Education/CredentialsDoctorate: University of Western AustraliaBachelor of Science: University of Western Australia (Physiology) Contact Information Email tsopp@ucmail.uc.edu Research InterestsOne of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. We are currently studying how bile salts are involved in the absorption of lipids. I... Peer Reviewed Publications Kweon, Soo-Mi; Irimia-Dominguez, Jose; Kim, Gayeoun; Fueger, Patrick T; Asahina, Kinji; Lai, Keith K; Allende, Daniela S; Lai, Quincy R; Lou, Chih-Hong; Tsark, Walter M; Yang, Ju Dong; Ng, Dominic S; Lee, Ju-Seog; Tso, Patrick; Huang, Wendong; Lai, Keane K Y 2023. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. American journal of physiology. Gastrointestinal and liver physiology, 325 2, G147-G157LaRussa, Zachary; Kuo, Hsuan-Chih N; West, Kathryn; Shen, Zhijun; Wisniewski, Kevin; Tso, Patrick; Coschigano, Karen T; Lo, Chunmin C 2023. Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice. International journal of molecular sciences, 24 4, Zhu, Qi; Qi, Nathan; Shen, Ling; Lo, Chunmin C; Xu, Meifeng; Duan, Qing; Ollberding, Nicholas J; Wu, Zhe; Hui, David Y; Tso, Patrick; Liu, Min 2023. Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet. Nutrients, 15 9, Forman, Sarah; Tso, Patrick; Liu, Min 2022. Measurement of Hepatic Lipids. Methods in molecular biology (Clifton, N.J.), 2455 , 41-48He, Yu; Liu, Ning; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Weaning Stress in Piglets Alters the Expression of Intestinal Proteins Involved in Fat Absorption. The Journal of nutrition, 152 11, 2387-2395He, Yu; Qu, Jie; Yang, Qing; Wu, Zhenlong; Liu, Min; Tso, Patrick 2022. Effect of L-Glutamine on Chylomicron Formation and Fat-Induced Activation of Intestinal Mucosal Mast Cells in Sprague-Dawley Rats. Nutrients, 14 9, He, Yu; Song, Zhuan; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Preventive Effects of l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats. Journal of agricultural and food chemistry, 70 38, 11923-11934May-Zhang, Linda; Liu, Min; Black, Dennis; Tso, Patrick 2022. Apolipoprotein A5, a unique modulator of fasting and postprandial triglycerides. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867 9, 159185Wang, David Q-H; Portincasa, Piero; Liu, Min; Tso, Patrick 2022. Overcoming Ductal Block: Emergency ERCP and Sphincterotomy Plus Common Bile Duct Stenting Improves Therapeutic Outcomes in Severe Gallstone Pancreatitis. Digestive diseases and sciences, 67 1, 11-13Woo, Connie W; Tso, Patrick; Yiu, Jensen H C 2022. Commensal gut microbiota-based strategies for oral delivery of therapeutic proteins. Trends in pharmacological sciences, 43 12, 1004-1013Zhu, Qi; Yang, Qing; Shen, Ling; Qu, Jie; Xu, Meifeng; Wang, David Q-H; Tso, Patrick; Liu, Min 2022. Impact of Sequential Lipid Meals on Lymphatic Lipid Absorption and Transport in Rats. Genes, 13 2, Banan, Babak; Wei, Yan; Simo, Ornella; Tso, Patrick; Abumrad, Naji N; Flynn, Charles Robb; Sundaresan, Sinju; Albaugh, Vance L 2021. Intestinal Lymph Collection via Cannulation of the Mesenteric Lymphatic Duct in Mice. The Journal of surgical research, 260 , 399-408Liu, Min; Shen, Ling; Yang, Qing; Nauli, Andromeda M; Bingamon, Madison; Wang, David Q-H; Ulrich-Lai, Yvonne M; Tso, Patrick 2021. Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids. The Journal of physiology, 599 22, 5015-5030Qu, Jie; Fourman, Sarah; Fitzgerald, Maureen; Liu, Min; Nair, Supna; Oses-Prieto, Juan; Burlingame, Alma; Morris, John H; Davidson, W Sean; Tso, Patrick; Bhargava, Aditi 2021. Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. Scientific reports, 11 1, 13289Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251Chen, Jingqing; Yang, Yuchen; Li, Shuai; Yang, Ying; Dai, Zhaolai; Wang, Fengchao; Wu, Zhenlong; Tso, Patrick; Wu, Guoyao 2020. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT. Cells, 9 4, Ko, Chih-Wei; Qu, Jie; Black, Dennis D; Tso, Patrick 2020. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Nature reviews. Gastroenterology & hepatology, 17 3, 169-183Liu, Min; Shen, Ling; Xu, Meifeng; Wang, David Q-H; Tso, Patrick 2020. Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through ERα-PI3K Pathway in the Nucleus Tractus Solitarius. Genes, 11 12, Liu, Min; Wang, David Q-H; Black, Dennis D; Tso, Patrick 2020. Differential Effect of Four-Week Feeding of Different Dietary Fats on the Accumulation of Fat and the Cholesterol and Triglyceride Contents in the Different Fat Depots. Nutrients, 12 11, Mayer, Fahima; Gunawan, Amanda L; Tso, Patrick; Aponte, Gregory W 2020. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves. American journal of physiology. Gastrointestinal and liver physiology, 319 1, G23-G35Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2020. An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13. Genes, 11 12, Yiu, Jensen H C; Chan, Kam-Suen; Cheung, Jamie; Li, Jin; Liu, Yan; Wang, Yao; Fung, William W L; Cai, Jieling; Cheung, Samson W M; Dorweiler, Bernhard; Wan, Eric Y F; Tso, Patrick; Xu, Aimin; Woo, Connie W 2020. Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver. Circulation research, 127 10, 1236-1252Zhou, Anna; Qu, Jie; Liu, Min; Tso, Patrick 2020. The Role of Interstitial Matrix and the Lymphatic System in Gastrointestinal Lipid and Lipoprotein Metabolism. Frontiers in physiology, 11 , 4Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, AlSiraj, Yasir; Chen, Xuqi; Thatcher, Sean E; Temel, Ryan E; Cai, Lei; Blalock, Eric; Katz, Wendy; Ali, Heba M; Petriello, Michael; Deng, Pan; Morris, Andrew J; Wang, Xuping; Lusis, Aldons J; Arnold, Arthur P; Reue, Karen; Thompson, Katherine; Tso, Patrick; Cassis, Lisa A 2019. XX sex chromosome complement promotes atherosclerosis in mice. Nature communications, 10 1, 2631Ko, Chih-Wei; Qu, Jie; Liu, Min; Black, Dennis D; Tso, Patrick 2019. Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice. Current protocols in mouse biology, 9 1, e60Ko, Chih-Wei; Qu, Jie; Tso, Patrick 2019. Editorial on Sramkova et al., "Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction". The American journal of clinical nutrition, 109 6, 1495-1496Liu, Ning; Dai, Zhaolai; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Wu, Guoyao; Tso, Patrick; Wu, Zhenlong 2019. Maternal L-proline supplementation enhances fetal survival, placental development, and nutrient transport in mice†. Biology of reproduction, 100 4, 1073-1081Qu, Jie; Ko, Chih-Wei; Tso, Patrick; Bhargava, Aditi 2019. Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes. Cells, 8 4, Stahel, Priska; Xiao, Changting; Davis, Xenia; Tso, Patrick; Lewis, Gary F 2019. Glucose and GLP-2 (Glucagon-Like Peptide-2) Mobilize Intestinal Triglyceride by Distinct Mechanisms. Arteriosclerosis, thrombosis, and vascular biology, 39 8, 1565-1573Ji, Yun; Dai, Zhaolai; Sun, Shiqiang; Ma, Xiaoshi; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2018. Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress. Molecular nutrition & food research, 62 21, e1800494Langhans, Wolfgang; Adan, Roger; Arnold, Myrtha; Banks, William A; Card, J Patrick; Dailey, Megan J; Daniels, Derek; de Kloet, Annette D; de Lartigue, Guillaume; Dickson, Suzanne; Fedele, Shahana; Grill, Harvey J; Jansson, John-Olov; Kaufman, Sharon; Kolar, Grant; Krause, Eric; Lee, Shin J; Le Foll, Christelle; Levin, Barry E; Lutz, Thomas A; Mansouri, Abdelhak; Moran, Timothy H; Pacheco-López, Gustavo; Ramachandran, Deepti; Raybould, Helen; Rinaman, Linda; Samson, Willis K; Sanchez-Watts, Graciela; Seeley, Randy J; Skibicka, Karolina P; Small, Dana; Spector, Alan C; Tamashiro, Kellie L; Templeton, Brian; Trapp, Stefan; Tso, Patrick; Watts, Alan G; Weissfeld, Nadja; Williams, Diana; Wolfrum, Christian; Yosten, Gina; Woods, Stephen C 2018. New horizons for future research - Critical issues to consider for maximizing research excellence and impact. Molecular metabolism, 14 , 53-59Liu, Min; Tso, Patrick; Woods, Stephen C 2018. Receptor CD36 links a risk-associated allele to obesity and metabolic disorders. The Journal of biological chemistry, 293 34, 13349-13350Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Tso, Patrick; Vurma, Mustafa; Ko, Chih-Wei; Lee, Dana; DeMichele, Stephen 2018. Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats. American journal of physiology. Gastrointestinal and liver physiology, 315 1, G95-G103Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances. Liver research, 2 4, 186-199Wang, Tony Y; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Mouse models of gallstone disease. Current opinion in gastroenterology, 34 2, 59-70Whitt, Jordan; Woo, Vivienne; Lee, Patrick; Moncivaiz, Jessica; Haberman, Yael; Denson, Lee; Tso, Patrick; Alenghat, Theresa 2018. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology, 155 2, 501-513Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Zhang, Feng; Zarkada, Georgia; Han, Jinah; Li, Jinyu; Dubrac, Alexandre; Ola, Roxana; Genet, Gael; Boyé, Kevin; Michon, Pauline; Künzel, Steffen E; Camporez, Joao Paulo; Singh, Abhishek K; Fong, Guo-Hua; Simons, Michael; Tso, Patrick; Fernández-Hernando, Carlos; Shulman, Gerald I; Sessa, William C; Eichmann, Anne 2018. Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.), 361 6402, 599-603Li, Xiaoming; Wang, Fei; Xu, Min; Howles, Philip; Tso, Patrick 2017. ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling. Scientific reports, 7 , 41289Ma, Xiaoshi; Dai, Zhaolai; Sun, Kaiji; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2017. Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review. Frontiers in immunology, 8 , 1271Packard, Amy E B; Zhang, Jintao; Myers, Brent; Ko, Chih-Wei; Wang, Fei; Tso, Patrick; Ulrich-Lai, Yvonne M 2017. Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner. Psychoneuroendocrinology, 86 , 34-44Rao, Raghavendra; Roche, Alexander; Febres, Gerardo; Bessler, Marc; Tso, Patrick; Korner, Judith 2017. Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 13 3, 468-473Wang, David Q-H; Portincasa, Piero; Tso, Patrick 2017. Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport. Hepatology (Baltimore, Md.), 66 4, 1337-1340Wang, Helen H; Li, Tiangang; Portincasa, Piero; Ford, David A; Neuschwander-Tetri, Brent A; Tso, Patrick; Wang, David Q-H 2017. New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile. Liver research, 1 1, 42-53Weng, Jonathan; Lou, Danwen; Benoit, Stephen C; Coschigano, Natalie; Woods, Stephen C; Tso, Patrick; Lo, Chunmin C 2017. Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology, , ajpregu.00034.2017Zhang, Ming; Sun, Kaiji; Wu, Yujun; Yang, Ying; Tso, Patrick; Wu, Zhenlong 2017. Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease. Frontiers in immunology, 8 , 942Zhang, Yupeng; He, Jing; Zhao, Jing; Xu, Min; Lou, Danwen; Tso, Patrick; Li, Zongfang; Li, Xiaoming 2017. Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochemical and biophysical research communications, 487 2, 327-332Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Kassis, Timothy; Yarlagadda, Sri Charan; Kohan, Alison B; Tso, Patrick; Breedveld, Victor; Dixon, J Brandon 2016. Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity. American journal of physiology. Gastrointestinal and liver physiology, 310 10, G776-89Kohan, Alison B; Yang, Qing; Xu, Min; Lee, Dana; Tso, Patrick 2016. Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. American journal of physiology. Gastrointestinal and liver physiology, 311 4, G648-G654McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P 2016. Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: A preliminary (1)H MRS study. Nutritional neuroscience, 19 4, 145-55McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P 2016. Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Early intervention in psychiatry, 10 3, 203-11Rider, T; LeBoeuf, R C; Tso, Patrick; Jandacek, R J 2016. The Use of Kits in the Analysis of Tissue Lipids Requires Validation. Lipids, 51 4, 497-504Sato, Hirokazu; Zhang, Linda S; Martinez, Kristina; Chang, Eugene B; Yang, Qing; Wang, Fei; Howles, Philip N; Hokari, Ryota; Miura, Soichiro; Tso, Patrick 2016. Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats. Gastroenterology, 151 5, 923-932Song, Chi Young; Ghafoor, Khuzema; Ghafoor, Hafiz U; Khan, Nayaab S; Thirunavukkarasu, Shyamala; Jennings, Brett L; Estes, Anne M; Zaidi, Sahar; Bridges, Dave; Tso, Patrick; Gonzalez, Frank J; Malik, Kafait U 2016. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension, 67 1, 206-13Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P 2016. Using the cerebrospinal fluid to understand ingestive behavior. Physiology & behavior, , Han, Shuxin; Han, Sean Shuxin; Zhang, Rongli; Jain, Rajan; Shi, Hong; Zhang, Lilei; Zhou, Guangjin; Sangwung, Panjamaporn; Tugal, Derin; Atkins, G Brandon; Prosdocimo, Domenick A; Lu, Yuan; Han, Xiaonan; Tso, Patrick; Liao, Xudong; Epstein, Jonathan A; Jain, Mukesh K 2015. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature communications, 6 , 7231Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick 2015. ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. American journal of physiology. Gastrointestinal and liver physiology, 308 6, G472-81McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M 2015. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry research, 230 2, 447-53Pressler, Josh W; Haller, April; Sorrell, Joyce; Wang, Fei; Seeley, Randy J; Tso, Patrick; Sandoval, Darleen A 2015. Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice. Diabetes, 64 2, 498-507Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiological reports, 3 9, Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats. Physiology & behavior, 152 Pt A, 62-7Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick 2015. Apolipoprotein A-IV: a protein intimately involved in metabolism. Journal of lipid research, 56 8, 1403-18Wang, Fei; Yang, Qing; Huesman, Sarah; Xu, Min; Li, Xiaoming; Lou, Danwen; Woods, Stephen C; Marziano, Corina; Tso, Patrick 2015. The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion. American journal of physiology. Gastrointestinal and liver physiology, 309 8, G680-7Wang, Fei; Yoder, Stephanie M; Yang, Qing; Kohan, Alison B; Kindel, Tammy L; Wang, Jacob; Tso, Patrick 2015. Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight. American journal of physiology. Gastrointestinal and liver physiology, 309 10, G807-15Yan, Chunling; He, Yanlin; Xu, Yuanzhong; Shu, Gang; Wang, Chunmei; Yang, Yongjie; Saito, Kenji; Xu, Pingwen; Hinton, Antentor Othrell; Yan, Xiaofeng; Yu, Likai; Wu, Qi; Tso, Patrick; Tong, Qingchun; Xu, Yong 2015. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates POMC Neurons in the Arcuate Nucleus. Neuroendocrinology, , Zhang, Linda S; Sato, Hirokazu; Yang, Qing; Ryan, Robert O; Wang, David Q-H; Howles, Philip N; Tso, Patrick 2015. Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats. American journal of physiology. Gastrointestinal and liver physiology, 309 11, G918-25Zhang, Linda S; Xu, Min; Yang, Qing; Lou, Danwen; Howles, Philip N; Tso, Patrick 2015. ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids, 50 4, 371-9Zhang, Linda S; Xu, Min; Yang, Qing; Ryan, Robert O; Howles, Philip; Tso, Patrick 2015. Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice. American journal of physiology. Gastrointestinal and liver physiology, 308 7, G634-42Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K 2014. Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. Journal of psychiatric research, 50 , 42-50Jandacek, Ronald J; Heubi, James E; Buckley, Donna D; Khoury, Jane C; Turner, Wayman E; Sjödin, Andreas; Olson, James R; Shelton, Christie; Helms, Kim; Bailey, Tina D; Carter, Shirley; Tso, Patrick; Pavuk, Marian 2014. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. The Journal of nutritional biochemistry, 25 4, 483-8Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick 2014. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. The Journal of biological chemistry, 289 4, 2396-404Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C 2014. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, 155 5, 1700-7McNamara, Robert K; Rider, Therese; Jandacek, Ronald; Tso, Patrick 2014. Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis. Psychiatry research, 215 3, 560-7McNamara, Robert K; Strimpfel, Jennifer; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Welge, Jeffrey A; Strawn, Jeffrey R; Delbello, Melissa P 2014. Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition, 2 2, 38-46Ohlsson, Lena; Kohan, Alison B; Tso, Patrick; Ahrén, Bo 2014. GLP-1 released to the mesenteric lymph duct in mice: effects of glucose and fat. Regulatory peptides, 189 , 40-5Poole, Daniel P; Lee, Mike; Tso, Patrick; Bunnett, Nigel W; Yo, Sek Jin; Lieu, TinaMarie; Shiu, Amy; Wang, Jen-Chywan; Nomura, Daniel K; Aponte, Gregory W 2014. Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. American journal of physiology. Gastrointestinal and liver physiology, 306 8, G686-98Shen, Ling; Liu, Yin; Wang, David Q H; Tso, Patrick; Woods, Stephen C; Liu, Min 2014. Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-?. Endocrinology, 155 10, 3882-90Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean 2014. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. The Journal of biological chemistry, 289 9, 5596-608Wang, Fei; Kohan, Alison B; Dong, H Henry; Yang, Qing; Xu, Min; Huesman, Sarah; Lou, Danwen; Hui, David Y; Tso, Patrick 2014. Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph. Physiological reports, 2 3, e00247Ji, Yong; Sakata, Yasuhisa; Li, Xiaoming; Zhang, Chao; Yang, Qing; Xu, Min; Wollin, Armin; Langhans, Wolfgang; Tso, Patrick 2013. Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. American journal of physiology. Gastrointestinal and liver physiology, 304 8, G732-40Kohan, Alison B; Vandersall, Abbey E; Yang, Qing; Xu, Min; Jandacek, Ronald J; Tso, Patrick 2013. The transport of DDT from chylomicrons to adipocytes does not mimic triacylglycerol transport. Biochimica et biophysica acta, 1831 2, 300-5Kohan, Alison B; Wang, Fei; Li, Xiaoming; Vandersall, Abbey E; Huesman, Sarah; Xu, Min; Yang, Qing; Lou, Danwen; Tso, Patrick 2013. Is apolipoprotein A-IV rate limiting in the intestinal transport and absorption of triglyceride? American journal of physiology. Gastrointestinal and liver physiology, 304 12, G1128-35McNamara, Robert K; Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W 2013. Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats. Pharmacology, biochemistry, and behavior, 114-115 , 1-8McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N 2013. Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk. Cardiovascular psychiatry and neurology, 2013 , 796462McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Dwivedi, Yogesh; Ren, Xinguo; Pandey, Ghanshyam N 2013. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. Journal of psychiatric research, 47 9, 1187-91McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Weber, Wade; Chu, Wen-Jang; Strakowski, Stephen M; Adler, Caleb M; Delbello, Melissa P 2013. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. Nutritional neuroscience, 16 4, 183-90Trevaskis, Natalie L; Caliph, Suzanne M; Nguyen, Gary; Tso, Patrick; Charman, William N; Porter, Christopher J H 2013. A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport. Pharmaceutical research, 30 12, 3254-70Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick 2013. Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect. Physiology & behavior, 120 , 136-42Yeap, Yan Yan; Trevaskis, Natalie L; Quach, Tim; Tso, Patrick; Charman, William N; Porter, Christopher J H 2013. Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation. Molecular pharmaceutics, 10 5, 1874-89Zippin, Jonathan H; Chen, Yanqiu; Straub, Susanne G; Hess, Kenneth C; Diaz, Ana; Lee, Dana; Tso, Patrick; Holz, George G; Sharp, Geoffrey W G; Levin, Lonny R; Buck, Jochen 2013. CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. The Journal of biological chemistry, 288 46, 33283-91Arnold, Myrtha; Dai, Yunting; Tso, Patrick; Langhans, Wolfgang 2012. Meal-contingent intestinal lymph sampling from awake, unrestrained rats. American journal of physiology. 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Physiology & behavior, 98 1-2, 223-8Yoder, Stephanie M; Yang, Qing; Kindel, Tammy L; Tso, Patrick 2009. Stimulation of incretin secretion by dietary lipid: is it dose dependent? American journal of physiology. Gastrointestinal and liver physiology, 297 2, G299-305Battle, Michele A; Bondow, Benjamin J; Iverson, Moriah A; Adams, Scott J; Jandacek, Ronald J; Tso, Patrick; Duncan, Stephen A 2008. GATA4 is essential for jejunal function in mice. Gastroenterology, 135 5, 1676-1686.e1Labonté, Eric D; Camarota, Lisa M; Rojas, Juan C; Jandacek, Ronald J; Gilham, Dean E; Davies, Joanna P; Ioannou, Yiannis A; Tso, Patrick; Hui, David Y; Howles, Philip N 2008. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. American journal of physiology. Gastrointestinal and liver physiology, 295 4, G776-83Lo, Chun-Min; Samuelson, Linda C; Chambers, James Brad; King, Alexandra; Heiman, Justin; Jandacek, Ronald J; Sakai, Randall R; Benoit, Stephen C; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2008. Characterization of mice lacking the gene for cholecystokinin. American journal of physiology. Regulatory, integrative and comparative physiology, 294 3, R803-10Lu, Wendell J; Yang, Qing; Sun, William; Woods, Stephen C; D'Alessio, David; Tso, Patrick 2008. Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. American journal of physiology. Gastrointestinal and liver physiology, 294 5, G1130-8McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Hahn, Chang-Gyu; Richtand, Neil M 2008. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry research, 160 3, 285-99McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Campbell, Nick; Lipton, Jack 2008. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse (New York, N.Y.), 62 10, 725-35Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiology & behavior, 95 1-2, 161-7Shen, Ling; Tso, Patrick; Woods, Stephen C; Clegg, Deborah J; Barber, Kyna L; Carey, Katherine; Liu, Min 2008. 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The Journal of nutritional biochemistry, 18 3, 163-7Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick 2007. Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. American journal of physiology. Regulatory, integrative and comparative physiology, 292 1, R268-73McNamara, Robert K; Hahn, Chang-Gyu; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Richtand, Neil M 2007. 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The Journal of biological chemistry, 282 39, 28385-94Duncan, Elizabeth A; Rider, Therese R; Jandacek, Ronald J; Clegg, Deborah J; Benoit, Stephen C; Tso, Patrick; Woods, Stephen C 2006. The regulation of alcohol intake by melanin-concentrating hormone in rats. Pharmacology, biochemistry, and behavior, 85 4, 728-35Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Nauli, Andromeda M; Nassir, Fatiha; Zheng, Shuqin; Yang, Qing; Lo, Chun-Min; Vonlehmden, Sarah B; Lee, Dana; Jandacek, Ronald J; Abumrad, Nada A; Tso, Patrick 2006. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology, 131 4, 1197-207Trevaskis, Natalie L; Tso, Patrick; Rider, Therese; Charman, William N; Porter, Christopher J H; Jandacek, Ronald 2006. Tissue uptake of DDT is independent of chylomicron metabolism. Archives of toxicology, 80 4, 196-200Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. American journal of physiology. Gastrointestinal and liver physiology, 288 2, G292-9Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. 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Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Tso, Patrick; Liu, Min 2004. Apolipoprotein A-IV, food intake, and obesity. Physiology & behavior, 83 4, 631-43Tso, Patrick; Liu, Min 2004. Ingested fat and satiety. Physiology & behavior, 81 2, 275-87Tso, Patrick; Sun, William; Liu, Min 2004. Gastrointestinal satiety signals IV. Apolipoprotein A-IV. American journal of physiology. Gastrointestinal and liver physiology, 286 6, G885-90Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J 2004. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology & behavior, 83 4, 573-8Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Tso, Patrick; Heubi, James E 2004. Cholic acid supplementation enhances cholesterol absorption in humans. Gastroenterology, 126 3, 724-31Clegg, Deborah J; Benoit, Stephen C; Air, Ellen L; Jackman, Alana; Tso, Patrick; D'Alessio, David; Woods, Stephen C; Seeley, Randy J 2003. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology, 144 7, 2941-6Liu, Min; Doi, Takashi; Tso, Patrick 2003. Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), 228 10, 1181-9Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick 2003. Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, 971 2, 232-8Nauli, Andromeda M; Zheng, Shuqin; Yang, Qing; Li, Ronggui; Jandacek, Ronald; Tso, Patrick 2003. Intestinal alkaline phosphatase release is not associated with chylomicron formation. American journal of physiology. Gastrointestinal and liver physiology, 284 4, G583-7Woods, Stephen C; Seeley, Randy J; Rushing, Paul A; D'Alessio, David; Tso, Patrick 2003. A controlled high-fat diet induces an obese syndrome in rats. The Journal of nutrition, 133 4, 1081-7Kirby, R Jason; Zheng, Shuqin; Tso, Patrick; Howles, Philip N; Hui, David Y 2002. Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. The Journal of biological chemistry, 277 6, 4104-9Tso, Patrick; Ding, Kexi; DeMichele, Stephen; Huang, Yung-Sheng 2002. Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. The Journal of nutrition, 132 2, 218-21Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A 2002. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, 43 4, 654-60Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K . Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins, leukotrienes, and essential fatty acids, 86 1-2, 71-7McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W . Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover Prostaglandins, leukotrienes, and essential fatty acids, 83 4-6, 185-91McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick . The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins, leukotrienes, and essential fatty acids, 78 4-5, 293-304
Research InterestsOne of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. We are currently studying how bile salts are involved in the absorption of lipids. I...
Peer Reviewed Publications Kweon, Soo-Mi; Irimia-Dominguez, Jose; Kim, Gayeoun; Fueger, Patrick T; Asahina, Kinji; Lai, Keith K; Allende, Daniela S; Lai, Quincy R; Lou, Chih-Hong; Tsark, Walter M; Yang, Ju Dong; Ng, Dominic S; Lee, Ju-Seog; Tso, Patrick; Huang, Wendong; Lai, Keane K Y 2023. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. American journal of physiology. Gastrointestinal and liver physiology, 325 2, G147-G157LaRussa, Zachary; Kuo, Hsuan-Chih N; West, Kathryn; Shen, Zhijun; Wisniewski, Kevin; Tso, Patrick; Coschigano, Karen T; Lo, Chunmin C 2023. Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice. International journal of molecular sciences, 24 4, Zhu, Qi; Qi, Nathan; Shen, Ling; Lo, Chunmin C; Xu, Meifeng; Duan, Qing; Ollberding, Nicholas J; Wu, Zhe; Hui, David Y; Tso, Patrick; Liu, Min 2023. Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet. Nutrients, 15 9, Forman, Sarah; Tso, Patrick; Liu, Min 2022. Measurement of Hepatic Lipids. Methods in molecular biology (Clifton, N.J.), 2455 , 41-48He, Yu; Liu, Ning; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Weaning Stress in Piglets Alters the Expression of Intestinal Proteins Involved in Fat Absorption. The Journal of nutrition, 152 11, 2387-2395He, Yu; Qu, Jie; Yang, Qing; Wu, Zhenlong; Liu, Min; Tso, Patrick 2022. Effect of L-Glutamine on Chylomicron Formation and Fat-Induced Activation of Intestinal Mucosal Mast Cells in Sprague-Dawley Rats. Nutrients, 14 9, He, Yu; Song, Zhuan; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Preventive Effects of l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats. Journal of agricultural and food chemistry, 70 38, 11923-11934May-Zhang, Linda; Liu, Min; Black, Dennis; Tso, Patrick 2022. Apolipoprotein A5, a unique modulator of fasting and postprandial triglycerides. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867 9, 159185Wang, David Q-H; Portincasa, Piero; Liu, Min; Tso, Patrick 2022. Overcoming Ductal Block: Emergency ERCP and Sphincterotomy Plus Common Bile Duct Stenting Improves Therapeutic Outcomes in Severe Gallstone Pancreatitis. Digestive diseases and sciences, 67 1, 11-13Woo, Connie W; Tso, Patrick; Yiu, Jensen H C 2022. Commensal gut microbiota-based strategies for oral delivery of therapeutic proteins. Trends in pharmacological sciences, 43 12, 1004-1013Zhu, Qi; Yang, Qing; Shen, Ling; Qu, Jie; Xu, Meifeng; Wang, David Q-H; Tso, Patrick; Liu, Min 2022. Impact of Sequential Lipid Meals on Lymphatic Lipid Absorption and Transport in Rats. Genes, 13 2, Banan, Babak; Wei, Yan; Simo, Ornella; Tso, Patrick; Abumrad, Naji N; Flynn, Charles Robb; Sundaresan, Sinju; Albaugh, Vance L 2021. Intestinal Lymph Collection via Cannulation of the Mesenteric Lymphatic Duct in Mice. The Journal of surgical research, 260 , 399-408Liu, Min; Shen, Ling; Yang, Qing; Nauli, Andromeda M; Bingamon, Madison; Wang, David Q-H; Ulrich-Lai, Yvonne M; Tso, Patrick 2021. Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids. The Journal of physiology, 599 22, 5015-5030Qu, Jie; Fourman, Sarah; Fitzgerald, Maureen; Liu, Min; Nair, Supna; Oses-Prieto, Juan; Burlingame, Alma; Morris, John H; Davidson, W Sean; Tso, Patrick; Bhargava, Aditi 2021. Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. Scientific reports, 11 1, 13289Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251Chen, Jingqing; Yang, Yuchen; Li, Shuai; Yang, Ying; Dai, Zhaolai; Wang, Fengchao; Wu, Zhenlong; Tso, Patrick; Wu, Guoyao 2020. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT. Cells, 9 4, Ko, Chih-Wei; Qu, Jie; Black, Dennis D; Tso, Patrick 2020. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Nature reviews. Gastroenterology & hepatology, 17 3, 169-183Liu, Min; Shen, Ling; Xu, Meifeng; Wang, David Q-H; Tso, Patrick 2020. Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through ERα-PI3K Pathway in the Nucleus Tractus Solitarius. Genes, 11 12, Liu, Min; Wang, David Q-H; Black, Dennis D; Tso, Patrick 2020. Differential Effect of Four-Week Feeding of Different Dietary Fats on the Accumulation of Fat and the Cholesterol and Triglyceride Contents in the Different Fat Depots. Nutrients, 12 11, Mayer, Fahima; Gunawan, Amanda L; Tso, Patrick; Aponte, Gregory W 2020. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves. American journal of physiology. Gastrointestinal and liver physiology, 319 1, G23-G35Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2020. An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13. Genes, 11 12, Yiu, Jensen H C; Chan, Kam-Suen; Cheung, Jamie; Li, Jin; Liu, Yan; Wang, Yao; Fung, William W L; Cai, Jieling; Cheung, Samson W M; Dorweiler, Bernhard; Wan, Eric Y F; Tso, Patrick; Xu, Aimin; Woo, Connie W 2020. Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver. Circulation research, 127 10, 1236-1252Zhou, Anna; Qu, Jie; Liu, Min; Tso, Patrick 2020. The Role of Interstitial Matrix and the Lymphatic System in Gastrointestinal Lipid and Lipoprotein Metabolism. Frontiers in physiology, 11 , 4Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, AlSiraj, Yasir; Chen, Xuqi; Thatcher, Sean E; Temel, Ryan E; Cai, Lei; Blalock, Eric; Katz, Wendy; Ali, Heba M; Petriello, Michael; Deng, Pan; Morris, Andrew J; Wang, Xuping; Lusis, Aldons J; Arnold, Arthur P; Reue, Karen; Thompson, Katherine; Tso, Patrick; Cassis, Lisa A 2019. XX sex chromosome complement promotes atherosclerosis in mice. Nature communications, 10 1, 2631Ko, Chih-Wei; Qu, Jie; Liu, Min; Black, Dennis D; Tso, Patrick 2019. Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice. Current protocols in mouse biology, 9 1, e60Ko, Chih-Wei; Qu, Jie; Tso, Patrick 2019. Editorial on Sramkova et al., "Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction". The American journal of clinical nutrition, 109 6, 1495-1496Liu, Ning; Dai, Zhaolai; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Wu, Guoyao; Tso, Patrick; Wu, Zhenlong 2019. Maternal L-proline supplementation enhances fetal survival, placental development, and nutrient transport in mice†. Biology of reproduction, 100 4, 1073-1081Qu, Jie; Ko, Chih-Wei; Tso, Patrick; Bhargava, Aditi 2019. Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes. Cells, 8 4, Stahel, Priska; Xiao, Changting; Davis, Xenia; Tso, Patrick; Lewis, Gary F 2019. Glucose and GLP-2 (Glucagon-Like Peptide-2) Mobilize Intestinal Triglyceride by Distinct Mechanisms. Arteriosclerosis, thrombosis, and vascular biology, 39 8, 1565-1573Ji, Yun; Dai, Zhaolai; Sun, Shiqiang; Ma, Xiaoshi; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2018. Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress. Molecular nutrition & food research, 62 21, e1800494Langhans, Wolfgang; Adan, Roger; Arnold, Myrtha; Banks, William A; Card, J Patrick; Dailey, Megan J; Daniels, Derek; de Kloet, Annette D; de Lartigue, Guillaume; Dickson, Suzanne; Fedele, Shahana; Grill, Harvey J; Jansson, John-Olov; Kaufman, Sharon; Kolar, Grant; Krause, Eric; Lee, Shin J; Le Foll, Christelle; Levin, Barry E; Lutz, Thomas A; Mansouri, Abdelhak; Moran, Timothy H; Pacheco-López, Gustavo; Ramachandran, Deepti; Raybould, Helen; Rinaman, Linda; Samson, Willis K; Sanchez-Watts, Graciela; Seeley, Randy J; Skibicka, Karolina P; Small, Dana; Spector, Alan C; Tamashiro, Kellie L; Templeton, Brian; Trapp, Stefan; Tso, Patrick; Watts, Alan G; Weissfeld, Nadja; Williams, Diana; Wolfrum, Christian; Yosten, Gina; Woods, Stephen C 2018. New horizons for future research - Critical issues to consider for maximizing research excellence and impact. Molecular metabolism, 14 , 53-59Liu, Min; Tso, Patrick; Woods, Stephen C 2018. Receptor CD36 links a risk-associated allele to obesity and metabolic disorders. The Journal of biological chemistry, 293 34, 13349-13350Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Tso, Patrick; Vurma, Mustafa; Ko, Chih-Wei; Lee, Dana; DeMichele, Stephen 2018. Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats. American journal of physiology. Gastrointestinal and liver physiology, 315 1, G95-G103Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances. Liver research, 2 4, 186-199Wang, Tony Y; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Mouse models of gallstone disease. Current opinion in gastroenterology, 34 2, 59-70Whitt, Jordan; Woo, Vivienne; Lee, Patrick; Moncivaiz, Jessica; Haberman, Yael; Denson, Lee; Tso, Patrick; Alenghat, Theresa 2018. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology, 155 2, 501-513Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Zhang, Feng; Zarkada, Georgia; Han, Jinah; Li, Jinyu; Dubrac, Alexandre; Ola, Roxana; Genet, Gael; Boyé, Kevin; Michon, Pauline; Künzel, Steffen E; Camporez, Joao Paulo; Singh, Abhishek K; Fong, Guo-Hua; Simons, Michael; Tso, Patrick; Fernández-Hernando, Carlos; Shulman, Gerald I; Sessa, William C; Eichmann, Anne 2018. Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.), 361 6402, 599-603Li, Xiaoming; Wang, Fei; Xu, Min; Howles, Philip; Tso, Patrick 2017. ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling. Scientific reports, 7 , 41289Ma, Xiaoshi; Dai, Zhaolai; Sun, Kaiji; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2017. Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review. Frontiers in immunology, 8 , 1271Packard, Amy E B; Zhang, Jintao; Myers, Brent; Ko, Chih-Wei; Wang, Fei; Tso, Patrick; Ulrich-Lai, Yvonne M 2017. Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner. Psychoneuroendocrinology, 86 , 34-44Rao, Raghavendra; Roche, Alexander; Febres, Gerardo; Bessler, Marc; Tso, Patrick; Korner, Judith 2017. Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 13 3, 468-473Wang, David Q-H; Portincasa, Piero; Tso, Patrick 2017. Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport. Hepatology (Baltimore, Md.), 66 4, 1337-1340Wang, Helen H; Li, Tiangang; Portincasa, Piero; Ford, David A; Neuschwander-Tetri, Brent A; Tso, Patrick; Wang, David Q-H 2017. New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile. Liver research, 1 1, 42-53Weng, Jonathan; Lou, Danwen; Benoit, Stephen C; Coschigano, Natalie; Woods, Stephen C; Tso, Patrick; Lo, Chunmin C 2017. Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology, , ajpregu.00034.2017Zhang, Ming; Sun, Kaiji; Wu, Yujun; Yang, Ying; Tso, Patrick; Wu, Zhenlong 2017. Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease. Frontiers in immunology, 8 , 942Zhang, Yupeng; He, Jing; Zhao, Jing; Xu, Min; Lou, Danwen; Tso, Patrick; Li, Zongfang; Li, Xiaoming 2017. Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochemical and biophysical research communications, 487 2, 327-332Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Kassis, Timothy; Yarlagadda, Sri Charan; Kohan, Alison B; Tso, Patrick; Breedveld, Victor; Dixon, J Brandon 2016. Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity. American journal of physiology. Gastrointestinal and liver physiology, 310 10, G776-89Kohan, Alison B; Yang, Qing; Xu, Min; Lee, Dana; Tso, Patrick 2016. Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. American journal of physiology. Gastrointestinal and liver physiology, 311 4, G648-G654McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P 2016. Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: A preliminary (1)H MRS study. Nutritional neuroscience, 19 4, 145-55McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P 2016. Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Early intervention in psychiatry, 10 3, 203-11Rider, T; LeBoeuf, R C; Tso, Patrick; Jandacek, R J 2016. The Use of Kits in the Analysis of Tissue Lipids Requires Validation. Lipids, 51 4, 497-504Sato, Hirokazu; Zhang, Linda S; Martinez, Kristina; Chang, Eugene B; Yang, Qing; Wang, Fei; Howles, Philip N; Hokari, Ryota; Miura, Soichiro; Tso, Patrick 2016. Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats. Gastroenterology, 151 5, 923-932Song, Chi Young; Ghafoor, Khuzema; Ghafoor, Hafiz U; Khan, Nayaab S; Thirunavukkarasu, Shyamala; Jennings, Brett L; Estes, Anne M; Zaidi, Sahar; Bridges, Dave; Tso, Patrick; Gonzalez, Frank J; Malik, Kafait U 2016. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension, 67 1, 206-13Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P 2016. Using the cerebrospinal fluid to understand ingestive behavior. Physiology & behavior, , Han, Shuxin; Han, Sean Shuxin; Zhang, Rongli; Jain, Rajan; Shi, Hong; Zhang, Lilei; Zhou, Guangjin; Sangwung, Panjamaporn; Tugal, Derin; Atkins, G Brandon; Prosdocimo, Domenick A; Lu, Yuan; Han, Xiaonan; Tso, Patrick; Liao, Xudong; Epstein, Jonathan A; Jain, Mukesh K 2015. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature communications, 6 , 7231Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick 2015. ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. American journal of physiology. Gastrointestinal and liver physiology, 308 6, G472-81McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M 2015. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry research, 230 2, 447-53Pressler, Josh W; Haller, April; Sorrell, Joyce; Wang, Fei; Seeley, Randy J; Tso, Patrick; Sandoval, Darleen A 2015. Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice. Diabetes, 64 2, 498-507Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiological reports, 3 9, Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats. Physiology & behavior, 152 Pt A, 62-7Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick 2015. Apolipoprotein A-IV: a protein intimately involved in metabolism. Journal of lipid research, 56 8, 1403-18Wang, Fei; Yang, Qing; Huesman, Sarah; Xu, Min; Li, Xiaoming; Lou, Danwen; Woods, Stephen C; Marziano, Corina; Tso, Patrick 2015. The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion. American journal of physiology. Gastrointestinal and liver physiology, 309 8, G680-7Wang, Fei; Yoder, Stephanie M; Yang, Qing; Kohan, Alison B; Kindel, Tammy L; Wang, Jacob; Tso, Patrick 2015. Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight. American journal of physiology. Gastrointestinal and liver physiology, 309 10, G807-15Yan, Chunling; He, Yanlin; Xu, Yuanzhong; Shu, Gang; Wang, Chunmei; Yang, Yongjie; Saito, Kenji; Xu, Pingwen; Hinton, Antentor Othrell; Yan, Xiaofeng; Yu, Likai; Wu, Qi; Tso, Patrick; Tong, Qingchun; Xu, Yong 2015. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates POMC Neurons in the Arcuate Nucleus. Neuroendocrinology, , Zhang, Linda S; Sato, Hirokazu; Yang, Qing; Ryan, Robert O; Wang, David Q-H; Howles, Philip N; Tso, Patrick 2015. Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats. American journal of physiology. Gastrointestinal and liver physiology, 309 11, G918-25Zhang, Linda S; Xu, Min; Yang, Qing; Lou, Danwen; Howles, Philip N; Tso, Patrick 2015. ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids, 50 4, 371-9Zhang, Linda S; Xu, Min; Yang, Qing; Ryan, Robert O; Howles, Philip; Tso, Patrick 2015. Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice. American journal of physiology. Gastrointestinal and liver physiology, 308 7, G634-42Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K 2014. Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. Journal of psychiatric research, 50 , 42-50Jandacek, Ronald J; Heubi, James E; Buckley, Donna D; Khoury, Jane C; Turner, Wayman E; Sjödin, Andreas; Olson, James R; Shelton, Christie; Helms, Kim; Bailey, Tina D; Carter, Shirley; Tso, Patrick; Pavuk, Marian 2014. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. The Journal of nutritional biochemistry, 25 4, 483-8Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick 2014. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. The Journal of biological chemistry, 289 4, 2396-404Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C 2014. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, 155 5, 1700-7McNamara, Robert K; Rider, Therese; Jandacek, Ronald; Tso, Patrick 2014. Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis. Psychiatry research, 215 3, 560-7McNamara, Robert K; Strimpfel, Jennifer; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Welge, Jeffrey A; Strawn, Jeffrey R; Delbello, Melissa P 2014. Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition, 2 2, 38-46Ohlsson, Lena; Kohan, Alison B; Tso, Patrick; Ahrén, Bo 2014. 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Physiology & behavior, 98 1-2, 223-8Yoder, Stephanie M; Yang, Qing; Kindel, Tammy L; Tso, Patrick 2009. Stimulation of incretin secretion by dietary lipid: is it dose dependent? American journal of physiology. Gastrointestinal and liver physiology, 297 2, G299-305Battle, Michele A; Bondow, Benjamin J; Iverson, Moriah A; Adams, Scott J; Jandacek, Ronald J; Tso, Patrick; Duncan, Stephen A 2008. GATA4 is essential for jejunal function in mice. Gastroenterology, 135 5, 1676-1686.e1Labonté, Eric D; Camarota, Lisa M; Rojas, Juan C; Jandacek, Ronald J; Gilham, Dean E; Davies, Joanna P; Ioannou, Yiannis A; Tso, Patrick; Hui, David Y; Howles, Philip N 2008. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. American journal of physiology. Gastrointestinal and liver physiology, 295 4, G776-83Lo, Chun-Min; Samuelson, Linda C; Chambers, James Brad; King, Alexandra; Heiman, Justin; Jandacek, Ronald J; Sakai, Randall R; Benoit, Stephen C; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2008. Characterization of mice lacking the gene for cholecystokinin. American journal of physiology. Regulatory, integrative and comparative physiology, 294 3, R803-10Lu, Wendell J; Yang, Qing; Sun, William; Woods, Stephen C; D'Alessio, David; Tso, Patrick 2008. Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. American journal of physiology. Gastrointestinal and liver physiology, 294 5, G1130-8McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Hahn, Chang-Gyu; Richtand, Neil M 2008. 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The Journal of biological chemistry, 282 39, 28385-94Duncan, Elizabeth A; Rider, Therese R; Jandacek, Ronald J; Clegg, Deborah J; Benoit, Stephen C; Tso, Patrick; Woods, Stephen C 2006. The regulation of alcohol intake by melanin-concentrating hormone in rats. Pharmacology, biochemistry, and behavior, 85 4, 728-35Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Nauli, Andromeda M; Nassir, Fatiha; Zheng, Shuqin; Yang, Qing; Lo, Chun-Min; Vonlehmden, Sarah B; Lee, Dana; Jandacek, Ronald J; Abumrad, Nada A; Tso, Patrick 2006. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology, 131 4, 1197-207Trevaskis, Natalie L; Tso, Patrick; Rider, Therese; Charman, William N; Porter, Christopher J H; Jandacek, Ronald 2006. Tissue uptake of DDT is independent of chylomicron metabolism. Archives of toxicology, 80 4, 196-200Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. American journal of physiology. Gastrointestinal and liver physiology, 288 2, G292-9Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. The Journal of biological chemistry, 280 46, 38576-82Proulx, Karine; Cota, Daniela; Castañeda, Tamara R; Tschöp, Matthias H; D'Alessio, David A; Tso, Patrick; Woods, Stephen C; Seeley, Randy J 2005. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. American journal of physiology. Regulatory, integrative and comparative physiology, 289 3, R729-37Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick 2005. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. American journal of physiology. Gastrointestinal and liver physiology, 288 5, G943-9Redgrave, Trevor G; Wallace, Peter; Jandacek, Ronald J; Tso, Patrick 2005. Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. The Journal of nutritional biochemistry, 16 6, 383-4Jandacek, Ronald J; Heubi, James E; Tso, Patrick 2004. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology, 127 1, 139-44Jandacek, Ronald J; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2004. Rapid clearance of hexachlorobenzene from chylomicrons. Lipids, 39 10, 993-5Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick 2004. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Endocrinology, 145 7, 3232-8Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick 2004. Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. American journal of physiology. Endocrinology and metabolism, 287 2, E366-70Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean 2004. Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Tso, Patrick; Liu, Min 2004. Apolipoprotein A-IV, food intake, and obesity. Physiology & behavior, 83 4, 631-43Tso, Patrick; Liu, Min 2004. Ingested fat and satiety. Physiology & behavior, 81 2, 275-87Tso, Patrick; Sun, William; Liu, Min 2004. Gastrointestinal satiety signals IV. Apolipoprotein A-IV. American journal of physiology. Gastrointestinal and liver physiology, 286 6, G885-90Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J 2004. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology & behavior, 83 4, 573-8Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Tso, Patrick; Heubi, James E 2004. Cholic acid supplementation enhances cholesterol absorption in humans. Gastroenterology, 126 3, 724-31Clegg, Deborah J; Benoit, Stephen C; Air, Ellen L; Jackman, Alana; Tso, Patrick; D'Alessio, David; Woods, Stephen C; Seeley, Randy J 2003. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology, 144 7, 2941-6Liu, Min; Doi, Takashi; Tso, Patrick 2003. Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), 228 10, 1181-9Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick 2003. Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, 971 2, 232-8Nauli, Andromeda M; Zheng, Shuqin; Yang, Qing; Li, Ronggui; Jandacek, Ronald; Tso, Patrick 2003. Intestinal alkaline phosphatase release is not associated with chylomicron formation. American journal of physiology. Gastrointestinal and liver physiology, 284 4, G583-7Woods, Stephen C; Seeley, Randy J; Rushing, Paul A; D'Alessio, David; Tso, Patrick 2003. A controlled high-fat diet induces an obese syndrome in rats. The Journal of nutrition, 133 4, 1081-7Kirby, R Jason; Zheng, Shuqin; Tso, Patrick; Howles, Philip N; Hui, David Y 2002. Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. The Journal of biological chemistry, 277 6, 4104-9Tso, Patrick; Ding, Kexi; DeMichele, Stephen; Huang, Yung-Sheng 2002. Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. The Journal of nutrition, 132 2, 218-21Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A 2002. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, 43 4, 654-60Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K . Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins, leukotrienes, and essential fatty acids, 86 1-2, 71-7McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W . Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover Prostaglandins, leukotrienes, and essential fatty acids, 83 4-6, 185-91McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick . The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins, leukotrienes, and essential fatty acids, 78 4-5, 293-304
Kweon, Soo-Mi; Irimia-Dominguez, Jose; Kim, Gayeoun; Fueger, Patrick T; Asahina, Kinji; Lai, Keith K; Allende, Daniela S; Lai, Quincy R; Lou, Chih-Hong; Tsark, Walter M; Yang, Ju Dong; Ng, Dominic S; Lee, Ju-Seog; Tso, Patrick; Huang, Wendong; Lai, Keane K Y 2023. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. American journal of physiology. Gastrointestinal and liver physiology, 325 2, G147-G157LaRussa, Zachary; Kuo, Hsuan-Chih N; West, Kathryn; Shen, Zhijun; Wisniewski, Kevin; Tso, Patrick; Coschigano, Karen T; Lo, Chunmin C 2023. Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice. International journal of molecular sciences, 24 4, Zhu, Qi; Qi, Nathan; Shen, Ling; Lo, Chunmin C; Xu, Meifeng; Duan, Qing; Ollberding, Nicholas J; Wu, Zhe; Hui, David Y; Tso, Patrick; Liu, Min 2023. Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet. Nutrients, 15 9, Forman, Sarah; Tso, Patrick; Liu, Min 2022. Measurement of Hepatic Lipids. Methods in molecular biology (Clifton, N.J.), 2455 , 41-48He, Yu; Liu, Ning; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Weaning Stress in Piglets Alters the Expression of Intestinal Proteins Involved in Fat Absorption. The Journal of nutrition, 152 11, 2387-2395He, Yu; Qu, Jie; Yang, Qing; Wu, Zhenlong; Liu, Min; Tso, Patrick 2022. Effect of L-Glutamine on Chylomicron Formation and Fat-Induced Activation of Intestinal Mucosal Mast Cells in Sprague-Dawley Rats. Nutrients, 14 9, He, Yu; Song, Zhuan; Ji, Yun; Tso, Patrick; Wu, Zhenlong 2022. Preventive Effects of l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats. Journal of agricultural and food chemistry, 70 38, 11923-11934May-Zhang, Linda; Liu, Min; Black, Dennis; Tso, Patrick 2022. Apolipoprotein A5, a unique modulator of fasting and postprandial triglycerides. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867 9, 159185Wang, David Q-H; Portincasa, Piero; Liu, Min; Tso, Patrick 2022. Overcoming Ductal Block: Emergency ERCP and Sphincterotomy Plus Common Bile Duct Stenting Improves Therapeutic Outcomes in Severe Gallstone Pancreatitis. Digestive diseases and sciences, 67 1, 11-13Woo, Connie W; Tso, Patrick; Yiu, Jensen H C 2022. Commensal gut microbiota-based strategies for oral delivery of therapeutic proteins. Trends in pharmacological sciences, 43 12, 1004-1013Zhu, Qi; Yang, Qing; Shen, Ling; Qu, Jie; Xu, Meifeng; Wang, David Q-H; Tso, Patrick; Liu, Min 2022. Impact of Sequential Lipid Meals on Lymphatic Lipid Absorption and Transport in Rats. Genes, 13 2, Banan, Babak; Wei, Yan; Simo, Ornella; Tso, Patrick; Abumrad, Naji N; Flynn, Charles Robb; Sundaresan, Sinju; Albaugh, Vance L 2021. Intestinal Lymph Collection via Cannulation of the Mesenteric Lymphatic Duct in Mice. The Journal of surgical research, 260 , 399-408Liu, Min; Shen, Ling; Yang, Qing; Nauli, Andromeda M; Bingamon, Madison; Wang, David Q-H; Ulrich-Lai, Yvonne M; Tso, Patrick 2021. Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids. The Journal of physiology, 599 22, 5015-5030Qu, Jie; Fourman, Sarah; Fitzgerald, Maureen; Liu, Min; Nair, Supna; Oses-Prieto, Juan; Burlingame, Alma; Morris, John H; Davidson, W Sean; Tso, Patrick; Bhargava, Aditi 2021. Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. Scientific reports, 11 1, 13289Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251Chen, Jingqing; Yang, Yuchen; Li, Shuai; Yang, Ying; Dai, Zhaolai; Wang, Fengchao; Wu, Zhenlong; Tso, Patrick; Wu, Guoyao 2020. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT. Cells, 9 4, Ko, Chih-Wei; Qu, Jie; Black, Dennis D; Tso, Patrick 2020. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Nature reviews. Gastroenterology & hepatology, 17 3, 169-183Liu, Min; Shen, Ling; Xu, Meifeng; Wang, David Q-H; Tso, Patrick 2020. Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through ERα-PI3K Pathway in the Nucleus Tractus Solitarius. Genes, 11 12, Liu, Min; Wang, David Q-H; Black, Dennis D; Tso, Patrick 2020. Differential Effect of Four-Week Feeding of Different Dietary Fats on the Accumulation of Fat and the Cholesterol and Triglyceride Contents in the Different Fat Depots. Nutrients, 12 11, Mayer, Fahima; Gunawan, Amanda L; Tso, Patrick; Aponte, Gregory W 2020. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves. American journal of physiology. Gastrointestinal and liver physiology, 319 1, G23-G35Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2020. An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13. Genes, 11 12, Yiu, Jensen H C; Chan, Kam-Suen; Cheung, Jamie; Li, Jin; Liu, Yan; Wang, Yao; Fung, William W L; Cai, Jieling; Cheung, Samson W M; Dorweiler, Bernhard; Wan, Eric Y F; Tso, Patrick; Xu, Aimin; Woo, Connie W 2020. Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver. Circulation research, 127 10, 1236-1252Zhou, Anna; Qu, Jie; Liu, Min; Tso, Patrick 2020. The Role of Interstitial Matrix and the Lymphatic System in Gastrointestinal Lipid and Lipoprotein Metabolism. Frontiers in physiology, 11 , 4Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, AlSiraj, Yasir; Chen, Xuqi; Thatcher, Sean E; Temel, Ryan E; Cai, Lei; Blalock, Eric; Katz, Wendy; Ali, Heba M; Petriello, Michael; Deng, Pan; Morris, Andrew J; Wang, Xuping; Lusis, Aldons J; Arnold, Arthur P; Reue, Karen; Thompson, Katherine; Tso, Patrick; Cassis, Lisa A 2019. XX sex chromosome complement promotes atherosclerosis in mice. Nature communications, 10 1, 2631Ko, Chih-Wei; Qu, Jie; Liu, Min; Black, Dennis D; Tso, Patrick 2019. Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice. Current protocols in mouse biology, 9 1, e60Ko, Chih-Wei; Qu, Jie; Tso, Patrick 2019. Editorial on Sramkova et al., "Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction". The American journal of clinical nutrition, 109 6, 1495-1496Liu, Ning; Dai, Zhaolai; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Wu, Guoyao; Tso, Patrick; Wu, Zhenlong 2019. Maternal L-proline supplementation enhances fetal survival, placental development, and nutrient transport in mice†. Biology of reproduction, 100 4, 1073-1081Qu, Jie; Ko, Chih-Wei; Tso, Patrick; Bhargava, Aditi 2019. Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes. Cells, 8 4, Stahel, Priska; Xiao, Changting; Davis, Xenia; Tso, Patrick; Lewis, Gary F 2019. Glucose and GLP-2 (Glucagon-Like Peptide-2) Mobilize Intestinal Triglyceride by Distinct Mechanisms. Arteriosclerosis, thrombosis, and vascular biology, 39 8, 1565-1573Ji, Yun; Dai, Zhaolai; Sun, Shiqiang; Ma, Xiaoshi; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2018. Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress. Molecular nutrition & food research, 62 21, e1800494Langhans, Wolfgang; Adan, Roger; Arnold, Myrtha; Banks, William A; Card, J Patrick; Dailey, Megan J; Daniels, Derek; de Kloet, Annette D; de Lartigue, Guillaume; Dickson, Suzanne; Fedele, Shahana; Grill, Harvey J; Jansson, John-Olov; Kaufman, Sharon; Kolar, Grant; Krause, Eric; Lee, Shin J; Le Foll, Christelle; Levin, Barry E; Lutz, Thomas A; Mansouri, Abdelhak; Moran, Timothy H; Pacheco-López, Gustavo; Ramachandran, Deepti; Raybould, Helen; Rinaman, Linda; Samson, Willis K; Sanchez-Watts, Graciela; Seeley, Randy J; Skibicka, Karolina P; Small, Dana; Spector, Alan C; Tamashiro, Kellie L; Templeton, Brian; Trapp, Stefan; Tso, Patrick; Watts, Alan G; Weissfeld, Nadja; Williams, Diana; Wolfrum, Christian; Yosten, Gina; Woods, Stephen C 2018. New horizons for future research - Critical issues to consider for maximizing research excellence and impact. Molecular metabolism, 14 , 53-59Liu, Min; Tso, Patrick; Woods, Stephen C 2018. Receptor CD36 links a risk-associated allele to obesity and metabolic disorders. The Journal of biological chemistry, 293 34, 13349-13350Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Tso, Patrick; Vurma, Mustafa; Ko, Chih-Wei; Lee, Dana; DeMichele, Stephen 2018. Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats. American journal of physiology. Gastrointestinal and liver physiology, 315 1, G95-G103Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances. Liver research, 2 4, 186-199Wang, Tony Y; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H 2018. Mouse models of gallstone disease. Current opinion in gastroenterology, 34 2, 59-70Whitt, Jordan; Woo, Vivienne; Lee, Patrick; Moncivaiz, Jessica; Haberman, Yael; Denson, Lee; Tso, Patrick; Alenghat, Theresa 2018. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology, 155 2, 501-513Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Zhang, Feng; Zarkada, Georgia; Han, Jinah; Li, Jinyu; Dubrac, Alexandre; Ola, Roxana; Genet, Gael; Boyé, Kevin; Michon, Pauline; Künzel, Steffen E; Camporez, Joao Paulo; Singh, Abhishek K; Fong, Guo-Hua; Simons, Michael; Tso, Patrick; Fernández-Hernando, Carlos; Shulman, Gerald I; Sessa, William C; Eichmann, Anne 2018. Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.), 361 6402, 599-603Li, Xiaoming; Wang, Fei; Xu, Min; Howles, Philip; Tso, Patrick 2017. ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling. Scientific reports, 7 , 41289Ma, Xiaoshi; Dai, Zhaolai; Sun, Kaiji; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong 2017. Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review. Frontiers in immunology, 8 , 1271Packard, Amy E B; Zhang, Jintao; Myers, Brent; Ko, Chih-Wei; Wang, Fei; Tso, Patrick; Ulrich-Lai, Yvonne M 2017. Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner. Psychoneuroendocrinology, 86 , 34-44Rao, Raghavendra; Roche, Alexander; Febres, Gerardo; Bessler, Marc; Tso, Patrick; Korner, Judith 2017. Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 13 3, 468-473Wang, David Q-H; Portincasa, Piero; Tso, Patrick 2017. Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport. Hepatology (Baltimore, Md.), 66 4, 1337-1340Wang, Helen H; Li, Tiangang; Portincasa, Piero; Ford, David A; Neuschwander-Tetri, Brent A; Tso, Patrick; Wang, David Q-H 2017. New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile. Liver research, 1 1, 42-53Weng, Jonathan; Lou, Danwen; Benoit, Stephen C; Coschigano, Natalie; Woods, Stephen C; Tso, Patrick; Lo, Chunmin C 2017. Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology, , ajpregu.00034.2017Zhang, Ming; Sun, Kaiji; Wu, Yujun; Yang, Ying; Tso, Patrick; Wu, Zhenlong 2017. Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease. Frontiers in immunology, 8 , 942Zhang, Yupeng; He, Jing; Zhao, Jing; Xu, Min; Lou, Danwen; Tso, Patrick; Li, Zongfang; Li, Xiaoming 2017. Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochemical and biophysical research communications, 487 2, 327-332Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Kassis, Timothy; Yarlagadda, Sri Charan; Kohan, Alison B; Tso, Patrick; Breedveld, Victor; Dixon, J Brandon 2016. Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity. American journal of physiology. Gastrointestinal and liver physiology, 310 10, G776-89Kohan, Alison B; Yang, Qing; Xu, Min; Lee, Dana; Tso, Patrick 2016. Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. American journal of physiology. Gastrointestinal and liver physiology, 311 4, G648-G654McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P 2016. Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: A preliminary (1)H MRS study. Nutritional neuroscience, 19 4, 145-55McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P 2016. Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Early intervention in psychiatry, 10 3, 203-11Rider, T; LeBoeuf, R C; Tso, Patrick; Jandacek, R J 2016. The Use of Kits in the Analysis of Tissue Lipids Requires Validation. Lipids, 51 4, 497-504Sato, Hirokazu; Zhang, Linda S; Martinez, Kristina; Chang, Eugene B; Yang, Qing; Wang, Fei; Howles, Philip N; Hokari, Ryota; Miura, Soichiro; Tso, Patrick 2016. Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats. Gastroenterology, 151 5, 923-932Song, Chi Young; Ghafoor, Khuzema; Ghafoor, Hafiz U; Khan, Nayaab S; Thirunavukkarasu, Shyamala; Jennings, Brett L; Estes, Anne M; Zaidi, Sahar; Bridges, Dave; Tso, Patrick; Gonzalez, Frank J; Malik, Kafait U 2016. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension, 67 1, 206-13Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P 2016. Using the cerebrospinal fluid to understand ingestive behavior. 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Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes, 57 8, 2092-8Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean 2008. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. The Journal of biological chemistry, 283 25, 17314-23D'Alessio, David; Lu, Wendell; Sun, William; Zheng, Shuqin; Yang, Qing; Seeley, Randy; Woods, Stephen C; Tso, Patrick 2007. Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. American journal of physiology. Regulatory, integrative and comparative physiology, 293 6, R2163-9Jandacek, Ronald J; Tso, Patrick 2007. Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention. The Journal of nutritional biochemistry, 18 3, 163-7Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick 2007. Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. American journal of physiology. Regulatory, integrative and comparative physiology, 292 1, R268-73McNamara, Robert K; Hahn, Chang-Gyu; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Richtand, Neil M 2007. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biological psychiatry, 62 1, 17-24McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Hahn, Chang-Gyu; Richtand, Neil M; Stanford, Kevin E 2007. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. Schizophrenia research, 91 1-3, 37-50Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology, 148 6, 2681-9Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean 2007. Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. The Journal of biological chemistry, 282 39, 28385-94Duncan, Elizabeth A; Rider, Therese R; Jandacek, Ronald J; Clegg, Deborah J; Benoit, Stephen C; Tso, Patrick; Woods, Stephen C 2006. The regulation of alcohol intake by melanin-concentrating hormone in rats. Pharmacology, biochemistry, and behavior, 85 4, 728-35Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Nauli, Andromeda M; Nassir, Fatiha; Zheng, Shuqin; Yang, Qing; Lo, Chun-Min; Vonlehmden, Sarah B; Lee, Dana; Jandacek, Ronald J; Abumrad, Nada A; Tso, Patrick 2006. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology, 131 4, 1197-207Trevaskis, Natalie L; Tso, Patrick; Rider, Therese; Charman, William N; Porter, Christopher J H; Jandacek, Ronald 2006. Tissue uptake of DDT is independent of chylomicron metabolism. Archives of toxicology, 80 4, 196-200Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. American journal of physiology. Gastrointestinal and liver physiology, 288 2, G292-9Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. The Journal of biological chemistry, 280 46, 38576-82Proulx, Karine; Cota, Daniela; Castañeda, Tamara R; Tschöp, Matthias H; D'Alessio, David A; Tso, Patrick; Woods, Stephen C; Seeley, Randy J 2005. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. American journal of physiology. Regulatory, integrative and comparative physiology, 289 3, R729-37Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick 2005. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. American journal of physiology. Gastrointestinal and liver physiology, 288 5, G943-9Redgrave, Trevor G; Wallace, Peter; Jandacek, Ronald J; Tso, Patrick 2005. Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. The Journal of nutritional biochemistry, 16 6, 383-4Jandacek, Ronald J; Heubi, James E; Tso, Patrick 2004. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology, 127 1, 139-44Jandacek, Ronald J; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2004. Rapid clearance of hexachlorobenzene from chylomicrons. Lipids, 39 10, 993-5Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick 2004. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Endocrinology, 145 7, 3232-8Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick 2004. Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. American journal of physiology. Endocrinology and metabolism, 287 2, E366-70Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean 2004. Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Tso, Patrick; Liu, Min 2004. Apolipoprotein A-IV, food intake, and obesity. Physiology & behavior, 83 4, 631-43Tso, Patrick; Liu, Min 2004. Ingested fat and satiety. Physiology & behavior, 81 2, 275-87Tso, Patrick; Sun, William; Liu, Min 2004. Gastrointestinal satiety signals IV. Apolipoprotein A-IV. American journal of physiology. Gastrointestinal and liver physiology, 286 6, G885-90Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J 2004. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology & behavior, 83 4, 573-8Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Tso, Patrick; Heubi, James E 2004. Cholic acid supplementation enhances cholesterol absorption in humans. Gastroenterology, 126 3, 724-31Clegg, Deborah J; Benoit, Stephen C; Air, Ellen L; Jackman, Alana; Tso, Patrick; D'Alessio, David; Woods, Stephen C; Seeley, Randy J 2003. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology, 144 7, 2941-6Liu, Min; Doi, Takashi; Tso, Patrick 2003. Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), 228 10, 1181-9Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick 2003. Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, 971 2, 232-8Nauli, Andromeda M; Zheng, Shuqin; Yang, Qing; Li, Ronggui; Jandacek, Ronald; Tso, Patrick 2003. Intestinal alkaline phosphatase release is not associated with chylomicron formation. American journal of physiology. Gastrointestinal and liver physiology, 284 4, G583-7Woods, Stephen C; Seeley, Randy J; Rushing, Paul A; D'Alessio, David; Tso, Patrick 2003. A controlled high-fat diet induces an obese syndrome in rats. The Journal of nutrition, 133 4, 1081-7Kirby, R Jason; Zheng, Shuqin; Tso, Patrick; Howles, Philip N; Hui, David Y 2002. Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. The Journal of biological chemistry, 277 6, 4104-9Tso, Patrick; Ding, Kexi; DeMichele, Stephen; Huang, Yung-Sheng 2002. Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. The Journal of nutrition, 132 2, 218-21Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A 2002. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, 43 4, 654-60Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K . Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins, leukotrienes, and essential fatty acids, 86 1-2, 71-7McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W . Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover Prostaglandins, leukotrienes, and essential fatty acids, 83 4-6, 185-91McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick . The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins, leukotrienes, and essential fatty acids, 78 4-5, 293-304