy A; Hershey, Andrew D; Richtand, Neil W; Privitera, Michael; Dalvi, Arif; Sahay, Alok; Szaflarski, Jerzy P; Ficker, David M; Ratner, Nancy; Sharp, Frank R 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain research. Molecular brain research, 132 2, 155-67Bennett, Michael R; Rizvi, Tilat A; Karyala, Saikumar; McKinnon, Randall D; Ratner, Nancy 2003. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 18, 7207-17Manent, Jan; Oguievetskaia, Ksenia; Bayer, Jan; Ratner, Nancy; Giovannini, Marco 2003. Magnetic cell sorting for enriching Schwann cells from adult mouse peripheral nerves. Journal of neuroscience methods, 123 2, 167-73Miller, Shyra J; Li, Hongzhen; Rizvi, Tilat A; Huang, Yuan; Johansson, Gunnar; Bowersock, Jason; Sidani, Amer; Vitullo, John; Vogel, Kristine; Parysek, Linda M; DeClue, Jeffrey E; Ratner, Nancy 2003. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Molecular and cellular biology, 23 6, 2213-24Yang, Feng-Chun; Ingram, David A; Chen, Shi; Hingtgen, Cynthia M; Ratner, Nancy; Monk, Kelly R; Clegg, Travis; White, Hilary; Mead, Laura; Wenning, Mary Jo; Williams, David A; Kapur, Reuben; Atkinson, Simon J; Clapp, D Wade 2003. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of clinical investigation, 112 12, 1851-61Bashour, Anne-Marie; Meng, J-J; Ip, Wallace; MacCollin, Mia; Ratner, Nancy 2002. The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Molecular and cellular biology, 22 4, 1150-7Morfini, Gerardo; Szebenyi, Györgyi; Elluru, Ravindhra; Ratner, Nancy; Brady, Scott T 2002. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The EMBO journal, 21 3, 281-93Rizvi, Tilat A; Huang, Yuan; Sidani, Amer; Atit, Radhika; Largaespada, David A; Boissy, Raymond E; Ratner, Nancy 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 22, 9831-40Xu, Yanfang; Chiamvimonvat, Nipavan; Vázquez, Ana E; Akunuru, Shailaja; Ratner, Nancy; Yamoah, Ebenezer N 2002. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 21, 9194-202Rosenbaum, Thorsten; Kim, Haesun A; Boissy, Ying L; Ling, B O; Ratner, Nancy 1999. Neurofibromin, the Neurofibromatosis Type 1 Ras-GAP, Is Required for Appropriate P0 Expression and Myelination. Annals of the New York Academy of Sciences, 883 1, 203-214
Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2018. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget, 9 22, 15860-15875Fisher, Michael J; Belzberg, Allan J; de Blank, Peter; De Raedt, Thomas; Elefteriou, Florent; Ferner, Rosalie E; Giovannini, Marco; Harris, Gordon J; Kalamarides, Michel; Karajannis, Matthias A; Kim, AeRang; Lázaro, Conxi; Le, Lu Q; Li, Wei; Listernick, Robert; Martin, Staci; Morrison, Helen; Pasmant, Eric; Ratner, Nancy; Schorry, Elisabeth; Ullrich, Nicole J; Viskochil, David; Weiss, Brian; Widemann, Brigitte C; Zhu, Yuan; Bakker, Annette; Serra, Eduard 2018. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. American journal of medical genetics. Part A, 176 5, 1258-1269Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy 2017. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports, 7 , 43315Currier, Mark A; Sprague, Les; Rizvi, Tilat A; Nartker, Brooke; Chen, Chun-Yu; Wang, Pin-Yi; Hutzen, Brian J; Franczek, Meghan R; Patel, Ami V; Chaney, Katherine E; Streby, Keri A; Ecsedy, Jeffrey A; Conner, Joe; Ratner, Nancy; Cripe, Timothy P 2017. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation. Oncotarget, 8 11, 17412-17427Haworth, Kellie B; Arnold, Michael A; Pierson, Christopher R; Choi, Kwangmin; Yeager, Nicholas D; Ratner, Nancy; Roberts, Ryan D; Finlay, Jonathan L; Cripe, Timothy P 2017. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy. Oncotarget, 8 47, 82037-82048López-Juárez, Alejandro; Titus, Haley E; Silbak, Sadiq H; Pressler, Joshua W; Rizvi, Tilat A; Bogard, Madeleine; Bennett, Michael R; Ciraolo, Georgianne; Williams, Michael T; Vorhees, Charles V; Ratner, Nancy 2017. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell reports, 19 3, 545-557Maertens, Ophélia; McCurrach, Mila E; Braun, Benjamin S; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q; Lauchle, Jennifer O; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P; Clapp, D Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen 2017. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer research, 77 21, 5706-5711Reilly, Karlyne M; Kim, AeRang; Blakely, Jaishri; Ferner, Rosalie E; Gutmann, David H; Legius, Eric; Miettinen, Markku M; Randall, R Lor; Ratner, Nancy; Jumbé, N L; Bakker, Annette; Viskochil, David; Widemann, Brigitte C; Stewart, Douglas R 2017. Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future. Journal of the National Cancer Institute, 109 8, Titus, Haley E; López-Juárez, Alejandro; Silbak, Sadiq H; Rizvi, Tilat A; Bogard, Madeleine; Ratner, Nancy 2017. Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK, nitric oxide, and notch signaling. Glia, 65 12, 1990-2002Angelika Ihle, Michaela; Merkelbach-Bruse, Sabine; Hartmann, Wolfgang; Bauer, Sebastian; Ratner, Nancy; Sonobe, Hiroshi; Nishio, Jun; Larsson, Olle; Åman, Pierre; Pedeutour, Florence; Taguchi, Takahiro; Wardelmann, Eva; Buettner, Reinhard; Schildhaus, Hans-Ulrich 2016. HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat. The journal of pathology. Clinical research, 2 2, 59-71Dombi, Eva; Baldwin, Andrea; Marcus, Leigh J; Fisher, Michael J; Weiss, Brian; Kim, AeRang; Whitcomb, Patricia; Martin, Staci; Aschbacher-Smith, Lindsey E; Rizvi, Tilat A; Wu, Jianqiang; Ershler, Rachel; Wolters, Pamela; Therrien, Janet; Glod, John; Belasco, Jean B; Schorry, Elizabeth; Brofferio, Alessandra; Starosta, Amy J; Gillespie, Andrea; Doyle, Austin L; Ratner, Nancy; Widemann, Brigitte C 2016. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. The New England journal of medicine, 375 26, 2550-2560Eiymo Mwa Mpollo, Marthe-Sandrine; Brandt, Eric B; Shanmukhappa, Shiva Kumar; Arumugam, Paritha I; Tiwari, Swati; Loberg, Anastacia; Pillis, Devin; Rizvi, Tilat; Lindsey, Mark; Jonck, Bart; Carmeliet, Peter; Kalra, Vijay K; Le Cras, Timothy D; Ratner, Nancy; Wills-Karp, Marsha; Hershey, Gurjit K Khurana; Malik, Punam 2016. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. The Journal of clinical investigation, 126 2, 571-84Kendall, Jed J; Chaney, Katherine E; Patel, Ami V; Rizvi, Tilat A; Largaespada, David A; Ratner, Nancy 2016. CK2 blockade causes MPNST cell apoptosis and promotes degradation of ?-catenin. Oncotarget, 7 33, 53191-53203Patel, Ami V; Chaney, Katherine E; Choi, Kwangmin; Largaespada, David A; Kumar, Ashish R; Ratner, Nancy 2016. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine, 9 , 110-119Ratner, Nancy; Brodeur, Garrett M; Dale, Russell C; Schor, Nina F 2016. The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder. Annals of neurology, 80 1, 13-23Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy 2016. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell reports, 14 8, 1979-90Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Janhofer, David; Dombi, Eva; Dunn, Richard S; Kim, Mi-Ok; Masters, Andrea R; Jones, David R; Cripe, Timothy P; Ratner, Nancy 2015. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatric blood & cancer, 62 10, 1709-16Patel, Ami V; Johansson, Gunnar; Colbert, Melissa C; Dasgupta, Biplab; Ratner, Nancy 2015. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-oncology, 17 12, 1599-608Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Jankowski, Michael P; Dasgupta, Biplab 2015. Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 6 , 6075Ratner, Nancy; Miller, Shyra J 2015. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature reviews. Cancer, 15 5, 290-301Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena 2015. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. American journal of medical genetics. Part A, 167A 1, 1-10Wu, Jianqiang; Huang, Gang; Ratner, Nancy 2015. Runx1: a new driver in neurofibromagenesis. Oncoscience, 2 11, 904-5Ehrman, Lisa A; Nardini, Diana; Ehrman, Sarah; Rizvi, Tilat A; Gulick, James; Krenz, Maike; Dasgupta, Biplab; Robbins, Jeffrey; Ratner, Nancy; Nakafuku, Masato; Waclaw, Ronald R 2014. The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 10, 3767-78Lee, Mary P; Ratner, Nancy; Yutzey, Katherine E 2014. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells. BMC genomics, 15 , 821Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Yutaka, Yoshida; Jankowski, Michael P; Dasgupta, Biplab 2014. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature communications, 5 , 4993Rahrmann, Eric P; Moriarity, Branden S; Otto, George M; Watson, Adrienne L; Choi, Kwangmin; Collins, Margaret H; Wallace, Margaret; Webber, Beau R; Forster, Colleen L; Rizzardi, Anthony E; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2014. Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American journal of pathology, 184 7, 2082-98Watson, Adrienne L; Anderson, Leah K; Greeley, Andrew D; Keng, Vincent W; Rahrmann, Eric P; Halfond, Amanda L; Powell, Natasha M; Collins, Margaret H; Rizvi, Tilat; Moertel, Christopher L; Ratner, Nancy; Largaespada, David A 2014. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget, 5 6, 1502-14Widemann, Brigitte C; Acosta, Maria T; Ammoun, Sylvia; Belzberg, Allan J; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D Wade; Dombi, Eva; Evans, Gareth D; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Hanemann, C Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R; Legius, Eric; Packer, Roger J; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R; Ullrich, Nicole; Bakker, Annette C; Morrison, Helen 2014. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. American journal of medical genetics. Part A, 164A 3, 563-78Guo, Li; Lee, Audrey A; Rizvi, Tilat A; Ratner, Nancy; Kirschner, Lawrence S 2013. The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 46, 17967-75Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Jessen, Walter J; Miller, Shyra J; Jousma, Edwin; Wu, Jianqiang; Rizvi, Tilat A; Brundage, Meghan E; Eaves, David; Widemann, Brigitte; Kim, Mi-Ok; Dombi, Eva; Sabo, Jessica; Hardiman Dudley, Atira; Niwa-Kawakita, Michiko; Page, Grier P; Giovannini, Marco; Aronow, Bruce J; Cripe, Timothy P; Ratner, Nancy 2013. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of clinical investigation, 123 1, 340-7Largaespada, David; Ratner, Nancy 2013. Interweaving the strands: ?-catenin, an HIV co-receptor, and Schwann cell tumors. Cancer cell, 23 3, 269-71Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2013. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell reports, 4 6, 1197-212Plotkin, Scott R; Blakeley, Jaishri O; Evans, D Gareth; Hanemann, C Oliver; Hulsebos, Theo J M; Hunter-Schaedle, Kim; Kalpana, Ganjam V; Korf, Bruce; Messiaen, Ludwine; Papi, Laura; Ratner, Nancy; Sherman, Larry S; Smith, Miriam J; Stemmer-Rachamimov, Anat O; Vitte, Jeremie; Giovannini, Marco 2013. Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. American journal of medical genetics. Part A, 161A 3, 405-16Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy 2013. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta neuropathologica, 125 1, 159-68Rahrmann, Eric P; Watson, Adrienne L; Keng, Vincent W; Choi, Kwangmin; Moriarity, Branden S; Beckmann, Dominic A; Wolf, Natalie K; Sarver, Aaron; Collins, Margaret H; Moertel, Christopher L; Wallace, Margaret R; Gel, Bernat; Serra, Eduard; Ratner, Nancy; Largaespada, David A 2013. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature genetics, 45 7, 756-66Watson, Adrienne L; Rahrmann, Eric P; Moriarity, Branden S; Choi, Kwangmin; Conboy, Caitlin B; Greeley, Andrew D; Halfond, Amanda L; Anderson, Leah K; Wahl, Brian R; Keng, Vincent W; Rizzardi, Anthony E; Forster, Colleen L; Collins, Margaret H; Sarver, Aaron L; Wallace, Margaret R; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A 2013. Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer discovery, 3 6, 674-89Acosta, Maria T; Bearden, Carrie E; Castellanos, F Xavier; Castellanos, Xavier F; Cutting, Laurie; Elgersma, Ype; Gioia, Gerard; Gutmann, David H; Lee, Yong-Seok; Legius, Eric; Muenke, Maximillian; North, Kathryn; Parada, Luis F; Ratner, Nancy; Hunter-Schaedle, Kim; Silva, Alcino J 2012. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American journal of medical genetics. Part A, 158A 9, 2225-32Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Gutmann, David H; Parada, Luis F; Silva, Alcino J; Ratner, Nancy 2012. Neurofibromatosis type 1: modeling CNS dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 41, 14087-93Kalamarides, Michel; Acosta, Maria T; Babovic-Vuksanovic, Dusica; Carpen, Olli; Cichowski, Karen; Evans, D Gareth; Giancotti, Filippo; Hanemann, C Oliver; Ingram, David; Lloyd, Alison C; Mayes, Debra A; Messiaen, Ludwine; Morrison, Helen; North, Kathryn; Packer, Roger; Pan, Duojia; Stemmer-Rachamimov, Anat; Upadhyaya, Meena; Viskochil, David; Wallace, Margret R; Hunter-Schaedle, Kim; Ratner, Nancy 2012. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta neuropathologica, 123 3, 369-80Keng, Vincent W; Rahrmann, Eric P; Watson, Adrienne L; Tschida, Barbara R; Moertel, Christopher L; Jessen, Walter J; Rizvi, Tilat A; Collins, Margaret H; Ratner, Nancy; Largaespada, David A 2012. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer research, 72 13, 3405-13Keng, Vincent W; Watson, Adrienne L; Rahrmann, Eric P; Li, Hua; Tschida, Barbara R; Moriarity, Branden S; Choi, Kwangmin; Rizvi, Tilat A; Collins, Margaret H; Wallace, Margaret R; Ratner, Nancy; Largaespada, David A 2012. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma, 2012 , 620834Patel, Ami V; Eaves, David; Jessen, Walter J; Rizvi, Tilat A; Ecsedy, Jeffrey A; Qian, Mark G; Aronow, Bruce J; Perentesis, John P; Serra, Eduard; Cripe, Timothy P; Miller, Shyra J; Ratner, Nancy 2012. Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target. Clinical cancer research : an official journal of the American Association for Cancer Research, 18 18, 5020-30Patmore, Deanna M; Welch, Sara; Fulkerson, Patricia C; Wu, Jianqiang; Choi, Kwangmin; Eaves, David; Kordich, Jennifer J; Collins, Margaret H; Cripe, Timothy P; Ratner, Nancy 2012. In vivo regulation of TGF-? by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer research, 72 20, 5317-27Wu, Jianqiang; Dombi, Eva; Jousma, Edwin; Scott Dunn, R; Lindquist, Diana; Schnell, Beverly M; Kim, Mi-Ok; Kim, Aerang; Widemann, Brigitte C; Cripe, Timothy P; Ratner, Nancy 2012. Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatric blood & cancer, 58 2, 173-80Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2011. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research, 71 13, 4675-85Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda 2011. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Molecular cancer therapeutics, 10 9, 1740-50Yang, Jilong; Ylipää, Antti; Sun, Yan; Zheng, Hong; Chen, Kexin; Nykter, Matti; Trent, Jonathan; Ratner, Nancy; Lev, Dina C; Zhang, Wei 2011. Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Clinical cancer research : an official journal of the American Association for Cancer Research, 17 24, 7563-73Hummel, Trent R; Jessen, Walter J; Miller, Shyra J; Kluwe, Lan; Mautner, Victor F; Wallace, Margaret R; Lázaro, Conxi; Page, Grier P; Worley, Paul F; Aronow, Bruce J; Schorry, Elizabeth K; Ratner, Nancy 2010. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical cancer research : an official journal of the American Association for Cancer Research, 16 20, 5048-57Kissil, Joseph L; Blakeley, Jaishri O; Ferner, Rosalie E; Huson, Susan M; Kalamarides, Michel; Mautner, Victor-Felix; McCormick, Frank; Morrison, Helen; Packer, Roger; Ramesh, Vijaya; Ratner, Nancy; Rauen, Katherine A; Stevenson, David A; Hunter-Schaedle, Kim; North, Kathryn 2010. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. American journal of medical genetics. Part A, 152A 2, 269-83Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P 2009. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PloS one, 4 1, e4235Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Li, Hua; Upadhyaya, Meena; Giovannini, Marco; Muir, David; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Nielsen, G Petur; Lazaro, Conxi; Stemmer-Rachamimov, Anat; Page, Grier; Aronow, Bruce J; Ratner, Nancy 2009. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO molecular medicine, 1 4, 236-48Carroll, Steven L; Ratner, Nancy 2008. How does the Schwann cell lineage form tumors in NF1? Glia, 56 14, 1590-605Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular cancer therapeutics, 7 5, 1237-45Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy 2008. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell, 3 6, 658-69Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy 2008. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer cell, 13 2, 105-16Mahller, Yonatan Y; Vaikunth, Sachin S; Currier, Mark A; Miller, Shyra J; Ripberger, Maria C; Hsu, Ya-Hsuan; Mehrian-Shai, Ruty; Collins, Margaret H; Crombleholme, Timothy M; Ratner, Nancy; Cripe, Timothy P 2007. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molecular therapy : the journal of the American Society of Gene Therapy, 15 2, 279-86Monk, Kelly R; Wu, Jianqiang; Williams, Jon P; Finney, Brenda A; Fitzgerald, Maureen E; Filippi, Marie-Dominique; Ratner, Nancy 2007. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron glia biology, 3 3, 233-44Mahller, Yonatan Y; Rangwala, Fatima; Ratner, Nancy; Cripe, Timothy P 2006. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric blood & cancer, 46 7, 745-54Miller, Shyra J; Rangwala, Fatima; Williams, Jon; Ackerman, Peter; Kong, Sue; Jegga, Anil G; Kaiser, Sergio; Aronow, Bruce J; Frahm, Silke; Kluwe, Lan; Mautner, Victor; Upadhyaya, Meena; Muir, David; Wallace, Margaret; Hagen, Jussara; Quelle, Dawn E; Watson, Mark A; Perry, Arie; Gutmann, David H; Ratner, Nancy 2006. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer research, 66 5, 2584-91Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Ratner, Nancy; Williams, Jon P; Kordich, Jennifer J; Kim, Haesun A 2006. Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells. Methods in enzymology, 407 , 22-33Wu, Jianqiang; Crimmins, Jason T; Monk, Kelly R; Williams, Jon P; Fitzgerald, Maureen E; Tedesco, Susan; Ratner, Nancy 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. The American journal of pathology, 168 5, 1686-96Aguirre, Adan; Rizvi, Tilat A; Ratner, Nancy; Gallo, Vittorio 2005. Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 48, 11092-106Ling, Benjamin C; Wu, Jianqiang; Miller, Shyra J; Monk, Kelly R; Shamekh, Rania; Rizvi, Tilat A; Decourten-Myers, Gabrielle; Vogel, Kristine S; DeClue, Jeffrey E; Ratner, Nancy 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer cell, 7 1, 65-75Corfas, Gabriel; Velardez, Miguel Omar; Ko, Chien-Ping; Ratner, Nancy; Peles, Elior 2004. Mechanisms and roles of axon-Schwann cell interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 42, 9250-60Huang, Yuan; Rangwala, Fatima; Fulkerson, Patricia C; Ling, Bo; Reed, Erin; Cox, Adrienne D; Kamholz, John; Ratner, Nancy 2004. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene, 23 2, 368-78Stemmer-Rachamimov, Anat O; Louis, David N; Nielsen, Gunnlaugur P; Antonescu, Cristina R; Borowsky, Alexander D; Bronson, Roderick T; Burns, Dennis K; Cervera, Pascale; McLaughlin, Margaret E; Reifenberger, Guido; Schmale, Michael C; MacCollin, Mia; Chao, Richard C; Cichowski, Karen; Kalamarides, Michel; Messerli, Shanta M; McClatchey, Andrea I; Niwa-Kawakita, Michiko; Ratner, Nancy; Reilly, Karlyne M; Zhu, Yuan; Giovannini, Marco 2004. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer research, 64 10, 3718-24Stickney, John T; Bacon, W Clark; Rojas, Meghan; Ratner, Nancy; Ip, Wallace 2004. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer research, 64 8, 2717-24Tang, Yang; Lu, Aigang; Ran, Ruiqiong; Aronow, Bruce J; Schorry, Elizabeth K; Hopkin, Robert J; Gilbert, Donald L; Glauser, Tracy A; Hershey, Andrew D; Richtand, Neil W; Privitera, Michael; Dalvi, Arif; Sahay, Alok; Szaflarski, Jerzy P; Ficker, David M; Ratner, Nancy; Sharp, Frank R 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain research. Molecular brain research, 132 2, 155-67Bennett, Michael R; Rizvi, Tilat A; Karyala, Saikumar; McKinnon, Randall D; Ratner, Nancy 2003. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 18, 7207-17Manent, Jan; Oguievetskaia, Ksenia; Bayer, Jan; Ratner, Nancy; Giovannini, Marco 2003. Magnetic cell sorting for enriching Schwann cells from adult mouse peripheral nerves. Journal of neuroscience methods, 123 2, 167-73Miller, Shyra J; Li, Hongzhen; Rizvi, Tilat A; Huang, Yuan; Johansson, Gunnar; Bowersock, Jason; Sidani, Amer; Vitullo, John; Vogel, Kristine; Parysek, Linda M; DeClue, Jeffrey E; Ratner, Nancy 2003. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Molecular and cellular biology, 23 6, 2213-24Yang, Feng-Chun; Ingram, David A; Chen, Shi; Hingtgen, Cynthia M; Ratner, Nancy; Monk, Kelly R; Clegg, Travis; White, Hilary; Mead, Laura; Wenning, Mary Jo; Williams, David A; Kapur, Reuben; Atkinson, Simon J; Clapp, D Wade 2003. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of clinical investigation, 112 12, 1851-61Bashour, Anne-Marie; Meng, J-J; Ip, Wallace; MacCollin, Mia; Ratner, Nancy 2002. The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Molecular and cellular biology, 22 4, 1150-7Morfini, Gerardo; Szebenyi, Györgyi; Elluru, Ravindhra; Ratner, Nancy; Brady, Scott T 2002. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The EMBO journal, 21 3, 281-93Rizvi, Tilat A; Huang, Yuan; Sidani, Amer; Atit, Radhika; Largaespada, David A; Boissy, Raymond E; Ratner, Nancy 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 22, 9831-40Xu, Yanfang; Chiamvimonvat, Nipavan; Vázquez, Ana E; Akunuru, Shailaja; Ratner, Nancy; Yamoah, Ebenezer N 2002. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 21, 9194-202Rosenbaum, Thorsten; Kim, Haesun A; Boissy, Ying L; Ling, B O; Ratner, Nancy 1999. Neurofibromin, the Neurofibromatosis Type 1 Ras-GAP, Is Required for Appropriate P0 Expression and Myelination. Annals of the New York Academy of Sciences, 883 1, 203-214