Education/CredentialsPostdoctoral Fellow: Cincinnati Children's Hospital Medical Center (Oncology)PhD: University of Michigan (Human Genetics)MS: University of Michigan (Human Genetics)BS: Miami University (Microbiology and Classical Humanities) Contact Information Childrens Hospital Bldg R 486 Office 513-636-1155 Email vinnedla@ucmail.uc.edu Research InterestsMy long-standing research interest is to elucidate the molecular genetic mechanisms that regulate mammary gland development and breast pathology, such as breast cancer. My lab uses a combination of mouse and human models, including 2D and 3D cell culture models, patient tissues, xenograft tumors, and genetically engineered mouse models. Using these tools, my research career has focused on identifying and characterizing novel tumor suppressors and oncogenes that regulate genome stability, DNA damage respon... Peer Reviewed Publications Wilcher, Katherine E; Page, Evan R H; Privette Vinnedge, Lisa M 2023. The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia. Experimental hematology, 123 , 18-27Greene, Allie N; Nguyen, Elizabeth T; Paranjpe, Aditi; Lane, Adam; Privette Vinnedge, Lisa M; Solomon, Matia B 2022. In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. The European journal of neuroscience, 56 6, 4720-4743Greene, Allie N; Solomon, Matia B; Privette Vinnedge, Lisa M 2022. Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis. Frontiers in aging neuroscience, 14 , 1018180Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Muhammad, B; Parks, L G; Komurov, K; Privette Vinnedge, L M 2022. Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability. Translational oncology, 16 , 101323Singh, Navneet; Romick-Rosendale, Lindsey; Watanabe-Chailland, Miki; Privette Vinnedge, Lisa M; Komurov, Kakajan 2022. Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers. PloS one, 17 12, e0256788Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Greene, Allie N; Parks, Lois G; Solomon, Matia B; Privette Vinnedge, Lisa M 2020. Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells. Frontiers in molecular neuroscience, 13 , 594319Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Wen, Yu; Xu, He N; Privette Vinnedge, Lisa; Feng, Min; Li, Lin Z 2019. Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells. Molecular imaging and biology, 21 3, 410-416Ghisays, Valentina; Nguyen, Elizabeth T; Streicher, Joshua; Pease, Nicholas A; Fitzgerald, Maureen; Estrada, Christina M; Franco-Villanueva, Ana; Privette Vinnedge, Lisa; Solomon, Matia B 2018. Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice. Neuroscience, 371 , 254-267Modur, Vishnu; Singh, Navneet; Mohanty, Vakul; Chung, Eunah; Muhammad, Belal; Choi, Kwangmin; Chen, Xiaoting; Chetal, Kashish; Ratner, Nancy; Salomonis, Nathan; Weirauch, Matthew T; Waltz, Susan; Huang, Gang; Privette-Vinnedge, Lisa; Park, Joo-Seop; Janssen, Edith M; Komurov, Kakajan 2018. Defective transcription elongation in a subset of cancers confers immunotherapy resistance. Nature communications, 9 1, 4410O'Donovan, Sinead M; Franco-Villanueva, Ana; Ghisays, Valentina; Caldwell, Jody L; Haroutunian, Vahraim; Privette Vinnedge, Lisa M; McCullumsmith, Robert E; Solomon, Matia B 2018. Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia. Schizophrenia research, 202 , 188-194Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M 2018. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59 , 40-50.e3Wise-Draper, Trisha; Sendilnathan, Arun; Palackdharry, Sarah; Pease, Nicholas; Qualtieri, Julianne; Butler, Randall; Sadraei, Nooshin Hashemi; Morris, John C; Patil, Yash; Wilson, Keith; Mark, Jonathan; Casper, Keith; Takiar, Vinita; Lane, Adam; Privette Vinnedge, Lisa 2018. Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma. Translational oncology, 11 1, 168-174Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I 2016. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 8, 2062-73Pease, Nicholas A; Wise-Draper, Trisha; Privette Vinnedge, Lisa 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of oncology, 2015 , 106517Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I 2015. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene, 34 18, 2325-36Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I 2013. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex.), 12 1, 51-66Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene, 30 24, 2741-52Gonzalez, Maria E; Makarova, Olga; Peterson, Esther A; Privette, Lisa M; Petty, Elizabeth M 2009. Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. Cellular signalling, 21 4, 477-87Privette, Lisa M; Petty, Elizabeth M 2008. CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. Translational oncology, 1 2, 57-64Privette, Lisa M; Weier, Jingly Fung; Nguyen, Ha Nam; Yu, Xiaochun; Petty, Elizabeth M 2008. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia (New York, N.Y.), 10 7, 643-52Gonzalez, Maria E; Peterson, Esther A; Privette, Lisa M; Loffreda-Wren, Janice L; Kalikin, Linda M; Petty, Elizabeth M 2007. High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. Cancer research, 67 18, 8554-64Privette, Lisa M; González, Maria E; Ding, Lei; Kleer, Celina G; Petty, Elizabeth M 2007. Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer research, 67 13, 6064-74
Research InterestsMy long-standing research interest is to elucidate the molecular genetic mechanisms that regulate mammary gland development and breast pathology, such as breast cancer. My lab uses a combination of mouse and human models, including 2D and 3D cell culture models, patient tissues, xenograft tumors, and genetically engineered mouse models. Using these tools, my research career has focused on identifying and characterizing novel tumor suppressors and oncogenes that regulate genome stability, DNA damage respon...
Peer Reviewed Publications Wilcher, Katherine E; Page, Evan R H; Privette Vinnedge, Lisa M 2023. The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia. Experimental hematology, 123 , 18-27Greene, Allie N; Nguyen, Elizabeth T; Paranjpe, Aditi; Lane, Adam; Privette Vinnedge, Lisa M; Solomon, Matia B 2022. In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. The European journal of neuroscience, 56 6, 4720-4743Greene, Allie N; Solomon, Matia B; Privette Vinnedge, Lisa M 2022. Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis. Frontiers in aging neuroscience, 14 , 1018180Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Muhammad, B; Parks, L G; Komurov, K; Privette Vinnedge, L M 2022. Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability. Translational oncology, 16 , 101323Singh, Navneet; Romick-Rosendale, Lindsey; Watanabe-Chailland, Miki; Privette Vinnedge, Lisa M; Komurov, Kakajan 2022. Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers. PloS one, 17 12, e0256788Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Greene, Allie N; Parks, Lois G; Solomon, Matia B; Privette Vinnedge, Lisa M 2020. Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells. Frontiers in molecular neuroscience, 13 , 594319Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Wen, Yu; Xu, He N; Privette Vinnedge, Lisa; Feng, Min; Li, Lin Z 2019. Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells. Molecular imaging and biology, 21 3, 410-416Ghisays, Valentina; Nguyen, Elizabeth T; Streicher, Joshua; Pease, Nicholas A; Fitzgerald, Maureen; Estrada, Christina M; Franco-Villanueva, Ana; Privette Vinnedge, Lisa; Solomon, Matia B 2018. Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice. Neuroscience, 371 , 254-267Modur, Vishnu; Singh, Navneet; Mohanty, Vakul; Chung, Eunah; Muhammad, Belal; Choi, Kwangmin; Chen, Xiaoting; Chetal, Kashish; Ratner, Nancy; Salomonis, Nathan; Weirauch, Matthew T; Waltz, Susan; Huang, Gang; Privette-Vinnedge, Lisa; Park, Joo-Seop; Janssen, Edith M; Komurov, Kakajan 2018. Defective transcription elongation in a subset of cancers confers immunotherapy resistance. Nature communications, 9 1, 4410O'Donovan, Sinead M; Franco-Villanueva, Ana; Ghisays, Valentina; Caldwell, Jody L; Haroutunian, Vahraim; Privette Vinnedge, Lisa M; McCullumsmith, Robert E; Solomon, Matia B 2018. Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia. Schizophrenia research, 202 , 188-194Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M 2018. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59 , 40-50.e3Wise-Draper, Trisha; Sendilnathan, Arun; Palackdharry, Sarah; Pease, Nicholas; Qualtieri, Julianne; Butler, Randall; Sadraei, Nooshin Hashemi; Morris, John C; Patil, Yash; Wilson, Keith; Mark, Jonathan; Casper, Keith; Takiar, Vinita; Lane, Adam; Privette Vinnedge, Lisa 2018. Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma. Translational oncology, 11 1, 168-174Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I 2016. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 8, 2062-73Pease, Nicholas A; Wise-Draper, Trisha; Privette Vinnedge, Lisa 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of oncology, 2015 , 106517Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I 2015. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene, 34 18, 2325-36Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I 2013. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex.), 12 1, 51-66Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene, 30 24, 2741-52Gonzalez, Maria E; Makarova, Olga; Peterson, Esther A; Privette, Lisa M; Petty, Elizabeth M 2009. Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. Cellular signalling, 21 4, 477-87Privette, Lisa M; Petty, Elizabeth M 2008. CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. Translational oncology, 1 2, 57-64Privette, Lisa M; Weier, Jingly Fung; Nguyen, Ha Nam; Yu, Xiaochun; Petty, Elizabeth M 2008. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia (New York, N.Y.), 10 7, 643-52Gonzalez, Maria E; Peterson, Esther A; Privette, Lisa M; Loffreda-Wren, Janice L; Kalikin, Linda M; Petty, Elizabeth M 2007. High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. Cancer research, 67 18, 8554-64Privette, Lisa M; González, Maria E; Ding, Lei; Kleer, Celina G; Petty, Elizabeth M 2007. Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer research, 67 13, 6064-74
Wilcher, Katherine E; Page, Evan R H; Privette Vinnedge, Lisa M 2023. The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia. Experimental hematology, 123 , 18-27Greene, Allie N; Nguyen, Elizabeth T; Paranjpe, Aditi; Lane, Adam; Privette Vinnedge, Lisa M; Solomon, Matia B 2022. In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. The European journal of neuroscience, 56 6, 4720-4743Greene, Allie N; Solomon, Matia B; Privette Vinnedge, Lisa M 2022. Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis. Frontiers in aging neuroscience, 14 , 1018180Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Muhammad, B; Parks, L G; Komurov, K; Privette Vinnedge, L M 2022. Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability. Translational oncology, 16 , 101323Singh, Navneet; Romick-Rosendale, Lindsey; Watanabe-Chailland, Miki; Privette Vinnedge, Lisa M; Komurov, Kakajan 2022. Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers. PloS one, 17 12, e0256788Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801Greene, Allie N; Parks, Lois G; Solomon, Matia B; Privette Vinnedge, Lisa M 2020. Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells. Frontiers in molecular neuroscience, 13 , 594319Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette 2020. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 7, Wen, Yu; Xu, He N; Privette Vinnedge, Lisa; Feng, Min; Li, Lin Z 2019. Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells. Molecular imaging and biology, 21 3, 410-416Ghisays, Valentina; Nguyen, Elizabeth T; Streicher, Joshua; Pease, Nicholas A; Fitzgerald, Maureen; Estrada, Christina M; Franco-Villanueva, Ana; Privette Vinnedge, Lisa; Solomon, Matia B 2018. Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice. Neuroscience, 371 , 254-267Modur, Vishnu; Singh, Navneet; Mohanty, Vakul; Chung, Eunah; Muhammad, Belal; Choi, Kwangmin; Chen, Xiaoting; Chetal, Kashish; Ratner, Nancy; Salomonis, Nathan; Weirauch, Matthew T; Waltz, Susan; Huang, Gang; Privette-Vinnedge, Lisa; Park, Joo-Seop; Janssen, Edith M; Komurov, Kakajan 2018. Defective transcription elongation in a subset of cancers confers immunotherapy resistance. Nature communications, 9 1, 4410O'Donovan, Sinead M; Franco-Villanueva, Ana; Ghisays, Valentina; Caldwell, Jody L; Haroutunian, Vahraim; Privette Vinnedge, Lisa M; McCullumsmith, Robert E; Solomon, Matia B 2018. Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia. Schizophrenia research, 202 , 188-194Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M 2018. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59 , 40-50.e3Wise-Draper, Trisha; Sendilnathan, Arun; Palackdharry, Sarah; Pease, Nicholas; Qualtieri, Julianne; Butler, Randall; Sadraei, Nooshin Hashemi; Morris, John C; Patil, Yash; Wilson, Keith; Mark, Jonathan; Casper, Keith; Takiar, Vinita; Lane, Adam; Privette Vinnedge, Lisa 2018. Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma. Translational oncology, 11 1, 168-174Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I 2016. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 8, 2062-73Pease, Nicholas A; Wise-Draper, Trisha; Privette Vinnedge, Lisa 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of oncology, 2015 , 106517Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I 2015. 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