Contact Information Medical Sciences Building 3310 Office 513-558-0947 Email webergf@ucmail.uc.edu Research InterestsCancers are increasingly classified on the molecular level (Weber 2007; Weber 2010a; Weber 2010b; Weber et al. 2012). Gain-of-function mutations of oncogenes or loss-of-function mutations of tumor suppressor genes underlie excessive cell division. Activation of senescence suppressor genes or inactivation of senescence genes underlies immortalization. While molecular studies have made their relation to the uncontrolled expansion of tumor cells obvious, it has not been clear why these defects also induce th... Peer Reviewed Publications An, Yu; Fnu, Gulimirerouzi; Xie, Changchun; Weber, Georg F 2023. Meta-analysis of Osteopontin splice variants in cancer. BMC cancer, 23 1, 373Fnu, Gulimirerouzi; Weber, Georg F 2023. Osteopontin induces mitochondrial biogenesis in deadherent cancer cells. Oncotarget, 14 , 957-969Weber, Georg F 2023. Crossroads: the role of biomarkers in the management of lumps in the breast. Oncotarget, 14 , 358-362Fnu, Gulimirerouzi; Hudock, Kristin; Powers-Fletcher, Margaret; Huang, Ruo-Pan; Weber, Georg F 2022. Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response. Immunology, 167 2, 165-180Ziółkowski, Piotr; Woźniak, Marta; Mansour, Ahmad; An, Yu; Weber, Georg F 2022. Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis. Breast cancer research : BCR, 24 1, 64Butti, Ramesh; Nimma, Ramakrishna; Kundu, Gautam; Bulbule, Anuradha; Kumar, Totakura V S; Gunasekaran, Vinoth Prasanna; Tomar, Deepti; Kumar, Dhiraj; Mane, Anupama; Gill, Satyajit S; Patil, Tushar; Weber, Georg F; Kundu, Gopal C 2021. Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. Oncogene, 40 11, 2002-2017Fnu, Gulimirerouzi; Agrawal, Palak; Kundu, Gopal C; Weber, Georg F 2021. Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44. Biomolecules, 11 6, Fnu, Gulimirerouzi; Weber, Georg F 2021. Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment. Frontiers in oncology, 11 , 765329Wang, Xia; Weber, Georg F 2021. Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin. Frontiers in genetics, 12 , 700789Hartung, Franz; Patil, Aditya; Meshram, Rohan J; Weber, Georg F 2020. Gene expression signatures of site-specificity in cancer metastases. Clinical & experimental metastasis, 37 1, 159-171Weber, Georg F 2020. Cancer research - can the entity be bigger than the sum of its parts? Oncoscience, 7 3-4, 17-18Alsarkhi, Lamyaa Kadhim; Weber, Georg F 2018. Anti?osteopontin autoantibodies in various types of cancer. Oncology reports, 40 6, 3879-3889Walaszek, Kinga; Lower, Elyse E; Ziolkowski, Piotr; Weber, Georg F 2018. Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis. British journal of cancer, 119 10, 1259-1266Weber, Georg F 2018. The Phylogeny of Osteopontin-Analysis of the Protein Sequence. International journal of molecular sciences, 19 9, Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Aparicio-Bautista, Diana Ivette; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochimica et biophysica acta. Reviews on cancer, 1868 1, 93-108.ABriones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Ivette Aparicio-Bautista, Diana; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data in brief, 14 , 538-542Hartung, Franz; Wang, Yunguan; Aronow, Bruce; Weber, Georg F 2017. A core program of gene expression characterizes cancer metastases. Oncotarget, 8 60, 102161-102175Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F 2016. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Laboratory investigation; a journal of technical methods and pathology, 96 12, 1234-1245Unruh D, Ünlu B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY 2016. Antibody-based targeting of alternatively spliced Tissue Factor: a new approach to impede the primary growth and aggressiveness of pancreatic ductal adenocarcinoma. Oncotarget, , Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75Weber GF 2016. Metabolism in cancer metastasis International Journal of Cancer, , Weber, Georg F 2016. Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression. Frontiers in oncology, 6 , 257Weber, Georg F 2016. Metabolism in cancer metastasis. International journal of cancer, 138 9, 2061-6Zduniak, Krzysztof; Agrawal, Anil; Agrawal, Siddarth; Hossain, Md Monir; Ziolkowski, Piotr; Weber, Georg F 2016. Osteopontin splice variants are differential predictors of breast cancer treatment responses. BMC cancer, 16 , 441Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for cancer BBA Reviews on Cancer, 1855 , 202-222Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for the skeletal system Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders. Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer. Biochimica et biophysica acta, 1855 2, 202-22Weber GF 2015. Somnambulism and allergy Clinical and Experimental Neuroimmunology , 6 , 321Weber GF 2015. Molecular analysis of a recurrent sarcoma identifies a mutation in FAF1 Sarcoma, 839182 , doi:10.1155/2015/839182Weber, Georg F 2015. Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma, 2015 , 839182Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF 2015. Nuclear Osteopontin-c is a marker for breast cancer prognosis British Journal of Cancer , 112 , 729-738Zduniak, K; Ziolkowski, P; Ahlin, C; Agrawal, A; Agrawal, S; Blomqvist, C; Fjällskog, M-L; Weber, G F 2015. Nuclear osteopontin-c is a prognostic breast cancer marker. British journal of cancer, 112 4, 729-38Shen H, Weber GF 2014. The osteopontin-c splice junction is important for anchorage-independent growth Molecular Carcinogenesis, 53 , 480-487Shi Z, Mirza M, Wang B, Kennedy MA, Weber GF 2014. Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells Cancer Letters, 344 , 47-53Shi Z, Wang B, Kennedy MA, Weber GF 2014. Metabolic skewing during anchorage independence. Induction by osteopontin-c PlosOne, 9 , e105675Shi, Zhanquan; Wang, Bo; Chihanga, Tafadzwa; Kennedy, Michael A; Weber, Georg F 2014. Energy metabolism during anchorage-independence. Induction by osteopontin-c. PloS one, 9 8, e105675Weber GF, Johnson BN, Yamamoto BK, Gudelsky GA 2014. Effects of stress and MDMA on hippocampal gene expression BioMed Research International, 2014 , 141396Hartung F, Weber GF 2013. RNA blood levels of osteopontin splice variants are cancer markers SpringerPlus, 2 , 110Milanowski P, Carter TJ, Weber GF 2013. Enzyme catalysis and the outcome of biochemical reactions Journal of Proteomics and Bioinformatics , 6 , 132-141Ramchandani D, Weber GF 2013. An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer Oncology Reports, 30 , 1860-1868Wang B, Shi Z, Weber GF, Kennedy MA 2013. Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data Analytical and Bioanalytical Chemistry, 405 , 8419-8429Weber GF 2013. Gene therapy--why can it fail? Medical Hypotheses, 80 , 613-616Weber GF 2013. Dynamic knowledge - a century of evolution Sociology Mind , 3 , 268-277Weber, Georg F 2013. Why does cancer therapy lack effective anti-metastasis drugs? Cancer letters, 328 2, 207-11Weber GF 2012. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Letters, 328 , 207-211Weber GF, Warren J, Shoma H, Chen T, Halim A, Chakravarty G 2012. Biomarkers - A pot of gold or a can of worms? Meeting report from the 2nd world congress on biomarkers in clinical research, 2011, Baltimore, USA Cancer Biology & Therapy , 13 , 831-835Tilli TM, Franco VF, Robbs BK, Wanderley JL, Silva F, Duarte de Mello K, Viola JPB, Weber GF, Gimba ERP 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression Molecular Cancer Research , 9 , 280-293Tilli, Tatiana M; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, João Luiz Mendes; da Silva, Fabrício Ribeiro de Azevedo; de Mello, Kivvi Duarte; Viola, João P B; Weber, Georg F; Gimba, Etel R 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Molecular cancer research : MCR, 9 3, 280-93Weber GF 2011. The cancer biomarker Osteopontin: Combination with other markers Cancer Genomics and Proteomics, 8 , 263-288Weber GF, Lett GS, Haubein NC 2011. Categorical meta-analysis of Osteopontin as a clinical cancer marker Oncology Reports, 25 , 433-441Zhang R, Pan X, Huang Z, Weber GF, Zhang G 2011. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines PloS one, 6 , e23831Weber GF 2010. Molecular genetics and metastasis Encyclopedia of Life Sciences, , DOI 10.1002/9780470015902.a0022447Weber GF 2010. Toward a molecular classification of cancer Biomarker Theme Issue of Toxicology, 278 , 195-198Weber GF, Lett GS, Haubein NC 2010. Osteopontin is a marker for cancer aggressiveness and patient survival British Journal of Cancer , 103 , 861-869Weber, G F; Lett, G S; Haubein, N C 2010. Osteopontin is a marker for cancer aggressiveness and patient survival. British journal of cancer, 103 6, 861-9Weber, Georg F 2010. Toward a molecular classification of cancer. Toxicology, 278 2, 195-8Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma Surgery, 146 , 232-240Sullivan, Jennifer; Blair, Laurel; Alnajar, Amer; Aziz, Tamer; Ng, Chee Yuan; Chipitsyna, Galina; Gong, Qiaoke; Witkiewicz, Agnes; Weber, Georg F; Denhardt, David T; Yeo, Charles J; Arafat, Hwyda A 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Surgery, 146 2, 232-40Weber GF 2009. Drug targets in cancer metastasis American Association for Cancer Research 100th Annual Meeting Education Book, , 137-140Mirza M, Shaughnessy E, Hurley JK, Vanpatten KA, Pestano GA, He B, Weber GF 2008. Osteopontin-c is a highly selective marker for breast cancer International Journal of Cancer , 122 , 889-897Mirza, Mana; Shaughnessy, Elizabeth; Hurley, John K; Vanpatten, Kristie A; Pestano, Gary A; He, Bin; Weber, Georg F 2008. Osteopontin-c is a selective marker of breast cancer. International journal of cancer, 122 4, 889-97Syed M, Fenoglio-Preiser C, Skau KA, Weber GF 2008. Acetylcholinesterase supports anchorage independence in colon cancer Clinical and Experimental Metastasis, 25 , 787-798Syed, Moyeenuddin; Fenoglio-Preiser, Cecilia; Skau, Kenneth A; Weber, Georg F 2008. Acetylcholinesterase supports anchorage independence in colon cancer. Clinical & experimental metastasis, 25 7, 787-98Weber GF 2008. Molecular mechanisms of metastasis Cancer Letters, 270 , 181-190Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for migration of transformed cells The Journal of Virology, 82 , 4946-4954Whalen, Kerry A; Weber, Georg F; Benjamin, Thomas L; Schaffhausen, Brian S 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. Journal of virology, 82 10, 4946-54He B, Mirza M, Weber GF 2006. An osteopontin splice variant induces anchorage independence in human breast cancer cells Oncogene, 25 , 2192-2202Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA 2006. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling Cancer Research, 66 , 6521-6529Craig-Mylius C, Weber GF, Coburn JL, Glickstein LG 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response Journal of Leukocyte Biology, 77 , 710-718Craig-Mylius, Kathleen; Weber, Georg F; Coburn, Jenifer; Glickstein, Lisa 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. Journal of leukocyte biology, 77 5, 710-8He B, Weber GF 2004. Synergistic activation of the CMV promoter by NF-kB P50 and Cyclic GMP-Dependent Kinase Biochemical and Biophysical Research Communications , 321 , 13-20Weber GF 2004. The absence of CD44 ameliorates Faslpr/lpr disease Autoimmunity , 37 , 1-8Weber, Georg F 2004. The absence of CD44 ameliorates Fas(lpr/lpr) disease. Autoimmunity, 37 1, 1-8He, Bin; Weber, Georg F 2003. Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation. European journal of biochemistry, 270 10, 2174-85Zhang, Guoxin; He, Bin; Weber, Georg F 2003. Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer. Molecular and cellular biology, 23 18, 6507-19Weber, Georg F; Bronson, Roderick T; Ilagan, John; Cantor, Harvey; Schmits, Rudolf; Mak, Tak W 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer research, 62 8, 2281-6Weber, Georg F; Zawaideh, Samer; Hikita, Sherry; Kumar, Vikram A; Cantor, Harvey; Ashkar, Samy 2002. Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. Journal of leukocyte biology, 72 4, 752-61Ashkar, S; Weber, G F; Panoutsakopoulou, V; Sanchirico, M E; Jansson, M; Zawaideh, S; Rittling, S R; Denhardt, D T; Glimcher, M J; Cantor, H 2000. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science (New York, N.Y.), 287 5454, 860-4Weber, G F; Ashkar, S 2000. Stress response genes: the genes that make cancer metastasize. Journal of molecular medicine (Berlin, Germany), 78 8, 404-8Pestano, G A; Zhou, Y; Trimble, L A; Daley, J; Weber, G F; Cantor, H 1999. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science (New York, N.Y.), 284 5417, 1187-91Weber, G F 1999. Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. Neuroscience and biobehavioral reviews, 23 8, 1079-86Weber, G F; Ashkar, S; Cantor, H 1997. Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proceedings of the Association of American Physicians, 109 1, 1-9Weber, G F; Daley, J; Kraeft, S K; Chen, L B; Cantor, H 1997. Measurement of apoptosis in heterogenous cell populations. Cytometry, 27 2, 136-44Weber, G F; Mirza, N M; Yunis, E J; Dubey, D; Cantor, H 1997. Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth, development, and aging : GDA, 61 3-4, 191-207Weber, G F; Ashkar, S; Glimcher, M J; Cantor, H 1996. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (New York, N.Y.), 271 5248, 509-12Weber, G F; Cantor, H 1996. The immunology of Eta-1/osteopontin. Cytokine & growth factor reviews, 7 3, 241-8Weber, G F; Abromson-Leeman, S; Cantor, H 1995. A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity, 2 4, 363-72Weber, G F 1994. The pathophysiology of reactive oxygen intermediates in the central nervous system. Medical hypotheses, 43 4, 223-30Weber, G F; Cantor, H 1994. Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. Journal of immunology (Baltimore, Md. : 1950), 152 9, 4433-43Chang, T K; Weber, G F; Crespi, C L; Waxman, D J 1993. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer research, 53 23, 5629-37Weber, G F; Bruch, H P 1993. Hydroxyethyl starch and diseases mediated by free radicals. Free radical biology & medicine, 14 1, 96-7Weber, G F; Waxman, D J 1993. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases. Archives of biochemistry and biophysics, 307 2, 369-78Weber, G F; Waxman, D J 1993. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. Biochemical pharmacology, 45 8, 1685-94LeBlanc, G A; Sundseth, S S; Weber, G F; Waxman, D J 1992. Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer research, 52 3, 540-7Weber, G F; Bruch, H P 1992. [The pharmacology of superoxide dismutase]. Die Pharmazie, 47 3, 159-67Weber, G F; Nair, M G 1992. Inhibition of the neutrophil NADPH oxidase by folic acid and antagonists of the folic acid metabolism. Immunopharmacology and immunotoxicology, 14 3, 523-38Weber, G F; Nair, M G; McCord, J M 1991. The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation. Immunopharmacology and immunotoxicology, 13 3, 379-93Weber, Georg F . The cancer biomarker osteopontin: combination with other markers. Cancer genomics & proteomics, 8 6, 263-88
Research InterestsCancers are increasingly classified on the molecular level (Weber 2007; Weber 2010a; Weber 2010b; Weber et al. 2012). Gain-of-function mutations of oncogenes or loss-of-function mutations of tumor suppressor genes underlie excessive cell division. Activation of senescence suppressor genes or inactivation of senescence genes underlies immortalization. While molecular studies have made their relation to the uncontrolled expansion of tumor cells obvious, it has not been clear why these defects also induce th...
Peer Reviewed Publications An, Yu; Fnu, Gulimirerouzi; Xie, Changchun; Weber, Georg F 2023. Meta-analysis of Osteopontin splice variants in cancer. BMC cancer, 23 1, 373Fnu, Gulimirerouzi; Weber, Georg F 2023. Osteopontin induces mitochondrial biogenesis in deadherent cancer cells. Oncotarget, 14 , 957-969Weber, Georg F 2023. Crossroads: the role of biomarkers in the management of lumps in the breast. Oncotarget, 14 , 358-362Fnu, Gulimirerouzi; Hudock, Kristin; Powers-Fletcher, Margaret; Huang, Ruo-Pan; Weber, Georg F 2022. Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response. Immunology, 167 2, 165-180Ziółkowski, Piotr; Woźniak, Marta; Mansour, Ahmad; An, Yu; Weber, Georg F 2022. Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis. Breast cancer research : BCR, 24 1, 64Butti, Ramesh; Nimma, Ramakrishna; Kundu, Gautam; Bulbule, Anuradha; Kumar, Totakura V S; Gunasekaran, Vinoth Prasanna; Tomar, Deepti; Kumar, Dhiraj; Mane, Anupama; Gill, Satyajit S; Patil, Tushar; Weber, Georg F; Kundu, Gopal C 2021. Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. Oncogene, 40 11, 2002-2017Fnu, Gulimirerouzi; Agrawal, Palak; Kundu, Gopal C; Weber, Georg F 2021. Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44. Biomolecules, 11 6, Fnu, Gulimirerouzi; Weber, Georg F 2021. Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment. Frontiers in oncology, 11 , 765329Wang, Xia; Weber, Georg F 2021. Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin. Frontiers in genetics, 12 , 700789Hartung, Franz; Patil, Aditya; Meshram, Rohan J; Weber, Georg F 2020. Gene expression signatures of site-specificity in cancer metastases. Clinical & experimental metastasis, 37 1, 159-171Weber, Georg F 2020. Cancer research - can the entity be bigger than the sum of its parts? Oncoscience, 7 3-4, 17-18Alsarkhi, Lamyaa Kadhim; Weber, Georg F 2018. Anti?osteopontin autoantibodies in various types of cancer. Oncology reports, 40 6, 3879-3889Walaszek, Kinga; Lower, Elyse E; Ziolkowski, Piotr; Weber, Georg F 2018. Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis. British journal of cancer, 119 10, 1259-1266Weber, Georg F 2018. The Phylogeny of Osteopontin-Analysis of the Protein Sequence. International journal of molecular sciences, 19 9, Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Aparicio-Bautista, Diana Ivette; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochimica et biophysica acta. Reviews on cancer, 1868 1, 93-108.ABriones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Ivette Aparicio-Bautista, Diana; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data in brief, 14 , 538-542Hartung, Franz; Wang, Yunguan; Aronow, Bruce; Weber, Georg F 2017. A core program of gene expression characterizes cancer metastases. Oncotarget, 8 60, 102161-102175Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F 2016. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Laboratory investigation; a journal of technical methods and pathology, 96 12, 1234-1245Unruh D, Ünlu B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY 2016. Antibody-based targeting of alternatively spliced Tissue Factor: a new approach to impede the primary growth and aggressiveness of pancreatic ductal adenocarcinoma. Oncotarget, , Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75Weber GF 2016. Metabolism in cancer metastasis International Journal of Cancer, , Weber, Georg F 2016. Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression. Frontiers in oncology, 6 , 257Weber, Georg F 2016. Metabolism in cancer metastasis. International journal of cancer, 138 9, 2061-6Zduniak, Krzysztof; Agrawal, Anil; Agrawal, Siddarth; Hossain, Md Monir; Ziolkowski, Piotr; Weber, Georg F 2016. Osteopontin splice variants are differential predictors of breast cancer treatment responses. BMC cancer, 16 , 441Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for cancer BBA Reviews on Cancer, 1855 , 202-222Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for the skeletal system Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders. Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer. Biochimica et biophysica acta, 1855 2, 202-22Weber GF 2015. Somnambulism and allergy Clinical and Experimental Neuroimmunology , 6 , 321Weber GF 2015. Molecular analysis of a recurrent sarcoma identifies a mutation in FAF1 Sarcoma, 839182 , doi:10.1155/2015/839182Weber, Georg F 2015. Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma, 2015 , 839182Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF 2015. Nuclear Osteopontin-c is a marker for breast cancer prognosis British Journal of Cancer , 112 , 729-738Zduniak, K; Ziolkowski, P; Ahlin, C; Agrawal, A; Agrawal, S; Blomqvist, C; Fjällskog, M-L; Weber, G F 2015. Nuclear osteopontin-c is a prognostic breast cancer marker. British journal of cancer, 112 4, 729-38Shen H, Weber GF 2014. The osteopontin-c splice junction is important for anchorage-independent growth Molecular Carcinogenesis, 53 , 480-487Shi Z, Mirza M, Wang B, Kennedy MA, Weber GF 2014. Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells Cancer Letters, 344 , 47-53Shi Z, Wang B, Kennedy MA, Weber GF 2014. Metabolic skewing during anchorage independence. Induction by osteopontin-c PlosOne, 9 , e105675Shi, Zhanquan; Wang, Bo; Chihanga, Tafadzwa; Kennedy, Michael A; Weber, Georg F 2014. Energy metabolism during anchorage-independence. Induction by osteopontin-c. PloS one, 9 8, e105675Weber GF, Johnson BN, Yamamoto BK, Gudelsky GA 2014. Effects of stress and MDMA on hippocampal gene expression BioMed Research International, 2014 , 141396Hartung F, Weber GF 2013. RNA blood levels of osteopontin splice variants are cancer markers SpringerPlus, 2 , 110Milanowski P, Carter TJ, Weber GF 2013. Enzyme catalysis and the outcome of biochemical reactions Journal of Proteomics and Bioinformatics , 6 , 132-141Ramchandani D, Weber GF 2013. An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer Oncology Reports, 30 , 1860-1868Wang B, Shi Z, Weber GF, Kennedy MA 2013. Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data Analytical and Bioanalytical Chemistry, 405 , 8419-8429Weber GF 2013. Gene therapy--why can it fail? Medical Hypotheses, 80 , 613-616Weber GF 2013. Dynamic knowledge - a century of evolution Sociology Mind , 3 , 268-277Weber, Georg F 2013. Why does cancer therapy lack effective anti-metastasis drugs? Cancer letters, 328 2, 207-11Weber GF 2012. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Letters, 328 , 207-211Weber GF, Warren J, Shoma H, Chen T, Halim A, Chakravarty G 2012. Biomarkers - A pot of gold or a can of worms? Meeting report from the 2nd world congress on biomarkers in clinical research, 2011, Baltimore, USA Cancer Biology & Therapy , 13 , 831-835Tilli TM, Franco VF, Robbs BK, Wanderley JL, Silva F, Duarte de Mello K, Viola JPB, Weber GF, Gimba ERP 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression Molecular Cancer Research , 9 , 280-293Tilli, Tatiana M; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, João Luiz Mendes; da Silva, Fabrício Ribeiro de Azevedo; de Mello, Kivvi Duarte; Viola, João P B; Weber, Georg F; Gimba, Etel R 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Molecular cancer research : MCR, 9 3, 280-93Weber GF 2011. The cancer biomarker Osteopontin: Combination with other markers Cancer Genomics and Proteomics, 8 , 263-288Weber GF, Lett GS, Haubein NC 2011. Categorical meta-analysis of Osteopontin as a clinical cancer marker Oncology Reports, 25 , 433-441Zhang R, Pan X, Huang Z, Weber GF, Zhang G 2011. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines PloS one, 6 , e23831Weber GF 2010. Molecular genetics and metastasis Encyclopedia of Life Sciences, , DOI 10.1002/9780470015902.a0022447Weber GF 2010. Toward a molecular classification of cancer Biomarker Theme Issue of Toxicology, 278 , 195-198Weber GF, Lett GS, Haubein NC 2010. Osteopontin is a marker for cancer aggressiveness and patient survival British Journal of Cancer , 103 , 861-869Weber, G F; Lett, G S; Haubein, N C 2010. Osteopontin is a marker for cancer aggressiveness and patient survival. British journal of cancer, 103 6, 861-9Weber, Georg F 2010. Toward a molecular classification of cancer. Toxicology, 278 2, 195-8Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma Surgery, 146 , 232-240Sullivan, Jennifer; Blair, Laurel; Alnajar, Amer; Aziz, Tamer; Ng, Chee Yuan; Chipitsyna, Galina; Gong, Qiaoke; Witkiewicz, Agnes; Weber, Georg F; Denhardt, David T; Yeo, Charles J; Arafat, Hwyda A 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Surgery, 146 2, 232-40Weber GF 2009. Drug targets in cancer metastasis American Association for Cancer Research 100th Annual Meeting Education Book, , 137-140Mirza M, Shaughnessy E, Hurley JK, Vanpatten KA, Pestano GA, He B, Weber GF 2008. Osteopontin-c is a highly selective marker for breast cancer International Journal of Cancer , 122 , 889-897Mirza, Mana; Shaughnessy, Elizabeth; Hurley, John K; Vanpatten, Kristie A; Pestano, Gary A; He, Bin; Weber, Georg F 2008. Osteopontin-c is a selective marker of breast cancer. International journal of cancer, 122 4, 889-97Syed M, Fenoglio-Preiser C, Skau KA, Weber GF 2008. Acetylcholinesterase supports anchorage independence in colon cancer Clinical and Experimental Metastasis, 25 , 787-798Syed, Moyeenuddin; Fenoglio-Preiser, Cecilia; Skau, Kenneth A; Weber, Georg F 2008. Acetylcholinesterase supports anchorage independence in colon cancer. Clinical & experimental metastasis, 25 7, 787-98Weber GF 2008. Molecular mechanisms of metastasis Cancer Letters, 270 , 181-190Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for migration of transformed cells The Journal of Virology, 82 , 4946-4954Whalen, Kerry A; Weber, Georg F; Benjamin, Thomas L; Schaffhausen, Brian S 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. Journal of virology, 82 10, 4946-54He B, Mirza M, Weber GF 2006. An osteopontin splice variant induces anchorage independence in human breast cancer cells Oncogene, 25 , 2192-2202Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA 2006. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling Cancer Research, 66 , 6521-6529Craig-Mylius C, Weber GF, Coburn JL, Glickstein LG 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response Journal of Leukocyte Biology, 77 , 710-718Craig-Mylius, Kathleen; Weber, Georg F; Coburn, Jenifer; Glickstein, Lisa 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. Journal of leukocyte biology, 77 5, 710-8He B, Weber GF 2004. Synergistic activation of the CMV promoter by NF-kB P50 and Cyclic GMP-Dependent Kinase Biochemical and Biophysical Research Communications , 321 , 13-20Weber GF 2004. The absence of CD44 ameliorates Faslpr/lpr disease Autoimmunity , 37 , 1-8Weber, Georg F 2004. The absence of CD44 ameliorates Fas(lpr/lpr) disease. Autoimmunity, 37 1, 1-8He, Bin; Weber, Georg F 2003. Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation. European journal of biochemistry, 270 10, 2174-85Zhang, Guoxin; He, Bin; Weber, Georg F 2003. Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer. Molecular and cellular biology, 23 18, 6507-19Weber, Georg F; Bronson, Roderick T; Ilagan, John; Cantor, Harvey; Schmits, Rudolf; Mak, Tak W 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer research, 62 8, 2281-6Weber, Georg F; Zawaideh, Samer; Hikita, Sherry; Kumar, Vikram A; Cantor, Harvey; Ashkar, Samy 2002. Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. Journal of leukocyte biology, 72 4, 752-61Ashkar, S; Weber, G F; Panoutsakopoulou, V; Sanchirico, M E; Jansson, M; Zawaideh, S; Rittling, S R; Denhardt, D T; Glimcher, M J; Cantor, H 2000. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science (New York, N.Y.), 287 5454, 860-4Weber, G F; Ashkar, S 2000. Stress response genes: the genes that make cancer metastasize. Journal of molecular medicine (Berlin, Germany), 78 8, 404-8Pestano, G A; Zhou, Y; Trimble, L A; Daley, J; Weber, G F; Cantor, H 1999. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science (New York, N.Y.), 284 5417, 1187-91Weber, G F 1999. Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. Neuroscience and biobehavioral reviews, 23 8, 1079-86Weber, G F; Ashkar, S; Cantor, H 1997. Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proceedings of the Association of American Physicians, 109 1, 1-9Weber, G F; Daley, J; Kraeft, S K; Chen, L B; Cantor, H 1997. Measurement of apoptosis in heterogenous cell populations. Cytometry, 27 2, 136-44Weber, G F; Mirza, N M; Yunis, E J; Dubey, D; Cantor, H 1997. Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth, development, and aging : GDA, 61 3-4, 191-207Weber, G F; Ashkar, S; Glimcher, M J; Cantor, H 1996. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (New York, N.Y.), 271 5248, 509-12Weber, G F; Cantor, H 1996. The immunology of Eta-1/osteopontin. Cytokine & growth factor reviews, 7 3, 241-8Weber, G F; Abromson-Leeman, S; Cantor, H 1995. A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity, 2 4, 363-72Weber, G F 1994. The pathophysiology of reactive oxygen intermediates in the central nervous system. Medical hypotheses, 43 4, 223-30Weber, G F; Cantor, H 1994. Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. Journal of immunology (Baltimore, Md. : 1950), 152 9, 4433-43Chang, T K; Weber, G F; Crespi, C L; Waxman, D J 1993. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer research, 53 23, 5629-37Weber, G F; Bruch, H P 1993. Hydroxyethyl starch and diseases mediated by free radicals. Free radical biology & medicine, 14 1, 96-7Weber, G F; Waxman, D J 1993. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases. Archives of biochemistry and biophysics, 307 2, 369-78Weber, G F; Waxman, D J 1993. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. Biochemical pharmacology, 45 8, 1685-94LeBlanc, G A; Sundseth, S S; Weber, G F; Waxman, D J 1992. Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer research, 52 3, 540-7Weber, G F; Bruch, H P 1992. [The pharmacology of superoxide dismutase]. Die Pharmazie, 47 3, 159-67Weber, G F; Nair, M G 1992. Inhibition of the neutrophil NADPH oxidase by folic acid and antagonists of the folic acid metabolism. Immunopharmacology and immunotoxicology, 14 3, 523-38Weber, G F; Nair, M G; McCord, J M 1991. The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation. Immunopharmacology and immunotoxicology, 13 3, 379-93Weber, Georg F . The cancer biomarker osteopontin: combination with other markers. Cancer genomics & proteomics, 8 6, 263-88
An, Yu; Fnu, Gulimirerouzi; Xie, Changchun; Weber, Georg F 2023. Meta-analysis of Osteopontin splice variants in cancer. BMC cancer, 23 1, 373Fnu, Gulimirerouzi; Weber, Georg F 2023. Osteopontin induces mitochondrial biogenesis in deadherent cancer cells. Oncotarget, 14 , 957-969Weber, Georg F 2023. Crossroads: the role of biomarkers in the management of lumps in the breast. Oncotarget, 14 , 358-362Fnu, Gulimirerouzi; Hudock, Kristin; Powers-Fletcher, Margaret; Huang, Ruo-Pan; Weber, Georg F 2022. Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response. Immunology, 167 2, 165-180Ziółkowski, Piotr; Woźniak, Marta; Mansour, Ahmad; An, Yu; Weber, Georg F 2022. Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis. Breast cancer research : BCR, 24 1, 64Butti, Ramesh; Nimma, Ramakrishna; Kundu, Gautam; Bulbule, Anuradha; Kumar, Totakura V S; Gunasekaran, Vinoth Prasanna; Tomar, Deepti; Kumar, Dhiraj; Mane, Anupama; Gill, Satyajit S; Patil, Tushar; Weber, Georg F; Kundu, Gopal C 2021. Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. Oncogene, 40 11, 2002-2017Fnu, Gulimirerouzi; Agrawal, Palak; Kundu, Gopal C; Weber, Georg F 2021. Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44. Biomolecules, 11 6, Fnu, Gulimirerouzi; Weber, Georg F 2021. Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment. Frontiers in oncology, 11 , 765329Wang, Xia; Weber, Georg F 2021. Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin. Frontiers in genetics, 12 , 700789Hartung, Franz; Patil, Aditya; Meshram, Rohan J; Weber, Georg F 2020. Gene expression signatures of site-specificity in cancer metastases. Clinical & experimental metastasis, 37 1, 159-171Weber, Georg F 2020. Cancer research - can the entity be bigger than the sum of its parts? Oncoscience, 7 3-4, 17-18Alsarkhi, Lamyaa Kadhim; Weber, Georg F 2018. Anti?osteopontin autoantibodies in various types of cancer. Oncology reports, 40 6, 3879-3889Walaszek, Kinga; Lower, Elyse E; Ziolkowski, Piotr; Weber, Georg F 2018. Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis. British journal of cancer, 119 10, 1259-1266Weber, Georg F 2018. The Phylogeny of Osteopontin-Analysis of the Protein Sequence. International journal of molecular sciences, 19 9, Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Aparicio-Bautista, Diana Ivette; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochimica et biophysica acta. Reviews on cancer, 1868 1, 93-108.ABriones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Ivette Aparicio-Bautista, Diana; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data in brief, 14 , 538-542Hartung, Franz; Wang, Yunguan; Aronow, Bruce; Weber, Georg F 2017. A core program of gene expression characterizes cancer metastases. Oncotarget, 8 60, 102161-102175Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F 2016. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Laboratory investigation; a journal of technical methods and pathology, 96 12, 1234-1245Unruh D, Ünlu B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY 2016. Antibody-based targeting of alternatively spliced Tissue Factor: a new approach to impede the primary growth and aggressiveness of pancreatic ductal adenocarcinoma. Oncotarget, , Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75Weber GF 2016. Metabolism in cancer metastasis International Journal of Cancer, , Weber, Georg F 2016. Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression. Frontiers in oncology, 6 , 257Weber, Georg F 2016. Metabolism in cancer metastasis. International journal of cancer, 138 9, 2061-6Zduniak, Krzysztof; Agrawal, Anil; Agrawal, Siddarth; Hossain, Md Monir; Ziolkowski, Piotr; Weber, Georg F 2016. Osteopontin splice variants are differential predictors of breast cancer treatment responses. BMC cancer, 16 , 441Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for cancer BBA Reviews on Cancer, 1855 , 202-222Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for the skeletal system Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders. Bone, 81 , 7-15Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer. Biochimica et biophysica acta, 1855 2, 202-22Weber GF 2015. Somnambulism and allergy Clinical and Experimental Neuroimmunology , 6 , 321Weber GF 2015. Molecular analysis of a recurrent sarcoma identifies a mutation in FAF1 Sarcoma, 839182 , doi:10.1155/2015/839182Weber, Georg F 2015. Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma, 2015 , 839182Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF 2015. Nuclear Osteopontin-c is a marker for breast cancer prognosis British Journal of Cancer , 112 , 729-738Zduniak, K; Ziolkowski, P; Ahlin, C; Agrawal, A; Agrawal, S; Blomqvist, C; Fjällskog, M-L; Weber, G F 2015. Nuclear osteopontin-c is a prognostic breast cancer marker. British journal of cancer, 112 4, 729-38Shen H, Weber GF 2014. The osteopontin-c splice junction is important for anchorage-independent growth Molecular Carcinogenesis, 53 , 480-487Shi Z, Mirza M, Wang B, Kennedy MA, Weber GF 2014. Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells Cancer Letters, 344 , 47-53Shi Z, Wang B, Kennedy MA, Weber GF 2014. Metabolic skewing during anchorage independence. Induction by osteopontin-c PlosOne, 9 , e105675Shi, Zhanquan; Wang, Bo; Chihanga, Tafadzwa; Kennedy, Michael A; Weber, Georg F 2014. Energy metabolism during anchorage-independence. Induction by osteopontin-c. PloS one, 9 8, e105675Weber GF, Johnson BN, Yamamoto BK, Gudelsky GA 2014. Effects of stress and MDMA on hippocampal gene expression BioMed Research International, 2014 , 141396Hartung F, Weber GF 2013. RNA blood levels of osteopontin splice variants are cancer markers SpringerPlus, 2 , 110Milanowski P, Carter TJ, Weber GF 2013. Enzyme catalysis and the outcome of biochemical reactions Journal of Proteomics and Bioinformatics , 6 , 132-141Ramchandani D, Weber GF 2013. An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer Oncology Reports, 30 , 1860-1868Wang B, Shi Z, Weber GF, Kennedy MA 2013. Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data Analytical and Bioanalytical Chemistry, 405 , 8419-8429Weber GF 2013. Gene therapy--why can it fail? Medical Hypotheses, 80 , 613-616Weber GF 2013. Dynamic knowledge - a century of evolution Sociology Mind , 3 , 268-277Weber, Georg F 2013. Why does cancer therapy lack effective anti-metastasis drugs? Cancer letters, 328 2, 207-11Weber GF 2012. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Letters, 328 , 207-211Weber GF, Warren J, Shoma H, Chen T, Halim A, Chakravarty G 2012. Biomarkers - A pot of gold or a can of worms? Meeting report from the 2nd world congress on biomarkers in clinical research, 2011, Baltimore, USA Cancer Biology & Therapy , 13 , 831-835Tilli TM, Franco VF, Robbs BK, Wanderley JL, Silva F, Duarte de Mello K, Viola JPB, Weber GF, Gimba ERP 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression Molecular Cancer Research , 9 , 280-293Tilli, Tatiana M; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, João Luiz Mendes; da Silva, Fabrício Ribeiro de Azevedo; de Mello, Kivvi Duarte; Viola, João P B; Weber, Georg F; Gimba, Etel R 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Molecular cancer research : MCR, 9 3, 280-93Weber GF 2011. The cancer biomarker Osteopontin: Combination with other markers Cancer Genomics and Proteomics, 8 , 263-288Weber GF, Lett GS, Haubein NC 2011. Categorical meta-analysis of Osteopontin as a clinical cancer marker Oncology Reports, 25 , 433-441Zhang R, Pan X, Huang Z, Weber GF, Zhang G 2011. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines PloS one, 6 , e23831Weber GF 2010. Molecular genetics and metastasis Encyclopedia of Life Sciences, , DOI 10.1002/9780470015902.a0022447Weber GF 2010. Toward a molecular classification of cancer Biomarker Theme Issue of Toxicology, 278 , 195-198Weber GF, Lett GS, Haubein NC 2010. Osteopontin is a marker for cancer aggressiveness and patient survival British Journal of Cancer , 103 , 861-869Weber, G F; Lett, G S; Haubein, N C 2010. Osteopontin is a marker for cancer aggressiveness and patient survival. British journal of cancer, 103 6, 861-9Weber, Georg F 2010. Toward a molecular classification of cancer. Toxicology, 278 2, 195-8Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma Surgery, 146 , 232-240Sullivan, Jennifer; Blair, Laurel; Alnajar, Amer; Aziz, Tamer; Ng, Chee Yuan; Chipitsyna, Galina; Gong, Qiaoke; Witkiewicz, Agnes; Weber, Georg F; Denhardt, David T; Yeo, Charles J; Arafat, Hwyda A 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Surgery, 146 2, 232-40Weber GF 2009. Drug targets in cancer metastasis American Association for Cancer Research 100th Annual Meeting Education Book, , 137-140Mirza M, Shaughnessy E, Hurley JK, Vanpatten KA, Pestano GA, He B, Weber GF 2008. Osteopontin-c is a highly selective marker for breast cancer International Journal of Cancer , 122 , 889-897Mirza, Mana; Shaughnessy, Elizabeth; Hurley, John K; Vanpatten, Kristie A; Pestano, Gary A; He, Bin; Weber, Georg F 2008. Osteopontin-c is a selective marker of breast cancer. International journal of cancer, 122 4, 889-97Syed M, Fenoglio-Preiser C, Skau KA, Weber GF 2008. Acetylcholinesterase supports anchorage independence in colon cancer Clinical and Experimental Metastasis, 25 , 787-798Syed, Moyeenuddin; Fenoglio-Preiser, Cecilia; Skau, Kenneth A; Weber, Georg F 2008. Acetylcholinesterase supports anchorage independence in colon cancer. Clinical & experimental metastasis, 25 7, 787-98Weber GF 2008. Molecular mechanisms of metastasis Cancer Letters, 270 , 181-190Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for migration of transformed cells The Journal of Virology, 82 , 4946-4954Whalen, Kerry A; Weber, Georg F; Benjamin, Thomas L; Schaffhausen, Brian S 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. Journal of virology, 82 10, 4946-54He B, Mirza M, Weber GF 2006. An osteopontin splice variant induces anchorage independence in human breast cancer cells Oncogene, 25 , 2192-2202Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA 2006. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling Cancer Research, 66 , 6521-6529Craig-Mylius C, Weber GF, Coburn JL, Glickstein LG 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response Journal of Leukocyte Biology, 77 , 710-718Craig-Mylius, Kathleen; Weber, Georg F; Coburn, Jenifer; Glickstein, Lisa 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. Journal of leukocyte biology, 77 5, 710-8He B, Weber GF 2004. Synergistic activation of the CMV promoter by NF-kB P50 and Cyclic GMP-Dependent Kinase Biochemical and Biophysical Research Communications , 321 , 13-20Weber GF 2004. The absence of CD44 ameliorates Faslpr/lpr disease Autoimmunity , 37 , 1-8Weber, Georg F 2004. The absence of CD44 ameliorates Fas(lpr/lpr) disease. Autoimmunity, 37 1, 1-8He, Bin; Weber, Georg F 2003. Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation. European journal of biochemistry, 270 10, 2174-85Zhang, Guoxin; He, Bin; Weber, Georg F 2003. Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer. Molecular and cellular biology, 23 18, 6507-19Weber, Georg F; Bronson, Roderick T; Ilagan, John; Cantor, Harvey; Schmits, Rudolf; Mak, Tak W 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer research, 62 8, 2281-6Weber, Georg F; Zawaideh, Samer; Hikita, Sherry; Kumar, Vikram A; Cantor, Harvey; Ashkar, Samy 2002. Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. Journal of leukocyte biology, 72 4, 752-61Ashkar, S; Weber, G F; Panoutsakopoulou, V; Sanchirico, M E; Jansson, M; Zawaideh, S; Rittling, S R; Denhardt, D T; Glimcher, M J; Cantor, H 2000. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science (New York, N.Y.), 287 5454, 860-4Weber, G F; Ashkar, S 2000. Stress response genes: the genes that make cancer metastasize. Journal of molecular medicine (Berlin, Germany), 78 8, 404-8Pestano, G A; Zhou, Y; Trimble, L A; Daley, J; Weber, G F; Cantor, H 1999. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science (New York, N.Y.), 284 5417, 1187-91Weber, G F 1999. Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. Neuroscience and biobehavioral reviews, 23 8, 1079-86Weber, G F; Ashkar, S; Cantor, H 1997. Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proceedings of the Association of American Physicians, 109 1, 1-9Weber, G F; Daley, J; Kraeft, S K; Chen, L B; Cantor, H 1997. Measurement of apoptosis in heterogenous cell populations. Cytometry, 27 2, 136-44Weber, G F; Mirza, N M; Yunis, E J; Dubey, D; Cantor, H 1997. Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth, development, and aging : GDA, 61 3-4, 191-207Weber, G F; Ashkar, S; Glimcher, M J; Cantor, H 1996. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (New York, N.Y.), 271 5248, 509-12Weber, G F; Cantor, H 1996. The immunology of Eta-1/osteopontin. Cytokine & growth factor reviews, 7 3, 241-8Weber, G F; Abromson-Leeman, S; Cantor, H 1995. A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity, 2 4, 363-72Weber, G F 1994. The pathophysiology of reactive oxygen intermediates in the central nervous system. Medical hypotheses, 43 4, 223-30Weber, G F; Cantor, H 1994. Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. Journal of immunology (Baltimore, Md. : 1950), 152 9, 4433-43Chang, T K; Weber, G F; Crespi, C L; Waxman, D J 1993. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer research, 53 23, 5629-37Weber, G F; Bruch, H P 1993. Hydroxyethyl starch and diseases mediated by free radicals. Free radical biology & medicine, 14 1, 96-7Weber, G F; Waxman, D J 1993. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases. Archives of biochemistry and biophysics, 307 2, 369-78Weber, G F; Waxman, D J 1993. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. Biochemical pharmacology, 45 8, 1685-94LeBlanc, G A; Sundseth, S S; Weber, G F; Waxman, D J 1992. Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer research, 52 3, 540-7Weber, G F; Bruch, H P 1992. [The pharmacology of superoxide dismutase]. Die Pharmazie, 47 3, 159-67Weber, G F; Nair, M G 1992. Inhibition of the neutrophil NADPH oxidase by folic acid and antagonists of the folic acid metabolism. Immunopharmacology and immunotoxicology, 14 3, 523-38Weber, G F; Nair, M G; McCord, J M 1991. The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation. Immunopharmacology and immunotoxicology, 13 3, 379-93Weber, Georg F . The cancer biomarker osteopontin: combination with other markers. Cancer genomics & proteomics, 8 6, 263-88