James Mulloy, Ph.D., PhD

Ågerstam, Helena; Karlsson, Christine; Hansen, Nils; Sandén, Carl; Askmyr, Maria; von Palffy, Sofia; Högberg, Carl; Rissler, Marianne; Wunderlich, Mark; Juliusson, Gunnar; Richter, Johan; Sjöström, Kjell; Bhatia, Ravi; Mulloy, James C; Järås, Marcus; Fioretos, Thoas 2015. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 112 34, 10786-91

Benito, Juliana M; Godfrey, Laura; Kojima, Kensuke; Hogdal, Leah; Wunderlich, Mark; Geng, Huimin; Marzo, Isabel; Harutyunyan, Karine G; Golfman, Leonard; North, Phillip; Kerry, Jon; Ballabio, Erica; Chonghaile, Triona Ní; Gonzalo, Oscar; Qiu, Yihua; Jeremias, Irmela; Debose, LaKiesha; O'Brien, Eric; Ma, Helen; Zhou, Ping; Jacamo, Rodrigo; Park, Eugene; Coombes, Kevin R; Zhang, Nianxiang; Thomas, Deborah A; O'Brien, Susan; Kantarjian, Hagop M; Leverson, Joel D; Kornblau, Steven M; Andreeff, Michael; Müschen, Markus; Zweidler-McKay, Patrick A; Mulloy, James C; Letai, Anthony; Milne, Thomas A; Konopleva, Marina 2015. MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell reports, 13 12, 2715-27

Glait-Santar, Chen; Desmond, Ronan; Feng, Xingmin; Bat, Taha; Chen, Jichun; Heuston, Elisabeth; Mizukawa, Benjamin; Mulloy, James C; Bodine, David M; Larochelle, Andre; Dunbar, Cynthia E 2015. Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells. Stem cells (Dayton, Ohio), 33 12, 3635-42

Goyama, Susumu; Wunderlich, Mark; Mulloy, James C 2015. Xenograft models for normal and malignant stem cells. Blood, 125 17, 2630-40

Maiques-Diaz, Alba; Hernando, Miriam; Sánchez-López, Amanda; Rio-Machin, Ana; Shrestha, Mahesh; Mulloy, James C; Cigudosa, Juan C; Alvarez, Sara 2015. MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia. British journal of haematology, 172 5, 807-10

Roychoudhury, Jayeeta; Clark, Jason P; Gracia-Maldonado, Gabriel; Unnisa, Zeenath; Wunderlich, Mark; Link, Kevin A; Dasgupta, Nupur; Aronow, Bruce; Huang, Gang; Mulloy, James C; Kumar, Ashish R 2015. MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood, 125 16, 2544-52

Kong, Guangyao; Wunderlich, Mark; Yang, David; Ranheim, Erik A; Young, Ken H; Wang, Jinyong; Chang, Yuan-I; Du, Juan; Liu, Yangang; Tey, Sin Ruow; Zhang, Xinmin; Juckett, Mark; Mattison, Ryan; Damnernsawad, Alisa; Zhang, Jingfang; Mulloy, James C; Zhang, Jing 2014. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of clinical investigation, 124 6, 2762-73

Vadukoot, Anish K; AbdulSalam, Safnas F; Wunderlich, Mark; Pullen, Eboni D; Landero-Figueroa, Julio; Mulloy, James C; Merino, Eddie J 2014. Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells. Bioorganic & medicinal chemistry, 22 24, 6885-92

Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton 2014. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. The Journal of clinical investigation, 124 1, 222-36

Wunderlich, Mark; Brooks, Ryan A; Panchal, Rushi; Rhyasen, Garrett W; Danet-Desnoyers, Gwenn; Mulloy, James C 2014. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues Blood, 123 24, e134-44

Zhao, Xinghui; Chen, Aili; Yan, Xiaomei; Zhang, Yue; He, Fuhong; Hayashi, Yoshihiro; Dong, Yunzhu; Rao, Yalan; Li, Bo; Conway, Rajeana M; Maiques-Diaz, Alba; Elf, Shannon E; Huang, Nuomin; Zuber, Johannes; Xiao, Zhijian; Tse, William; Tenen, Daniel G; Wang, Qianfei; Chen, Wei; Mulloy, James C; Nimer, Stephen D; Huang, Gang 2014. Downregulation of RUNX1/CBFbeta by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood, 123 11, 1729-38

Araten, David J; Krejci, Ondrej; Ditata, Kimberly; Wunderlich, Mark; Sanders, Katie J; Zamechek, Leah; Mulloy, James C 2013. The rate of spontaneous mutations in human myeloid cells. Mutation research, 749 1-2, 49-57

Bell-Horwath, Tiffany R; Vadukoot, Anish K; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C; Merino, Edward J 2013. Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia. Bioorganic & medicinal chemistry letters, 23 10, 2951-4

Chen, Ping; Price, Colles; Li, Zejuan; Li, Yuanyuan; Cao, Donglin; Wiley, Anissa; He, Chunjiang; Gurbuxani, Sandeep; Kunjamma, Rejani B; Huang, Hao; Jiang, Xi; Arnovitz, Stephen; Xu, Mengyi; Hong, Gia-Ming; Elkahloun, Abdel G; Neilly, Mary Beth; Wunderlich, Mark; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun 2013. miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110 28, 11511-6

Goyama, Susumu; Mulloy, James C 2013. NF-kappaB: a coordinator for epigenetic regulation by MLL Cancer cell, 24 4, 401-2

Goyama, Susumu; Mulloy, James C 2013. Making healthy stem cells: the new role of TPO. Cell stem cell, 12 1, 8-9

Goyama, Susumu; Schibler, Janet; Cunningham, Lea; Zhang, Yue; Rao, Yalan; Nishimoto, Nahoko; Nakagawa, Masahiro; Olsson, Andre; Wunderlich, Mark; Link, Kevin A; Mizukawa, Benjamin; Grimes, H Leighton; Kurokawa, Mineo; Liu, P Paul; Huang, Gang; Mulloy, James C 2013. Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. The Journal of clinical investigation, 123 9, 3876-88

Huang, Hao; Jiang, Xi; Li, Zejuan; Li, Yuanyuan; Song, Chun-Xiao; He, Chunjiang; Sun, Miao; Chen, Ping; Gurbuxani, Sandeep; Wang, Jiapeng; Hong, Gia-Ming; Elkahloun, Abdel G; Arnovitz, Stephen; Wang, Jinhua; Szulwach, Keith; Lin, Li; Street, Craig; Wunderlich, Mark; Dawlaty, Meelad; Neilly, Mary Beth; Jaenisch, Rudolf; Yang, Feng-Chun; Mulloy, James C; Jin, Peng; Liu, Paul P; Rowley, Janet D; Xu, Mingjiang; He, Chuan; Chen, Jianjun 2013. TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110 29, 11994-9

Mulloy, James C 2013. A new inducible model for t(8;21) AML. EMBO molecular medicine, 5 12, 1795-7

Neviani, Paolo; Harb, Jason G; Oaks, Joshua J; Santhanam, Ramasamy; Walker, Christopher J; Ellis, Justin J; Ferenchak, Gregory; Dorrance, Adrienne M; Paisie, Carolyn A; Eiring, Anna M; Ma, Yihui; Mao, Hsiaoyin C; Zhang, Bin; Wunderlich, Mark; May, Philippa C; Sun, Chaode; Saddoughi, Sahar A; Bielawski, Jacek; Blum, William; Klisovic, Rebecca B; Solt, Janelle A; Byrd, John C; Volinia, Stefano; Cortes, Jorge; Huettner, Claudia S; Koschmieder, Steffen; Holyoake, Tessa L; Devine, Steven; Caligiuri, Michael A; Croce, Carlo M; Garzon, Ramiro; Ogretmen, Besim; Arlinghaus, Ralph B; Chen, Ching-Shih; Bittman, Robert; Hokland, Peter; Roy, Denis-Claude; Milojkovic, Dragana; Apperley, Jane; Goldman, John M; Reid, Alistair; Mulloy, James C; Bhatia, Ravi; Marcucci, Guido; Perrotti, Danilo 2013. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of clinical investigation, 123 10, 4144-57

Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T 2013. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 1, 90-104

Wunderlich, Mark; Mizukawa, Benjamin; Chou, Fu-Sheng; Sexton, Christina; Shrestha, Mahesh; Saunthararajah, Yogen; Mulloy, James C 2013. AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model. Blood, 121 12, e90-7

Chou, Fu-Sheng; Griesinger, Andrea; Wunderlich, Mark; Lin, Shan; Link, Kevin A; Shrestha, Mahesh; Goyama, Susumu; Mizukawa, Benjamin; Shen, Shuhong; Marcucci, Guido; Mulloy, James C 2012. The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO. Blood, 120 4, 709-19

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T 2012. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 4, 858-67

Jiang, Xi; Huang, Hao; Li, Zejuan; He, Chunjiang; Li, Yuanyuan; Chen, Ping; Gurbuxani, Sandeep; Arnovitz, Stephen; Hong, Gia-Ming; Price, Colles; Ren, Haomin; Kunjamma, Rejani B; Neilly, Mary Beth; Salat, Justin; Wunderlich, Mark; Slany, Robert K; Zhang, Yanming; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Rowley, Janet D; Chen, Jianjun 2012. MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109 47, 19397-402

Li, Zejuan; Huang, Hao; Chen, Ping; He, Miao; Li, Yuanyuan; Arnovitz, Stephen; Jiang, Xi; He, Chunjiang; Hyjek, Elizabeth; Zhang, Jun; Zhang, Zhiyu; Elkahloun, Abdel; Cao, Donglin; Shen, Chen; Wunderlich, Mark; Wang, Yungui; Neilly, Mary Beth; Jin, Jie; Wei, Minjie; Lu, Jun; Valk, Peter J M; Delwel, Ruud; Lowenberg, Bob; Le Beau, Michelle M; Vardiman, James; Mulloy, James C; Zeleznik-Le, Nancy J; Liu, Paul P; Zhang, Jiwang; Chen, Jianjun 2012. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nature communications, 3 , 688

Yoshimi, Mayumi; Goyama, Susumu; Kawazu, Masahito; Nakagawa, Masahiro; Ichikawa, Motoshi; Imai, Yoichi; Kumano, Keiki; Asai, Takashi; Mulloy, James C; Kraft, Andrew S; Takahashi, Tsuyoshi; Shirafuji, Naoki; Kurokawa, Mineo 2012. Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. European journal of immunology, 42 4, 1044-50

Zhang, Yue; Yan, Xiaomei; Sashida, Goro; Zhao, Xinghui; Rao, Yalan; Goyama, Susumu; Whitman, Susan P; Zorko, Nicholas; Bernot, Kelsie; Conway, Rajeana M; Witte, David; Wang, Qian-Fei; Tenen, Daniel G; Xiao, Zhijian; Marcucci, Guido; Mulloy, James C; Grimes, H Leighton; Caligiuri, Michael A; Huang, Gang 2012. Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood, 120 5, 1118-29

Chou, Fu-Sheng; Mulloy, James C 2011. The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. Journal of cellular biochemistry, 112 6, 1491-8

Chou, Fu-Sheng; Wunderlich, Mark; Griesinger, Andrea; Mulloy, James C 2011. N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood, 117 7, 2237-40

Goyama, Susumu; Mulloy, James C 2011. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. International journal of hematology, 94 2, 126-33

Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C 2011. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 19, 5235-45

Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi 2011. Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 42, 36469-77

Zuber, Johannes; Shi, Junwei; Wang, Eric; Rappaport, Amy R; Herrmann, Harald; Sison, Edward A; Magoon, Daniel; Qi, Jun; Blatt, Katharina; Wunderlich, Mark; Taylor, Meredith J; Johns, Christopher; Chicas, Agustin; Mulloy, James C; Kogan, Scott C; Brown, Patrick; Valent, Peter; Bradner, James E; Lowe, Scott W; Vakoc, Christopher R 2011. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478 7370, 524-8

Alvarez, Sara; Suela, Javier; Valencia, Ana; Fernández, Agustín; Wunderlich, Mark; Agirre, Xabier; Prósper, Felipe; Martín-Subero, José Ignacio; Maiques, Alba; Acquadro, Francesco; Rodriguez Perales, Sandra; Calasanz, María José; Roman-Gómez, Jose; Siebert, Reiner; Mulloy, James C; Cervera, José; Sanz, Miguel Angel; Esteller, Manel; Cigudosa, Juan C 2010. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PloS one, 5 8, e12197

Kamikubo, Yasuhiko; Zhao, Ling; Wunderlich, Mark; Corpora, Takeshi; Hyde, R Katherine; Paul, Thomas A; Kundu, Mondira; Garrett, Lisa; Compton, Sheila; Huang, Gang; Wolff, Linda; Ito, Yoshiaki; Bushweller, John; Mulloy, James C; Liu, P Paul 2010. Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1. Cancer cell, 17 5, 455-68

Link, Kevin A; Chou, Fu-Sheng; Mulloy, James C 2010. Core binding factor at the crossroads: determining the fate of the HSC. Journal of cellular physiology, 222 1, 50-6

Mi, Shuangli; Li, Zejuan; Chen, Ping; He, Chunjiang; Cao, Donglin; Elkahloun, Abdel; Lu, Jun; Pelloso, Luis A; Wunderlich, Mark; Huang, Hao; Luo, Roger T; Sun, Miao; He, Miao; Neilly, Mary Beth; Zeleznik-Le, Nancy J; Thirman, Michael J; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun 2010. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proceedings of the National Academy of Sciences of the United States of America, 107 8, 3710-5

Mulloy, James C 2010. Peripheral T cell lymphoma: new model + new insight. The Journal of experimental medicine, 207 5, 911-3

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47

Wunderlich, Mark; Mulloy, James C 2009. Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction. Methods in molecular biology (Clifton, N.J.), 538 , 263-85

Krejci, Ondrej; Wunderlich, Mark; Geiger, Hartmut; Chou, Fu-Sheng; Schleimer, David; Jansen, Michael; Andreassen, Paul R; Mulloy, James C 2008. p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Blood, 111 4, 2190-9

Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping 2008. Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 21, 3314-9

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 6, 483-95

Wunderlich, Mark; Krejci, Ondrej; Wei, Junping; Mulloy, James C 2006. Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood, 108 5, 1690-7

Mulloy, James C; Jankovic, Vladimir; Wunderlich, Mark; Delwel, Ruud; Cammenga, Jorg; Krejci, Ondrej; Zhao, Hui; Valk, Peter J M; Lowenberg, Bob; Nimer, Stephen D 2005. AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion. Proceedings of the National Academy of Sciences of the United States of America, 102 11, 4016-21

Cammenga, Jörg; Mulloy, James C; Berguido, Francisco J; MacGrogan, Donal; Viale, Agnes; Nimer, Stephen D 2003. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood, 101 6, 2206-14

Mulloy, James C; Cammenga, Jorg; Berguido, Francisco J; Wu, Kaida; Zhou, Ping; Comenzo, Raymond L; Jhanwar, Suresh; Moore, Malcolm A S; Nimer, Stephen D 2003. Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood, 102 13, 4369-76

Mulloy, James C; Cammenga, Jörg; MacKenzie, Karen L; Berguido, Francisco J; Moore, Malcolm A S; Nimer, Stephen D 2002. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood, 99 1, 15-23