Education/CredentialsDoctoral Degree: Mario Negri Institute for Pharmacological Research (Pharmacological Research)Fellowship : Mario Negri Institute for Pharmacological ResearchPharmacy Degree: University of Genoa (Pharmacy)Bachelor's Degree: University of Genoa (Pharmaceutical Chemistry) Contact Information Medical Sciences Building 6115 Office 513-558-6009 Email conforl@ucmail.uc.edu Research Interests My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. Our main focus areas are: 1. Role of ion channels in T cell response and adaptation to hypoxia. Hypoxia (low oxygen availability) can occur in physiologica... Peer Reviewed Publications Agresta, Laura; Lehn, Maria; Lampe, Kristin; Cantrell, Rachel; Hennies, Cassandra; Szabo, Sara; Wise-Draper, Trisha; Conforti, Laura; Hoebe, Kasper; Janssen, Edith M 2020. CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 8 1, Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura 2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11 , 143Dirar, Qassim; Russell, Teal; Liu, Lumei; Ahn, Sarah; Dotti, Gianpietro; Aravamudhan, Shyam; Conforti, Laura; Yun, Yeoheung 2020. Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. PloS one, 15 9, e0238819Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura 2020. Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. Science advances, 6 47, Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura 2020. PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for immunotherapy of cancer, 8 2, Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura 2018. A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 527, Rossi, Francesca; Geiszler, Philippine C; Meng, Weina; Barron, Matthew R; Prior, Malcolm; Herd-Smith, Anna; Loreto, Andrea; Lopez, Maria Yanez; Faas, Henryk; Pardon, Marie-Christine; Conforti, Laura 2018. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research, 339 , 140-152Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura 2017. Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 1, 53-61Conforti, Laura 2017. Potassium channels of T lymphocytes take center stage in the fight against cancer. Journal for immunotherapy of cancer, 5 , 2Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura 2016. Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. Journal of autoimmunity, 69 , 86-93Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura 2015. The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. Molecular biology of the cell, 26 9, 1640-51Chimote, A. A.; Hajdu, P.; Kucher, V.; Boiko, N.; Kuras, Z.; Szilagyi, O.; Yun, Y. H.; Conforti, L. 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells , 191 12 , 6273-80Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. Journal of immunology (Baltimore, Md. : 1950), 191 12, 6273-80Hajdu, Péter; Chimote, Ameet A.; Thompson, Tyler H.; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity Biomaterials, 34 38 , 10249-10257Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials, 34 38, 10249-57Chimote AA, Kuras Z, Conforti, L 2012. Disruption of Kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes The Journal of Biological Chemistry, 287 3, 2055-2067Conforti, Laura 2012. The ion channel network in T lymphocytes, a target for immunotherapy. Clinical immunology (Orlando, Fla.), 142 2, 105-6Kuras Z, Kucher V, Gordon SM, Neumeier L, Chimote AA, Filipovich AH, Conforti L 2012. Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated via the Disc large 1 (Dlg1)-tyrosine kinase Lck complex American Journal of Physiology. Cell Physiology, 302 10, C1504-1512Kuras, Z.; Yun, Y. H.; Chimote, A. A.; Neumeier, L.; Conforti, L. 2012. KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells PLoS ONE, 7 8 , e43859Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura 2012. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PloS one, 7 8, e43859Li HC, Kucher V, Li EY, Conforti L, Zahedi K, Soleimani M 2012. The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane American Journal of Physiology. Cell Physiology, 302 12, C1713-1730Martin GV, Yun YH, Conforti L 2012. Modulation of T cell activation by localized K+ accumulation at the immunological synapse--a mathematical model Journal of Theoretical Biology, 300 , 173-182Nicolaou SA, Neumeier L, Takimoto K, Lee SM, Duncan HJ, Kant SK, Mongey AB, Filipovich AH, Conforti L 2010. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus Cell Calcium, 47 1, 19-28Nicolaou SA, Neumeier L, Steckly A, Kucher V, Takimoto K, Conforti L 2009. Kv1.3 localization in the immunological synapse regulates the calcium response to antigen stimulation in T lymphocytes J Immunol, 183 10, 6296-6302Nyakeriga AM, Fichtenbaum CJ, Goebel J, Nicolaou S, Conforti L, Chougnet C 2009. Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infection Journal of Virology, 83 3, 1193-1200Li H, Li E, Neumeier L, Conforti L, Soleimani M 2007. Identification of a novel signal in the cytoplasmic tail of the Na+:HCO3- cotransporter NBC1 that mediates basolateral targeting American Journal of Physiology. Renal Physiology, 292 4, F1245-55Nicolaou SA, Neumeier L, Peng Y, Devor D, Conforti L 2007. The Ca²+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human t lymphocytes Am J Physiol - Cell Physiol, 292 4, C1431-C1439Nicolaou SA, Szigligeti P, Duncan HJ, Neumeier L, Lee SM, Mongey AB, Kant SK, Filipovich AH, Conforti L. 2007. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Journal of Immunology (Baltimore, Md. : 1950), 179 1, 346-356Nicolaou, Stella A; Neumeier, Lisa; Peng, Youqing; Devor, Daniel C; Conforti, Laura 2007. The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. American journal of physiology. Cell physiology, 292 4, C1431-9Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Molleran Lee S, Filipovich AH, Conforti L 2006. Signaling during hypoxia in human T lymphocytes - critical role of the src proteing tyrosine kinase p56lck in the oxygen-sensitivity of Kv1.3 channels Journal of Physiology, 573 2, 357-370Szigligeti, Peter; Neumeier, Lisa; Duke, Eugene; Chougnet, Claire; Takimoto, Koichi; Lee, Susan Molleran; Filipovich, Alexandra H; Conforti, Laura 2006. Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels. The Journal of physiology, 573 Pt 2, 357-70Li HC, Szigligeti P, Worrell R, Matthews J, Conforti L, Soleimani, M 2005. Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis American Journal of Physiology - Renal Physiology, 289 1, F61-71Robbins JR, Lee SM, Filipovich AH, Szigligeti P, Neumeier L, Petrovic, Conforti, L 2005. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels The Journal of Physiology, 564 Pt 1, 131-143Zakrzewska A, Schnell PO, Striet JB, Hui A, Petrovic M, Robbins JR, Conforti L, Gozal D, Wathelet M, Czyzyk-Krzeska M 2005. Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and cbp in oxygen-sensitive cells Journal of Neurochemistry, 94 5, 1288-1296Li HC, Worrell RT, Matthews JB, Husseinzadeh H, Neumeier L, Petrovic S, Conforti L, Soleimani M 2004. Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane The Journal of Biological Chemistry, 279 41, 43190-43197Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. Slc26a7: a basolateral cl-/hco3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology - Renal Physiology, 286 1 , F161-F169Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology. Renal Physiology, 286 1, F161-169Sutliff RL, Conforti L, Weber CS, Kranias EG, Paul RJ 2004. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse Vascular Pharmacology, 41 6, 197-204Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich, Alexandra AH 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation Journal of Immunology (Baltimore, Md. : 1950), 170 2, 695-702Conforti L, Takimoto K, Petrovic M, Pongs O, Millhorn D 2003. The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity. Biochemical and Biophysical Research Communications, 306 2, 450-456Sievers, Caroline; Platt, Nick; Perry, V Hugh; Coleman, Michael P; Conforti, Laura 2003. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neuroscience research, 46 2, 161-9Xu Jie, Wang Z, Barone S, Petrovic M, Amlal H, Conforti L, Petrovic S, Soleimani M 2003. Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant American Journal of Physiology. Renal Physiology, 284 1, F41-50Takimoto K, Yang E-K, Conforti L 2002. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels Journal of Biological Chemistry, 277 30, 26904-26911Thorne GD, Conforti L, Paul RJ 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels American Journal of Physiology - Heart and Circulatory Physiology, 283 1 52-1, H247-H253Thorne, George D; Conforti, Laura; Paul, Richard J 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels. American journal of physiology. Heart and circulatory physiology, 283 1, H247-53Wang Z, Conforti L, Petrovic S, Amlal H, Burnham CE, Soleimani M 2001. Mouse Na+:HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution Kidney International, 59 4, 1405-1414Conforti L, Bodi I, Nisbet J W, Millhorn DE 2000. O2-sensitive K+ channels: role of the Kv1.2 alpha subunit in mediating the hypoxic response The Journal of Physiology, 524 3, 783-793Conforti L, Millhorn DE 2000. Regulation of Shaker-type potassium channels by hypoxia Advances in Experimental Medicine and Biology, 475 , 265-274Kobayashi S, Conforti L, Millhorn DE 2000. Gene expression and function of adenosine A2A receptors in the rat carotid body American Journal of Physiology - Lung Cellular and Molecular Physiology, 279 2, L273-282Millhorn D, Beitner-Johnson D, Conforti L, Conrad P, Kobayashi S, Yuan Y, Rust R 2000. Gene Regulation During Hypoxia in Excitable Oxygen-Sensing Cells: Depolarization-Transcription Coupling Advances in Experimental Medicine and Biology, , 131-142Conforti L, Kobayashi S, Beitner-Johnson D, Conrad PW, Freeman T, Millhorn DE 1999. Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells Respiration Physiology, 115 2, 249-260Kobayashi S, Conforti L, Zhu WH, Beitner-Johnson D, Millhorn DE 1999. Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells Pflugers Archiv European Journal of Physiology, 438 6, 750-759Kobayashi S, Beitner-Johnson D, Conforti L, Millhorn DE 1998. Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A The Journal of Physiology, 512 ( Pt 2) , 351-363Peng M, Conforti L, Millhorn DE 1998. Expression of somatostatin receptor genes and acetylcholine receptor development in rat skeletal muscle during postnatal development International Journal of Molecular Medicine, 1 5, 841-848Conforti L, Millhorn DE 1997. Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia The Journal of Physiology, 502 2, 293-305Kobayashi S, Conforti L, Pun RY, Millhorn DE 1997. Adenosine modulates hypoxic chemoreception in PC12 cells via A2 receptor stimulation The Journal of Physiology, 508 1, 95-107Millhorn DE, Raymond R, Conforti L, Zhu W, Beitner-Johnson D, Filisko T, Genter MB, Kobayashi S, Peng M 1997. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia Kidney International, 51 2, 527-35Zhu WH, Conforti L, Millhorn DE 1997. Expression of dopamine D2 receptor in PC-12 cells and regulation of membrane conductances by dopamine American Journal of Physiology - Cell Physiology, 273 42, C1143-C1150Millhorn DE, Conforti L, Beitner-Johnson D, Zhu W, Raymond R, Filisko T, Kobayashi S, Peng M, Genter MB 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line Advances in Experimental Medicine and Biology, 410 , 135-42Zhu WH, Conforti L, Czyzyk-Krzeska MF, Millhorn DE 1996. Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current American Journal of Physiology - Cell Physiology, 271 40, C658-665Conforti L, Sumii K, Sperelakis N 1995. Dioctanoyl-glycerol inhibits l-type calcium current in embryonic chick cardiomyocytes independent of protein kinase c activation Journal of Molecular and Cellular Cardiology, 27 5, 1219-1224Conforti L, Sumii K, Sperelakis N 1994. Diphenylamine-2-carboxylate blocks voltage-dependent na+ and ca2+ channels in rat ventricular cardiomyocytes European Journal of Pharmacology, 259 2, 215-218Conforti L, Tohse N, Sperelakis N 1993. Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytes - contribution to the plateau phase of action potential Journal of Molecular and Cellular Cardiology, 25 2, 159-173Cox D, Conforti L, Sperelakis N, Matlib M 1993. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157 Journal of Cardiovascular Pharmacology, 21 4, 595-599Conforti L, Tohse N, Sperelakis N 1991. Influence of sympathetic innervation on the membrane electrical properties of neonatal rat cardiomyocytes in culture Journal of Developmental Physiology, 15 4, 237-246Tohse N, Conforti L, Sperelakis N 1991. Bay K 8644 enhances Ca2+ channel activities in embryonic chick heart cells without prolongation of open times European Journal of Pharmacology, 203 2, 307-10GEPC, Latini R, Tognoni G., Conforti L, Gondoni L, Santoro E, Rocchetti M 1988. Multicentre, cross sectional study of ventricular arrhythmias in chronically haemodialysed patients Lancet, 8606 , 305-307Latini R, Zuanetti G, Conforti L, Schwartz PJ, Lazzara R 1988. Demonstration of a different sensitivity to epinephrine in isolated and in vivo hearts European Journal of Pharmacology, 156 1, 87-94Chen Z, Colombo T, Conforti L, Donelli M, Fiedorowicz RJ, Marchi S, Paolini A, Riva E, Zuanetti G, Latini R 1987. Effects of three new anthracyclines and doxorubicin on the rat isolated heart The Journal of Pharmacy and Pharmacology, 39 11, 947-950Caccia S, Conforti L, Conti I 1986. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat Journal of Pharmacy and Pharmacology, 38 6, 469-472 Abstract Publications Chimote A, Kuras Z, Yun Y, Neumeier L, Conforti L 2012. Kca3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. , , Hajdu P, Collins B, Hooper E, Thompson T, Yun Y, Conforti L 2012. Targeting T cells with functionalized lipid nanovesicles , , Chimote A, Vergamini S, Filipovich A, Conforti L 2011. Disruption of membrane trafficking underlies the reduction in Kv1.3 channel surface expression in T lymphocytes during hypoxia , , Kuras Z, Yun Y, Chimote A, Conforti L 2011. Ca²+-activated K+ channels (KCa3.1) control activated T cell migration , , Kuras Z, Kucher V, Neumeier L, Dillehay K, Conforti L 2010. Selective downregulation of human Kv1.2 channes by PKA-I , , Yun Y, Conforti L 2010. Kv1.3 channel mobility and function in Systemic Lupus Erythematosus , , Nicolaou S, Neumeier L, Molleran L, Ragupathy M, Duncan H, Kant K, Filipovich A, Mongey A, Conforti L 2008. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in Systemic Lupus Erythematosis , , Yun H, Conforti L 2008. Creation of Artificial Antigen-Presenting Cell Membrane Surface for the Study of T-Cell Activation , , Bodi L, D'Souza K, Rubio M, Nicolaou S, Fuller B, Conforti L, Molketin J, Schwartz A 2007. Deletion of calcineurin partially rescues impaired cardiac function in mouse model with targeted overexpression of L-type calcium channel a1c. Journal of Molecular and Cellular Cardiology, 42 , A37Yun Y, Dong Z, Shanov C, Bange A, Heineman W, Halsall H, Conforti L, Bhattacharya A, Schulz M 2007. On-line carbon nanotube-based biosensors in microfluidic channels , , Nicolaou S, Szigligeti P, Duncan H, Lee S, Kant K, Filipovich A, Conforti L 2006. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Clinical Immunol, 119 , A68Nicolaou S, Szigligeti P, Neumeier L, Conforti L 2006. Kv1.3 channel redistribution in the immunological synapse varies according to the T lymphocyte activation state FASEB J, 20 , A215.11Hong C, Petrovic S, Szigligeti P, Conforti L, Soleimani M 2005. The amino terminal domain regulates the electrogenecity whereas the carboxyl terminal domain mediates the targeting of NBC1 to the basolateral membrane Journal of American Society of Nephrology, 16 , 124ASzigligeti P, Neumeier L, Lee S, Filipovich A, Conforti L 2005. Hypoxia-induced inhibition of Kv1.3 channes in human CD4+ T lymphocytes is mediated by the src protein tyrosine kinase p56Lck FASEB J, 19 5, A389Conforti L, Anjak A, Neumeier L 2004. Heteromultimeric Kc1.2-Kv1.3 channels underlie the O2-sensitive K current in PC12 cells FASEB J, 18 5, A1065Zakrewshka A, Schnell P, Striet J, Hui A, Petrovic M, Conforti L, Czyzyk-Krzeska M 2003. Hypoxia-induced hyperphosphorylation of p300 CBP transcription coactivators requires calcium and specific glucose metabolic pathway , , Conforti L, Petrovic M, Takimoto K, Mohammad D 2002. Oxygen-sensitive ion channels in human T lymphocytes The pharmacologist, 44 2, Suppl 1: A141Petrovic M, Mohammad D, Ma Q, Conforti L 2002. Oxygen-sensitive potassium channels in T lymphocytes FASEB J, 16 , A60Petrovic M, Conforti L, Burnham C, Petrovic S, Wang Z, Xu J, Amlal H, Soleimani M 2001. The 3-prime end of NBC1 mediates the inhibition of camp and affects the electrogenecity but not the pH activity of the kidney Na+:HCO3- cotransporter , , Xu J, Wang Z, Petrovic S, Petrovic M, Conforti L, Soleimani M 2001. Characterization of the Na+:HCO3- contransporter NBC4: Expression, functional properties and novel splicing variant , , Conforti L, Millhorn D 2000. Critical role of the Kv1.2 alpha subunit in the response to hypoxia of native O2-sensitive K channels FASEB J, 14 , A638Thorne G, Conforti L, Paul R 2000. Impaired oxygen sensitivity following organ culture: new approaches to studying the mechanisms of hypoxic coronary vasodilation FASEB J, 14 , A414Kobayashi S, Conforti L, Zhu W, Beitner-Johnson D, Millhorn D 1999. Chronic hypoxia down-regulates G□o in PC12 cells: a mechanism for attenuated dopamine D2 receptor-mediated inhibition of Ca²+ current FASEB J, 13 , A805.6Millhorn D, Conforti L, Beitner-Johnson D, Kobayashi S, Conrad Wm Raymond R, Rust R, Freeman T 1999. Oxygen chemosensitivity: stimulus-transcription coupling FASEB J, 13 , A806.1Sutliff R, Conforti L, Kranias E, Paul R 1999. Mechanisms underlying altered portal vein mechanical activity in phospholamban gene-ablated mice FASEB J, 13 , A123.4Conforti L, Bodi L, Millhorn D 1998. Oxygen0sensitivity of the Shaker Kv1.2 potassium channel FASEB J, 12 , A438Conforti L, Millhorn D 1997. Oxygen-sensitivity and enhanced expression of a delayed-rectifier K channel in PC12 cells during hypoxia FASEB J, 11 , A329Kobayashi S, Conforti L, Millhorn D 1997. Adenosine modulates hypoxic chemoreceptin in PC12 cells via A2 receptor stimulation FASEB J, 11 , A197Zhu W, Conforti L, Millhorn D 1997. Receptor modulation of membrane conductances in PC12 cells FASEB J, 11 , A133Kobayashi S, Conforti L, Zhu W, Millhorn D 1996. Adenosine stimulates voltage-dependent K current in pheochromocytoma (PC12) cells via activation of A2 receptors , , Peng M, Liu Z, Conforti L, Millhorn D 1996. Inhibition of the nicotinic-type acetylcholine receptor epsilon subunit mRNA expression by somatostating (SST) J Neurosc, 22 3, 1965aZhu W, Conforti L, Millhorn D 1996. Interaction of dopamine receptors iwth the O2-sensitive K+ current in PC12 cells , , Zhu W, Conforti L, Millhorn D 1995. Excitation-secretion in PC12 cells during hypoxia J Neurosc, 21 1, 65AConforti L, Tohse N, Sperelakis N 1992. Developmental changes in fast sodium current of rat ventricular cardiomycocytes Biophysical J, 61 , 305AConforti L, Tohse N, Sperelakis N 1991. Fast sodium current in 18-day-old fetal rat ventricular cardiomycocytes J Mol Cell Cardiol, 23 , S97Tohse N, Conforti L, Sperelakis N 1991. Preferential recruitment of one subtype of cardiac L-type Ca²+ channel by Bay K 8644 Biophysical J, 59 , 86ALatini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 1987. Demonstration and analysis of possible mechanisms for amplification of epinephrine effects in vivo Fed Proc, 46 , 1256Nyakeriga A, Nicolaou S, Goebel J, Conforti L, Chougnet C 11-2006. HIV gp120-CD4 interactions affect Lck redistribution and activation in primary T cells , , Conforti L 11-2003. Oxygen sensing and ion channels , , Conforti L 11-2003. Molecular basis and functional role of oxygen sensitive potassium channels , , Li H, Petrovic S, Petrovic M, Conforti L, Barone S, Soleimani M 11-2003. Membrane targeting of the Na+:HCO3- contransporter NBC1 is dependent on an acid carboxy terminal motif , , Petrovic S, Barone S, Xu J, Ma L, Conforti L, Kujala M, Kere J, Soleimani M 11-2003. Identification of a basolateral Cl/HCO3- exchanger specific to intercalated cells in outer medullary collecting duct: co-localization with AE1 , , Conforti L, Millhorn D 11-1996. Selective inhibition of a slow-inactivating voltage dependent potassium channel in PC12 cells by hypoxia , , Marticn G, Yun Y, Conforti L 10-2010. Modeling of Potassium Accumulation at the Immunological Synapse and its Effect on T-Cell Function , , Yun Y, Neumeier L, Schulz M, Shanov V, Conforti L 10-2009. Spatiotemporal Dynamics of Immunological Synapse Formation in T Cells , , Chen Z ,Colombo T, Conforti L, Donelli M, Fiedorowicz R, Marchi S, Pollini A, Riva E, Zuanetti G, Latini R 10-1986. Comparative evaluation of the effect of three new anthracycline and doxorubicin on isolated rat heart , , Conforti L, Millhorn D 09-1999. Oxygen-sensitivity of Kv1 potassium channels , , Conforti L, Freeman T. Millhorn D 06-1999. Regulation of Shaker-type potassium channels by hypoxia , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 06-1996. Regulation of gene expression in O2-sensitive cells: signal transduction and genomic mechanisms , , Latini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 06-1987. Analysis of the role of peripheral nervous system in the different sensitivity to epinephrine in isolated vs intact hears , , Conforti L 05-2005. Hypoxia-induced inhibition of T lymphocyte activation: a key role of Kv1.3 channels and p56lck , , Curran K, Robbins J, Conforti L 04-2004. Pre-exposure to hypoxia decreases calcium-mediated acute activation in human T lymphocytes , , Lazzara R, Zaza Am, Zuanetti G, De Ferrari G, Latini R, Conforti L, Schwartz P 04-1986. Analisi dei fattori che influenzano la sensibilita' alle catecolamine in vivo e in cuori isolati. , , Nicolaou S, Neumeier L, Peng Y, Devor D, Conforti L 03-2007. The Ca²-activated K channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes , , Robbins J, Lee S, Filipovich A, Conforti L 03-2004. Hypoxia modulates T cell receptor-mediated activation in a subset of human T lymphocytes via Kv1.3 channels , , Szigligeti P, Robbins J, Petrovic M, Conforti L 03-2004. Differential effects of hypoxia on ion channels in human T lymphocytes: Selective modulation of Kv1.3 channels , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 03-1996. Regulation of gene transcriptions in O2-sensitive cells by reduced O2 tension: signal transduction and genomic mechanisms , ,
Research Interests My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. Our main focus areas are: 1. Role of ion channels in T cell response and adaptation to hypoxia. Hypoxia (low oxygen availability) can occur in physiologica...
Peer Reviewed Publications Agresta, Laura; Lehn, Maria; Lampe, Kristin; Cantrell, Rachel; Hennies, Cassandra; Szabo, Sara; Wise-Draper, Trisha; Conforti, Laura; Hoebe, Kasper; Janssen, Edith M 2020. CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 8 1, Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura 2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11 , 143Dirar, Qassim; Russell, Teal; Liu, Lumei; Ahn, Sarah; Dotti, Gianpietro; Aravamudhan, Shyam; Conforti, Laura; Yun, Yeoheung 2020. Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. PloS one, 15 9, e0238819Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura 2020. Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. Science advances, 6 47, Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura 2020. PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for immunotherapy of cancer, 8 2, Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura 2018. A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 527, Rossi, Francesca; Geiszler, Philippine C; Meng, Weina; Barron, Matthew R; Prior, Malcolm; Herd-Smith, Anna; Loreto, Andrea; Lopez, Maria Yanez; Faas, Henryk; Pardon, Marie-Christine; Conforti, Laura 2018. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research, 339 , 140-152Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura 2017. Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 1, 53-61Conforti, Laura 2017. Potassium channels of T lymphocytes take center stage in the fight against cancer. Journal for immunotherapy of cancer, 5 , 2Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura 2016. Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. Journal of autoimmunity, 69 , 86-93Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura 2015. The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. Molecular biology of the cell, 26 9, 1640-51Chimote, A. A.; Hajdu, P.; Kucher, V.; Boiko, N.; Kuras, Z.; Szilagyi, O.; Yun, Y. H.; Conforti, L. 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells , 191 12 , 6273-80Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. Journal of immunology (Baltimore, Md. : 1950), 191 12, 6273-80Hajdu, Péter; Chimote, Ameet A.; Thompson, Tyler H.; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity Biomaterials, 34 38 , 10249-10257Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials, 34 38, 10249-57Chimote AA, Kuras Z, Conforti, L 2012. Disruption of Kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes The Journal of Biological Chemistry, 287 3, 2055-2067Conforti, Laura 2012. The ion channel network in T lymphocytes, a target for immunotherapy. Clinical immunology (Orlando, Fla.), 142 2, 105-6Kuras Z, Kucher V, Gordon SM, Neumeier L, Chimote AA, Filipovich AH, Conforti L 2012. Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated via the Disc large 1 (Dlg1)-tyrosine kinase Lck complex American Journal of Physiology. Cell Physiology, 302 10, C1504-1512Kuras, Z.; Yun, Y. H.; Chimote, A. A.; Neumeier, L.; Conforti, L. 2012. KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells PLoS ONE, 7 8 , e43859Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura 2012. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PloS one, 7 8, e43859Li HC, Kucher V, Li EY, Conforti L, Zahedi K, Soleimani M 2012. The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane American Journal of Physiology. Cell Physiology, 302 12, C1713-1730Martin GV, Yun YH, Conforti L 2012. Modulation of T cell activation by localized K+ accumulation at the immunological synapse--a mathematical model Journal of Theoretical Biology, 300 , 173-182Nicolaou SA, Neumeier L, Takimoto K, Lee SM, Duncan HJ, Kant SK, Mongey AB, Filipovich AH, Conforti L 2010. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus Cell Calcium, 47 1, 19-28Nicolaou SA, Neumeier L, Steckly A, Kucher V, Takimoto K, Conforti L 2009. Kv1.3 localization in the immunological synapse regulates the calcium response to antigen stimulation in T lymphocytes J Immunol, 183 10, 6296-6302Nyakeriga AM, Fichtenbaum CJ, Goebel J, Nicolaou S, Conforti L, Chougnet C 2009. Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infection Journal of Virology, 83 3, 1193-1200Li H, Li E, Neumeier L, Conforti L, Soleimani M 2007. Identification of a novel signal in the cytoplasmic tail of the Na+:HCO3- cotransporter NBC1 that mediates basolateral targeting American Journal of Physiology. Renal Physiology, 292 4, F1245-55Nicolaou SA, Neumeier L, Peng Y, Devor D, Conforti L 2007. The Ca²+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human t lymphocytes Am J Physiol - Cell Physiol, 292 4, C1431-C1439Nicolaou SA, Szigligeti P, Duncan HJ, Neumeier L, Lee SM, Mongey AB, Kant SK, Filipovich AH, Conforti L. 2007. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Journal of Immunology (Baltimore, Md. : 1950), 179 1, 346-356Nicolaou, Stella A; Neumeier, Lisa; Peng, Youqing; Devor, Daniel C; Conforti, Laura 2007. The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. American journal of physiology. Cell physiology, 292 4, C1431-9Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Molleran Lee S, Filipovich AH, Conforti L 2006. Signaling during hypoxia in human T lymphocytes - critical role of the src proteing tyrosine kinase p56lck in the oxygen-sensitivity of Kv1.3 channels Journal of Physiology, 573 2, 357-370Szigligeti, Peter; Neumeier, Lisa; Duke, Eugene; Chougnet, Claire; Takimoto, Koichi; Lee, Susan Molleran; Filipovich, Alexandra H; Conforti, Laura 2006. Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels. The Journal of physiology, 573 Pt 2, 357-70Li HC, Szigligeti P, Worrell R, Matthews J, Conforti L, Soleimani, M 2005. Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis American Journal of Physiology - Renal Physiology, 289 1, F61-71Robbins JR, Lee SM, Filipovich AH, Szigligeti P, Neumeier L, Petrovic, Conforti, L 2005. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels The Journal of Physiology, 564 Pt 1, 131-143Zakrzewska A, Schnell PO, Striet JB, Hui A, Petrovic M, Robbins JR, Conforti L, Gozal D, Wathelet M, Czyzyk-Krzeska M 2005. Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and cbp in oxygen-sensitive cells Journal of Neurochemistry, 94 5, 1288-1296Li HC, Worrell RT, Matthews JB, Husseinzadeh H, Neumeier L, Petrovic S, Conforti L, Soleimani M 2004. Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane The Journal of Biological Chemistry, 279 41, 43190-43197Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. Slc26a7: a basolateral cl-/hco3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology - Renal Physiology, 286 1 , F161-F169Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology. Renal Physiology, 286 1, F161-169Sutliff RL, Conforti L, Weber CS, Kranias EG, Paul RJ 2004. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse Vascular Pharmacology, 41 6, 197-204Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich, Alexandra AH 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation Journal of Immunology (Baltimore, Md. : 1950), 170 2, 695-702Conforti L, Takimoto K, Petrovic M, Pongs O, Millhorn D 2003. The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity. Biochemical and Biophysical Research Communications, 306 2, 450-456Sievers, Caroline; Platt, Nick; Perry, V Hugh; Coleman, Michael P; Conforti, Laura 2003. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neuroscience research, 46 2, 161-9Xu Jie, Wang Z, Barone S, Petrovic M, Amlal H, Conforti L, Petrovic S, Soleimani M 2003. Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant American Journal of Physiology. Renal Physiology, 284 1, F41-50Takimoto K, Yang E-K, Conforti L 2002. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels Journal of Biological Chemistry, 277 30, 26904-26911Thorne GD, Conforti L, Paul RJ 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels American Journal of Physiology - Heart and Circulatory Physiology, 283 1 52-1, H247-H253Thorne, George D; Conforti, Laura; Paul, Richard J 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels. American journal of physiology. Heart and circulatory physiology, 283 1, H247-53Wang Z, Conforti L, Petrovic S, Amlal H, Burnham CE, Soleimani M 2001. Mouse Na+:HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution Kidney International, 59 4, 1405-1414Conforti L, Bodi I, Nisbet J W, Millhorn DE 2000. O2-sensitive K+ channels: role of the Kv1.2 alpha subunit in mediating the hypoxic response The Journal of Physiology, 524 3, 783-793Conforti L, Millhorn DE 2000. Regulation of Shaker-type potassium channels by hypoxia Advances in Experimental Medicine and Biology, 475 , 265-274Kobayashi S, Conforti L, Millhorn DE 2000. Gene expression and function of adenosine A2A receptors in the rat carotid body American Journal of Physiology - Lung Cellular and Molecular Physiology, 279 2, L273-282Millhorn D, Beitner-Johnson D, Conforti L, Conrad P, Kobayashi S, Yuan Y, Rust R 2000. Gene Regulation During Hypoxia in Excitable Oxygen-Sensing Cells: Depolarization-Transcription Coupling Advances in Experimental Medicine and Biology, , 131-142Conforti L, Kobayashi S, Beitner-Johnson D, Conrad PW, Freeman T, Millhorn DE 1999. Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells Respiration Physiology, 115 2, 249-260Kobayashi S, Conforti L, Zhu WH, Beitner-Johnson D, Millhorn DE 1999. Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells Pflugers Archiv European Journal of Physiology, 438 6, 750-759Kobayashi S, Beitner-Johnson D, Conforti L, Millhorn DE 1998. Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A The Journal of Physiology, 512 ( Pt 2) , 351-363Peng M, Conforti L, Millhorn DE 1998. Expression of somatostatin receptor genes and acetylcholine receptor development in rat skeletal muscle during postnatal development International Journal of Molecular Medicine, 1 5, 841-848Conforti L, Millhorn DE 1997. Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia The Journal of Physiology, 502 2, 293-305Kobayashi S, Conforti L, Pun RY, Millhorn DE 1997. Adenosine modulates hypoxic chemoreception in PC12 cells via A2 receptor stimulation The Journal of Physiology, 508 1, 95-107Millhorn DE, Raymond R, Conforti L, Zhu W, Beitner-Johnson D, Filisko T, Genter MB, Kobayashi S, Peng M 1997. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia Kidney International, 51 2, 527-35Zhu WH, Conforti L, Millhorn DE 1997. Expression of dopamine D2 receptor in PC-12 cells and regulation of membrane conductances by dopamine American Journal of Physiology - Cell Physiology, 273 42, C1143-C1150Millhorn DE, Conforti L, Beitner-Johnson D, Zhu W, Raymond R, Filisko T, Kobayashi S, Peng M, Genter MB 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line Advances in Experimental Medicine and Biology, 410 , 135-42Zhu WH, Conforti L, Czyzyk-Krzeska MF, Millhorn DE 1996. Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current American Journal of Physiology - Cell Physiology, 271 40, C658-665Conforti L, Sumii K, Sperelakis N 1995. Dioctanoyl-glycerol inhibits l-type calcium current in embryonic chick cardiomyocytes independent of protein kinase c activation Journal of Molecular and Cellular Cardiology, 27 5, 1219-1224Conforti L, Sumii K, Sperelakis N 1994. Diphenylamine-2-carboxylate blocks voltage-dependent na+ and ca2+ channels in rat ventricular cardiomyocytes European Journal of Pharmacology, 259 2, 215-218Conforti L, Tohse N, Sperelakis N 1993. Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytes - contribution to the plateau phase of action potential Journal of Molecular and Cellular Cardiology, 25 2, 159-173Cox D, Conforti L, Sperelakis N, Matlib M 1993. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157 Journal of Cardiovascular Pharmacology, 21 4, 595-599Conforti L, Tohse N, Sperelakis N 1991. Influence of sympathetic innervation on the membrane electrical properties of neonatal rat cardiomyocytes in culture Journal of Developmental Physiology, 15 4, 237-246Tohse N, Conforti L, Sperelakis N 1991. Bay K 8644 enhances Ca2+ channel activities in embryonic chick heart cells without prolongation of open times European Journal of Pharmacology, 203 2, 307-10GEPC, Latini R, Tognoni G., Conforti L, Gondoni L, Santoro E, Rocchetti M 1988. Multicentre, cross sectional study of ventricular arrhythmias in chronically haemodialysed patients Lancet, 8606 , 305-307Latini R, Zuanetti G, Conforti L, Schwartz PJ, Lazzara R 1988. Demonstration of a different sensitivity to epinephrine in isolated and in vivo hearts European Journal of Pharmacology, 156 1, 87-94Chen Z, Colombo T, Conforti L, Donelli M, Fiedorowicz RJ, Marchi S, Paolini A, Riva E, Zuanetti G, Latini R 1987. Effects of three new anthracyclines and doxorubicin on the rat isolated heart The Journal of Pharmacy and Pharmacology, 39 11, 947-950Caccia S, Conforti L, Conti I 1986. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat Journal of Pharmacy and Pharmacology, 38 6, 469-472
Agresta, Laura; Lehn, Maria; Lampe, Kristin; Cantrell, Rachel; Hennies, Cassandra; Szabo, Sara; Wise-Draper, Trisha; Conforti, Laura; Hoebe, Kasper; Janssen, Edith M 2020. CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 8 1, Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura 2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11 , 143Dirar, Qassim; Russell, Teal; Liu, Lumei; Ahn, Sarah; Dotti, Gianpietro; Aravamudhan, Shyam; Conforti, Laura; Yun, Yeoheung 2020. Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. PloS one, 15 9, e0238819Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura 2020. Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. Science advances, 6 47, Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura 2020. PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for immunotherapy of cancer, 8 2, Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura 2018. A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 527, Rossi, Francesca; Geiszler, Philippine C; Meng, Weina; Barron, Matthew R; Prior, Malcolm; Herd-Smith, Anna; Loreto, Andrea; Lopez, Maria Yanez; Faas, Henryk; Pardon, Marie-Christine; Conforti, Laura 2018. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research, 339 , 140-152Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura 2017. Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 1, 53-61Conforti, Laura 2017. Potassium channels of T lymphocytes take center stage in the fight against cancer. Journal for immunotherapy of cancer, 5 , 2Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura 2016. Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. Journal of autoimmunity, 69 , 86-93Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura 2015. The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. Molecular biology of the cell, 26 9, 1640-51Chimote, A. A.; Hajdu, P.; Kucher, V.; Boiko, N.; Kuras, Z.; Szilagyi, O.; Yun, Y. H.; Conforti, L. 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells , 191 12 , 6273-80Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. Journal of immunology (Baltimore, Md. : 1950), 191 12, 6273-80Hajdu, Péter; Chimote, Ameet A.; Thompson, Tyler H.; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity Biomaterials, 34 38 , 10249-10257Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials, 34 38, 10249-57Chimote AA, Kuras Z, Conforti, L 2012. Disruption of Kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes The Journal of Biological Chemistry, 287 3, 2055-2067Conforti, Laura 2012. The ion channel network in T lymphocytes, a target for immunotherapy. Clinical immunology (Orlando, Fla.), 142 2, 105-6Kuras Z, Kucher V, Gordon SM, Neumeier L, Chimote AA, Filipovich AH, Conforti L 2012. Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated via the Disc large 1 (Dlg1)-tyrosine kinase Lck complex American Journal of Physiology. Cell Physiology, 302 10, C1504-1512Kuras, Z.; Yun, Y. H.; Chimote, A. A.; Neumeier, L.; Conforti, L. 2012. KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells PLoS ONE, 7 8 , e43859Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura 2012. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PloS one, 7 8, e43859Li HC, Kucher V, Li EY, Conforti L, Zahedi K, Soleimani M 2012. The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane American Journal of Physiology. Cell Physiology, 302 12, C1713-1730Martin GV, Yun YH, Conforti L 2012. Modulation of T cell activation by localized K+ accumulation at the immunological synapse--a mathematical model Journal of Theoretical Biology, 300 , 173-182Nicolaou SA, Neumeier L, Takimoto K, Lee SM, Duncan HJ, Kant SK, Mongey AB, Filipovich AH, Conforti L 2010. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus Cell Calcium, 47 1, 19-28Nicolaou SA, Neumeier L, Steckly A, Kucher V, Takimoto K, Conforti L 2009. Kv1.3 localization in the immunological synapse regulates the calcium response to antigen stimulation in T lymphocytes J Immunol, 183 10, 6296-6302Nyakeriga AM, Fichtenbaum CJ, Goebel J, Nicolaou S, Conforti L, Chougnet C 2009. Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infection Journal of Virology, 83 3, 1193-1200Li H, Li E, Neumeier L, Conforti L, Soleimani M 2007. Identification of a novel signal in the cytoplasmic tail of the Na+:HCO3- cotransporter NBC1 that mediates basolateral targeting American Journal of Physiology. Renal Physiology, 292 4, F1245-55Nicolaou SA, Neumeier L, Peng Y, Devor D, Conforti L 2007. The Ca²+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human t lymphocytes Am J Physiol - Cell Physiol, 292 4, C1431-C1439Nicolaou SA, Szigligeti P, Duncan HJ, Neumeier L, Lee SM, Mongey AB, Kant SK, Filipovich AH, Conforti L. 2007. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Journal of Immunology (Baltimore, Md. : 1950), 179 1, 346-356Nicolaou, Stella A; Neumeier, Lisa; Peng, Youqing; Devor, Daniel C; Conforti, Laura 2007. The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. American journal of physiology. Cell physiology, 292 4, C1431-9Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Molleran Lee S, Filipovich AH, Conforti L 2006. Signaling during hypoxia in human T lymphocytes - critical role of the src proteing tyrosine kinase p56lck in the oxygen-sensitivity of Kv1.3 channels Journal of Physiology, 573 2, 357-370Szigligeti, Peter; Neumeier, Lisa; Duke, Eugene; Chougnet, Claire; Takimoto, Koichi; Lee, Susan Molleran; Filipovich, Alexandra H; Conforti, Laura 2006. Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels. The Journal of physiology, 573 Pt 2, 357-70Li HC, Szigligeti P, Worrell R, Matthews J, Conforti L, Soleimani, M 2005. Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis American Journal of Physiology - Renal Physiology, 289 1, F61-71Robbins JR, Lee SM, Filipovich AH, Szigligeti P, Neumeier L, Petrovic, Conforti, L 2005. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels The Journal of Physiology, 564 Pt 1, 131-143Zakrzewska A, Schnell PO, Striet JB, Hui A, Petrovic M, Robbins JR, Conforti L, Gozal D, Wathelet M, Czyzyk-Krzeska M 2005. Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and cbp in oxygen-sensitive cells Journal of Neurochemistry, 94 5, 1288-1296Li HC, Worrell RT, Matthews JB, Husseinzadeh H, Neumeier L, Petrovic S, Conforti L, Soleimani M 2004. Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane The Journal of Biological Chemistry, 279 41, 43190-43197Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. Slc26a7: a basolateral cl-/hco3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology - Renal Physiology, 286 1 , F161-F169Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology. Renal Physiology, 286 1, F161-169Sutliff RL, Conforti L, Weber CS, Kranias EG, Paul RJ 2004. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse Vascular Pharmacology, 41 6, 197-204Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich, Alexandra AH 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation Journal of Immunology (Baltimore, Md. : 1950), 170 2, 695-702Conforti L, Takimoto K, Petrovic M, Pongs O, Millhorn D 2003. The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity. Biochemical and Biophysical Research Communications, 306 2, 450-456Sievers, Caroline; Platt, Nick; Perry, V Hugh; Coleman, Michael P; Conforti, Laura 2003. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neuroscience research, 46 2, 161-9Xu Jie, Wang Z, Barone S, Petrovic M, Amlal H, Conforti L, Petrovic S, Soleimani M 2003. Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant American Journal of Physiology. Renal Physiology, 284 1, F41-50Takimoto K, Yang E-K, Conforti L 2002. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels Journal of Biological Chemistry, 277 30, 26904-26911Thorne GD, Conforti L, Paul RJ 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels American Journal of Physiology - Heart and Circulatory Physiology, 283 1 52-1, H247-H253Thorne, George D; Conforti, Laura; Paul, Richard J 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels. American journal of physiology. Heart and circulatory physiology, 283 1, H247-53Wang Z, Conforti L, Petrovic S, Amlal H, Burnham CE, Soleimani M 2001. Mouse Na+:HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution Kidney International, 59 4, 1405-1414Conforti L, Bodi I, Nisbet J W, Millhorn DE 2000. O2-sensitive K+ channels: role of the Kv1.2 alpha subunit in mediating the hypoxic response The Journal of Physiology, 524 3, 783-793Conforti L, Millhorn DE 2000. Regulation of Shaker-type potassium channels by hypoxia Advances in Experimental Medicine and Biology, 475 , 265-274Kobayashi S, Conforti L, Millhorn DE 2000. Gene expression and function of adenosine A2A receptors in the rat carotid body American Journal of Physiology - Lung Cellular and Molecular Physiology, 279 2, L273-282Millhorn D, Beitner-Johnson D, Conforti L, Conrad P, Kobayashi S, Yuan Y, Rust R 2000. Gene Regulation During Hypoxia in Excitable Oxygen-Sensing Cells: Depolarization-Transcription Coupling Advances in Experimental Medicine and Biology, , 131-142Conforti L, Kobayashi S, Beitner-Johnson D, Conrad PW, Freeman T, Millhorn DE 1999. Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells Respiration Physiology, 115 2, 249-260Kobayashi S, Conforti L, Zhu WH, Beitner-Johnson D, Millhorn DE 1999. Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells Pflugers Archiv European Journal of Physiology, 438 6, 750-759Kobayashi S, Beitner-Johnson D, Conforti L, Millhorn DE 1998. Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A The Journal of Physiology, 512 ( Pt 2) , 351-363Peng M, Conforti L, Millhorn DE 1998. Expression of somatostatin receptor genes and acetylcholine receptor development in rat skeletal muscle during postnatal development International Journal of Molecular Medicine, 1 5, 841-848Conforti L, Millhorn DE 1997. Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia The Journal of Physiology, 502 2, 293-305Kobayashi S, Conforti L, Pun RY, Millhorn DE 1997. Adenosine modulates hypoxic chemoreception in PC12 cells via A2 receptor stimulation The Journal of Physiology, 508 1, 95-107Millhorn DE, Raymond R, Conforti L, Zhu W, Beitner-Johnson D, Filisko T, Genter MB, Kobayashi S, Peng M 1997. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia Kidney International, 51 2, 527-35Zhu WH, Conforti L, Millhorn DE 1997. Expression of dopamine D2 receptor in PC-12 cells and regulation of membrane conductances by dopamine American Journal of Physiology - Cell Physiology, 273 42, C1143-C1150Millhorn DE, Conforti L, Beitner-Johnson D, Zhu W, Raymond R, Filisko T, Kobayashi S, Peng M, Genter MB 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line Advances in Experimental Medicine and Biology, 410 , 135-42Zhu WH, Conforti L, Czyzyk-Krzeska MF, Millhorn DE 1996. Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current American Journal of Physiology - Cell Physiology, 271 40, C658-665Conforti L, Sumii K, Sperelakis N 1995. Dioctanoyl-glycerol inhibits l-type calcium current in embryonic chick cardiomyocytes independent of protein kinase c activation Journal of Molecular and Cellular Cardiology, 27 5, 1219-1224Conforti L, Sumii K, Sperelakis N 1994. Diphenylamine-2-carboxylate blocks voltage-dependent na+ and ca2+ channels in rat ventricular cardiomyocytes European Journal of Pharmacology, 259 2, 215-218Conforti L, Tohse N, Sperelakis N 1993. Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytes - contribution to the plateau phase of action potential Journal of Molecular and Cellular Cardiology, 25 2, 159-173Cox D, Conforti L, Sperelakis N, Matlib M 1993. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157 Journal of Cardiovascular Pharmacology, 21 4, 595-599Conforti L, Tohse N, Sperelakis N 1991. Influence of sympathetic innervation on the membrane electrical properties of neonatal rat cardiomyocytes in culture Journal of Developmental Physiology, 15 4, 237-246Tohse N, Conforti L, Sperelakis N 1991. Bay K 8644 enhances Ca2+ channel activities in embryonic chick heart cells without prolongation of open times European Journal of Pharmacology, 203 2, 307-10GEPC, Latini R, Tognoni G., Conforti L, Gondoni L, Santoro E, Rocchetti M 1988. Multicentre, cross sectional study of ventricular arrhythmias in chronically haemodialysed patients Lancet, 8606 , 305-307Latini R, Zuanetti G, Conforti L, Schwartz PJ, Lazzara R 1988. Demonstration of a different sensitivity to epinephrine in isolated and in vivo hearts European Journal of Pharmacology, 156 1, 87-94Chen Z, Colombo T, Conforti L, Donelli M, Fiedorowicz RJ, Marchi S, Paolini A, Riva E, Zuanetti G, Latini R 1987. Effects of three new anthracyclines and doxorubicin on the rat isolated heart The Journal of Pharmacy and Pharmacology, 39 11, 947-950Caccia S, Conforti L, Conti I 1986. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat Journal of Pharmacy and Pharmacology, 38 6, 469-472
Abstract Publications Chimote A, Kuras Z, Yun Y, Neumeier L, Conforti L 2012. Kca3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. , , Hajdu P, Collins B, Hooper E, Thompson T, Yun Y, Conforti L 2012. Targeting T cells with functionalized lipid nanovesicles , , Chimote A, Vergamini S, Filipovich A, Conforti L 2011. Disruption of membrane trafficking underlies the reduction in Kv1.3 channel surface expression in T lymphocytes during hypoxia , , Kuras Z, Yun Y, Chimote A, Conforti L 2011. Ca²+-activated K+ channels (KCa3.1) control activated T cell migration , , Kuras Z, Kucher V, Neumeier L, Dillehay K, Conforti L 2010. Selective downregulation of human Kv1.2 channes by PKA-I , , Yun Y, Conforti L 2010. Kv1.3 channel mobility and function in Systemic Lupus Erythematosus , , Nicolaou S, Neumeier L, Molleran L, Ragupathy M, Duncan H, Kant K, Filipovich A, Mongey A, Conforti L 2008. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in Systemic Lupus Erythematosis , , Yun H, Conforti L 2008. Creation of Artificial Antigen-Presenting Cell Membrane Surface for the Study of T-Cell Activation , , Bodi L, D'Souza K, Rubio M, Nicolaou S, Fuller B, Conforti L, Molketin J, Schwartz A 2007. Deletion of calcineurin partially rescues impaired cardiac function in mouse model with targeted overexpression of L-type calcium channel a1c. Journal of Molecular and Cellular Cardiology, 42 , A37Yun Y, Dong Z, Shanov C, Bange A, Heineman W, Halsall H, Conforti L, Bhattacharya A, Schulz M 2007. On-line carbon nanotube-based biosensors in microfluidic channels , , Nicolaou S, Szigligeti P, Duncan H, Lee S, Kant K, Filipovich A, Conforti L 2006. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Clinical Immunol, 119 , A68Nicolaou S, Szigligeti P, Neumeier L, Conforti L 2006. Kv1.3 channel redistribution in the immunological synapse varies according to the T lymphocyte activation state FASEB J, 20 , A215.11Hong C, Petrovic S, Szigligeti P, Conforti L, Soleimani M 2005. The amino terminal domain regulates the electrogenecity whereas the carboxyl terminal domain mediates the targeting of NBC1 to the basolateral membrane Journal of American Society of Nephrology, 16 , 124ASzigligeti P, Neumeier L, Lee S, Filipovich A, Conforti L 2005. Hypoxia-induced inhibition of Kv1.3 channes in human CD4+ T lymphocytes is mediated by the src protein tyrosine kinase p56Lck FASEB J, 19 5, A389Conforti L, Anjak A, Neumeier L 2004. Heteromultimeric Kc1.2-Kv1.3 channels underlie the O2-sensitive K current in PC12 cells FASEB J, 18 5, A1065Zakrewshka A, Schnell P, Striet J, Hui A, Petrovic M, Conforti L, Czyzyk-Krzeska M 2003. Hypoxia-induced hyperphosphorylation of p300 CBP transcription coactivators requires calcium and specific glucose metabolic pathway , , Conforti L, Petrovic M, Takimoto K, Mohammad D 2002. Oxygen-sensitive ion channels in human T lymphocytes The pharmacologist, 44 2, Suppl 1: A141Petrovic M, Mohammad D, Ma Q, Conforti L 2002. Oxygen-sensitive potassium channels in T lymphocytes FASEB J, 16 , A60Petrovic M, Conforti L, Burnham C, Petrovic S, Wang Z, Xu J, Amlal H, Soleimani M 2001. The 3-prime end of NBC1 mediates the inhibition of camp and affects the electrogenecity but not the pH activity of the kidney Na+:HCO3- cotransporter , , Xu J, Wang Z, Petrovic S, Petrovic M, Conforti L, Soleimani M 2001. Characterization of the Na+:HCO3- contransporter NBC4: Expression, functional properties and novel splicing variant , , Conforti L, Millhorn D 2000. Critical role of the Kv1.2 alpha subunit in the response to hypoxia of native O2-sensitive K channels FASEB J, 14 , A638Thorne G, Conforti L, Paul R 2000. Impaired oxygen sensitivity following organ culture: new approaches to studying the mechanisms of hypoxic coronary vasodilation FASEB J, 14 , A414Kobayashi S, Conforti L, Zhu W, Beitner-Johnson D, Millhorn D 1999. Chronic hypoxia down-regulates G□o in PC12 cells: a mechanism for attenuated dopamine D2 receptor-mediated inhibition of Ca²+ current FASEB J, 13 , A805.6Millhorn D, Conforti L, Beitner-Johnson D, Kobayashi S, Conrad Wm Raymond R, Rust R, Freeman T 1999. Oxygen chemosensitivity: stimulus-transcription coupling FASEB J, 13 , A806.1Sutliff R, Conforti L, Kranias E, Paul R 1999. Mechanisms underlying altered portal vein mechanical activity in phospholamban gene-ablated mice FASEB J, 13 , A123.4Conforti L, Bodi L, Millhorn D 1998. Oxygen0sensitivity of the Shaker Kv1.2 potassium channel FASEB J, 12 , A438Conforti L, Millhorn D 1997. Oxygen-sensitivity and enhanced expression of a delayed-rectifier K channel in PC12 cells during hypoxia FASEB J, 11 , A329Kobayashi S, Conforti L, Millhorn D 1997. Adenosine modulates hypoxic chemoreceptin in PC12 cells via A2 receptor stimulation FASEB J, 11 , A197Zhu W, Conforti L, Millhorn D 1997. Receptor modulation of membrane conductances in PC12 cells FASEB J, 11 , A133Kobayashi S, Conforti L, Zhu W, Millhorn D 1996. Adenosine stimulates voltage-dependent K current in pheochromocytoma (PC12) cells via activation of A2 receptors , , Peng M, Liu Z, Conforti L, Millhorn D 1996. Inhibition of the nicotinic-type acetylcholine receptor epsilon subunit mRNA expression by somatostating (SST) J Neurosc, 22 3, 1965aZhu W, Conforti L, Millhorn D 1996. Interaction of dopamine receptors iwth the O2-sensitive K+ current in PC12 cells , , Zhu W, Conforti L, Millhorn D 1995. Excitation-secretion in PC12 cells during hypoxia J Neurosc, 21 1, 65AConforti L, Tohse N, Sperelakis N 1992. Developmental changes in fast sodium current of rat ventricular cardiomycocytes Biophysical J, 61 , 305AConforti L, Tohse N, Sperelakis N 1991. Fast sodium current in 18-day-old fetal rat ventricular cardiomycocytes J Mol Cell Cardiol, 23 , S97Tohse N, Conforti L, Sperelakis N 1991. Preferential recruitment of one subtype of cardiac L-type Ca²+ channel by Bay K 8644 Biophysical J, 59 , 86ALatini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 1987. Demonstration and analysis of possible mechanisms for amplification of epinephrine effects in vivo Fed Proc, 46 , 1256Nyakeriga A, Nicolaou S, Goebel J, Conforti L, Chougnet C 11-2006. HIV gp120-CD4 interactions affect Lck redistribution and activation in primary T cells , , Conforti L 11-2003. Oxygen sensing and ion channels , , Conforti L 11-2003. Molecular basis and functional role of oxygen sensitive potassium channels , , Li H, Petrovic S, Petrovic M, Conforti L, Barone S, Soleimani M 11-2003. Membrane targeting of the Na+:HCO3- contransporter NBC1 is dependent on an acid carboxy terminal motif , , Petrovic S, Barone S, Xu J, Ma L, Conforti L, Kujala M, Kere J, Soleimani M 11-2003. Identification of a basolateral Cl/HCO3- exchanger specific to intercalated cells in outer medullary collecting duct: co-localization with AE1 , , Conforti L, Millhorn D 11-1996. Selective inhibition of a slow-inactivating voltage dependent potassium channel in PC12 cells by hypoxia , , Marticn G, Yun Y, Conforti L 10-2010. Modeling of Potassium Accumulation at the Immunological Synapse and its Effect on T-Cell Function , , Yun Y, Neumeier L, Schulz M, Shanov V, Conforti L 10-2009. Spatiotemporal Dynamics of Immunological Synapse Formation in T Cells , , Chen Z ,Colombo T, Conforti L, Donelli M, Fiedorowicz R, Marchi S, Pollini A, Riva E, Zuanetti G, Latini R 10-1986. Comparative evaluation of the effect of three new anthracycline and doxorubicin on isolated rat heart , , Conforti L, Millhorn D 09-1999. Oxygen-sensitivity of Kv1 potassium channels , , Conforti L, Freeman T. Millhorn D 06-1999. Regulation of Shaker-type potassium channels by hypoxia , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 06-1996. Regulation of gene expression in O2-sensitive cells: signal transduction and genomic mechanisms , , Latini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 06-1987. Analysis of the role of peripheral nervous system in the different sensitivity to epinephrine in isolated vs intact hears , , Conforti L 05-2005. Hypoxia-induced inhibition of T lymphocyte activation: a key role of Kv1.3 channels and p56lck , , Curran K, Robbins J, Conforti L 04-2004. Pre-exposure to hypoxia decreases calcium-mediated acute activation in human T lymphocytes , , Lazzara R, Zaza Am, Zuanetti G, De Ferrari G, Latini R, Conforti L, Schwartz P 04-1986. Analisi dei fattori che influenzano la sensibilita' alle catecolamine in vivo e in cuori isolati. , , Nicolaou S, Neumeier L, Peng Y, Devor D, Conforti L 03-2007. The Ca²-activated K channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes , , Robbins J, Lee S, Filipovich A, Conforti L 03-2004. Hypoxia modulates T cell receptor-mediated activation in a subset of human T lymphocytes via Kv1.3 channels , , Szigligeti P, Robbins J, Petrovic M, Conforti L 03-2004. Differential effects of hypoxia on ion channels in human T lymphocytes: Selective modulation of Kv1.3 channels , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 03-1996. Regulation of gene transcriptions in O2-sensitive cells by reduced O2 tension: signal transduction and genomic mechanisms , ,
Chimote A, Kuras Z, Yun Y, Neumeier L, Conforti L 2012. Kca3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. , , Hajdu P, Collins B, Hooper E, Thompson T, Yun Y, Conforti L 2012. Targeting T cells with functionalized lipid nanovesicles , , Chimote A, Vergamini S, Filipovich A, Conforti L 2011. Disruption of membrane trafficking underlies the reduction in Kv1.3 channel surface expression in T lymphocytes during hypoxia , , Kuras Z, Yun Y, Chimote A, Conforti L 2011. Ca²+-activated K+ channels (KCa3.1) control activated T cell migration , , Kuras Z, Kucher V, Neumeier L, Dillehay K, Conforti L 2010. Selective downregulation of human Kv1.2 channes by PKA-I , , Yun Y, Conforti L 2010. Kv1.3 channel mobility and function in Systemic Lupus Erythematosus , , Nicolaou S, Neumeier L, Molleran L, Ragupathy M, Duncan H, Kant K, Filipovich A, Mongey A, Conforti L 2008. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in Systemic Lupus Erythematosis , , Yun H, Conforti L 2008. Creation of Artificial Antigen-Presenting Cell Membrane Surface for the Study of T-Cell Activation , , Bodi L, D'Souza K, Rubio M, Nicolaou S, Fuller B, Conforti L, Molketin J, Schwartz A 2007. Deletion of calcineurin partially rescues impaired cardiac function in mouse model with targeted overexpression of L-type calcium channel a1c. Journal of Molecular and Cellular Cardiology, 42 , A37Yun Y, Dong Z, Shanov C, Bange A, Heineman W, Halsall H, Conforti L, Bhattacharya A, Schulz M 2007. On-line carbon nanotube-based biosensors in microfluidic channels , , Nicolaou S, Szigligeti P, Duncan H, Lee S, Kant K, Filipovich A, Conforti L 2006. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Clinical Immunol, 119 , A68Nicolaou S, Szigligeti P, Neumeier L, Conforti L 2006. Kv1.3 channel redistribution in the immunological synapse varies according to the T lymphocyte activation state FASEB J, 20 , A215.11Hong C, Petrovic S, Szigligeti P, Conforti L, Soleimani M 2005. The amino terminal domain regulates the electrogenecity whereas the carboxyl terminal domain mediates the targeting of NBC1 to the basolateral membrane Journal of American Society of Nephrology, 16 , 124ASzigligeti P, Neumeier L, Lee S, Filipovich A, Conforti L 2005. Hypoxia-induced inhibition of Kv1.3 channes in human CD4+ T lymphocytes is mediated by the src protein tyrosine kinase p56Lck FASEB J, 19 5, A389Conforti L, Anjak A, Neumeier L 2004. Heteromultimeric Kc1.2-Kv1.3 channels underlie the O2-sensitive K current in PC12 cells FASEB J, 18 5, A1065Zakrewshka A, Schnell P, Striet J, Hui A, Petrovic M, Conforti L, Czyzyk-Krzeska M 2003. Hypoxia-induced hyperphosphorylation of p300 CBP transcription coactivators requires calcium and specific glucose metabolic pathway , , Conforti L, Petrovic M, Takimoto K, Mohammad D 2002. Oxygen-sensitive ion channels in human T lymphocytes The pharmacologist, 44 2, Suppl 1: A141Petrovic M, Mohammad D, Ma Q, Conforti L 2002. Oxygen-sensitive potassium channels in T lymphocytes FASEB J, 16 , A60Petrovic M, Conforti L, Burnham C, Petrovic S, Wang Z, Xu J, Amlal H, Soleimani M 2001. The 3-prime end of NBC1 mediates the inhibition of camp and affects the electrogenecity but not the pH activity of the kidney Na+:HCO3- cotransporter , , Xu J, Wang Z, Petrovic S, Petrovic M, Conforti L, Soleimani M 2001. Characterization of the Na+:HCO3- contransporter NBC4: Expression, functional properties and novel splicing variant , , Conforti L, Millhorn D 2000. Critical role of the Kv1.2 alpha subunit in the response to hypoxia of native O2-sensitive K channels FASEB J, 14 , A638Thorne G, Conforti L, Paul R 2000. Impaired oxygen sensitivity following organ culture: new approaches to studying the mechanisms of hypoxic coronary vasodilation FASEB J, 14 , A414Kobayashi S, Conforti L, Zhu W, Beitner-Johnson D, Millhorn D 1999. Chronic hypoxia down-regulates G□o in PC12 cells: a mechanism for attenuated dopamine D2 receptor-mediated inhibition of Ca²+ current FASEB J, 13 , A805.6Millhorn D, Conforti L, Beitner-Johnson D, Kobayashi S, Conrad Wm Raymond R, Rust R, Freeman T 1999. Oxygen chemosensitivity: stimulus-transcription coupling FASEB J, 13 , A806.1Sutliff R, Conforti L, Kranias E, Paul R 1999. Mechanisms underlying altered portal vein mechanical activity in phospholamban gene-ablated mice FASEB J, 13 , A123.4Conforti L, Bodi L, Millhorn D 1998. Oxygen0sensitivity of the Shaker Kv1.2 potassium channel FASEB J, 12 , A438Conforti L, Millhorn D 1997. Oxygen-sensitivity and enhanced expression of a delayed-rectifier K channel in PC12 cells during hypoxia FASEB J, 11 , A329Kobayashi S, Conforti L, Millhorn D 1997. Adenosine modulates hypoxic chemoreceptin in PC12 cells via A2 receptor stimulation FASEB J, 11 , A197Zhu W, Conforti L, Millhorn D 1997. Receptor modulation of membrane conductances in PC12 cells FASEB J, 11 , A133Kobayashi S, Conforti L, Zhu W, Millhorn D 1996. Adenosine stimulates voltage-dependent K current in pheochromocytoma (PC12) cells via activation of A2 receptors , , Peng M, Liu Z, Conforti L, Millhorn D 1996. Inhibition of the nicotinic-type acetylcholine receptor epsilon subunit mRNA expression by somatostating (SST) J Neurosc, 22 3, 1965aZhu W, Conforti L, Millhorn D 1996. Interaction of dopamine receptors iwth the O2-sensitive K+ current in PC12 cells , , Zhu W, Conforti L, Millhorn D 1995. Excitation-secretion in PC12 cells during hypoxia J Neurosc, 21 1, 65AConforti L, Tohse N, Sperelakis N 1992. Developmental changes in fast sodium current of rat ventricular cardiomycocytes Biophysical J, 61 , 305AConforti L, Tohse N, Sperelakis N 1991. Fast sodium current in 18-day-old fetal rat ventricular cardiomycocytes J Mol Cell Cardiol, 23 , S97Tohse N, Conforti L, Sperelakis N 1991. Preferential recruitment of one subtype of cardiac L-type Ca²+ channel by Bay K 8644 Biophysical J, 59 , 86ALatini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 1987. Demonstration and analysis of possible mechanisms for amplification of epinephrine effects in vivo Fed Proc, 46 , 1256Nyakeriga A, Nicolaou S, Goebel J, Conforti L, Chougnet C 11-2006. HIV gp120-CD4 interactions affect Lck redistribution and activation in primary T cells , , Conforti L 11-2003. Oxygen sensing and ion channels , , Conforti L 11-2003. Molecular basis and functional role of oxygen sensitive potassium channels , , Li H, Petrovic S, Petrovic M, Conforti L, Barone S, Soleimani M 11-2003. Membrane targeting of the Na+:HCO3- contransporter NBC1 is dependent on an acid carboxy terminal motif , , Petrovic S, Barone S, Xu J, Ma L, Conforti L, Kujala M, Kere J, Soleimani M 11-2003. Identification of a basolateral Cl/HCO3- exchanger specific to intercalated cells in outer medullary collecting duct: co-localization with AE1 , , Conforti L, Millhorn D 11-1996. Selective inhibition of a slow-inactivating voltage dependent potassium channel in PC12 cells by hypoxia , , Marticn G, Yun Y, Conforti L 10-2010. Modeling of Potassium Accumulation at the Immunological Synapse and its Effect on T-Cell Function , , Yun Y, Neumeier L, Schulz M, Shanov V, Conforti L 10-2009. Spatiotemporal Dynamics of Immunological Synapse Formation in T Cells , , Chen Z ,Colombo T, Conforti L, Donelli M, Fiedorowicz R, Marchi S, Pollini A, Riva E, Zuanetti G, Latini R 10-1986. Comparative evaluation of the effect of three new anthracycline and doxorubicin on isolated rat heart , , Conforti L, Millhorn D 09-1999. Oxygen-sensitivity of Kv1 potassium channels , , Conforti L, Freeman T. Millhorn D 06-1999. Regulation of Shaker-type potassium channels by hypoxia , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 06-1996. Regulation of gene expression in O2-sensitive cells: signal transduction and genomic mechanisms , , Latini R, Zuanetti G, Conforti L, Schwartz P, Lazzara R 06-1987. Analysis of the role of peripheral nervous system in the different sensitivity to epinephrine in isolated vs intact hears , , Conforti L 05-2005. Hypoxia-induced inhibition of T lymphocyte activation: a key role of Kv1.3 channels and p56lck , , Curran K, Robbins J, Conforti L 04-2004. Pre-exposure to hypoxia decreases calcium-mediated acute activation in human T lymphocytes , , Lazzara R, Zaza Am, Zuanetti G, De Ferrari G, Latini R, Conforti L, Schwartz P 04-1986. Analisi dei fattori che influenzano la sensibilita' alle catecolamine in vivo e in cuori isolati. , , Nicolaou S, Neumeier L, Peng Y, Devor D, Conforti L 03-2007. The Ca²-activated K channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes , , Robbins J, Lee S, Filipovich A, Conforti L 03-2004. Hypoxia modulates T cell receptor-mediated activation in a subset of human T lymphocytes via Kv1.3 channels , , Szigligeti P, Robbins J, Petrovic M, Conforti L 03-2004. Differential effects of hypoxia on ion channels in human T lymphocytes: Selective modulation of Kv1.3 channels , , Millhorn D, Raymond R, Filisko T, Zhu W, Conforti L 03-1996. Regulation of gene transcriptions in O2-sensitive cells by reduced O2 tension: signal transduction and genomic mechanisms , ,