Education/CredentialsFellowship: University of MichiganDoctoral Degree: Peking University (Physiology)Bachelor's Degree: Hebei Medical University (Clinical Medicine) Contact Information Vontz Center Office 513-558-5343 Email fanyb@ucmail.uc.edu Research InterestsThe main focuses of my laboratory are: 1) The roles of TFEB in angiogenesis, aortic aneurysm and tumor vascular biology. 2) Identification of novel molecular targets for the treatment of vascular diseases. Peer Reviewed Publications Wang, Chenran; Nagayach, Aarti; Patel, Harsh; Dao, Lan; Zhu, Hui; Wasylishen, Amanda R; Fan, Yanbo; Kendler, Ady; Guo, Ziyuan 2024. Utilizing human cerebral organoids to model breast cancer brain metastasis in culture. Breast cancer research : BCR, 26 1, 108Wang, Xiaohong; Du, Wa; Li, Yutian; Yang, Hui-Hui; Zhang, Yu; Akbar, Rubab; Morgan, Hannah; Peng, Tianqing; Chen, Jing; Sadayappan, Sakthivel; Hu, Yueh-Chiang; Fan, Yanbo; Huang, Wei; Fan, Guo-Chang 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI insight, 9 5, Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. Gastroenterology, , Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. bioRxiv : the preprint server for biology, , Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Tang, Xin; Walter, Ellen; Wohleb, Eric; Fan, Yanbo; Wang, Chenran 2023. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy, , 1-16Tang, Xin; Walter, Ellen; Wohleb, Eric; Fan, Yanbo; Wang, Chenran 2023. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy, , 1-16Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway. Cardiovascular research, , Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang 2022. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in immunology, 13 , 930397Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2, Fan, Yanbo; Wolford, Brooke N; Lu, Haocheng; Liang, Wenying; Sun, Jinjian; Zhou, Wei; Rom, Oren; Mahajan, Anubha; Surakka, Ida; Graham, Sarah E; Liu, Zhipeng; Kim, Hyunbae; Ramdas, Shweta; Fritsche, Lars G; Nielsen, Jonas B; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Yang, Dongshan; Song, Jun; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Zhang, Kezhong; Willer, Cristen J; Chen, Y Eugene 2021. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience, 24 11, 103196Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo#; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, , Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, , Liu, Yuhao; Zhao, Ying; Shukha, Yousef; Lu, Haocheng; Wang, Lu; Liu, Zhipeng; Liu, Cai; Zhao, Yang; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Fan, Yanbo; Chang, Lin; Yurdagul, Arif; Pattillo, Christopher B; Orr, A Wayne; Aviram, Michael; Wen, Bo; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Sun, Duxin; Hayek, Tony; Chen, Y Eugene; Rom, Oren 2021. Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis. Cell reports, 36 4, 109420Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, , e023601Lu, Haocheng; Sun, Jinjian; Hamblin, Milton H; Chen, Y Eugene; Fan, Yanbo 2021. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine, 63 , 103207Zhao, Guizhen; Chang, Ziyi; Zhao, Yang; Guo, Yanhong; Lu, Haocheng; Liang, Wenying; Rom, Oren; Wang, Huilun; Sun, Jinjian; Zhu, Tianqing; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Chen, Y Eugene; Zhang, Jifeng 2021. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI insight, 6 5, Chang, Ziyi; Zhao, Guizhen; Zhao, Yang; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Rom, Oren; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Lin, Jiandie D; Chen, Y Eugene; Zhang, Jifeng 2020. BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm by Reducing Inflammation and Extracellular Matrix Degradation. Arteriosclerosis, thrombosis, and vascular biology, 40 10, 2494-2507Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Chang, Ziyi; Rom, Oren; Zhao, Yang; Zhao, Guizhen; Xiong, Wenhao; Wang, Huilun; Zhu, Tianqing; Guo, Yanhong; Chang, Lin; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB. Circulation, , Rom, Oren; Liu, Yuhao; Liu, Zhipeng; Zhao, Ying; Wu, Jianfeng; Ghrayeb, Alia; Villacorta, Luis; Fan, Yanbo; Chang, Lin; Wang, Lu; Liu, Cai; Yang, Dongshan; Song, Jun; Rech, Jason C; Guo, Yanhong; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Koike, Yui; Lu, Haocheng; Koike, Tomonari; Hayek, Tony; Pennathur, Subramaniam; Xi, Chuanwu; Wen, Bo; Sun, Duxin; Garcia-Barrio, Minerva T; Aviram, Michael; Gottlieb, Eyal; Mor, Inbal; Liu, Wanqing; Zhang, Jifeng; Chen, Y Eugene 2020. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Science translational medicine, 12 572, Sun, Jinjian; Lu, Haocheng; Liang, Wenying; Zhao, Guizhen; Ren, Lu; Hu, Die; Chang, Ziyi; Liu, Yuhao; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120315310Sun, Yifang; Venugopal, Jessica; Guo, Chiao; Fan, Yanbo; Li, Jianping; Gong, Yanjun; Chen, Y Eugene; Zhang, Haoming; Eitzman, Daniel T 2020. Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120314146Zhang, Xuejing; Tang, Xuelian; Ma, Feifei; Fan, Yanbo; Sun, Ping; Zhu, Tianqing; Zhang, Jifeng; Hamblin, Milton H; Chen, Y Eugene; Yin, Ke-Jie 2020. Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury. Brain pathology (Zurich, Switzerland), , Zhao, Yang; Chang, Ziyi; Zhao, Guizhen; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Wang, Huilun; Villacorta, Luis; Garcia-Barrio, Minerva T; Zhu, Tianqing; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Schopfer, Francisco J; Freeman, Bruce A; Zhang, Jifeng; Chen, Y Eugene 2020. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovascular drugs and therapy, , Liang, Wenying*; Fan, Yanbo*,#; Lu, Haocheng; Chang, Ziyi; Hu, Wenting; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Wang, Jintao; Adili, Reheman; Garcia-Barrio, Minerva T; Holinstat, Michael; Eitzman, Daniel; Zhang, Jifeng; Chen, Y Eugene 2019. KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arteriosclerosis, thrombosis, and vascular biology, 39 3, 402-412Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Zhang, Jifeng; Rom, Oren; Garcia-Barrio, Minerva T; Li, Shengdi; Villacorta, Luis; Schopfer, Francisco J; Freeman, Bruce A; Chen, Y Eugene; Fan, Yanbo 2019. Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells. Physiological genomics, 51 6, 224-233Rom, Oren; Xu, Guan; Guo, Yanhong; Zhu, Yunhao; Wang, Huilun; Zhang, Jifeng; Fan, Yanbo; Liang, Wenying; Lu, Haocheng; Liu, Yuhao; Aviram, Michael; Liu, Zhipeng; Kim, Seongho; Liu, Wanqing; Wang, Xueding; Chen, Y Eugene; Villacorta, Luis 2019. Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice. EBioMedicine, 41 , 62-72Chang, Lin; Xiong, Wenhao; Zhao, Xiangjie; Fan, Yanbo; Guo, Yanhong; Garcia-Barrio, Minerva; Zhang, Jifeng; Jiang, Zhisheng; Lin, Jiandie D; Chen, Y Eugene 2018. Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen. Circulation, 138 1, 67-79Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Garcia-Barrio, Minerva T; Guo, Yanhong; Zhang, Ji; Zhu, Tianqing; Hao, Yibai; Zhang, Jifeng; Chen, Y Eugene 2018. Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. Circulation research, 122 7, 945-957Hu, Wenting; Lu, Haocheng; Zhang, Jifeng; Fan, Yanbo; Chang, Ziyi; Liang, Wenying; Wang, Huilun; Zhu, Tianqing; Garcia-Barrio, Minerva T; Peng, Daoquan; Chen, Y Eugene; Guo, Yanhong 2018. Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-?B signaling pathway. Atherosclerosis, 278 , 39-48Qiao, Congzhen; Li, Shengdi; Lu, Haocheng; Meng, Fan; Fan, Yanbo; Guo, Yanhong; Chen, Y Eugene; Zhang, Jifeng 2018. Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells. Scientific reports, 8 1, 2360Xiong, Wenhao; Zhao, Xiangjie; Villacorta, Luis; Rom, Oren; Garcia-Barrio, Minerva T; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Zhang, Jifeng; Zeng, Rong; Chen, Y Eugene; Jiang, Zhisheng; Chang, Lin 2018. Brown Adipocyte-Specific PPAR? (Peroxisome Proliferator-Activated Receptor ?) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 8, 1738-1747Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Hu, Wenting; Zhang, Jifeng; Chen, Y Eugene 2017. Krüppel-like factors and vascular wall homeostasis. Journal of molecular cell biology, 9 5, 352-363Lu, Haocheng*; Fan, Yanbo*,#; Qiao, Congzhen; Liang, Wenying; Hu, Wenting; Zhu, Tianqing; Zhang, Jifeng; Chen, Y Eugene 2017. TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Science signaling, 10 464, Zhang, Jifeng; Niimi, Manabu; Yang, Dongshan; Liang, Jingyan; Xu, Jie; Kimura, Tokuhide; Mathew, Anna V; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Song, Jun; Ackermann, Rose; Koike, Yui; Schwendeman, Anna; Lai, Liangxue; Pennathur, Subramaniam; Garcia-Barrio, Minerva; Fan, Jianglin; Chen, Y Eugene 2017. Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arteriosclerosis, thrombosis, and vascular biology, 37 6, 1068-1075Fan, Yanbo; Lu, Haocheng; Guo, Yanhong; Zhu, Tianqing; Garcia-Barrio, Minerva T; Jiang, Zhisheng; Willer, Cristen J; Zhang, Jifeng; Chen, Y Eugene 2016. Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice. Gastroenterology, 150 5, 1208-1218Fan, Yanbo; Willer, Cristen J; Chen, Y Eugene 2016. Reply. Gastroenterology, 151 5, 1034-1035Zhang, Ji; Qiao, Congzhen; Chang, Lin; Guo, Yanhong; Fan, Yanbo; Villacorta, Luis; Chen, Y Eugene; Zhang, Jifeng 2016. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PloS one, 11 6, e0157372Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Lomberk, Gwen A; Zhou, Zhou; Sun, Lijie; Mathison, Angela J; Garcia-Barrio, Minerva T; Zhang, Ji; Zeng, Lixia; Li, Lei; Pennathur, Subramaniam; Willer, Cristen J; Rader, Daniel J; Urrutia, Raul; Chen, Y Eugene 2015. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. The Journal of clinical investigation, 125 10, 3819-30Yin, Ke-Jie; Hamblin, Milton; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2015. Krüpple-like factors in the central nervous system: novel mediators in stroke. Metabolic brain disease, 30 2, 401-10Holmen, Oddgeir L*; Zhang, He*; Fan, Yanbo*; Hovelson, Daniel H; Schmidt, Ellen M; Zhou, Wei; Guo, Yanhong; Zhang, Ji; Langhammer, Arnulf; Løchen, Maja-Lisa; Ganesh, Santhi K; Vatten, Lars; Skorpen, Frank; Dalen, Håvard; Zhang, Jifeng; Pennathur, Subramaniam; Chen, Jin; Platou, Carl; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Boehnke, Michael; Chen, Y Eugene; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J 2014. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature genetics, 46 4, 345-51Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Chang, Lin; Lin, Jiandie D; Chen, Y Eugene 2013. Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells. The Journal of biological chemistry, 288 7, 4625-36Liu, Ling; Zhou, Zhou; Huang, Shengping; Guo, Yanhong; Fan, Yanbo; Zhang, Ji; Zhang, Jifeng; Fu, Mingui; Chen, Y Eugene 2013. Zc3h12c inhibits vascular inflammation by repressing NF-?B activation and pro-inflammatory gene expression in endothelial cells. The Biochemical journal, 451 1, 55-60Yang, Dongshan; Zhang, Jifeng; Xu, Jie; Zhu, Tianqing; Fan, Yanbo; Fan, Jianglin; Chen, Y Eugene 2013. Production of apolipoprotein C-III knockout rabbits using zinc finger nucleases. Journal of visualized experiments : JoVE, 81, e50957Yin, Ke-Jie*; Fan, Yanbo*; Hamblin, Milton; Zhang, Jifeng; Zhu, Tainqing; Li, Siming; Hawse, John R; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Lin, Jiandie D; Chen, Y Eugene 2013. KLF11 mediates PPAR? cerebrovascular protection in ischaemic stroke. Brain : a journal of neurology, 136 Pt 4, 1274-87Fan, Yanbo; Guo, Yanhong; Zhang, Jifeng; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Chen, Y Eugene 2012. Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-?B signaling pathway. Arteriosclerosis, thrombosis, and vascular biology, 32 12, 2981-8Fan, Yanbo; Chen, Y Eugene 2011. Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents. Circulation journal : official journal of the Japanese Circulation Society, 75 5, 1051-2Fan, Yanbo; Guo, Yanhong; Hamblin, Milton; Chang, Lin; Zhang, Jifeng; Chen, Y Eugene 2011. Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor ?. The Journal of biological chemistry, 286 47, 40584-94Hamblin, Milton; Chang, Lin; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2009. PPARs and the cardiovascular system. Antioxidants & redox signaling, 11 6, 1415-52Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping 2009. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 29 1, 67-74Fan, Yanbo; Wang, Ying; Tang, Zhihui; Zhang, Hong; Qin, Xiaomei; Zhu, Yi; Guan, Youfei; Wang, Xian; Staels, Bart; Chien, Shu; Wang, Nanping 2008. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 28 2, 315-21Qin, Xiaomei; Xie, Xuefen; Fan, Yanbo; Tian, Jianwei; Guan, Youfei; Wang, Xian; Zhu, Yi; Wang, Nanping 2008. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology (Baltimore, Md.), 48 2, 432-41Tang, Zhihui; Wang, Ying; Fan, Yanbo; Zhu, Yi; Chien, Shu; Wang, Nanping 2008. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Circulation, 118 7, 764-72Zhang, Hong; Li, Yuanyuan; Fan, Yanbo; Wu, Jing; Zhao, Beilei; Guan, Youfei; Chien, Shu; Wang, Nanping 2008. Klotho is a target gene of PPAR-gamma. Kidney international, 74 6, 732-9Zhou, Yunfeng; Zhang, Xiaoyan; Chen, Lihong; Wu, Jing; Dang, Huaixin; Wei, Mingfen; Fan, Yanbo; Zhang, Yahua; Zhu, Yi; Wang, Nanping; Breyer, Matthew D; Guan, Youfei 2008. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. American journal of physiology. Renal physiology, 295 3, F662-71Qin, Xiaomei; Tian, Jianwei; Zhang, Peng; Fan, Yanbo; Chen, Li; Guan, Youfei; Fu, Yi; Zhu, Yi; Chien, Shu; Wang, Nanping 2007. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovascular research, 74 3, 506-14
Research InterestsThe main focuses of my laboratory are: 1) The roles of TFEB in angiogenesis, aortic aneurysm and tumor vascular biology. 2) Identification of novel molecular targets for the treatment of vascular diseases.
Peer Reviewed Publications Wang, Chenran; Nagayach, Aarti; Patel, Harsh; Dao, Lan; Zhu, Hui; Wasylishen, Amanda R; Fan, Yanbo; Kendler, Ady; Guo, Ziyuan 2024. Utilizing human cerebral organoids to model breast cancer brain metastasis in culture. Breast cancer research : BCR, 26 1, 108Wang, Xiaohong; Du, Wa; Li, Yutian; Yang, Hui-Hui; Zhang, Yu; Akbar, Rubab; Morgan, Hannah; Peng, Tianqing; Chen, Jing; Sadayappan, Sakthivel; Hu, Yueh-Chiang; Fan, Yanbo; Huang, Wei; Fan, Guo-Chang 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI insight, 9 5, Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. Gastroenterology, , Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. bioRxiv : the preprint server for biology, , Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Tang, Xin; Walter, Ellen; Wohleb, Eric; Fan, Yanbo; Wang, Chenran 2023. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy, , 1-16Tang, Xin; Walter, Ellen; Wohleb, Eric; Fan, Yanbo; Wang, Chenran 2023. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy, , 1-16Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway. Cardiovascular research, , Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang 2022. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in immunology, 13 , 930397Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2, Fan, Yanbo; Wolford, Brooke N; Lu, Haocheng; Liang, Wenying; Sun, Jinjian; Zhou, Wei; Rom, Oren; Mahajan, Anubha; Surakka, Ida; Graham, Sarah E; Liu, Zhipeng; Kim, Hyunbae; Ramdas, Shweta; Fritsche, Lars G; Nielsen, Jonas B; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Yang, Dongshan; Song, Jun; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Zhang, Kezhong; Willer, Cristen J; Chen, Y Eugene 2021. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience, 24 11, 103196Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo#; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, , Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, , Liu, Yuhao; Zhao, Ying; Shukha, Yousef; Lu, Haocheng; Wang, Lu; Liu, Zhipeng; Liu, Cai; Zhao, Yang; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Fan, Yanbo; Chang, Lin; Yurdagul, Arif; Pattillo, Christopher B; Orr, A Wayne; Aviram, Michael; Wen, Bo; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Sun, Duxin; Hayek, Tony; Chen, Y Eugene; Rom, Oren 2021. Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis. Cell reports, 36 4, 109420Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, , e023601Lu, Haocheng; Sun, Jinjian; Hamblin, Milton H; Chen, Y Eugene; Fan, Yanbo 2021. Transcription factor EB regulates cardiovascular homeostasis. 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