Education/Credentials Postgraduate Researcher: University of CaliforniaDoctoral Degree: King's College London (Pharmacology)Bachelor's Degree: King's College London (Pharmacology) Contact Information Cardiovascular Rsrch Cntr 5938 Office 513-558-6654 Email normanab@ucmail.uc.edu Research InterestsThe focus of the Norman Laboratory is translational research to develop medications for the treatment of cocaine abuse. Drug self-administration by animals is a valid model of human addictive behavior. It has long been considered axiomatic that drugs of abuse are self-administered because of their pleasurable (hedonic or euphoric) effects, which in turn makes these drugs positively reinforcing. Unfortunately, these assumptions result in well-known paradoxes and the idea that reinforcemen... Peer Reviewed Publications Desai, Jhanvi N; Tron Esqueda, Luis E; Norman, Andrew B 2023. The ascending limb of the cocaine unit dose-response function in rats as an experimental artifact. Scientific reports, 13 1, 16614Kirley, Terence L; Norman, Andrew B 2023. Characterization and optimization of fluorescein isothiocyanate labeling of humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 35 , 101520Kirley, Terence L; Norman, Andrew B 2023. Reformulation and Thermal Stability of a Therapeutic Anti-Cocaine mAb. Journal of pharmaceutical sciences, 112 6, 1595-1602Koch, Sheryl E; Marckel, Jordan A; Rubinstein, Jack; Norman, Andrew B 2023. A humanized anti-cocaine mAb antagonizes the cardiovascular effects of cocaine in rats. Pharmacology research & perspectives, 11 1, e01045Webster, Rose P; Marckel, Jordan A; Norman, Andrew B 2023. Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity. Human vaccines & immunotherapeutics, 19 3, 2274222Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Scientific reports, 13 1, 14566Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose. Heliyon, 9 7, e17988Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2022. Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites. Biochemistry and biophysics reports, 30 , 101278Kirley, Terence L; Norman, Andrew B 2022. Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 32 , 101354Kirley, Terence L; Norman, Andrew B 2022. Critical evaluation of fluorescent dyes to evaluate the stability and ligand binding properties of an anti-cocaine mAb, h2E2. Journal of immunological methods, 508 , 113323Kirley, Terence L; Norman, Andrew B; Greis, Kenneth D 2022. Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb. The Journal of biological chemistry, 298 3, 101689Tsibulsky, Vladimir L; Norman, Andrew B 2022. The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information. Scientific reports, 12 1, 19683Turner, Mackenzie E; Wetzel, Hanna N; Zinani, Dakota B; Crutchfield, Christopher A; Norman, Andrew B 2022. Effects of a recombinant humanized anti-cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice. Pharmacology research & perspectives, 10 5, e01009Wetzel, Hanna N; Tsibulsky, Vladimir L; Norman, Andrew B 2022. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats. Scientific reports, 12 1, 8782Zinani, Dakota B; Wetzel, Hanna N; Norman, Andrew B 2022. The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats. Brain research, 1774 , 147707Kirley, Terence L; Norman, Andrew B 2021. Cocaine binding to the Fab fragment of a humanized anti-cocaine mAb quantitated by dye absorption and fluorescence spectroscopy. Journal of immunological methods, 496 , 113103Kirley, Terence L; Norman, Andrew B 2021. Ligand binding to a humanized anti-cocaine mAb measured by dye absorption spectroscopy. Biochemical and biophysical research communications, 535 , 93-98Tsibulsky, Vladimir L; Norman, Andrew B 2021. Dramatic increase in lever-pressing activity in rats after training on the progressive ratio schedule of cocaine self-administration. Scientific reports, 11 1, 19656Tsibulsky, Vladimir L; Norman, Andrew B 2021. Methodological and analytical issues of progressive ratio schedules: Definition and scaling of breakpoint. Journal of neuroscience methods, 356 , 109146Kirley, Terence L; Norman, Andrew B 2020. Multi-domain unfolding of the Fab fragment of a humanized anti-cocaine mAb characterized by non-reducing SDS-PAGE. Biochemical and biophysical research communications, 533 3, 580-585Kirley, Terence L; Norman, Andrew B 2020. Ligand binding to a humanized anti-cocaine mAb detected by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 23 , 100795Kirley, Terence L; Norman, Andrew B; Wetzel, Hanna N 2020. A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics. Journal of immunological methods, 476 , 112676Tan, Kemin; Zhou, Min; Ahrendt, Angela J; Duke, Norma E C; Tabaja, Nassif; Ball, William J; Kirley, Terence L; Norman, Andrew B; Joachimiak, Andrzej; Schiffer, Marianne; Wilton, Rosemarie; Pokkuluri, P Raj 2019. Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2. Acta crystallographica. Section F, Structural biology communications, 75 Pt 11, 697-706Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 16 , 138-144Webster, Rose P; Cohen, Cinder F; Saeed, Fatima O; Wetzel, Hanna N; Ball, William J; Kirley, Terence L; Norman, Andrew B 2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program. Journal of immunological methods, 456 , 61-66Kirley, Terence L; Norman, Andrew B 2015. Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment. Human vaccines & immunotherapeutics, , 0Norman, Andrew B; Gooden, Felicia C T; Tabet, Michael R; Ball, William J 2014. A Recombinant Humanized Anti-cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats. Drug metabolism and disposition: the biological fate of chemicals, , Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2014. Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency. The Journal of pharmacology and experimental therapeutics, 348 2, 311-5Wetzel, Hanna N; Tabet, Michael R; Ball, William J; Norman, Andrew B 2014. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. International immunopharmacology, 23 2, 387-90Norman, Andrew B; Ball, William J 2012. Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody. Immunotherapy, 4 3, 335-43Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Fey, Brittney K; Tsibulsky, Vladimir L; Millard, Ronald W 2011. The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration. The Journal of pharmacology and experimental therapeutics, 338 2, 724-8Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2011. Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists. Journal of neuroscience methods, 194 2, 252-8Norman, Andrew B; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L; Pesce, Amadeo J 2010. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration. Synapse (New York, N.Y.), , Norman, Andrew B; Norman, Mantana K; Buesing, William R; Tabet, Michael R; Tsibulsky, Vladimir L; Ball, William J 2009. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. The Journal of pharmacology and experimental therapeutics, 328 3, 873-81Thompson, Valerie B; Heiman, Justin; Chambers, James B; Benoit, Stephen C; Buesing, William R; Norman, Mantana K; Norman, Andrew B; Lipton, Jack W 2009. Long-term behavioral consequences of prenatal MDMA exposure. Physiology & behavior, 96 4-5, 593-601Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Buesing, William R; Pesce, Amadeo J; Ball, William J 2007. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. The Journal of pharmacology and experimental therapeutics, 320 1, 145-53Tsibulsky, Vladimir L; Norman, Andrew B 2007. Mathematical models of behavior of individual animals. Current pharmaceutical design, 13 15, 1571-95Norman, Andrew B; Tsibulsky, Vladimir L 2006. The compulsion zone: a pharmacological theory of acquired cocaine self-administration. Brain research, 1116 1, 143-52Tsibulsky, Vladimir L; Norman, Andrew B 2005. Real time computation of in vivo drug levels during drug self-administration experiments. Brain research. Brain research protocols, 15 1, 38-45Norman, Andrew B; Buesing, William R; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L 2004. The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats. European journal of pharmacology, 483 2-3, 281-7Paula, Stefan; Tabet, Michael R; Farr, Carol D; Norman, Andrew B; Ball, W James 2004. Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody. Journal of medicinal chemistry, 47 1, 133-42Sutliff, Roy L; Haase, Chad; Russ, Rodney; Hoit, Brian D; Morris, Randal; Norman, Andrew B; Lewis, William 2003. Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome. Laboratory investigation; a journal of technical methods and pathology, 83 7, 983-9Norman, Andrew B; Welge, Jeffrey A; Tsibulsky, Vladimir L 2002. Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390. Brain research, 946 2, 253-61Kirley T.L.;Greis K.D.;Norman A.B. 12-01-2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE Biochemistry and Biophysics Reports, 16 , 138-144Cabovska B.;Norman A.;Stalcup A. 12-01-2003. Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins Analytical and Bioanalytical Chemistry, 376 1, 134-137Norman A.B.;Creese I. 12-01-1986. Effects of in vivo and in vitro treatments with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on pu Molecular Pharmacology, 30 2, 96-103Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 11-27-1989. A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal Brain Research, 503 1, 156-159Kirley T.;Greis K.;Norman A. 11-25-2016. Selective disulfide reduction for labeling and enhancement of Fab antibody fragments Biochemical and Biophysical Research Communications, 480 4, 752-757Sanberg P.;Emerich D.;Aebischer P.;Amisetti S.;Ouellette W.;Koutouzis T.;Cahill D.;Norman A. 11-19-1993. Substance P containing polymer implants protect against striatal excitotoxicity Brain Research, 628 1-2, 327-329Morrow A.L.;Norman A.B.;Battaglia G.;Loy R.;Creese I. 11-18-1985. UP-regulation of serotonergic binding sites labeled by [<sup>3</sup>H]WB4101 following f Life Sciences, 37 20, 1913-1922Geracioti T.D.;Goldsmith R.J.;Friedman L.M.;Norman A.B.;Somoza E.;Kasckow J.W.;Baker D.G.;Richtand N.M.;Anthenelli R.M.;Keck P.E. 11-17-1997. Cerebrospinal fluid neuroendocrinology of alcohol misusers Addiction Biology, 2 4, 401-409Norman A.B.;Battaglia G.;Morrow A.L.;Creese I. 11-13-1984. [<sup>3</sup>H]WB4101 labels S<inf>1</inf> serotonin receptors in rat cerebr European Journal of Pharmacology, 106 2, 461-462Wetzel H.;Tsibulsky V.;Norman A. 11-01-2016. The effects of a repeated dose of a recombinant humanized anti-cocaine monoclonal antibody on cocain Drug and Alcohol Dependence, 168 , 287-292Norman A.;Thomas S.;Pratt R.;Lu S.;Norgren R. 10-30-1992. Magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast age Brain Research, 594 2, 279-283Norman A.B.;Blaker S.N.;Thal L.;Creese I. 10-08-1986. Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtype Neuroscience Letters, 70 2, 289-294Sanberg P.;Bunsey M.;Giordano M.;Norman A. 10-01-1988. The Catalepsy Test: Its Ups and Downs Behavioral Neuroscience, 102 5, 748-759Norman A.;Tsibulsky V. 09-27-2001. Satiety threshold regulates maintained self-administration: Comment on Lynch and Carroll (2001) Experimental and Clinical Psychopharmacology, 9 2, 151-154Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 09-12-1986. Functional recovery of D<inf>1</inf>dopamine receptor-mediated stimulation of rat striat Neuroscience Letters, 69 3, 290-295Koster N.;Norman A.;Richtand N.;Nickell W.;Puche A.;Pixley S.;Shipley M. 09-06-1999. Olfactory receptor neurons express D2 dopamine receptors Journal of Comparative Neurology, 411 4, 666-673Kirley T.L.;Norman A.B. 09-05-2018. Unfolding of IgG domains detected by non-reducing SDS-PAGE Biochemical and Biophysical Research Communications, 503 2, 944-949Wetzel H.;Cohen C.;Norman A.;Webster R. 09-01-2017. A novel Python program for implementation of quality control in the ELISA Journal of Immunological Methods, 448 , 80-84Wetzel H.;Zhang T.;Norman A. 09-01-2017. A mathematical model of a recombinant humanized anti-cocaine monoclonal antibody's effects on cocain Life Sciences, 184 , 81-86Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 08-30-1985. D<inf>2</inf>dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyc Neuroscience Letters, 59 2, 177-182Kirley T.;Greis K.;Norman A. 08-26-2016. Structural characterization of expressed monoclonal antibodies by single sample mass spectral analys Biochemical and Biophysical Research Communications, 477 3, 363-368Tsibulsky V.;Norman A. 08-21-1999. Satiety threshold: A quantitative model of maintained cocaine self- administration Brain Research, 839 1, 85-93Norman A.;Wylie G.;Prince A. 08-21-1987. Supersensitivity of d-amphetamine-induced hyperthermia in rats following continuous treatment with n European Journal of Pharmacology, 140 3, 349-351Daniels J.;Baker D.G.;Norman A.B. 07-16-1996. Cocaine-induced tics in untreated Tourette's syndrome [1] American Journal of Psychiatry, 153 SUPPL., 965Dalia A.D.;Norman M.K.;Tabet M.R.;Schlueter K.T.;Tsibulsky V.L.;Norman A.B. 06-22-1998. Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of Brain Research, 797 1, 29-34Norman A.;Norman M.;Hall J.;Tsibulsky V. 06-12-1999. Priming threshold: A novel quantitative measure of the reinstatement of cocaine self-administration Brain Research, 831 1-2, 165-174Wetzel H.;Webster R.;Saeed F.;Kirley T.;Ball W.;Norman A. 06-03-2017. Characterization of a recombinant humanized anti-cocaine monoclonal antibody produced from multiple Biochemical and Biophysical Research Communications, 487 3, 690-694Warner A.;Norman A. 06-01-2000. Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: A clarification Therapeutic Drug Monitoring, 22 3, 266-270Calderon S.;Sanberg P.;Norman A. 05-31-1988. Quinolinic acid lesions of rat striatum abolish D1- and D2-dopamine receptor-mediated catalepsy Brain Research, 450 1-2, 403-407Webster R.P.;Cohen C.F.;Saeed F.O.;Wetzel H.N.;Ball W.J.;Kirley T.L.;Norman A.B. 05-01-2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program Journal of Immunological Methods, 456 , 61-66McConville B.;Sanberg P.;Fogelson M.;King J.;Cirino P.;Parker K.;Norman A. 04-15-1992. The effects of nicotine plus haloperidol compared to nicotine only and placebo nicotine only in redu Biological Psychiatry, 31 8, 832-840Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 03-27-1989. Magnetic resonance imaging of rat brain following kainic acid-induced lesions and fetal striatal tis Brain Research, 483 1, 188-191Strother W.N.;Norman A.B.;Lehman M.N. 03-12-1998. D1-dopamine receptor binding and tyrosine hydroxylase-immunoreactivity in the fetal and neonatal ham Developmental Brain Research, 106 1-2, 137-144Sanberg P.;Fogelson H.;Manderscheid P.;Parker K.;Norman A.;Mcconville B. 03-12-1988. NICOTINE GUM AND HALOPERIDOL IN TOURETTE'S SYNDROME The Lancet, 331 8585, 592McConville B.;Norman A.;Fogelson M.;Erenberg G. 03-05-1994. Sequential use of opioid antagonists and agonists In Tourette's syndrome The Lancet, 343 8897, 601Marckel J.;Wetzel H.;Amlal S.;Amlal H.;Norman A. 03-01-2019. A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Drug metabolism and disposition: the biological fate of chemicals, 47 3, 184-188Sanberg P.;Norman A. 03-01-1989. Underrecognized and underresearched side effects of neuroleptics. American Journal of Psychiatry, 146 3, 411-412Norman A.;Khosla U.;Klug J.;Thompson H. 02-28-1994. Autoradiographic measurement of tyrosine hydroxylase immunoreactivity in rat brain using enhanced ch Brain Research, 638 1-2, 352-356Morrow A.L.;Battaglia G.;Norman A.B.;Creese I. 02-26-1985. Identification of subtypes of [<sup>3</sup>H]prazosin-labelled ?<inf>1</inf> European Journal of Pharmacology, 109 2, 285-287Norman A.;Ford L.;Kolmonpunporn M.;Sanberg P. 02-13-1990. Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors i European Journal of Pharmacology, 176 3, 363-366Tsibulsky V.;Norman A. 02-12-2001. Satiety threshold during maintained cocaine self-administration in outbred mice NeuroReport, 12 2, 325-328Norman A.;Lu S.;Klug J.;Norgren R. 02-12-1993. Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine Brain Research, 603 1, 125-128Hess E.J.;Battaglia G.;Norman A.B.;Iorio L.C.;Creese I. 02-11-1986. Guanine nucleotide regulation of agonist interactions at [<sup>3</sup>H]SCH23390-labeled European Journal of Pharmacology, 121 1, 31-38Wetzel H.;Tabet M.;Ball W.;Norman A. 02-01-2016. Erratum: The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition International Immunopharmacology, 31 , 272-273Battaglia G.;Norman A.;Creese I. 01-19-1988. Age-related differential recovery rates of rat striatal D-1 dopamine receptors following irreversibl European Journal of Pharmacology, 145 3, 281-290Norman A.;Norgren R.;Wyatt L.;Hildebrand J.;Sanberg P. 01-08-1992. The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin i Brain Research, 569 1, 169-172Tsibulsky V.;Norman A. 01-01-2012. Simple deterministic mathematical model of maintained drug self-administration behavior and its phar Computational Neuroscience of Drug Addiction, , 3-18Geracioti T.;West S.;Baker D.;Hill K.;Ekhator N.;Wortman M.;Keck P.;Norman A. 01-01-1999. Low CSF concentration of a dopamine metabolite in tobacco smokers American Journal of Psychiatry, 156 1, 130-132Shapira N.;McCorville B.;Pagnucco M.;Norman A.;Keck J. 01-01-1997. Novel uyse of tramadol hydrochloride in the treatment of Tourette's syndrome [2] Journal of Clinical Psychiatry, 58 4, 174-175Bertram K.;Shipley M.;Ennis M.;Sanberg P.;Norman A. 01-01-1994. Permeability of the blood-brain barrier within rat intrastriatal transplants assessed by simultaneou Experimental Neurology, 127 2, 245-252Emerich D.;Lu S.;Norman A.;Pixley S.;Lehman M.;Norman A.;Norman A. 01-01-1993. Effect of Fetal Striatal and Astrocyte Transplants into Unilateral Excitotoxin-Lesioned Striatum Journal of Neural Transplantation and Plasticity, 4 4, 279-287Klug J.;Norman A. 01-01-1993. Long-term sensitization of apomorphine-induced rotation behavior in rats with dopamine deafferentati Pharmacology, Biochemistry and Behavior, 46 2, 397-403Lu S.;Norman A. 01-01-1993. Neurotransmitter Receptors in Fetal Tissue Transplants: Expression and Functional Significance Journal of Neural Transplantation and Plasticity, 4 3, 215-226Sanberg P.;Emerich D.;El-Etri M.;Shipley M.;Zanol M.;Cahill D.;Norman A. 01-01-1993. Nicotine potentiation of haloperidol-induced catalepsy: Striatal mechanisms Pharmacology, Biochemistry and Behavior, 46 2, 303-307Sanberg P.;Koutouzis T.;Freeman T.;Cahill D.;Norman A. 01-01-1993. Behavioral effects of fetal neural transplants: Relevance to Huntington's disease Brain Research Bulletin, 32 5, 493-496Rickards E.;Arevalo E.;Licamele W.;Bronheim S.;Sonnenschein K.;McConville B.;Norman A. 01-01-1992. Nicotine gum in Tourette's disorder [15] American Journal of Psychiatry, 149 3, 417-418 Kaplan S.; Nash D.; Norman A.; Sanberg P. 01-01-1991. An evaluation of the possible protective effects of neonatal striatal transplants against kainic aci Journal of Neural Transplantation and Plasticity, 2 1, 75-79Emerich D.;Norman A.;Sanberg P. 01-01-1991. Nicotine potentiates the behavioral effects of haloperidol Psychopharmacology Bulletin, 27 3, 385-390Emerich D.;Zanol M.;Norman A.;McConville B.;Sanberg P. 01-01-1991. Nicotine potentiates haloperidol-induced catalepsy and locomotor hypoactivity Pharmacology, Biochemistry and Behavior, 38 4, 875-880Emerich D.;Zubricki E.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Female rats are more sensitive to the locomotor alterations following quinolinic acid-induced striat Experimental Neurology, 111 3, 369-378Joyce J.;Emerich D.;Norman A.;Sanberg P. 01-01-1991. Regulation and Assessment of Receptors following Transplants Methods in Neurosciences, 7 C, 456-477Lu S.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Striatal, ventral mesencephalic and cortical transplants into the intact rat striatum: A neuroanatom Experimental Neurology, 113 2, 109-130McConville B.;Fogelson M.;Norman A.;Klykylo W.;Manderscheid P.;Parker K.;Sanberg P. 01-01-1991. Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder American Journal of Psychiatry, 148 6, 793-794Nickell W.;Norman A.;Wyatt L.;Shipley M. 01-01-1991. Olfactory bulb DA receptors may be located on terminals of the olfactory nerve NeuroReport, 2 1, 9-12Norman A.;Bertram K.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1991. Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature Brain Research Bulletin, 26 4, 593-597Norman A.;Ford L.;Sanberg P. 01-01-1991. Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum Experimental Neurology, 114 1, 132-135Norman A.;Pratt R.;Samaratunga R.;Thomas S.;Sanberg P. 01-01-1991. Magnetic Resonance Imaging of Rat Brain to Assess Kainic Acid-Induced Lesions and Transplants Methods in Neurosciences, 7 C, 408-428Sanberg P.R.;Kaplan S.M.;Norman A.B.;Sanberg P.R. 01-01-1991. AN Evaluation of the Possible Protective Effects of Neonatal Striatal Transplants Against Kainic Aci Journal of Neural Transplantation, 2 1, 75-79Giordano M.;Ford L.;Brauckmann J.;Norman A.;Sanberg P. 01-01-1990. MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum Brain Research Bulletin, 24 3, 313-319Giordano M.;Moody C.;Zubrycki E.;Dreshfield L.;Norman A.;Sanberg P. 01-01-1990. Prenatal exposure to cocaine in rats: Lack of long-term effects on locomotion and stereotypy Bulletin of the Psychonomic Society, 28 1, 51-54Lu S.;Giordano M.;Norman A.;Shipley M.;Sanberg P. 01-01-1990. Behavioral effects of neural transplants into the intact striatum Pharmacology, Biochemistry and Behavior, 37 1, 135-148Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1990. T1 and T2 weighted magnetic resonance imaging of excitotoxin lesions and neural transplants in rat b Experimental Neurology, 109 2, 164-170Norman A.;Wyatt L.;Hildebrand J.;Kolmonpunporn M.;Moody C.;Lehman M.;Sanberg P. 01-01-1990. Sensitization of rotation behavior in rats with unilateral 6-hydroxydopamine or kainic acid-induced Pharmacology, Biochemistry and Behavior, 37 4, 755-759Sanberg P.;Zubrycki E.;Ragozzino M.;Lu S.;Norman A.;Shipley M. 01-01-1990. NADPH-Diaphorase-containing neurons and cytochrome oxidase activity following striatal quinolinic ac Progress in Brain Research, 82 C, 427-431Ford L.;Norman A.;Sanberg P. 01-01-1989. The topography of MK-801-induced locomotor patterns in rats Physiology and Behavior, 46 4, 755-758Ford L.;Sanberg P.;Norman A.;Fogelson M. 01-01-1989. Mk-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats Archives of Neurology, 46 10, 1090-1096Moss D.;Manderscheid P.;Montgomery S.;Norman A.;Sanberg P. 01-01-1989. Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of tourette syndrome and othe Life Sciences, 44 21, 1521-1525Norman A.;Eubanks J.;Creese I. 01-01-1989. Irreversible and quaternary muscarinic antagonists discriminate multiple muscarinic receptor binding Journal of Pharmacology and Experimental Therapeutics, 248 3, 1116-1122Norman A.;Giordano M.;Sanberg P. 01-01-1989. Fetal striatal tissue grafts into excitotoxin-lesioned striatum: Pharmacological and behavioral aspe Pharmacology, Biochemistry and Behavior, 34 1, 139-147Norman A.;Lehman M.;Sanberg P. 01-01-1989. Functional effects of fetal striatal transplants Brain Research Bulletin, 22 1, 163-172Norman A.;Nash D.;Sanberg P. 01-01-1989. [<sup>3</sup>H]lysergic acid diethylamide (LSD): differential agonist and antagonist bin Neurochemistry International, 14 4, 497-504Norman A.;Wachendorf T.;Sanberg P. 01-01-1989. Differential effect of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on [<sup>3</su Life Sciences, 44 13, 831-836Norman A.B.;Borchers M.T.;Wachendorf T.J.;Price A.L.;Sanberg P.R. 01-01-1989. Loss of D<inf>1</inf> and D<inf>2</inf> dopamine receptors and muscarinic ch Brain Research Bulletin, 22 4, 633-636Sanberg P.;Calderon S.;Giordano M.;Tew J.;Norman A. 01-01-1989. The quinolinic acid model of Huntington's disease: Locomotor abnormalities Experimental Neurology, 105 1, 45-53Sanberg P.;McConville B.;Fogelson H.;Manderscheid P.;Parker K.;Blythe M.;Klykylo W.;Norman A. 01-01-1989. Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome Biomedicine and Pharmacotherapy, 43 1, 19-23Weissman E.;B. Norman A.;Calderon S.;Zubrycki E.;El-etri M.;Shipley M.;Sanberg P. 01-01-1989. The effect of prenatal treatment with MPTP or MPP<sup>+</sup> on the development of dopa Pharmacology, Biochemistry and Behavior, 34 3, 545-551Hess E.J.;Norman A.B.;Creese I. 01-01-1988. Chronic treatment with dopamine receptor antagonists: Behavioral and pharmacologic effects on D<i Journal of Neuroscience, 8 7, 2361-2370Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. A novel rotational behavior model for assessing the restructuring of striatal dopamine effector syst Progress in Brain Research, 78 C, 61-67Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. Striatal tissue transplants attenuate apomorphine-induced rotational behavior in rats with unilatera Neuropharmacology, 27 3, 333-336Sanberg P.;Nash D.;Calderon S.;Giordano M.;Shipley M.;Norman A. 01-01-1988. Neural transplants disrupt the blood-brain barrier and allow peripherally acting drugs to exert a ce Experimental Neurology, 102 1, 149-152Sanberg P.;Norman A. 01-01-1988. Adrenal transplants for Huntington's disease? [8] Nature, 335 6186, 122Battaglia G.;Norman A.;Creese I. 01-01-1987. Differential serotonin<inf>2</inf>receptor recovery in mature and senescent rat brain af Journal of Pharmacology and Experimental Therapeutics, 243 1, 69-75Hess E.J.;Battaglia G.;Norman A.B.;Creese I. 01-01-1987. Differential modification of striatal D<inf>1</inf>dopamine receptors and effector moiet Molecular Pharmacology, 31 1, 50-57Norman A.B.;Battaglia G.;Creese I. 01-01-1987. Differential recovery rates of rat D<inf>2</inf> dopamine receptors as a function of agi Journal of Neuroscience, 7 5, 1484-1491Sanberg P.;Calderon S.;Garver D.;Norman A. 01-01-1987. Brain tissue transplants in an animal model of Huntington's disease Psychopharmacology Bulletin, 23 3, 476-482Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 01-01-1986. Forskolin Potentiates the Stimulation of Rat Striatal Adenylate Cyclase Mediated by D?1 Dopamine Rec Journal of Neurochemistry, 46 4, 1180-1185Battaglia G.;Norman A.B.;Newton P.L.;Creese I. 01-01-1986. In Vitro and In Vivo Irreversible Blockade of Cortical S<inf>2</inf> Serotonin Receptors Journal of Neurochemistry, 46 2, 589-593Norman A.B.;Battaglia G.;Creese I. 01-01-1986. Regulation of putative muscarinic cholinergic receptor subtypes in rat brain Neurochemistry International, 9 2, 337-347Battaglia G.;Norman A.;Creese I. 01-01-1985. Forskolin effects on the stimulatory and inhibitory components of rat striatal adenylate cyclase Federation Proceedings, 44 3, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. Properties of<sup>3</sup>H-WB4101-labeled 5HT-1 receptors in rat brain Federation Proceedings, 44 4, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. [<sup>3</sup>H]WB4101 labels the 5-HT(1A) serotonin receptor subtype in rat brain. Guani Molecular Pharmacology, 28 6, 487-494
Research InterestsThe focus of the Norman Laboratory is translational research to develop medications for the treatment of cocaine abuse. Drug self-administration by animals is a valid model of human addictive behavior. It has long been considered axiomatic that drugs of abuse are self-administered because of their pleasurable (hedonic or euphoric) effects, which in turn makes these drugs positively reinforcing. Unfortunately, these assumptions result in well-known paradoxes and the idea that reinforcemen...
Peer Reviewed Publications Desai, Jhanvi N; Tron Esqueda, Luis E; Norman, Andrew B 2023. The ascending limb of the cocaine unit dose-response function in rats as an experimental artifact. Scientific reports, 13 1, 16614Kirley, Terence L; Norman, Andrew B 2023. Characterization and optimization of fluorescein isothiocyanate labeling of humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 35 , 101520Kirley, Terence L; Norman, Andrew B 2023. Reformulation and Thermal Stability of a Therapeutic Anti-Cocaine mAb. Journal of pharmaceutical sciences, 112 6, 1595-1602Koch, Sheryl E; Marckel, Jordan A; Rubinstein, Jack; Norman, Andrew B 2023. A humanized anti-cocaine mAb antagonizes the cardiovascular effects of cocaine in rats. Pharmacology research & perspectives, 11 1, e01045Webster, Rose P; Marckel, Jordan A; Norman, Andrew B 2023. Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity. Human vaccines & immunotherapeutics, 19 3, 2274222Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Scientific reports, 13 1, 14566Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose. Heliyon, 9 7, e17988Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2022. Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites. Biochemistry and biophysics reports, 30 , 101278Kirley, Terence L; Norman, Andrew B 2022. Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 32 , 101354Kirley, Terence L; Norman, Andrew B 2022. Critical evaluation of fluorescent dyes to evaluate the stability and ligand binding properties of an anti-cocaine mAb, h2E2. Journal of immunological methods, 508 , 113323Kirley, Terence L; Norman, Andrew B; Greis, Kenneth D 2022. Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb. The Journal of biological chemistry, 298 3, 101689Tsibulsky, Vladimir L; Norman, Andrew B 2022. The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information. Scientific reports, 12 1, 19683Turner, Mackenzie E; Wetzel, Hanna N; Zinani, Dakota B; Crutchfield, Christopher A; Norman, Andrew B 2022. Effects of a recombinant humanized anti-cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice. Pharmacology research & perspectives, 10 5, e01009Wetzel, Hanna N; Tsibulsky, Vladimir L; Norman, Andrew B 2022. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats. Scientific reports, 12 1, 8782Zinani, Dakota B; Wetzel, Hanna N; Norman, Andrew B 2022. The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats. Brain research, 1774 , 147707Kirley, Terence L; Norman, Andrew B 2021. Cocaine binding to the Fab fragment of a humanized anti-cocaine mAb quantitated by dye absorption and fluorescence spectroscopy. Journal of immunological methods, 496 , 113103Kirley, Terence L; Norman, Andrew B 2021. Ligand binding to a humanized anti-cocaine mAb measured by dye absorption spectroscopy. Biochemical and biophysical research communications, 535 , 93-98Tsibulsky, Vladimir L; Norman, Andrew B 2021. Dramatic increase in lever-pressing activity in rats after training on the progressive ratio schedule of cocaine self-administration. Scientific reports, 11 1, 19656Tsibulsky, Vladimir L; Norman, Andrew B 2021. Methodological and analytical issues of progressive ratio schedules: Definition and scaling of breakpoint. Journal of neuroscience methods, 356 , 109146Kirley, Terence L; Norman, Andrew B 2020. Multi-domain unfolding of the Fab fragment of a humanized anti-cocaine mAb characterized by non-reducing SDS-PAGE. Biochemical and biophysical research communications, 533 3, 580-585Kirley, Terence L; Norman, Andrew B 2020. Ligand binding to a humanized anti-cocaine mAb detected by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 23 , 100795Kirley, Terence L; Norman, Andrew B; Wetzel, Hanna N 2020. A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics. Journal of immunological methods, 476 , 112676Tan, Kemin; Zhou, Min; Ahrendt, Angela J; Duke, Norma E C; Tabaja, Nassif; Ball, William J; Kirley, Terence L; Norman, Andrew B; Joachimiak, Andrzej; Schiffer, Marianne; Wilton, Rosemarie; Pokkuluri, P Raj 2019. Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2. Acta crystallographica. Section F, Structural biology communications, 75 Pt 11, 697-706Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 16 , 138-144Webster, Rose P; Cohen, Cinder F; Saeed, Fatima O; Wetzel, Hanna N; Ball, William J; Kirley, Terence L; Norman, Andrew B 2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program. Journal of immunological methods, 456 , 61-66Kirley, Terence L; Norman, Andrew B 2015. Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment. Human vaccines & immunotherapeutics, , 0Norman, Andrew B; Gooden, Felicia C T; Tabet, Michael R; Ball, William J 2014. A Recombinant Humanized Anti-cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats. Drug metabolism and disposition: the biological fate of chemicals, , Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2014. Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency. The Journal of pharmacology and experimental therapeutics, 348 2, 311-5Wetzel, Hanna N; Tabet, Michael R; Ball, William J; Norman, Andrew B 2014. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. International immunopharmacology, 23 2, 387-90Norman, Andrew B; Ball, William J 2012. Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody. Immunotherapy, 4 3, 335-43Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Fey, Brittney K; Tsibulsky, Vladimir L; Millard, Ronald W 2011. The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration. The Journal of pharmacology and experimental therapeutics, 338 2, 724-8Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2011. Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists. Journal of neuroscience methods, 194 2, 252-8Norman, Andrew B; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L; Pesce, Amadeo J 2010. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration. Synapse (New York, N.Y.), , Norman, Andrew B; Norman, Mantana K; Buesing, William R; Tabet, Michael R; Tsibulsky, Vladimir L; Ball, William J 2009. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. The Journal of pharmacology and experimental therapeutics, 328 3, 873-81Thompson, Valerie B; Heiman, Justin; Chambers, James B; Benoit, Stephen C; Buesing, William R; Norman, Mantana K; Norman, Andrew B; Lipton, Jack W 2009. Long-term behavioral consequences of prenatal MDMA exposure. Physiology & behavior, 96 4-5, 593-601Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Buesing, William R; Pesce, Amadeo J; Ball, William J 2007. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. The Journal of pharmacology and experimental therapeutics, 320 1, 145-53Tsibulsky, Vladimir L; Norman, Andrew B 2007. Mathematical models of behavior of individual animals. Current pharmaceutical design, 13 15, 1571-95Norman, Andrew B; Tsibulsky, Vladimir L 2006. The compulsion zone: a pharmacological theory of acquired cocaine self-administration. Brain research, 1116 1, 143-52Tsibulsky, Vladimir L; Norman, Andrew B 2005. Real time computation of in vivo drug levels during drug self-administration experiments. Brain research. Brain research protocols, 15 1, 38-45Norman, Andrew B; Buesing, William R; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L 2004. The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats. European journal of pharmacology, 483 2-3, 281-7Paula, Stefan; Tabet, Michael R; Farr, Carol D; Norman, Andrew B; Ball, W James 2004. Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody. Journal of medicinal chemistry, 47 1, 133-42Sutliff, Roy L; Haase, Chad; Russ, Rodney; Hoit, Brian D; Morris, Randal; Norman, Andrew B; Lewis, William 2003. Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome. Laboratory investigation; a journal of technical methods and pathology, 83 7, 983-9Norman, Andrew B; Welge, Jeffrey A; Tsibulsky, Vladimir L 2002. Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390. Brain research, 946 2, 253-61Kirley T.L.;Greis K.D.;Norman A.B. 12-01-2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE Biochemistry and Biophysics Reports, 16 , 138-144Cabovska B.;Norman A.;Stalcup A. 12-01-2003. Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins Analytical and Bioanalytical Chemistry, 376 1, 134-137Norman A.B.;Creese I. 12-01-1986. Effects of in vivo and in vitro treatments with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on pu Molecular Pharmacology, 30 2, 96-103Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 11-27-1989. A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal Brain Research, 503 1, 156-159Kirley T.;Greis K.;Norman A. 11-25-2016. Selective disulfide reduction for labeling and enhancement of Fab antibody fragments Biochemical and Biophysical Research Communications, 480 4, 752-757Sanberg P.;Emerich D.;Aebischer P.;Amisetti S.;Ouellette W.;Koutouzis T.;Cahill D.;Norman A. 11-19-1993. Substance P containing polymer implants protect against striatal excitotoxicity Brain Research, 628 1-2, 327-329Morrow A.L.;Norman A.B.;Battaglia G.;Loy R.;Creese I. 11-18-1985. UP-regulation of serotonergic binding sites labeled by [<sup>3</sup>H]WB4101 following f Life Sciences, 37 20, 1913-1922Geracioti T.D.;Goldsmith R.J.;Friedman L.M.;Norman A.B.;Somoza E.;Kasckow J.W.;Baker D.G.;Richtand N.M.;Anthenelli R.M.;Keck P.E. 11-17-1997. Cerebrospinal fluid neuroendocrinology of alcohol misusers Addiction Biology, 2 4, 401-409Norman A.B.;Battaglia G.;Morrow A.L.;Creese I. 11-13-1984. [<sup>3</sup>H]WB4101 labels S<inf>1</inf> serotonin receptors in rat cerebr European Journal of Pharmacology, 106 2, 461-462Wetzel H.;Tsibulsky V.;Norman A. 11-01-2016. The effects of a repeated dose of a recombinant humanized anti-cocaine monoclonal antibody on cocain Drug and Alcohol Dependence, 168 , 287-292Norman A.;Thomas S.;Pratt R.;Lu S.;Norgren R. 10-30-1992. Magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast age Brain Research, 594 2, 279-283Norman A.B.;Blaker S.N.;Thal L.;Creese I. 10-08-1986. Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtype Neuroscience Letters, 70 2, 289-294Sanberg P.;Bunsey M.;Giordano M.;Norman A. 10-01-1988. The Catalepsy Test: Its Ups and Downs Behavioral Neuroscience, 102 5, 748-759Norman A.;Tsibulsky V. 09-27-2001. Satiety threshold regulates maintained self-administration: Comment on Lynch and Carroll (2001) Experimental and Clinical Psychopharmacology, 9 2, 151-154Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 09-12-1986. Functional recovery of D<inf>1</inf>dopamine receptor-mediated stimulation of rat striat Neuroscience Letters, 69 3, 290-295Koster N.;Norman A.;Richtand N.;Nickell W.;Puche A.;Pixley S.;Shipley M. 09-06-1999. Olfactory receptor neurons express D2 dopamine receptors Journal of Comparative Neurology, 411 4, 666-673Kirley T.L.;Norman A.B. 09-05-2018. Unfolding of IgG domains detected by non-reducing SDS-PAGE Biochemical and Biophysical Research Communications, 503 2, 944-949Wetzel H.;Cohen C.;Norman A.;Webster R. 09-01-2017. A novel Python program for implementation of quality control in the ELISA Journal of Immunological Methods, 448 , 80-84Wetzel H.;Zhang T.;Norman A. 09-01-2017. A mathematical model of a recombinant humanized anti-cocaine monoclonal antibody's effects on cocain Life Sciences, 184 , 81-86Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 08-30-1985. D<inf>2</inf>dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyc Neuroscience Letters, 59 2, 177-182Kirley T.;Greis K.;Norman A. 08-26-2016. Structural characterization of expressed monoclonal antibodies by single sample mass spectral analys Biochemical and Biophysical Research Communications, 477 3, 363-368Tsibulsky V.;Norman A. 08-21-1999. Satiety threshold: A quantitative model of maintained cocaine self- administration Brain Research, 839 1, 85-93Norman A.;Wylie G.;Prince A. 08-21-1987. Supersensitivity of d-amphetamine-induced hyperthermia in rats following continuous treatment with n European Journal of Pharmacology, 140 3, 349-351Daniels J.;Baker D.G.;Norman A.B. 07-16-1996. Cocaine-induced tics in untreated Tourette's syndrome [1] American Journal of Psychiatry, 153 SUPPL., 965Dalia A.D.;Norman M.K.;Tabet M.R.;Schlueter K.T.;Tsibulsky V.L.;Norman A.B. 06-22-1998. Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of Brain Research, 797 1, 29-34Norman A.;Norman M.;Hall J.;Tsibulsky V. 06-12-1999. Priming threshold: A novel quantitative measure of the reinstatement of cocaine self-administration Brain Research, 831 1-2, 165-174Wetzel H.;Webster R.;Saeed F.;Kirley T.;Ball W.;Norman A. 06-03-2017. Characterization of a recombinant humanized anti-cocaine monoclonal antibody produced from multiple Biochemical and Biophysical Research Communications, 487 3, 690-694Warner A.;Norman A. 06-01-2000. Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: A clarification Therapeutic Drug Monitoring, 22 3, 266-270Calderon S.;Sanberg P.;Norman A. 05-31-1988. Quinolinic acid lesions of rat striatum abolish D1- and D2-dopamine receptor-mediated catalepsy Brain Research, 450 1-2, 403-407Webster R.P.;Cohen C.F.;Saeed F.O.;Wetzel H.N.;Ball W.J.;Kirley T.L.;Norman A.B. 05-01-2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program Journal of Immunological Methods, 456 , 61-66McConville B.;Sanberg P.;Fogelson M.;King J.;Cirino P.;Parker K.;Norman A. 04-15-1992. The effects of nicotine plus haloperidol compared to nicotine only and placebo nicotine only in redu Biological Psychiatry, 31 8, 832-840Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 03-27-1989. Magnetic resonance imaging of rat brain following kainic acid-induced lesions and fetal striatal tis Brain Research, 483 1, 188-191Strother W.N.;Norman A.B.;Lehman M.N. 03-12-1998. D1-dopamine receptor binding and tyrosine hydroxylase-immunoreactivity in the fetal and neonatal ham Developmental Brain Research, 106 1-2, 137-144Sanberg P.;Fogelson H.;Manderscheid P.;Parker K.;Norman A.;Mcconville B. 03-12-1988. NICOTINE GUM AND HALOPERIDOL IN TOURETTE'S SYNDROME The Lancet, 331 8585, 592McConville B.;Norman A.;Fogelson M.;Erenberg G. 03-05-1994. Sequential use of opioid antagonists and agonists In Tourette's syndrome The Lancet, 343 8897, 601Marckel J.;Wetzel H.;Amlal S.;Amlal H.;Norman A. 03-01-2019. A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Drug metabolism and disposition: the biological fate of chemicals, 47 3, 184-188Sanberg P.;Norman A. 03-01-1989. Underrecognized and underresearched side effects of neuroleptics. American Journal of Psychiatry, 146 3, 411-412Norman A.;Khosla U.;Klug J.;Thompson H. 02-28-1994. Autoradiographic measurement of tyrosine hydroxylase immunoreactivity in rat brain using enhanced ch Brain Research, 638 1-2, 352-356Morrow A.L.;Battaglia G.;Norman A.B.;Creese I. 02-26-1985. Identification of subtypes of [<sup>3</sup>H]prazosin-labelled ?<inf>1</inf> European Journal of Pharmacology, 109 2, 285-287Norman A.;Ford L.;Kolmonpunporn M.;Sanberg P. 02-13-1990. Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors i European Journal of Pharmacology, 176 3, 363-366Tsibulsky V.;Norman A. 02-12-2001. Satiety threshold during maintained cocaine self-administration in outbred mice NeuroReport, 12 2, 325-328Norman A.;Lu S.;Klug J.;Norgren R. 02-12-1993. Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine Brain Research, 603 1, 125-128Hess E.J.;Battaglia G.;Norman A.B.;Iorio L.C.;Creese I. 02-11-1986. Guanine nucleotide regulation of agonist interactions at [<sup>3</sup>H]SCH23390-labeled European Journal of Pharmacology, 121 1, 31-38Wetzel H.;Tabet M.;Ball W.;Norman A. 02-01-2016. Erratum: The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition International Immunopharmacology, 31 , 272-273Battaglia G.;Norman A.;Creese I. 01-19-1988. Age-related differential recovery rates of rat striatal D-1 dopamine receptors following irreversibl European Journal of Pharmacology, 145 3, 281-290Norman A.;Norgren R.;Wyatt L.;Hildebrand J.;Sanberg P. 01-08-1992. The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin i Brain Research, 569 1, 169-172Tsibulsky V.;Norman A. 01-01-2012. Simple deterministic mathematical model of maintained drug self-administration behavior and its phar Computational Neuroscience of Drug Addiction, , 3-18Geracioti T.;West S.;Baker D.;Hill K.;Ekhator N.;Wortman M.;Keck P.;Norman A. 01-01-1999. Low CSF concentration of a dopamine metabolite in tobacco smokers American Journal of Psychiatry, 156 1, 130-132Shapira N.;McCorville B.;Pagnucco M.;Norman A.;Keck J. 01-01-1997. Novel uyse of tramadol hydrochloride in the treatment of Tourette's syndrome [2] Journal of Clinical Psychiatry, 58 4, 174-175Bertram K.;Shipley M.;Ennis M.;Sanberg P.;Norman A. 01-01-1994. Permeability of the blood-brain barrier within rat intrastriatal transplants assessed by simultaneou Experimental Neurology, 127 2, 245-252Emerich D.;Lu S.;Norman A.;Pixley S.;Lehman M.;Norman A.;Norman A. 01-01-1993. Effect of Fetal Striatal and Astrocyte Transplants into Unilateral Excitotoxin-Lesioned Striatum Journal of Neural Transplantation and Plasticity, 4 4, 279-287Klug J.;Norman A. 01-01-1993. Long-term sensitization of apomorphine-induced rotation behavior in rats with dopamine deafferentati Pharmacology, Biochemistry and Behavior, 46 2, 397-403Lu S.;Norman A. 01-01-1993. Neurotransmitter Receptors in Fetal Tissue Transplants: Expression and Functional Significance Journal of Neural Transplantation and Plasticity, 4 3, 215-226Sanberg P.;Emerich D.;El-Etri M.;Shipley M.;Zanol M.;Cahill D.;Norman A. 01-01-1993. Nicotine potentiation of haloperidol-induced catalepsy: Striatal mechanisms Pharmacology, Biochemistry and Behavior, 46 2, 303-307Sanberg P.;Koutouzis T.;Freeman T.;Cahill D.;Norman A. 01-01-1993. Behavioral effects of fetal neural transplants: Relevance to Huntington's disease Brain Research Bulletin, 32 5, 493-496Rickards E.;Arevalo E.;Licamele W.;Bronheim S.;Sonnenschein K.;McConville B.;Norman A. 01-01-1992. Nicotine gum in Tourette's disorder [15] American Journal of Psychiatry, 149 3, 417-418 Kaplan S.; Nash D.; Norman A.; Sanberg P. 01-01-1991. An evaluation of the possible protective effects of neonatal striatal transplants against kainic aci Journal of Neural Transplantation and Plasticity, 2 1, 75-79Emerich D.;Norman A.;Sanberg P. 01-01-1991. Nicotine potentiates the behavioral effects of haloperidol Psychopharmacology Bulletin, 27 3, 385-390Emerich D.;Zanol M.;Norman A.;McConville B.;Sanberg P. 01-01-1991. Nicotine potentiates haloperidol-induced catalepsy and locomotor hypoactivity Pharmacology, Biochemistry and Behavior, 38 4, 875-880Emerich D.;Zubricki E.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Female rats are more sensitive to the locomotor alterations following quinolinic acid-induced striat Experimental Neurology, 111 3, 369-378Joyce J.;Emerich D.;Norman A.;Sanberg P. 01-01-1991. Regulation and Assessment of Receptors following Transplants Methods in Neurosciences, 7 C, 456-477Lu S.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Striatal, ventral mesencephalic and cortical transplants into the intact rat striatum: A neuroanatom Experimental Neurology, 113 2, 109-130McConville B.;Fogelson M.;Norman A.;Klykylo W.;Manderscheid P.;Parker K.;Sanberg P. 01-01-1991. Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder American Journal of Psychiatry, 148 6, 793-794Nickell W.;Norman A.;Wyatt L.;Shipley M. 01-01-1991. Olfactory bulb DA receptors may be located on terminals of the olfactory nerve NeuroReport, 2 1, 9-12Norman A.;Bertram K.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1991. Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature Brain Research Bulletin, 26 4, 593-597Norman A.;Ford L.;Sanberg P. 01-01-1991. Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum Experimental Neurology, 114 1, 132-135Norman A.;Pratt R.;Samaratunga R.;Thomas S.;Sanberg P. 01-01-1991. Magnetic Resonance Imaging of Rat Brain to Assess Kainic Acid-Induced Lesions and Transplants Methods in Neurosciences, 7 C, 408-428Sanberg P.R.;Kaplan S.M.;Norman A.B.;Sanberg P.R. 01-01-1991. AN Evaluation of the Possible Protective Effects of Neonatal Striatal Transplants Against Kainic Aci Journal of Neural Transplantation, 2 1, 75-79Giordano M.;Ford L.;Brauckmann J.;Norman A.;Sanberg P. 01-01-1990. MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum Brain Research Bulletin, 24 3, 313-319Giordano M.;Moody C.;Zubrycki E.;Dreshfield L.;Norman A.;Sanberg P. 01-01-1990. Prenatal exposure to cocaine in rats: Lack of long-term effects on locomotion and stereotypy Bulletin of the Psychonomic Society, 28 1, 51-54Lu S.;Giordano M.;Norman A.;Shipley M.;Sanberg P. 01-01-1990. Behavioral effects of neural transplants into the intact striatum Pharmacology, Biochemistry and Behavior, 37 1, 135-148Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1990. T1 and T2 weighted magnetic resonance imaging of excitotoxin lesions and neural transplants in rat b Experimental Neurology, 109 2, 164-170Norman A.;Wyatt L.;Hildebrand J.;Kolmonpunporn M.;Moody C.;Lehman M.;Sanberg P. 01-01-1990. Sensitization of rotation behavior in rats with unilateral 6-hydroxydopamine or kainic acid-induced Pharmacology, Biochemistry and Behavior, 37 4, 755-759Sanberg P.;Zubrycki E.;Ragozzino M.;Lu S.;Norman A.;Shipley M. 01-01-1990. NADPH-Diaphorase-containing neurons and cytochrome oxidase activity following striatal quinolinic ac Progress in Brain Research, 82 C, 427-431Ford L.;Norman A.;Sanberg P. 01-01-1989. The topography of MK-801-induced locomotor patterns in rats Physiology and Behavior, 46 4, 755-758Ford L.;Sanberg P.;Norman A.;Fogelson M. 01-01-1989. Mk-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats Archives of Neurology, 46 10, 1090-1096Moss D.;Manderscheid P.;Montgomery S.;Norman A.;Sanberg P. 01-01-1989. Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of tourette syndrome and othe Life Sciences, 44 21, 1521-1525Norman A.;Eubanks J.;Creese I. 01-01-1989. Irreversible and quaternary muscarinic antagonists discriminate multiple muscarinic receptor binding Journal of Pharmacology and Experimental Therapeutics, 248 3, 1116-1122Norman A.;Giordano M.;Sanberg P. 01-01-1989. Fetal striatal tissue grafts into excitotoxin-lesioned striatum: Pharmacological and behavioral aspe Pharmacology, Biochemistry and Behavior, 34 1, 139-147Norman A.;Lehman M.;Sanberg P. 01-01-1989. Functional effects of fetal striatal transplants Brain Research Bulletin, 22 1, 163-172Norman A.;Nash D.;Sanberg P. 01-01-1989. [<sup>3</sup>H]lysergic acid diethylamide (LSD): differential agonist and antagonist bin Neurochemistry International, 14 4, 497-504Norman A.;Wachendorf T.;Sanberg P. 01-01-1989. Differential effect of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on [<sup>3</su Life Sciences, 44 13, 831-836Norman A.B.;Borchers M.T.;Wachendorf T.J.;Price A.L.;Sanberg P.R. 01-01-1989. Loss of D<inf>1</inf> and D<inf>2</inf> dopamine receptors and muscarinic ch Brain Research Bulletin, 22 4, 633-636Sanberg P.;Calderon S.;Giordano M.;Tew J.;Norman A. 01-01-1989. The quinolinic acid model of Huntington's disease: Locomotor abnormalities Experimental Neurology, 105 1, 45-53Sanberg P.;McConville B.;Fogelson H.;Manderscheid P.;Parker K.;Blythe M.;Klykylo W.;Norman A. 01-01-1989. Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome Biomedicine and Pharmacotherapy, 43 1, 19-23Weissman E.;B. Norman A.;Calderon S.;Zubrycki E.;El-etri M.;Shipley M.;Sanberg P. 01-01-1989. The effect of prenatal treatment with MPTP or MPP<sup>+</sup> on the development of dopa Pharmacology, Biochemistry and Behavior, 34 3, 545-551Hess E.J.;Norman A.B.;Creese I. 01-01-1988. Chronic treatment with dopamine receptor antagonists: Behavioral and pharmacologic effects on D<i Journal of Neuroscience, 8 7, 2361-2370Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. A novel rotational behavior model for assessing the restructuring of striatal dopamine effector syst Progress in Brain Research, 78 C, 61-67Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. Striatal tissue transplants attenuate apomorphine-induced rotational behavior in rats with unilatera Neuropharmacology, 27 3, 333-336Sanberg P.;Nash D.;Calderon S.;Giordano M.;Shipley M.;Norman A. 01-01-1988. Neural transplants disrupt the blood-brain barrier and allow peripherally acting drugs to exert a ce Experimental Neurology, 102 1, 149-152Sanberg P.;Norman A. 01-01-1988. Adrenal transplants for Huntington's disease? [8] Nature, 335 6186, 122Battaglia G.;Norman A.;Creese I. 01-01-1987. Differential serotonin<inf>2</inf>receptor recovery in mature and senescent rat brain af Journal of Pharmacology and Experimental Therapeutics, 243 1, 69-75Hess E.J.;Battaglia G.;Norman A.B.;Creese I. 01-01-1987. Differential modification of striatal D<inf>1</inf>dopamine receptors and effector moiet Molecular Pharmacology, 31 1, 50-57Norman A.B.;Battaglia G.;Creese I. 01-01-1987. Differential recovery rates of rat D<inf>2</inf> dopamine receptors as a function of agi Journal of Neuroscience, 7 5, 1484-1491Sanberg P.;Calderon S.;Garver D.;Norman A. 01-01-1987. Brain tissue transplants in an animal model of Huntington's disease Psychopharmacology Bulletin, 23 3, 476-482Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 01-01-1986. Forskolin Potentiates the Stimulation of Rat Striatal Adenylate Cyclase Mediated by D?1 Dopamine Rec Journal of Neurochemistry, 46 4, 1180-1185Battaglia G.;Norman A.B.;Newton P.L.;Creese I. 01-01-1986. In Vitro and In Vivo Irreversible Blockade of Cortical S<inf>2</inf> Serotonin Receptors Journal of Neurochemistry, 46 2, 589-593Norman A.B.;Battaglia G.;Creese I. 01-01-1986. Regulation of putative muscarinic cholinergic receptor subtypes in rat brain Neurochemistry International, 9 2, 337-347Battaglia G.;Norman A.;Creese I. 01-01-1985. Forskolin effects on the stimulatory and inhibitory components of rat striatal adenylate cyclase Federation Proceedings, 44 3, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. Properties of<sup>3</sup>H-WB4101-labeled 5HT-1 receptors in rat brain Federation Proceedings, 44 4, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. [<sup>3</sup>H]WB4101 labels the 5-HT(1A) serotonin receptor subtype in rat brain. Guani Molecular Pharmacology, 28 6, 487-494
Desai, Jhanvi N; Tron Esqueda, Luis E; Norman, Andrew B 2023. The ascending limb of the cocaine unit dose-response function in rats as an experimental artifact. Scientific reports, 13 1, 16614Kirley, Terence L; Norman, Andrew B 2023. Characterization and optimization of fluorescein isothiocyanate labeling of humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 35 , 101520Kirley, Terence L; Norman, Andrew B 2023. Reformulation and Thermal Stability of a Therapeutic Anti-Cocaine mAb. Journal of pharmaceutical sciences, 112 6, 1595-1602Koch, Sheryl E; Marckel, Jordan A; Rubinstein, Jack; Norman, Andrew B 2023. A humanized anti-cocaine mAb antagonizes the cardiovascular effects of cocaine in rats. Pharmacology research & perspectives, 11 1, e01045Webster, Rose P; Marckel, Jordan A; Norman, Andrew B 2023. Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity. Human vaccines & immunotherapeutics, 19 3, 2274222Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Scientific reports, 13 1, 14566Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose. Heliyon, 9 7, e17988Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2022. Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites. Biochemistry and biophysics reports, 30 , 101278Kirley, Terence L; Norman, Andrew B 2022. Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 32 , 101354Kirley, Terence L; Norman, Andrew B 2022. Critical evaluation of fluorescent dyes to evaluate the stability and ligand binding properties of an anti-cocaine mAb, h2E2. Journal of immunological methods, 508 , 113323Kirley, Terence L; Norman, Andrew B; Greis, Kenneth D 2022. Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb. The Journal of biological chemistry, 298 3, 101689Tsibulsky, Vladimir L; Norman, Andrew B 2022. The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information. Scientific reports, 12 1, 19683Turner, Mackenzie E; Wetzel, Hanna N; Zinani, Dakota B; Crutchfield, Christopher A; Norman, Andrew B 2022. Effects of a recombinant humanized anti-cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice. Pharmacology research & perspectives, 10 5, e01009Wetzel, Hanna N; Tsibulsky, Vladimir L; Norman, Andrew B 2022. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats. Scientific reports, 12 1, 8782Zinani, Dakota B; Wetzel, Hanna N; Norman, Andrew B 2022. The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats. Brain research, 1774 , 147707Kirley, Terence L; Norman, Andrew B 2021. Cocaine binding to the Fab fragment of a humanized anti-cocaine mAb quantitated by dye absorption and fluorescence spectroscopy. Journal of immunological methods, 496 , 113103Kirley, Terence L; Norman, Andrew B 2021. Ligand binding to a humanized anti-cocaine mAb measured by dye absorption spectroscopy. Biochemical and biophysical research communications, 535 , 93-98Tsibulsky, Vladimir L; Norman, Andrew B 2021. Dramatic increase in lever-pressing activity in rats after training on the progressive ratio schedule of cocaine self-administration. Scientific reports, 11 1, 19656Tsibulsky, Vladimir L; Norman, Andrew B 2021. Methodological and analytical issues of progressive ratio schedules: Definition and scaling of breakpoint. Journal of neuroscience methods, 356 , 109146Kirley, Terence L; Norman, Andrew B 2020. Multi-domain unfolding of the Fab fragment of a humanized anti-cocaine mAb characterized by non-reducing SDS-PAGE. Biochemical and biophysical research communications, 533 3, 580-585Kirley, Terence L; Norman, Andrew B 2020. Ligand binding to a humanized anti-cocaine mAb detected by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 23 , 100795Kirley, Terence L; Norman, Andrew B; Wetzel, Hanna N 2020. A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics. Journal of immunological methods, 476 , 112676Tan, Kemin; Zhou, Min; Ahrendt, Angela J; Duke, Norma E C; Tabaja, Nassif; Ball, William J; Kirley, Terence L; Norman, Andrew B; Joachimiak, Andrzej; Schiffer, Marianne; Wilton, Rosemarie; Pokkuluri, P Raj 2019. Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2. Acta crystallographica. Section F, Structural biology communications, 75 Pt 11, 697-706Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE. Biochemistry and biophysics reports, 16 , 138-144Webster, Rose P; Cohen, Cinder F; Saeed, Fatima O; Wetzel, Hanna N; Ball, William J; Kirley, Terence L; Norman, Andrew B 2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program. Journal of immunological methods, 456 , 61-66Kirley, Terence L; Norman, Andrew B 2015. Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment. Human vaccines & immunotherapeutics, , 0Norman, Andrew B; Gooden, Felicia C T; Tabet, Michael R; Ball, William J 2014. A Recombinant Humanized Anti-cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats. Drug metabolism and disposition: the biological fate of chemicals, , Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2014. Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency. The Journal of pharmacology and experimental therapeutics, 348 2, 311-5Wetzel, Hanna N; Tabet, Michael R; Ball, William J; Norman, Andrew B 2014. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. International immunopharmacology, 23 2, 387-90Norman, Andrew B; Ball, William J 2012. Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody. Immunotherapy, 4 3, 335-43Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Fey, Brittney K; Tsibulsky, Vladimir L; Millard, Ronald W 2011. The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration. The Journal of pharmacology and experimental therapeutics, 338 2, 724-8Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Tsibulsky, Vladimir L 2011. Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists. Journal of neuroscience methods, 194 2, 252-8Norman, Andrew B; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L; Pesce, Amadeo J 2010. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration. Synapse (New York, N.Y.), , Norman, Andrew B; Norman, Mantana K; Buesing, William R; Tabet, Michael R; Tsibulsky, Vladimir L; Ball, William J 2009. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. The Journal of pharmacology and experimental therapeutics, 328 3, 873-81Thompson, Valerie B; Heiman, Justin; Chambers, James B; Benoit, Stephen C; Buesing, William R; Norman, Mantana K; Norman, Andrew B; Lipton, Jack W 2009. Long-term behavioral consequences of prenatal MDMA exposure. Physiology & behavior, 96 4-5, 593-601Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Buesing, William R; Pesce, Amadeo J; Ball, William J 2007. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. The Journal of pharmacology and experimental therapeutics, 320 1, 145-53Tsibulsky, Vladimir L; Norman, Andrew B 2007. Mathematical models of behavior of individual animals. Current pharmaceutical design, 13 15, 1571-95Norman, Andrew B; Tsibulsky, Vladimir L 2006. The compulsion zone: a pharmacological theory of acquired cocaine self-administration. Brain research, 1116 1, 143-52Tsibulsky, Vladimir L; Norman, Andrew B 2005. Real time computation of in vivo drug levels during drug self-administration experiments. Brain research. Brain research protocols, 15 1, 38-45Norman, Andrew B; Buesing, William R; Norman, Mantana K; Tabet, Michael R; Tsibulsky, Vladimir L 2004. The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats. European journal of pharmacology, 483 2-3, 281-7Paula, Stefan; Tabet, Michael R; Farr, Carol D; Norman, Andrew B; Ball, W James 2004. Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody. Journal of medicinal chemistry, 47 1, 133-42Sutliff, Roy L; Haase, Chad; Russ, Rodney; Hoit, Brian D; Morris, Randal; Norman, Andrew B; Lewis, William 2003. Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome. Laboratory investigation; a journal of technical methods and pathology, 83 7, 983-9Norman, Andrew B; Welge, Jeffrey A; Tsibulsky, Vladimir L 2002. Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390. Brain research, 946 2, 253-61Kirley T.L.;Greis K.D.;Norman A.B. 12-01-2018. Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE Biochemistry and Biophysics Reports, 16 , 138-144Cabovska B.;Norman A.;Stalcup A. 12-01-2003. Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins Analytical and Bioanalytical Chemistry, 376 1, 134-137Norman A.B.;Creese I. 12-01-1986. Effects of in vivo and in vitro treatments with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on pu Molecular Pharmacology, 30 2, 96-103Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 11-27-1989. A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal Brain Research, 503 1, 156-159Kirley T.;Greis K.;Norman A. 11-25-2016. Selective disulfide reduction for labeling and enhancement of Fab antibody fragments Biochemical and Biophysical Research Communications, 480 4, 752-757Sanberg P.;Emerich D.;Aebischer P.;Amisetti S.;Ouellette W.;Koutouzis T.;Cahill D.;Norman A. 11-19-1993. Substance P containing polymer implants protect against striatal excitotoxicity Brain Research, 628 1-2, 327-329Morrow A.L.;Norman A.B.;Battaglia G.;Loy R.;Creese I. 11-18-1985. UP-regulation of serotonergic binding sites labeled by [<sup>3</sup>H]WB4101 following f Life Sciences, 37 20, 1913-1922Geracioti T.D.;Goldsmith R.J.;Friedman L.M.;Norman A.B.;Somoza E.;Kasckow J.W.;Baker D.G.;Richtand N.M.;Anthenelli R.M.;Keck P.E. 11-17-1997. Cerebrospinal fluid neuroendocrinology of alcohol misusers Addiction Biology, 2 4, 401-409Norman A.B.;Battaglia G.;Morrow A.L.;Creese I. 11-13-1984. [<sup>3</sup>H]WB4101 labels S<inf>1</inf> serotonin receptors in rat cerebr European Journal of Pharmacology, 106 2, 461-462Wetzel H.;Tsibulsky V.;Norman A. 11-01-2016. The effects of a repeated dose of a recombinant humanized anti-cocaine monoclonal antibody on cocain Drug and Alcohol Dependence, 168 , 287-292Norman A.;Thomas S.;Pratt R.;Lu S.;Norgren R. 10-30-1992. Magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast age Brain Research, 594 2, 279-283Norman A.B.;Blaker S.N.;Thal L.;Creese I. 10-08-1986. Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtype Neuroscience Letters, 70 2, 289-294Sanberg P.;Bunsey M.;Giordano M.;Norman A. 10-01-1988. The Catalepsy Test: Its Ups and Downs Behavioral Neuroscience, 102 5, 748-759Norman A.;Tsibulsky V. 09-27-2001. Satiety threshold regulates maintained self-administration: Comment on Lynch and Carroll (2001) Experimental and Clinical Psychopharmacology, 9 2, 151-154Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 09-12-1986. Functional recovery of D<inf>1</inf>dopamine receptor-mediated stimulation of rat striat Neuroscience Letters, 69 3, 290-295Koster N.;Norman A.;Richtand N.;Nickell W.;Puche A.;Pixley S.;Shipley M. 09-06-1999. Olfactory receptor neurons express D2 dopamine receptors Journal of Comparative Neurology, 411 4, 666-673Kirley T.L.;Norman A.B. 09-05-2018. Unfolding of IgG domains detected by non-reducing SDS-PAGE Biochemical and Biophysical Research Communications, 503 2, 944-949Wetzel H.;Cohen C.;Norman A.;Webster R. 09-01-2017. A novel Python program for implementation of quality control in the ELISA Journal of Immunological Methods, 448 , 80-84Wetzel H.;Zhang T.;Norman A. 09-01-2017. A mathematical model of a recombinant humanized anti-cocaine monoclonal antibody's effects on cocain Life Sciences, 184 , 81-86Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 08-30-1985. D<inf>2</inf>dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyc Neuroscience Letters, 59 2, 177-182Kirley T.;Greis K.;Norman A. 08-26-2016. Structural characterization of expressed monoclonal antibodies by single sample mass spectral analys Biochemical and Biophysical Research Communications, 477 3, 363-368Tsibulsky V.;Norman A. 08-21-1999. Satiety threshold: A quantitative model of maintained cocaine self- administration Brain Research, 839 1, 85-93Norman A.;Wylie G.;Prince A. 08-21-1987. Supersensitivity of d-amphetamine-induced hyperthermia in rats following continuous treatment with n European Journal of Pharmacology, 140 3, 349-351Daniels J.;Baker D.G.;Norman A.B. 07-16-1996. Cocaine-induced tics in untreated Tourette's syndrome [1] American Journal of Psychiatry, 153 SUPPL., 965Dalia A.D.;Norman M.K.;Tabet M.R.;Schlueter K.T.;Tsibulsky V.L.;Norman A.B. 06-22-1998. Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of Brain Research, 797 1, 29-34Norman A.;Norman M.;Hall J.;Tsibulsky V. 06-12-1999. Priming threshold: A novel quantitative measure of the reinstatement of cocaine self-administration Brain Research, 831 1-2, 165-174Wetzel H.;Webster R.;Saeed F.;Kirley T.;Ball W.;Norman A. 06-03-2017. Characterization of a recombinant humanized anti-cocaine monoclonal antibody produced from multiple Biochemical and Biophysical Research Communications, 487 3, 690-694Warner A.;Norman A. 06-01-2000. Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: A clarification Therapeutic Drug Monitoring, 22 3, 266-270Calderon S.;Sanberg P.;Norman A. 05-31-1988. Quinolinic acid lesions of rat striatum abolish D1- and D2-dopamine receptor-mediated catalepsy Brain Research, 450 1-2, 403-407Webster R.P.;Cohen C.F.;Saeed F.O.;Wetzel H.N.;Ball W.J.;Kirley T.L.;Norman A.B. 05-01-2018. Evaluation of methods to reduce background using the Python-based ELISA_QC program Journal of Immunological Methods, 456 , 61-66McConville B.;Sanberg P.;Fogelson M.;King J.;Cirino P.;Parker K.;Norman A. 04-15-1992. The effects of nicotine plus haloperidol compared to nicotine only and placebo nicotine only in redu Biological Psychiatry, 31 8, 832-840Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 03-27-1989. Magnetic resonance imaging of rat brain following kainic acid-induced lesions and fetal striatal tis Brain Research, 483 1, 188-191Strother W.N.;Norman A.B.;Lehman M.N. 03-12-1998. D1-dopamine receptor binding and tyrosine hydroxylase-immunoreactivity in the fetal and neonatal ham Developmental Brain Research, 106 1-2, 137-144Sanberg P.;Fogelson H.;Manderscheid P.;Parker K.;Norman A.;Mcconville B. 03-12-1988. NICOTINE GUM AND HALOPERIDOL IN TOURETTE'S SYNDROME The Lancet, 331 8585, 592McConville B.;Norman A.;Fogelson M.;Erenberg G. 03-05-1994. Sequential use of opioid antagonists and agonists In Tourette's syndrome The Lancet, 343 8897, 601Marckel J.;Wetzel H.;Amlal S.;Amlal H.;Norman A. 03-01-2019. A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Drug metabolism and disposition: the biological fate of chemicals, 47 3, 184-188Sanberg P.;Norman A. 03-01-1989. Underrecognized and underresearched side effects of neuroleptics. American Journal of Psychiatry, 146 3, 411-412Norman A.;Khosla U.;Klug J.;Thompson H. 02-28-1994. Autoradiographic measurement of tyrosine hydroxylase immunoreactivity in rat brain using enhanced ch Brain Research, 638 1-2, 352-356Morrow A.L.;Battaglia G.;Norman A.B.;Creese I. 02-26-1985. Identification of subtypes of [<sup>3</sup>H]prazosin-labelled ?<inf>1</inf> European Journal of Pharmacology, 109 2, 285-287Norman A.;Ford L.;Kolmonpunporn M.;Sanberg P. 02-13-1990. Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors i European Journal of Pharmacology, 176 3, 363-366Tsibulsky V.;Norman A. 02-12-2001. Satiety threshold during maintained cocaine self-administration in outbred mice NeuroReport, 12 2, 325-328Norman A.;Lu S.;Klug J.;Norgren R. 02-12-1993. Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine Brain Research, 603 1, 125-128Hess E.J.;Battaglia G.;Norman A.B.;Iorio L.C.;Creese I. 02-11-1986. Guanine nucleotide regulation of agonist interactions at [<sup>3</sup>H]SCH23390-labeled European Journal of Pharmacology, 121 1, 31-38Wetzel H.;Tabet M.;Ball W.;Norman A. 02-01-2016. Erratum: The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition International Immunopharmacology, 31 , 272-273Battaglia G.;Norman A.;Creese I. 01-19-1988. Age-related differential recovery rates of rat striatal D-1 dopamine receptors following irreversibl European Journal of Pharmacology, 145 3, 281-290Norman A.;Norgren R.;Wyatt L.;Hildebrand J.;Sanberg P. 01-08-1992. The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin i Brain Research, 569 1, 169-172Tsibulsky V.;Norman A. 01-01-2012. Simple deterministic mathematical model of maintained drug self-administration behavior and its phar Computational Neuroscience of Drug Addiction, , 3-18Geracioti T.;West S.;Baker D.;Hill K.;Ekhator N.;Wortman M.;Keck P.;Norman A. 01-01-1999. Low CSF concentration of a dopamine metabolite in tobacco smokers American Journal of Psychiatry, 156 1, 130-132Shapira N.;McCorville B.;Pagnucco M.;Norman A.;Keck J. 01-01-1997. Novel uyse of tramadol hydrochloride in the treatment of Tourette's syndrome [2] Journal of Clinical Psychiatry, 58 4, 174-175Bertram K.;Shipley M.;Ennis M.;Sanberg P.;Norman A. 01-01-1994. Permeability of the blood-brain barrier within rat intrastriatal transplants assessed by simultaneou Experimental Neurology, 127 2, 245-252Emerich D.;Lu S.;Norman A.;Pixley S.;Lehman M.;Norman A.;Norman A. 01-01-1993. Effect of Fetal Striatal and Astrocyte Transplants into Unilateral Excitotoxin-Lesioned Striatum Journal of Neural Transplantation and Plasticity, 4 4, 279-287Klug J.;Norman A. 01-01-1993. Long-term sensitization of apomorphine-induced rotation behavior in rats with dopamine deafferentati Pharmacology, Biochemistry and Behavior, 46 2, 397-403Lu S.;Norman A. 01-01-1993. Neurotransmitter Receptors in Fetal Tissue Transplants: Expression and Functional Significance Journal of Neural Transplantation and Plasticity, 4 3, 215-226Sanberg P.;Emerich D.;El-Etri M.;Shipley M.;Zanol M.;Cahill D.;Norman A. 01-01-1993. Nicotine potentiation of haloperidol-induced catalepsy: Striatal mechanisms Pharmacology, Biochemistry and Behavior, 46 2, 303-307Sanberg P.;Koutouzis T.;Freeman T.;Cahill D.;Norman A. 01-01-1993. Behavioral effects of fetal neural transplants: Relevance to Huntington's disease Brain Research Bulletin, 32 5, 493-496Rickards E.;Arevalo E.;Licamele W.;Bronheim S.;Sonnenschein K.;McConville B.;Norman A. 01-01-1992. Nicotine gum in Tourette's disorder [15] American Journal of Psychiatry, 149 3, 417-418 Kaplan S.; Nash D.; Norman A.; Sanberg P. 01-01-1991. An evaluation of the possible protective effects of neonatal striatal transplants against kainic aci Journal of Neural Transplantation and Plasticity, 2 1, 75-79Emerich D.;Norman A.;Sanberg P. 01-01-1991. Nicotine potentiates the behavioral effects of haloperidol Psychopharmacology Bulletin, 27 3, 385-390Emerich D.;Zanol M.;Norman A.;McConville B.;Sanberg P. 01-01-1991. Nicotine potentiates haloperidol-induced catalepsy and locomotor hypoactivity Pharmacology, Biochemistry and Behavior, 38 4, 875-880Emerich D.;Zubricki E.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Female rats are more sensitive to the locomotor alterations following quinolinic acid-induced striat Experimental Neurology, 111 3, 369-378Joyce J.;Emerich D.;Norman A.;Sanberg P. 01-01-1991. Regulation and Assessment of Receptors following Transplants Methods in Neurosciences, 7 C, 456-477Lu S.;Shipley M.;Norman A.;Sanberg P. 01-01-1991. Striatal, ventral mesencephalic and cortical transplants into the intact rat striatum: A neuroanatom Experimental Neurology, 113 2, 109-130McConville B.;Fogelson M.;Norman A.;Klykylo W.;Manderscheid P.;Parker K.;Sanberg P. 01-01-1991. Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder American Journal of Psychiatry, 148 6, 793-794Nickell W.;Norman A.;Wyatt L.;Shipley M. 01-01-1991. Olfactory bulb DA receptors may be located on terminals of the olfactory nerve NeuroReport, 2 1, 9-12Norman A.;Bertram K.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1991. Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature Brain Research Bulletin, 26 4, 593-597Norman A.;Ford L.;Sanberg P. 01-01-1991. Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum Experimental Neurology, 114 1, 132-135Norman A.;Pratt R.;Samaratunga R.;Thomas S.;Sanberg P. 01-01-1991. Magnetic Resonance Imaging of Rat Brain to Assess Kainic Acid-Induced Lesions and Transplants Methods in Neurosciences, 7 C, 408-428Sanberg P.R.;Kaplan S.M.;Norman A.B.;Sanberg P.R. 01-01-1991. AN Evaluation of the Possible Protective Effects of Neonatal Striatal Transplants Against Kainic Aci Journal of Neural Transplantation, 2 1, 75-79Giordano M.;Ford L.;Brauckmann J.;Norman A.;Sanberg P. 01-01-1990. MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum Brain Research Bulletin, 24 3, 313-319Giordano M.;Moody C.;Zubrycki E.;Dreshfield L.;Norman A.;Sanberg P. 01-01-1990. Prenatal exposure to cocaine in rats: Lack of long-term effects on locomotion and stereotypy Bulletin of the Psychonomic Society, 28 1, 51-54Lu S.;Giordano M.;Norman A.;Shipley M.;Sanberg P. 01-01-1990. Behavioral effects of neural transplants into the intact striatum Pharmacology, Biochemistry and Behavior, 37 1, 135-148Norman A.;Thomas S.;Pratt R.;Samaratunga R.;Sanberg P. 01-01-1990. T1 and T2 weighted magnetic resonance imaging of excitotoxin lesions and neural transplants in rat b Experimental Neurology, 109 2, 164-170Norman A.;Wyatt L.;Hildebrand J.;Kolmonpunporn M.;Moody C.;Lehman M.;Sanberg P. 01-01-1990. Sensitization of rotation behavior in rats with unilateral 6-hydroxydopamine or kainic acid-induced Pharmacology, Biochemistry and Behavior, 37 4, 755-759Sanberg P.;Zubrycki E.;Ragozzino M.;Lu S.;Norman A.;Shipley M. 01-01-1990. NADPH-Diaphorase-containing neurons and cytochrome oxidase activity following striatal quinolinic ac Progress in Brain Research, 82 C, 427-431Ford L.;Norman A.;Sanberg P. 01-01-1989. The topography of MK-801-induced locomotor patterns in rats Physiology and Behavior, 46 4, 755-758Ford L.;Sanberg P.;Norman A.;Fogelson M. 01-01-1989. Mk-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats Archives of Neurology, 46 10, 1090-1096Moss D.;Manderscheid P.;Montgomery S.;Norman A.;Sanberg P. 01-01-1989. Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of tourette syndrome and othe Life Sciences, 44 21, 1521-1525Norman A.;Eubanks J.;Creese I. 01-01-1989. Irreversible and quaternary muscarinic antagonists discriminate multiple muscarinic receptor binding Journal of Pharmacology and Experimental Therapeutics, 248 3, 1116-1122Norman A.;Giordano M.;Sanberg P. 01-01-1989. Fetal striatal tissue grafts into excitotoxin-lesioned striatum: Pharmacological and behavioral aspe Pharmacology, Biochemistry and Behavior, 34 1, 139-147Norman A.;Lehman M.;Sanberg P. 01-01-1989. Functional effects of fetal striatal transplants Brain Research Bulletin, 22 1, 163-172Norman A.;Nash D.;Sanberg P. 01-01-1989. [<sup>3</sup>H]lysergic acid diethylamide (LSD): differential agonist and antagonist bin Neurochemistry International, 14 4, 497-504Norman A.;Wachendorf T.;Sanberg P. 01-01-1989. Differential effect of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on [<sup>3</su Life Sciences, 44 13, 831-836Norman A.B.;Borchers M.T.;Wachendorf T.J.;Price A.L.;Sanberg P.R. 01-01-1989. Loss of D<inf>1</inf> and D<inf>2</inf> dopamine receptors and muscarinic ch Brain Research Bulletin, 22 4, 633-636Sanberg P.;Calderon S.;Giordano M.;Tew J.;Norman A. 01-01-1989. The quinolinic acid model of Huntington's disease: Locomotor abnormalities Experimental Neurology, 105 1, 45-53Sanberg P.;McConville B.;Fogelson H.;Manderscheid P.;Parker K.;Blythe M.;Klykylo W.;Norman A. 01-01-1989. Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome Biomedicine and Pharmacotherapy, 43 1, 19-23Weissman E.;B. Norman A.;Calderon S.;Zubrycki E.;El-etri M.;Shipley M.;Sanberg P. 01-01-1989. The effect of prenatal treatment with MPTP or MPP<sup>+</sup> on the development of dopa Pharmacology, Biochemistry and Behavior, 34 3, 545-551Hess E.J.;Norman A.B.;Creese I. 01-01-1988. Chronic treatment with dopamine receptor antagonists: Behavioral and pharmacologic effects on D<i Journal of Neuroscience, 8 7, 2361-2370Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. A novel rotational behavior model for assessing the restructuring of striatal dopamine effector syst Progress in Brain Research, 78 C, 61-67Norman A.;Calderon S.;Giordano M.;Sanberg P. 01-01-1988. Striatal tissue transplants attenuate apomorphine-induced rotational behavior in rats with unilatera Neuropharmacology, 27 3, 333-336Sanberg P.;Nash D.;Calderon S.;Giordano M.;Shipley M.;Norman A. 01-01-1988. Neural transplants disrupt the blood-brain barrier and allow peripherally acting drugs to exert a ce Experimental Neurology, 102 1, 149-152Sanberg P.;Norman A. 01-01-1988. Adrenal transplants for Huntington's disease? [8] Nature, 335 6186, 122Battaglia G.;Norman A.;Creese I. 01-01-1987. Differential serotonin<inf>2</inf>receptor recovery in mature and senescent rat brain af Journal of Pharmacology and Experimental Therapeutics, 243 1, 69-75Hess E.J.;Battaglia G.;Norman A.B.;Creese I. 01-01-1987. Differential modification of striatal D<inf>1</inf>dopamine receptors and effector moiet Molecular Pharmacology, 31 1, 50-57Norman A.B.;Battaglia G.;Creese I. 01-01-1987. Differential recovery rates of rat D<inf>2</inf> dopamine receptors as a function of agi Journal of Neuroscience, 7 5, 1484-1491Sanberg P.;Calderon S.;Garver D.;Norman A. 01-01-1987. Brain tissue transplants in an animal model of Huntington's disease Psychopharmacology Bulletin, 23 3, 476-482Battaglia G.;Norman A.B.;Hess E.J.;Creese I. 01-01-1986. Forskolin Potentiates the Stimulation of Rat Striatal Adenylate Cyclase Mediated by D?1 Dopamine Rec Journal of Neurochemistry, 46 4, 1180-1185Battaglia G.;Norman A.B.;Newton P.L.;Creese I. 01-01-1986. In Vitro and In Vivo Irreversible Blockade of Cortical S<inf>2</inf> Serotonin Receptors Journal of Neurochemistry, 46 2, 589-593Norman A.B.;Battaglia G.;Creese I. 01-01-1986. Regulation of putative muscarinic cholinergic receptor subtypes in rat brain Neurochemistry International, 9 2, 337-347Battaglia G.;Norman A.;Creese I. 01-01-1985. Forskolin effects on the stimulatory and inhibitory components of rat striatal adenylate cyclase Federation Proceedings, 44 3, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. Properties of<sup>3</sup>H-WB4101-labeled 5HT-1 receptors in rat brain Federation Proceedings, 44 4, Norman A.B.;Battaglia G.;Creese I. 01-01-1985. [<sup>3</sup>H]WB4101 labels the 5-HT(1A) serotonin receptor subtype in rat brain. Guani Molecular Pharmacology, 28 6, 487-494