Timothy Phoenix

du Chatinier A, Meel MH, Das AI, Metselaar DS, Waranecki P, Bugiani M, Breur M, Simonds EF, Lu ED, Weiss WA, Garcia Vallejo JJ, Hoving EW, Phoenix TN*, Hulleman E.* 2022. Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma Neuro-Oncology Advances, 4(1) , doi: 10.1093/noajnl/vdac079

Khadka P, Reitman ZJ, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald NF, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonanno K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez EM, Qian K, Morin E, Langhnoja J, Lupien LE, Rendo V, Digiacomo J, Wang D, Zhou K, Kumbhani R, Guerra Garcia ME, Sinai CE, Becker S, Schneider R, Vogelzang J, Krug K, Goodale A, Abid T, Kalani Z, Piccioni F, Beroukhim R, Persky NS, Root DE, Carcaboso AM, Ebert BL, Fuller C, Babur O, Kieran MW, Jones C, Keshishian H, Ligon KL, Carr SA, Phoenix TN*, Bandopadhayay P.* 2022. PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation Nature Communications, 13(1) , 604. doi: 10.1038/s41467-022-28198-8

Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d'Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. 2022. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders Science, 375(6582) , 4459. doi: 10.1126/science.abm4459

Rao R, Han R, Ogurek S, Xue C, Wu LM, Zhang L, Zhang L, Hu J, Phoenix TN, Waggoner SN, Lu QR. 2022. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition Neuro-Oncology, 24(4), 584-597. doi: 10.1093/neuonc/noab228

Sweha SR, Chung C, Natarajan SK, Panwalkar P, Pun M, Ghali A, Bayliss J, Pratt D, Shankar A, Ravikumar V, Rao A, Cieslik M, Wilder-Romans K, Scott AJ, Wahl DR, Jessa S, Kleinman CL, Jabado N, Mackay A, Jones C, Martinez D, Santi M, Judkins AR, Yadav VN, Qin T, Phoenix TN, Koschmann CJ, Baker SJ, Chinnaiyan AM, Venneti S. 2022. Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas Science Translational Medicine, 13(615) , doi: 10.1126/scitranslmed.abf7860

Tsai JW, Cejas P, Wang DK, Patel S, Wu DW, Arounleut P, Wei X, Zhou N, Syamala S, Dubois FPB, Crane A, Pelton K, Vogelzang J, Sousa C, Baguette A, Chen X, Condurat AL, Dixon-Clarke SE, Zhou KN, Lu SD, Gonzalez EM, Chacon MS, Digiacomo JJ, Kumbhani R, Novikov D, Hunter J, Tsoli M, Ziegler DS, Dirksen U, Jäger N, Balasubramanian GP, Kramm CM, Nathrath M, Bielack S, Baker SJ, Zhang J, McFarland JM, Getz G, Aguet F, Jabado N, Witt O, Pfister SM, Ligon KL, Hovestadt V, Kleinman CL, Long H, Jones DTW*, Bandopadhayay P*, Phoenix TN.* 2022. FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits Cancer Research, , doi: 10.1158/0008-5472.CAN-22-0671

Wei X, Jessa S, Kleinman C, Phoenix TN 2021. Mapping Angiopoietin1 expression in the developing and adult brain Dev. Neurosci, Jul 15. doi: 10.1159/000518351 43(6), 321-334. doi: 10.1159/000518351

Wei X, Meel MH, Breur M, Bugiani M, Hulleman E, Phoenix TN 2021. Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas Acta Neuropathol Commun, Aug 23;9(1) , 142

Meel MH, de Gooijer MC, Metselaar DS, Sewing ACP, Zwaan K, Waranecki P, Breur M, Buil LCM, Lagerweij T, Wedekind LE, Twisk JWR, Koster J, Hashizume R, Raabe EH, Montero Carcaboso Á, Bugiani M, Phoenix TN, van Tellingen O, van Vuurden DG, Kaspers GJL, Hulleman E 2020. Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma Clinical Cancer Research, ,

Miklja Z, Yadav VN, Cartaxo RT, Siada R, Thomas CC, Cummings JR, Mullan B, Stallard S, Paul A, Bruzek AK, Wierzbicki K, Yang T, Garcia T, Wolfe I, Leonard M, Robertson PL, Garton HJL, Wahl DR, Sarkaria JN, Kline C, Mueller S, Nicolaides T, Glasser C, Leary SES, Venneti S, Kumar-Sinha C, Chinnaiyan AM, Mody R, Pai MP, Phoenix TN, Marini BL, Koschmann C 2020. Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma Journal of Clinical Investigation, ,

Patel SK, Hartley RM, Wei X, Furnish R, Escobar-Riquelme F, Bear H, Choi K, Fuller C, Phoenix TN 2020. Generation of diffuse intrinsic pontine glioma mouse models by brainstem targeted in utero electroporation Neuro-Oncology, 5 22, 381

Senthil Kumar S, Sengupta S, Zhu X, Mishra DK, Phoenix T, Dyer L, Fuller C, Stevenson CB, DeWire M, Fouladi M, Drissi R 2020. Diffuse intrinsic pontine glioma cells are vulnerable to mitotic abnormalities associated with BMI-1 modulation Molecular Cancer Research, Nov;18 11, 1711

Hovestadt, H, Smith, KS, Bihannic, L, Filbin, M, Shaw, M, Baumgartner, A, DeWitt, JC, Groves, A, Mayr, L, Richman, L, Shore, ME, Goumnerova, L, Rosencrance, C, Carter, R, Phoenix TN, Hadley J, Tong, Y, DeCuypere, M, Orr. BA, Sharma, T, Ligon, KL, Pomeroy, SL, Rivera, MN, Rozenblatt-Rosen, M, Rusert, JM, Wechsler-Reya, R, Li, X, Peyrl, A, Gojo, J, Kirchhofer, D, Lötsch, D, Czech, Dorfer, TC, Haberler, C, Geyregger, R, Halfmann, A, Gawad, C, Easton, J, Pfister, SM, Regev, A, Gajjar, A, Slavc, I, Robinson, GW, Bernstein, BE#, Suvà, ML#, Northcott, PA# 2019. Resolving the cellular architecture of medulloblastoma by single-cell genomics Nature, 572 7767, 74

Meel MH, Guillén Navarro M, de Gooijer MC, Metselaar DS, Waranecki P, Breur M, Lagerweij T, Wedekind LE, Koster J, van de Wetering MD, Schouten-van Meeteren N, Aronica E, van Tellingen O, Bugiani M, Phoenix TN, Kaspers GJL, Hulleman E 2019. MEK/MELK inhibition and blood-brain barrier-deficiencies in atypical teratoid/rhabdoid tumors Neuro-Oncology, 11 22, 58

Carter RA, Bihannic L, Rosencrance C, Hadley JL, Tong Y, Phoenix TN, Natarajan S, Easton J, Northcott PA, Gawad C. 2018. A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum Current Biology, ,

Hu XL, Chen G, Zhang S, Zheng J, Wu J, Bai QR, Wang Y, Li J, Wang H, Feng H, Li J, Sun X, Xia Q, Yang F, Hang J, Qi C, Phoenix TN, Temple S, Shen Q. 2017. Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells Neuron, 95 2, 309

Kawauchi D, Ogg RJ, Liu L, Shih DJH, Finkelstein D, Murphy BL, Rehg JE, Korshunov A, Calabrese C, Zindy F, Phoenix T, Kawaguchi Y, Gronych J, Gilbertson RJ, Lichter P, Gajjar A, Kool M, Northcott PA, Pfister SM, Roussel MF. 2017. Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells Oncogene, May 15,

Phoenix TN, Patmore DM, Boop, S, Boulos N, Jacus MO, Patel YT, Roussel MF, Goumnerova L, Perreault S, Wadhwa E, Cho YJ, Roussel MF, Stewart CF, Gilbertson, RJ. 2016. Medulloblastoma genotype dictates blood brain barrier phenotype Cancer Cell, 29 4, 508-22

Eden CJ, Ju B, Murugesan M, Phoenix TN, Nimmervoll B, Tong Y, Ellison DW, Finkelstein D, Wright K, Boulos N, Dapper J, Thiruvenkatam R, Lessman CA, Taylor MR, Gilbertson RJ. 2014. Orthotopic models of pediatric brain tumors in zebrafish. Oncogene, 34 13, 1736-42

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksfort J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. 2014. C11orf95-RELA fusions drive oncogenic NF-kB signalling in ependymoma Nature, 506 7489, 451-55

Liddelow SA, Temple S, Møllgård K, Gehwolf R, Wagner A, Bauer H, Bauer HC, Phoenix TN, Dziegielewska KM, Saunders NR. 2012. Molecular Characterization of Transport Mechanisms at the Developing Mouse Blood-CSF Interface: a Transcriptome Approach PLoS One, 7 3, e33554

Robinson G, Parker M, Kranenberg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Lei W, Zhu X, Chalhoub N, Baker SJ, Huether R, Wang J, Wu G, Rusch M, Hong X, Becksford J, Gupta P, Ma J, Easton J, Pounds S, Zhao D, Gajjar A, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Fulton LL, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. 2012. Novel Mutations Target Distinct Subgroups of Medulloblastoma Nature, 488 7409, 43-48

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. 2011. An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma Cancer Cell, 20 3, 384-99

Liddelow SA, Dziegielewska KM, Møllgård K, Phoenix TN, Temple S, Vandeberg JL, Saunders NR. 2011. SPARC/Osteonectin, an Endogenous Mechanism for Targeting Albumin to the Blood-Cerebrospinal Fluid Interface During Brain Development European Journal of Neuroscience, 34 7, 1062-73

Phoenix TN, and Temple S. 2010. Spred1, a Negative Regulator of MAPK-ERK, is Enriched in CNS Germinal Zones, Dampens NSC Proliferation and Maintains Neuroepithelial Structure Genes and Development, 24 1, 45-56

Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos J, Lemischka I, Studer L, Temple S. 2009. BMI-1 Regionally Maintains Neurogenic Stem Cells in the Forebrain Genes and Development, 23 5, 561-74

Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, and Temple S. 2006. The Timing of Cortical Neurogenesis is Encoded Within Lineages of Individual Progenitor Cells Nature Neuroscience, 9 6, 743-51