Education/CredentialsPost Doctoral Fellowship: University of Illinois (The domain structure of apolipoprotein A-1)Doctorate: Medical College of Pennsylvania (now Drexel University) (BioChemistry, "High density lipoprotein composition and cellular cholesterol efflux")B.S.: Indiana University (Biochemistry, Minor in Biology) Contact Information Office 513-558-3707 Email davidswm@ucmail.uc.edu Research InterestsThe mission of my laboratory is to determine the molecular basis underlying the protective effect of high density lipoproteins (HDL) against inflammation and atherosclerosis. We use a wide range of techniques spanning biophysical chemistry, molecular biology, and cell biology to understand: 1) the structural organization of the major HDL apolipoproteins and their transitions in response to lipid, 2) the molecular details of HDL interactions with cell surface receptors and transporters, 3) the protei... Peer Reviewed Publications Davidson, W Sean; Cooke, Allison L; Swertfeger, Debi K; Shah, Amy S 2021. The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes. Current atherosclerosis reports, 23 6, 23Bedi, Shimpi; Garcia, Erwin; Jeyarajah, Elias J; Shalaurova, Irina; Perez-Matos, Maria Camila; Jiang, Z Gordon; Dullaart, Robin P F; Matyus, Steven P; Kirk, William J; Otvos, James D; Davidson, W Sean; Connelly, Margery A 2020. Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay. Journal of clinical medicine, 9 9, Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251He, Yi; Ronsein, Graziella E; Tang, Chongren; Jarvik, Gail P; Davidson, W Sean; Kothari, Vishal; Song, Hyun D; Segrest, Jere P; Bornfeldt, Karin E; Heinecke, Jay W 2020. Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles. Circulation research, 127 9, 1198-1210Sacks, Frank M; Liang, Liang; Furtado, Jeremy D; Cai, Tianxi; Davidson, W Sean; He, Zeling; McClelland, Robyn L; Rimm, Eric B; Jensen, Majken K 2020. Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. Arteriosclerosis, thrombosis, and vascular biology, 40 11, 2714-2727Yelamanchili, Dedipya; Liu, Jing; Gotto, Antonio M; Hurley, Ayrea E; Lagor, Willam R; Gillard, Baiba K; Davidson, W Sean; Pownall, Henry J; Rosales, Corina 2020. Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 12, 158794Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, May-Zhang, Linda S; Yermalitsky, Valery; Melchior, John T; Morris, Jamie; Tallman, Keri A; Borja, Mark S; Pleasent, Tiffany; Amarnath, Venkataraman; Song, Wenliang; Yancey, Patricia G; Davidson, W Sean; Linton, MacRae F; Davies, Sean S 2019. Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia. The Journal of biological chemistry, 294 50, 19022-19033Rodriguez, Annabelle; Trigatti, Bernardo L; Mineo, Chieko; Knaack, Darcy; Wilkins, John T; Sahoo, Daisy; Asztalos, Bela F; Mora, Samia; Cuchel, Marina; Pownall, Henry J; Rosales, Corina; Bernatchez, Pascal; Ribeiro Martins da Silva, Amanda; Getz, Godfrey S; Barber, Jacob L; Shearer, Gregory C; Zivkovic, Angela M; Tietge, Uwe J F; Sacks, Frank M; Connelly, Margery A; Oda, Michael N; Davidson, W Sean; Sorci-Thomas, Mary G; Vaisar, Tomas; Ruotolo, Giacomo; Vickers, Kasey C; Martel, Catherine 2019. Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology, 39 12, 2457-2467Shao, Baohai; Zelnick, Leila R; Wimberger, Jake; Himmelfarb, Jonathan; Brunzell, John; Davidson, W Sean; Snell-Bergeon, Janet K; Bornfeldt, Karin E; de Boer, Ian H; Heinecke, Jay W 2019. Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus. Arteriosclerosis, thrombosis, and vascular biology, 39 7, 1483-1491Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean 2018. A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. Journal of lipid research, 59 7, 1244-1255Furtado, Jeremy D; Yamamoto, Rain; Melchior, John T; Andraski, Allison B; Gamez-Guerrero, Maria; Mulcahy, Patrick; He, Zeling; Cai, Tianxi; Davidson, W Sean; Sacks, Frank M 2018. Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies. Arteriosclerosis, thrombosis, and vascular biology, 38 12, 2827-2842Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang 2018. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nature communications, 9 1, 700Lima, Diogo B; Melchior, John T; Morris, Jamie; Barbosa, Valmir C; Chamot-Rooke, Julia; Fioramonte, Mariana; Souza, Tatiana A C B; Fischer, Juliana S G; Gozzo, Fabio C; Carvalho, Paulo C; Davidson, W Sean 2018. Characterization of homodimer interfaces with cross-linking mass spectrometry and isotopically labeled proteins. Nature protocols, 13 3, 431-458Rebholz, Sandra L; Melchior, John T; Davidson, W Sean; Jones, Helen N; Welge, Jeffrey A; Prentice, Andrew M; Moore, Sophie E; Woollett, Laura A 2018. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32 2, 717-727Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds ?IIb?3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S 2017. Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. International journal of obesity (2005), 41 1, 83-89Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Dolan, Lawrence M; Gordon, Scott M; Otvos, James D; Melchior, John T; Elder, Deborah A; Khoury, Jane; Geh, Esmond; Shah, Amy S 2017. Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease. Journal of lipid research, 58 9, 1916-1923Melchior, John T; Street, Scott E; Andraski, Allison B; Furtado, Jeremy D; Sacks, Frank M; Shute, Rebecca L; Greve, Emily I; Swertfeger, Debi K; Li, Hailong; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2017. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1. Journal of lipid research, 58 7, 1374-1385Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean 2017. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nature structural & molecular biology, 24 12, 1093-1099Rebholz, Sandra L; Melchior, John T; Welge, Jeffrey A; Remaley, Alan T; Davidson, W Sean; Woollett, Laura A 2017. Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes. Journal of clinical and laboratory medicine, 2 1, Rueda, Cesar M; Rodríguez-Perea, Ana Lucia; Moreno-Fernandez, Maria; Jackson, Courtney M; Melchior, John T; Davidson, W Sean; Chougnet, Claire A 2017. High density lipoproteins selectively promote the survival of human regulatory T cells. Journal of lipid research, 58 8, 1514-1523Swertfeger, Debi K; Li, Hailong; Rebholz, Sandra; Zhu, Xiaoting; Shah, Amy S; Davidson, W Sean; Lu, Long J 2017. Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma. Molecular & cellular proteomics : MCP, 16 4, 680-693Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Melchior, John T; Gordon, Scott M; Kuklenyik, Zsuzsanna; Woollett, Laura; Barr, John R; Jones, Jeffrey I; Toth, Christopher A; Shah, Amy S 2016. The effects of apolipoprotein B depletion on HDL subspecies composition and function. Journal of lipid research, 57 4, 674-86Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2016. Erratum. The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth. Diabetes 2013;62:2958-2967. Diabetes, 65 7, 2100Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean 2016. An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. The Journal of biological chemistry, 291 10, 5439-51Rosales, C; Davidson, W S; Gillard, B K; Gotto, A M; Pownall, H J 2016. Speciated High-Density Lipoprotein Biogenesis and Functionality. Current atherosclerosis reports, 18 5, 25Walsh, Kyle B; Hart, Kimberly; Roll, Susan; Sperling, Matthew; Unruh, Dusten; Davidson, W Sean; Lindsell, Christopher J; Adeoye, Opeolu 2016. Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 25 6, 1360-5Correa, Katharina; Lhorente, Jean P; López, María E; Bassini, Liane; Naswa, Sudhir; Deeb, Nader; Di Genova, Alex; Maass, Alejandro; Davidson, William S; Yáñez, José M 2015. Genome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomes. BMC genomics, 16 1, 854Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gutierrez, Alejandro P; Yáñez, José M; Fukui, Steve; Swift, Bruce; Davidson, William S 2015. Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar). PloS one, 10 3, e0119730Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Lubieniecki, Krzysztof P; Botwright, Natasha A; Taylor, Richard S; Evans, Brad S; Cook, Mathew T; Davidson, William S 2015. Expression analysis of sex-determining pathway genes during development in male and female Atlantic salmon (Salmo salar). Physiological genomics, , physiolgenomics.0001Lubieniecki, Krzysztof P; Lin, Song; Cabana, Emily I; Li, Jieying; Lai, Yvonne Y Y; Davidson, William S 2015. Genomic Instability of the Sex-Determining Locus in Atlantic Salmon (Salmo salar). G3 (Bethesda, Md.), 5 11, 2513-22Moen, Thomas; Torgersen, Jacob; Santi, Nina; Davidson, William S; Baranski, Matthew; Ødegård, Jørgen; Kjøglum, Sissel; Velle, Bente; Kent, Matthew; Lubieniecki, Krzysztof P; Isdal, Eivind; Lien, Sigbjørn 2015. Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon. Genetics, 200 4, 1313-26Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick 2014. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. The Journal of biological chemistry, 289 4, 2396-404Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C 2014. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, , en20131846Tessarolo, Jordan A; Tabesh, Mohammad J; Nesbitt, Michael; Davidson, William S 2014. Genomic organization and evolution of the trace amine-associated receptor (TAAR) repertoire in Atlantic salmon (Salmo salar). G3 (Bethesda, Md.), 4 6, 1135-41Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean 2014. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. The Journal of biological chemistry, 289 9, 5596-608Davidson, W Sean 2013. A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement. Journal of lipid research, , Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B 2013. Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. The Journal of biological chemistry, 288 7, 4854-66Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2013. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes, 62 8, 2958-67Gordon, Scott M; Deng, Jingyuan; Tomann, Alex B; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2013. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies. Molecular & cellular proteomics : MCP, 12 11, 3123-34Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M 2013. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation, 128 22, 2364-71Nguyen, Andrew D; Nguyen, Thi A; Cenik, Basar; Yu, Gang; Herz, Joachim; Walther, Tobias C; Davidson, W Sean; Farese, Robert V 2013. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). The Journal of biological chemistry, 288 12, 8627-35Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee 2013. Xanthophylls, phytosterols and pre-?1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study. Lipids, 48 12, 1185-96Shah, Amy S; Tan, Lirong; Long, Jason Lu; Davidson, W Sean 2013. Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond. Journal of lipid research, 54 10, 2575-85Smith, Loren E; Segrest, Jere P; Davidson, W Sean 2013. Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II. Journal of lipid research, 54 7, 1939-48Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick 2013. Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect. Physiology & behavior, 120 , 136-42Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B 2012. Improving the diffraction of apoA-IV crystals through extreme dehydration. Acta crystallographica. Section F, Structural biology and crystallization communications, 68 Pt 1, 105-10Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B 2012. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure (London, England : 1993), 20 5, 767-79Gordon, Scott M; Davidson, William S 2012. Apolipoprotein A-I mimetics and high-density lipoprotein function. Current opinion in endocrinology, diabetes, and obesity, 19 2, 109-14Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M 2012. CNS regulation of plasma cholesterol. Annals of medicine, 44 7, 656-63Rosenson, Robert S; Brewer, H Bryan; Davidson, W Sean; Fayad, Zahi A; Fuster, Valentin; Goldstein, James; Hellerstein, Marc; Jiang, Xian-Cheng; Phillips, Michael C; Rader, Daniel J; Remaley, Alan T; Rothblat, George H; Tall, Alan R; Yvan-Charvet, Laurent 2012. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation, 125 15, 1905-19Smith, Loren E; Yang, Jun; Goodman, Leah; Huang, Xinqi; Huang, Rong; Dressman, James; Morris, Jamie; Silva, R A Gangani D; Davidson, W Sean; Cavigiolio, Giorgio 2012. High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli. Journal of lipid research, 53 8, 1708-15Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick 2012. Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proceedings of the National Academy of Sciences of the United States of America, 109 24, 9641-6Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y 2011. Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. The Journal of biological chemistry, , Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean 2011. High density lipoprotein: it's not just about lipid transport anymore. Trends in endocrinology and metabolism: TEM, 22 1, 9-15Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean 2011. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nature structural & molecular biology, , Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean 2010. Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography. Journal of proteome research, 9 10, 5239-49Gordon, Scott; Durairaj, Anita; Lu, Jason L; Davidson, W Sean 2010. High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality. Current cardiovascular risk reports, 4 1, 1-8Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H 2010. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature neuroscience, 13 7, 877-82Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min 2010. Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology, 151 7, 3163-8Smith, Loren E; Davidson, W Sean 2010. The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux. Biochimica et biophysica acta, 1801 1, 64-9Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol 2009. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arteriosclerosis, thrombosis, and vascular biology, 29 6, 870-6Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick 2009. Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. American journal of physiology. Regulatory, integrative and comparative physiology, 296 1, R43-50Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min 2009. Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiology & behavior, 98 1-2, 223-8Tubb, Matthew R; Smith, Loren E; Davidson, W Sean 2009. Purification of recombinant apolipoproteins A-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease. Journal of lipid research, 50 7, 1497-504Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Oram, John F; Wolfbauer, Gertrud; Tang, Chongren; Davidson, W Sean; Albers, John J 2008. An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. The Journal of biological chemistry, 283 17, 11541-9Sethi, Amar A; Stonik, John A; Thomas, Fairwell; Demosky, Steve J; Amar, Marcelo; Neufeld, Edward; Brewer, H Bryan; Davidson, W Sean; D'Souza, Wilissa; Sviridov, Dmitri; Remaley, Alan T 2008. Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. The Journal of biological chemistry, 283 47, 32273-82Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiology & behavior, 95 1-2, 161-7Silva, R A Gangani D; Huang, Rong; Morris, Jamie; Fang, Jianwen; Gracheva, Elena O; Ren, Gang; Kontush, Anatol; Jerome, W Gray; Rye, Kerry-Anne; Davidson, W Sean 2008. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proceedings of the National Academy of Sciences of the United States of America, 105 34, 12176-81Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean 2008. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. The Journal of biological chemistry, 283 25, 17314-23Davidson, W Sean; Thompson, Thomas B 2007. The structure of apolipoprotein A-I in high density lipoproteins. The Journal of biological chemistry, 282 31, 22249-53Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology, 148 6, 2681-9Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean 2007. The structure of apolipoprotein A-II in discoidal high density lipoproteins. The Journal of biological chemistry, 282 13, 9713-21Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean 2007. Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. The Journal of biological chemistry, 282 39, 28385-94Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C 2007. ABCA1-induced cell surface binding sites for ApoA-I. Arteriosclerosis, thrombosis, and vascular biology, 27 7, 1603-9Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin 2006. The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins. Journal of lipid research, 47 2, 440-9Ghering, Amy B; Davidson, W Sean 2006. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. Journal of lipid research, 47 12, 2781-8Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Davidson, W Sean; Silva, R A Gangani D 2005. Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Current opinion in lipidology, 16 3, 295-300Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y 2005. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. The Journal of biological chemistry, 280 46, 38592-8Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. The Journal of biological chemistry, 280 46, 38576-82Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean 2005. A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading. Biochemistry, 44 8, 2759-69Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean 2005. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins. Biochemistry, 44 24, 8600-7Davidson, W Sean 2004. 5th Annual International Conference on HDL Cholesterol: metabolic pathways and drug developments. Expert opinion on therapeutic targets, 8 4, 359-66Maiorano, J Nicholas; Jandacek, Ronald J; Horace, Erica M; Davidson, W Sean 2004. Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size. Biochemistry, 43 37, 11717-26Narayanaswami, Vasanthy; Maiorano, J Nicholas; Dhanasekaran, Padmaja; Ryan, Robert O; Phillips, Michael C; Lund-Katz, Sissel; Davidson, W Sean 2004. Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. The Journal of biological chemistry, 279 14, 14273-9Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean 2004. Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Davidson, W Sean; Hilliard, George M 2003. The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study. The Journal of biological chemistry, 278 29, 27199-207Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2003. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. The Journal of biological chemistry, 278 41, 40121-7Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean 2002. The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1. The Journal of biological chemistry, 277 42, 39477-84Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S 2002. Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. The Journal of biological chemistry, 277 12, 9645-54Panagotopulos, S E; Horace, E M; Maiorano, J N; Davidson, W S 2001. Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins. The Journal of biological chemistry, 276 46, 42965-70Safi, W; Maiorano, J N; Davidson, W S 2001. A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I. Journal of lipid research, 42 5, 864-72Maiorano, J N; Davidson, W S 2000. The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins. The Journal of biological chemistry, 275 23, 17374-80Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A 1999. Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry, 38 43, 14387-95Woods, M O; Young, T L; Parfrey, P S; Hefferton, D; Green, J S; Davidson, W S 1999. Genetic heterogeneity of Bardet-Biedl syndrome in a distinct Canadian population: evidence for a fifth locus. Genomics, 55 1, 2-9Davidson, W S; Jonas, A; Clayton, D F; George, J M 1998. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. The Journal of biological chemistry, 273 16, 9443-9Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1998. Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. Journal of lipid research, 39 10, 1918-28Davidson, W S; Hazlett, T; Mantulin, W W; Jonas, A 1996. The role of apolipoprotein AI domains in lipid binding. Proceedings of the National Academy of Sciences of the United States of America, 93 24, 13605-10Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1996. Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. The Journal of biological chemistry, 271 39, 23792-8Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S 1996. Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles. Lipids, 31 11, 1107-13McGuire, K A; Davidson, W S; Jonas, A 1996. High yield overexpression and characterization of human recombinant proapolipoprotein A-I. Journal of lipid research, 37 7, 1519-28Bruce, C; Davidson, W S; Kussie, P; Lund-Katz, S; Phillips, M C; Ghosh, R; Tall, A R 1995. Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins. The Journal of biological chemistry, 270 19, 11532-42Davidson, W S; Gillotte, K L; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 11, 5882-90Davidson, W S; Rodrigueza, W V; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. Effects of acceptor particle size on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 29, 17106-113Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1995. Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability. The Journal of biological chemistry, 270 45, 26910-7Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C 1994. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. The Journal of biological chemistry, 269 37, 22975-82Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C 1994. The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. The Journal of biological chemistry, 269 12, 8959-65McLean, L R; Hagaman, K A; Davidson, W S 1993. Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids. Lipids, 28 6, 505-9Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1993. Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles. The Journal of biological chemistry, 268 31, 23250-7McLean, L R; Hagaman, K A; Owen, T J; Payne, M H; Davidson, W S; Krstenansky, J L 1991. Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine. Biochimica et biophysica acta, 1086 1, 106-14Davidson, W Sean; Shah, Amy S . High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes. Methodist DeBakey cardiovascular journal, 15 1, 55-61Mythreye, Karthikeyan; Satterwhite, Lisa L; Davidson, W Sean; Goldschmidt-Clermont, Pascal J . ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. Biochimica et biophysica acta, 1781 11-12, 703-9Shah, Amy S; Davidson, W Sean; Gao, Zhiqian; Dolan, Lawrence M; Kimball, Thomas R; Urbina, Elaine M . Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes. Journal of clinical lipidology, 10 3, 610-8Swertfeger, Debi K; Rebholz, Sandra; Li, Hailong; Shah, Amy S; Davidson, William Sean; Lu, Long J . Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins. Journal of clinical lipidology, 12 6, 1539-1548Toth, Peter P; Barter, Philip J; Rosenson, Robert S; Boden, William E; Chapman, M John; Cuchel, Marina; D'Agostino, Ralph B; Davidson, Michael H; Davidson, W Sean; Heinecke, Jay W; Karas, Richard H; Kontush, Anatol; Krauss, Ronald M; Miller, Michael; Rader, Daniel J . High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of clinical lipidology, 7 5, 484-525
Research InterestsThe mission of my laboratory is to determine the molecular basis underlying the protective effect of high density lipoproteins (HDL) against inflammation and atherosclerosis. We use a wide range of techniques spanning biophysical chemistry, molecular biology, and cell biology to understand: 1) the structural organization of the major HDL apolipoproteins and their transitions in response to lipid, 2) the molecular details of HDL interactions with cell surface receptors and transporters, 3) the protei...
Peer Reviewed Publications Davidson, W Sean; Cooke, Allison L; Swertfeger, Debi K; Shah, Amy S 2021. The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes. Current atherosclerosis reports, 23 6, 23Bedi, Shimpi; Garcia, Erwin; Jeyarajah, Elias J; Shalaurova, Irina; Perez-Matos, Maria Camila; Jiang, Z Gordon; Dullaart, Robin P F; Matyus, Steven P; Kirk, William J; Otvos, James D; Davidson, W Sean; Connelly, Margery A 2020. Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay. Journal of clinical medicine, 9 9, Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251He, Yi; Ronsein, Graziella E; Tang, Chongren; Jarvik, Gail P; Davidson, W Sean; Kothari, Vishal; Song, Hyun D; Segrest, Jere P; Bornfeldt, Karin E; Heinecke, Jay W 2020. Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles. Circulation research, 127 9, 1198-1210Sacks, Frank M; Liang, Liang; Furtado, Jeremy D; Cai, Tianxi; Davidson, W Sean; He, Zeling; McClelland, Robyn L; Rimm, Eric B; Jensen, Majken K 2020. Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. Arteriosclerosis, thrombosis, and vascular biology, 40 11, 2714-2727Yelamanchili, Dedipya; Liu, Jing; Gotto, Antonio M; Hurley, Ayrea E; Lagor, Willam R; Gillard, Baiba K; Davidson, W Sean; Pownall, Henry J; Rosales, Corina 2020. Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 12, 158794Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, May-Zhang, Linda S; Yermalitsky, Valery; Melchior, John T; Morris, Jamie; Tallman, Keri A; Borja, Mark S; Pleasent, Tiffany; Amarnath, Venkataraman; Song, Wenliang; Yancey, Patricia G; Davidson, W Sean; Linton, MacRae F; Davies, Sean S 2019. Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia. The Journal of biological chemistry, 294 50, 19022-19033Rodriguez, Annabelle; Trigatti, Bernardo L; Mineo, Chieko; Knaack, Darcy; Wilkins, John T; Sahoo, Daisy; Asztalos, Bela F; Mora, Samia; Cuchel, Marina; Pownall, Henry J; Rosales, Corina; Bernatchez, Pascal; Ribeiro Martins da Silva, Amanda; Getz, Godfrey S; Barber, Jacob L; Shearer, Gregory C; Zivkovic, Angela M; Tietge, Uwe J F; Sacks, Frank M; Connelly, Margery A; Oda, Michael N; Davidson, W Sean; Sorci-Thomas, Mary G; Vaisar, Tomas; Ruotolo, Giacomo; Vickers, Kasey C; Martel, Catherine 2019. Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology, 39 12, 2457-2467Shao, Baohai; Zelnick, Leila R; Wimberger, Jake; Himmelfarb, Jonathan; Brunzell, John; Davidson, W Sean; Snell-Bergeon, Janet K; Bornfeldt, Karin E; de Boer, Ian H; Heinecke, Jay W 2019. Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus. Arteriosclerosis, thrombosis, and vascular biology, 39 7, 1483-1491Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean 2018. A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. Journal of lipid research, 59 7, 1244-1255Furtado, Jeremy D; Yamamoto, Rain; Melchior, John T; Andraski, Allison B; Gamez-Guerrero, Maria; Mulcahy, Patrick; He, Zeling; Cai, Tianxi; Davidson, W Sean; Sacks, Frank M 2018. Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies. Arteriosclerosis, thrombosis, and vascular biology, 38 12, 2827-2842Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang 2018. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nature communications, 9 1, 700Lima, Diogo B; Melchior, John T; Morris, Jamie; Barbosa, Valmir C; Chamot-Rooke, Julia; Fioramonte, Mariana; Souza, Tatiana A C B; Fischer, Juliana S G; Gozzo, Fabio C; Carvalho, Paulo C; Davidson, W Sean 2018. Characterization of homodimer interfaces with cross-linking mass spectrometry and isotopically labeled proteins. Nature protocols, 13 3, 431-458Rebholz, Sandra L; Melchior, John T; Davidson, W Sean; Jones, Helen N; Welge, Jeffrey A; Prentice, Andrew M; Moore, Sophie E; Woollett, Laura A 2018. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32 2, 717-727Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds ?IIb?3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S 2017. Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. International journal of obesity (2005), 41 1, 83-89Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Dolan, Lawrence M; Gordon, Scott M; Otvos, James D; Melchior, John T; Elder, Deborah A; Khoury, Jane; Geh, Esmond; Shah, Amy S 2017. Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease. Journal of lipid research, 58 9, 1916-1923Melchior, John T; Street, Scott E; Andraski, Allison B; Furtado, Jeremy D; Sacks, Frank M; Shute, Rebecca L; Greve, Emily I; Swertfeger, Debi K; Li, Hailong; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2017. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1. Journal of lipid research, 58 7, 1374-1385Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean 2017. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nature structural & molecular biology, 24 12, 1093-1099Rebholz, Sandra L; Melchior, John T; Welge, Jeffrey A; Remaley, Alan T; Davidson, W Sean; Woollett, Laura A 2017. Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes. Journal of clinical and laboratory medicine, 2 1, Rueda, Cesar M; Rodríguez-Perea, Ana Lucia; Moreno-Fernandez, Maria; Jackson, Courtney M; Melchior, John T; Davidson, W Sean; Chougnet, Claire A 2017. High density lipoproteins selectively promote the survival of human regulatory T cells. Journal of lipid research, 58 8, 1514-1523Swertfeger, Debi K; Li, Hailong; Rebholz, Sandra; Zhu, Xiaoting; Shah, Amy S; Davidson, W Sean; Lu, Long J 2017. Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma. Molecular & cellular proteomics : MCP, 16 4, 680-693Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Melchior, John T; Gordon, Scott M; Kuklenyik, Zsuzsanna; Woollett, Laura; Barr, John R; Jones, Jeffrey I; Toth, Christopher A; Shah, Amy S 2016. The effects of apolipoprotein B depletion on HDL subspecies composition and function. Journal of lipid research, 57 4, 674-86Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2016. Erratum. The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth. Diabetes 2013;62:2958-2967. Diabetes, 65 7, 2100Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean 2016. An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. The Journal of biological chemistry, 291 10, 5439-51Rosales, C; Davidson, W S; Gillard, B K; Gotto, A M; Pownall, H J 2016. Speciated High-Density Lipoprotein Biogenesis and Functionality. Current atherosclerosis reports, 18 5, 25Walsh, Kyle B; Hart, Kimberly; Roll, Susan; Sperling, Matthew; Unruh, Dusten; Davidson, W Sean; Lindsell, Christopher J; Adeoye, Opeolu 2016. Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 25 6, 1360-5Correa, Katharina; Lhorente, Jean P; López, María E; Bassini, Liane; Naswa, Sudhir; Deeb, Nader; Di Genova, Alex; Maass, Alejandro; Davidson, William S; Yáñez, José M 2015. Genome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomes. BMC genomics, 16 1, 854Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gutierrez, Alejandro P; Yáñez, José M; Fukui, Steve; Swift, Bruce; Davidson, William S 2015. Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar). PloS one, 10 3, e0119730Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Lubieniecki, Krzysztof P; Botwright, Natasha A; Taylor, Richard S; Evans, Brad S; Cook, Mathew T; Davidson, William S 2015. Expression analysis of sex-determining pathway genes during development in male and female Atlantic salmon (Salmo salar). Physiological genomics, , physiolgenomics.0001Lubieniecki, Krzysztof P; Lin, Song; Cabana, Emily I; Li, Jieying; Lai, Yvonne Y Y; Davidson, William S 2015. Genomic Instability of the Sex-Determining Locus in Atlantic Salmon (Salmo salar). G3 (Bethesda, Md.), 5 11, 2513-22Moen, Thomas; Torgersen, Jacob; Santi, Nina; Davidson, William S; Baranski, Matthew; Ødegård, Jørgen; Kjøglum, Sissel; Velle, Bente; Kent, Matthew; Lubieniecki, Krzysztof P; Isdal, Eivind; Lien, Sigbjørn 2015. Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon. Genetics, 200 4, 1313-26Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick 2014. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. The Journal of biological chemistry, 289 4, 2396-404Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C 2014. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, , en20131846Tessarolo, Jordan A; Tabesh, Mohammad J; Nesbitt, Michael; Davidson, William S 2014. Genomic organization and evolution of the trace amine-associated receptor (TAAR) repertoire in Atlantic salmon (Salmo salar). G3 (Bethesda, Md.), 4 6, 1135-41Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean 2014. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. The Journal of biological chemistry, 289 9, 5596-608Davidson, W Sean 2013. A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement. Journal of lipid research, , Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B 2013. Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. The Journal of biological chemistry, 288 7, 4854-66Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2013. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes, 62 8, 2958-67Gordon, Scott M; Deng, Jingyuan; Tomann, Alex B; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2013. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies. Molecular & cellular proteomics : MCP, 12 11, 3123-34Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M 2013. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation, 128 22, 2364-71Nguyen, Andrew D; Nguyen, Thi A; Cenik, Basar; Yu, Gang; Herz, Joachim; Walther, Tobias C; Davidson, W Sean; Farese, Robert V 2013. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). The Journal of biological chemistry, 288 12, 8627-35Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee 2013. Xanthophylls, phytosterols and pre-?1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study. Lipids, 48 12, 1185-96Shah, Amy S; Tan, Lirong; Long, Jason Lu; Davidson, W Sean 2013. Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond. Journal of lipid research, 54 10, 2575-85Smith, Loren E; Segrest, Jere P; Davidson, W Sean 2013. Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II. Journal of lipid research, 54 7, 1939-48Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick 2013. Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect. Physiology & behavior, 120 , 136-42Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B 2012. Improving the diffraction of apoA-IV crystals through extreme dehydration. Acta crystallographica. Section F, Structural biology and crystallization communications, 68 Pt 1, 105-10Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B 2012. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure (London, England : 1993), 20 5, 767-79Gordon, Scott M; Davidson, William S 2012. Apolipoprotein A-I mimetics and high-density lipoprotein function. Current opinion in endocrinology, diabetes, and obesity, 19 2, 109-14Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M 2012. CNS regulation of plasma cholesterol. Annals of medicine, 44 7, 656-63Rosenson, Robert S; Brewer, H Bryan; Davidson, W Sean; Fayad, Zahi A; Fuster, Valentin; Goldstein, James; Hellerstein, Marc; Jiang, Xian-Cheng; Phillips, Michael C; Rader, Daniel J; Remaley, Alan T; Rothblat, George H; Tall, Alan R; Yvan-Charvet, Laurent 2012. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation, 125 15, 1905-19Smith, Loren E; Yang, Jun; Goodman, Leah; Huang, Xinqi; Huang, Rong; Dressman, James; Morris, Jamie; Silva, R A Gangani D; Davidson, W Sean; Cavigiolio, Giorgio 2012. High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli. Journal of lipid research, 53 8, 1708-15Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick 2012. Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proceedings of the National Academy of Sciences of the United States of America, 109 24, 9641-6Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y 2011. Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. The Journal of biological chemistry, , Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean 2011. High density lipoprotein: it's not just about lipid transport anymore. Trends in endocrinology and metabolism: TEM, 22 1, 9-15Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean 2011. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nature structural & molecular biology, , Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean 2010. Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography. Journal of proteome research, 9 10, 5239-49Gordon, Scott; Durairaj, Anita; Lu, Jason L; Davidson, W Sean 2010. High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality. Current cardiovascular risk reports, 4 1, 1-8Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H 2010. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature neuroscience, 13 7, 877-82Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min 2010. Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology, 151 7, 3163-8Smith, Loren E; Davidson, W Sean 2010. The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux. Biochimica et biophysica acta, 1801 1, 64-9Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol 2009. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arteriosclerosis, thrombosis, and vascular biology, 29 6, 870-6Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick 2009. Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. American journal of physiology. Regulatory, integrative and comparative physiology, 296 1, R43-50Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min 2009. Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiology & behavior, 98 1-2, 223-8Tubb, Matthew R; Smith, Loren E; Davidson, W Sean 2009. Purification of recombinant apolipoproteins A-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease. Journal of lipid research, 50 7, 1497-504Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Oram, John F; Wolfbauer, Gertrud; Tang, Chongren; Davidson, W Sean; Albers, John J 2008. An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. The Journal of biological chemistry, 283 17, 11541-9Sethi, Amar A; Stonik, John A; Thomas, Fairwell; Demosky, Steve J; Amar, Marcelo; Neufeld, Edward; Brewer, H Bryan; Davidson, W Sean; D'Souza, Wilissa; Sviridov, Dmitri; Remaley, Alan T 2008. Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. The Journal of biological chemistry, 283 47, 32273-82Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiology & behavior, 95 1-2, 161-7Silva, R A Gangani D; Huang, Rong; Morris, Jamie; Fang, Jianwen; Gracheva, Elena O; Ren, Gang; Kontush, Anatol; Jerome, W Gray; Rye, Kerry-Anne; Davidson, W Sean 2008. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proceedings of the National Academy of Sciences of the United States of America, 105 34, 12176-81Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean 2008. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. The Journal of biological chemistry, 283 25, 17314-23Davidson, W Sean; Thompson, Thomas B 2007. The structure of apolipoprotein A-I in high density lipoproteins. The Journal of biological chemistry, 282 31, 22249-53Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology, 148 6, 2681-9Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean 2007. The structure of apolipoprotein A-II in discoidal high density lipoproteins. The Journal of biological chemistry, 282 13, 9713-21Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean 2007. Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. The Journal of biological chemistry, 282 39, 28385-94Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C 2007. ABCA1-induced cell surface binding sites for ApoA-I. Arteriosclerosis, thrombosis, and vascular biology, 27 7, 1603-9Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin 2006. The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins. Journal of lipid research, 47 2, 440-9Ghering, Amy B; Davidson, W Sean 2006. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. Journal of lipid research, 47 12, 2781-8Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Davidson, W Sean; Silva, R A Gangani D 2005. Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Current opinion in lipidology, 16 3, 295-300Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y 2005. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. The Journal of biological chemistry, 280 46, 38592-8Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. The Journal of biological chemistry, 280 46, 38576-82Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean 2005. A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading. Biochemistry, 44 8, 2759-69Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean 2005. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins. Biochemistry, 44 24, 8600-7Davidson, W Sean 2004. 5th Annual International Conference on HDL Cholesterol: metabolic pathways and drug developments. Expert opinion on therapeutic targets, 8 4, 359-66Maiorano, J Nicholas; Jandacek, Ronald J; Horace, Erica M; Davidson, W Sean 2004. Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size. Biochemistry, 43 37, 11717-26Narayanaswami, Vasanthy; Maiorano, J Nicholas; Dhanasekaran, Padmaja; Ryan, Robert O; Phillips, Michael C; Lund-Katz, Sissel; Davidson, W Sean 2004. Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. The Journal of biological chemistry, 279 14, 14273-9Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean 2004. Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Davidson, W Sean; Hilliard, George M 2003. The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study. The Journal of biological chemistry, 278 29, 27199-207Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2003. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. The Journal of biological chemistry, 278 41, 40121-7Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean 2002. The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1. The Journal of biological chemistry, 277 42, 39477-84Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S 2002. Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. The Journal of biological chemistry, 277 12, 9645-54Panagotopulos, S E; Horace, E M; Maiorano, J N; Davidson, W S 2001. Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins. The Journal of biological chemistry, 276 46, 42965-70Safi, W; Maiorano, J N; Davidson, W S 2001. A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I. Journal of lipid research, 42 5, 864-72Maiorano, J N; Davidson, W S 2000. The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins. The Journal of biological chemistry, 275 23, 17374-80Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A 1999. Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry, 38 43, 14387-95Woods, M O; Young, T L; Parfrey, P S; Hefferton, D; Green, J S; Davidson, W S 1999. Genetic heterogeneity of Bardet-Biedl syndrome in a distinct Canadian population: evidence for a fifth locus. Genomics, 55 1, 2-9Davidson, W S; Jonas, A; Clayton, D F; George, J M 1998. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. The Journal of biological chemistry, 273 16, 9443-9Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1998. Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. Journal of lipid research, 39 10, 1918-28Davidson, W S; Hazlett, T; Mantulin, W W; Jonas, A 1996. The role of apolipoprotein AI domains in lipid binding. Proceedings of the National Academy of Sciences of the United States of America, 93 24, 13605-10Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1996. Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. The Journal of biological chemistry, 271 39, 23792-8Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S 1996. Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles. Lipids, 31 11, 1107-13McGuire, K A; Davidson, W S; Jonas, A 1996. High yield overexpression and characterization of human recombinant proapolipoprotein A-I. Journal of lipid research, 37 7, 1519-28Bruce, C; Davidson, W S; Kussie, P; Lund-Katz, S; Phillips, M C; Ghosh, R; Tall, A R 1995. Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins. The Journal of biological chemistry, 270 19, 11532-42Davidson, W S; Gillotte, K L; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 11, 5882-90Davidson, W S; Rodrigueza, W V; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. Effects of acceptor particle size on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 29, 17106-113Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1995. Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability. The Journal of biological chemistry, 270 45, 26910-7Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C 1994. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. The Journal of biological chemistry, 269 37, 22975-82Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C 1994. The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. The Journal of biological chemistry, 269 12, 8959-65McLean, L R; Hagaman, K A; Davidson, W S 1993. Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids. Lipids, 28 6, 505-9Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1993. Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles. The Journal of biological chemistry, 268 31, 23250-7McLean, L R; Hagaman, K A; Owen, T J; Payne, M H; Davidson, W S; Krstenansky, J L 1991. Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine. Biochimica et biophysica acta, 1086 1, 106-14Davidson, W Sean; Shah, Amy S . High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes. Methodist DeBakey cardiovascular journal, 15 1, 55-61Mythreye, Karthikeyan; Satterwhite, Lisa L; Davidson, W Sean; Goldschmidt-Clermont, Pascal J . ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. Biochimica et biophysica acta, 1781 11-12, 703-9Shah, Amy S; Davidson, W Sean; Gao, Zhiqian; Dolan, Lawrence M; Kimball, Thomas R; Urbina, Elaine M . Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes. Journal of clinical lipidology, 10 3, 610-8Swertfeger, Debi K; Rebholz, Sandra; Li, Hailong; Shah, Amy S; Davidson, William Sean; Lu, Long J . Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins. Journal of clinical lipidology, 12 6, 1539-1548Toth, Peter P; Barter, Philip J; Rosenson, Robert S; Boden, William E; Chapman, M John; Cuchel, Marina; D'Agostino, Ralph B; Davidson, Michael H; Davidson, W Sean; Heinecke, Jay W; Karas, Richard H; Kontush, Anatol; Krauss, Ronald M; Miller, Michael; Rader, Daniel J . High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of clinical lipidology, 7 5, 484-525
Davidson, W Sean; Cooke, Allison L; Swertfeger, Debi K; Shah, Amy S 2021. The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes. Current atherosclerosis reports, 23 6, 23Bedi, Shimpi; Garcia, Erwin; Jeyarajah, Elias J; Shalaurova, Irina; Perez-Matos, Maria Camila; Jiang, Z Gordon; Dullaart, Robin P F; Matyus, Steven P; Kirk, William J; Otvos, James D; Davidson, W Sean; Connelly, Margery A 2020. Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay. Journal of clinical medicine, 9 9, Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean 2020. Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH. Journal of lipid research, 61 2, 244-251He, Yi; Ronsein, Graziella E; Tang, Chongren; Jarvik, Gail P; Davidson, W Sean; Kothari, Vishal; Song, Hyun D; Segrest, Jere P; Bornfeldt, Karin E; Heinecke, Jay W 2020. Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles. Circulation research, 127 9, 1198-1210Sacks, Frank M; Liang, Liang; Furtado, Jeremy D; Cai, Tianxi; Davidson, W Sean; He, Zeling; McClelland, Robyn L; Rimm, Eric B; Jensen, Majken K 2020. Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. Arteriosclerosis, thrombosis, and vascular biology, 40 11, 2714-2727Yelamanchili, Dedipya; Liu, Jing; Gotto, Antonio M; Hurley, Ayrea E; Lagor, Willam R; Gillard, Baiba K; Davidson, W Sean; Pownall, Henry J; Rosales, Corina 2020. Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 12, 158794Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C 2020. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology, 161 4, May-Zhang, Linda S; Yermalitsky, Valery; Melchior, John T; Morris, Jamie; Tallman, Keri A; Borja, Mark S; Pleasent, Tiffany; Amarnath, Venkataraman; Song, Wenliang; Yancey, Patricia G; Davidson, W Sean; Linton, MacRae F; Davies, Sean S 2019. Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia. The Journal of biological chemistry, 294 50, 19022-19033Rodriguez, Annabelle; Trigatti, Bernardo L; Mineo, Chieko; Knaack, Darcy; Wilkins, John T; Sahoo, Daisy; Asztalos, Bela F; Mora, Samia; Cuchel, Marina; Pownall, Henry J; Rosales, Corina; Bernatchez, Pascal; Ribeiro Martins da Silva, Amanda; Getz, Godfrey S; Barber, Jacob L; Shearer, Gregory C; Zivkovic, Angela M; Tietge, Uwe J F; Sacks, Frank M; Connelly, Margery A; Oda, Michael N; Davidson, W Sean; Sorci-Thomas, Mary G; Vaisar, Tomas; Ruotolo, Giacomo; Vickers, Kasey C; Martel, Catherine 2019. Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology, 39 12, 2457-2467Shao, Baohai; Zelnick, Leila R; Wimberger, Jake; Himmelfarb, Jonathan; Brunzell, John; Davidson, W Sean; Snell-Bergeon, Janet K; Bornfeldt, Karin E; de Boer, Ian H; Heinecke, Jay W 2019. Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus. Arteriosclerosis, thrombosis, and vascular biology, 39 7, 1483-1491Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean 2018. A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. Journal of lipid research, 59 7, 1244-1255Furtado, Jeremy D; Yamamoto, Rain; Melchior, John T; Andraski, Allison B; Gamez-Guerrero, Maria; Mulcahy, Patrick; He, Zeling; Cai, Tianxi; Davidson, W Sean; Sacks, Frank M 2018. Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies. Arteriosclerosis, thrombosis, and vascular biology, 38 12, 2827-2842Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang 2018. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nature communications, 9 1, 700Lima, Diogo B; Melchior, John T; Morris, Jamie; Barbosa, Valmir C; Chamot-Rooke, Julia; Fioramonte, Mariana; Souza, Tatiana A C B; Fischer, Juliana S G; Gozzo, Fabio C; Carvalho, Paulo C; Davidson, W Sean 2018. Characterization of homodimer interfaces with cross-linking mass spectrometry and isotopically labeled proteins. Nature protocols, 13 3, 431-458Rebholz, Sandra L; Melchior, John T; Davidson, W Sean; Jones, Helen N; Welge, Jeffrey A; Prentice, Andrew M; Moore, Sophie E; Woollett, Laura A 2018. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32 2, 717-727Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min 2018. Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. The Journal of biological chemistry, 293 6, 2091-2101Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu 2018. Apolipoprotein A-IV binds ?IIb?3 integrin and inhibits thrombosis. Nature communications, 9 1, 3608Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S 2017. Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. International journal of obesity (2005), 41 1, 83-89Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Dolan, Lawrence M; Gordon, Scott M; Otvos, James D; Melchior, John T; Elder, Deborah A; Khoury, Jane; Geh, Esmond; Shah, Amy S 2017. Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease. Journal of lipid research, 58 9, 1916-1923Melchior, John T; Street, Scott E; Andraski, Allison B; Furtado, Jeremy D; Sacks, Frank M; Shute, Rebecca L; Greve, Emily I; Swertfeger, Debi K; Li, Hailong; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2017. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1. Journal of lipid research, 58 7, 1374-1385Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean 2017. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nature structural & molecular biology, 24 12, 1093-1099Rebholz, Sandra L; Melchior, John T; Welge, Jeffrey A; Remaley, Alan T; Davidson, W Sean; Woollett, Laura A 2017. Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes. Journal of clinical and laboratory medicine, 2 1, Rueda, Cesar M; Rodríguez-Perea, Ana Lucia; Moreno-Fernandez, Maria; Jackson, Courtney M; Melchior, John T; Davidson, W Sean; Chougnet, Claire A 2017. High density lipoproteins selectively promote the survival of human regulatory T cells. Journal of lipid research, 58 8, 1514-1523Swertfeger, Debi K; Li, Hailong; Rebholz, Sandra; Zhu, Xiaoting; Shah, Amy S; Davidson, W Sean; Lu, Long J 2017. Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma. Molecular & cellular proteomics : MCP, 16 4, 680-693Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Melchior, John T; Gordon, Scott M; Kuklenyik, Zsuzsanna; Woollett, Laura; Barr, John R; Jones, Jeffrey I; Toth, Christopher A; Shah, Amy S 2016. The effects of apolipoprotein B depletion on HDL subspecies composition and function. Journal of lipid research, 57 4, 674-86Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2016. Erratum. The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth. Diabetes 2013;62:2958-2967. Diabetes, 65 7, 2100Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. Journal of proteomics, 146 , 184-94Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean 2016. An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. The Journal of biological chemistry, 291 10, 5439-51Rosales, C; Davidson, W S; Gillard, B K; Gotto, A M; Pownall, H J 2016. Speciated High-Density Lipoprotein Biogenesis and Functionality. Current atherosclerosis reports, 18 5, 25Walsh, Kyle B; Hart, Kimberly; Roll, Susan; Sperling, Matthew; Unruh, Dusten; Davidson, W Sean; Lindsell, Christopher J; Adeoye, Opeolu 2016. Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 25 6, 1360-5Correa, Katharina; Lhorente, Jean P; López, María E; Bassini, Liane; Naswa, Sudhir; Deeb, Nader; Di Genova, Alex; Maass, Alejandro; Davidson, William S; Yáñez, José M 2015. Genome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomes. BMC genomics, 16 1, 854Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2015. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. Journal of proteome research, 14 6, 2686-95Gutierrez, Alejandro P; Yáñez, José M; Fukui, Steve; Swift, Bruce; Davidson, William S 2015. Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar). PloS one, 10 3, e0119730Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S 2015. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. Journal of proteome research, 14 7, 2943-50Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean 2015. Structure of HDL: particle subclasses and molecular components. Handbook of experimental pharmacology, 224 , 3-51Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason 2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. Journal of proteome research, 14 8, 3082-94Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick 2015. Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. PloS one, 10 11, e0142098Lubieniecki, Krzysztof P; Botwright, Natasha A; Taylor, Richard S; Evans, Brad S; Cook, Mathew T; Davidson, William S 2015. Expression analysis of sex-determining pathway genes during development in male and female Atlantic salmon (Salmo salar). Physiological genomics, , physiolgenomics.0001Lubieniecki, Krzysztof P; Lin, Song; Cabana, Emily I; Li, Jieying; Lai, Yvonne Y Y; Davidson, William S 2015. Genomic Instability of the Sex-Determining Locus in Atlantic Salmon (Salmo salar). G3 (Bethesda, Md.), 5 11, 2513-22Moen, Thomas; Torgersen, Jacob; Santi, Nina; Davidson, William S; Baranski, Matthew; Ødegård, Jørgen; Kjøglum, Sissel; Velle, Bente; Kent, Matthew; Lubieniecki, Krzysztof P; Isdal, Eivind; Lien, Sigbjørn 2015. Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon. Genetics, 200 4, 1313-26Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Davidson, W Sean 2014. HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease. Clinical chemistry, 60 11, e1-3Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick 2014. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. The Journal of biological chemistry, 289 4, 2396-404Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C 2014. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, , en20131846Tessarolo, Jordan A; Tabesh, Mohammad J; Nesbitt, Michael; Davidson, William S 2014. Genomic organization and evolution of the trace amine-associated receptor (TAAR) repertoire in Atlantic salmon (Salmo salar). G3 (Bethesda, Md.), 4 6, 1135-41Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean 2014. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. The Journal of biological chemistry, 289 9, 5596-608Davidson, W Sean 2013. A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement. Journal of lipid research, , Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B 2013. Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. The Journal of biological chemistry, 288 7, 4854-66Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S 2013. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes, 62 8, 2958-67Gordon, Scott M; Deng, Jingyuan; Tomann, Alex B; Shah, Amy S; Lu, L Jason; Davidson, W Sean 2013. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies. Molecular & cellular proteomics : MCP, 12 11, 3123-34Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M 2013. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation, 128 22, 2364-71Nguyen, Andrew D; Nguyen, Thi A; Cenik, Basar; Yu, Gang; Herz, Joachim; Walther, Tobias C; Davidson, W Sean; Farese, Robert V 2013. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). The Journal of biological chemistry, 288 12, 8627-35Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee 2013. Xanthophylls, phytosterols and pre-?1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study. Lipids, 48 12, 1185-96Shah, Amy S; Tan, Lirong; Long, Jason Lu; Davidson, W Sean 2013. Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond. Journal of lipid research, 54 10, 2575-85Smith, Loren E; Segrest, Jere P; Davidson, W Sean 2013. Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II. Journal of lipid research, 54 7, 1939-48Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick 2013. Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect. Physiology & behavior, 120 , 136-42Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B 2012. Improving the diffraction of apoA-IV crystals through extreme dehydration. Acta crystallographica. Section F, Structural biology and crystallization communications, 68 Pt 1, 105-10Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B 2012. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure (London, England : 1993), 20 5, 767-79Gordon, Scott M; Davidson, William S 2012. Apolipoprotein A-I mimetics and high-density lipoprotein function. Current opinion in endocrinology, diabetes, and obesity, 19 2, 109-14Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M 2012. CNS regulation of plasma cholesterol. Annals of medicine, 44 7, 656-63Rosenson, Robert S; Brewer, H Bryan; Davidson, W Sean; Fayad, Zahi A; Fuster, Valentin; Goldstein, James; Hellerstein, Marc; Jiang, Xian-Cheng; Phillips, Michael C; Rader, Daniel J; Remaley, Alan T; Rothblat, George H; Tall, Alan R; Yvan-Charvet, Laurent 2012. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation, 125 15, 1905-19Smith, Loren E; Yang, Jun; Goodman, Leah; Huang, Xinqi; Huang, Rong; Dressman, James; Morris, Jamie; Silva, R A Gangani D; Davidson, W Sean; Cavigiolio, Giorgio 2012. High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli. Journal of lipid research, 53 8, 1708-15Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick 2012. Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proceedings of the National Academy of Sciences of the United States of America, 109 24, 9641-6Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y 2011. Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. The Journal of biological chemistry, , Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean 2011. High density lipoprotein: it's not just about lipid transport anymore. Trends in endocrinology and metabolism: TEM, 22 1, 9-15Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean 2011. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nature structural & molecular biology, , Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean 2010. Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography. Journal of proteome research, 9 10, 5239-49Gordon, Scott; Durairaj, Anita; Lu, Jason L; Davidson, W Sean 2010. High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality. Current cardiovascular risk reports, 4 1, 1-8Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H 2010. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature neuroscience, 13 7, 877-82Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min 2010. Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology, 151 7, 3163-8Smith, Loren E; Davidson, W Sean 2010. The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux. Biochimica et biophysica acta, 1801 1, 64-9Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol 2009. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arteriosclerosis, thrombosis, and vascular biology, 29 6, 870-6Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick 2009. Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. American journal of physiology. Regulatory, integrative and comparative physiology, 296 1, R43-50Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min 2009. Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiology & behavior, 98 1-2, 223-8Tubb, Matthew R; Smith, Loren E; Davidson, W Sean 2009. Purification of recombinant apolipoproteins A-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease. Journal of lipid research, 50 7, 1497-504Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Oram, John F; Wolfbauer, Gertrud; Tang, Chongren; Davidson, W Sean; Albers, John J 2008. An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. The Journal of biological chemistry, 283 17, 11541-9Sethi, Amar A; Stonik, John A; Thomas, Fairwell; Demosky, Steve J; Amar, Marcelo; Neufeld, Edward; Brewer, H Bryan; Davidson, W Sean; D'Souza, Wilissa; Sviridov, Dmitri; Remaley, Alan T 2008. Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. The Journal of biological chemistry, 283 47, 32273-82Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiology & behavior, 95 1-2, 161-7Silva, R A Gangani D; Huang, Rong; Morris, Jamie; Fang, Jianwen; Gracheva, Elena O; Ren, Gang; Kontush, Anatol; Jerome, W Gray; Rye, Kerry-Anne; Davidson, W Sean 2008. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proceedings of the National Academy of Sciences of the United States of America, 105 34, 12176-81Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean 2008. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. The Journal of biological chemistry, 283 25, 17314-23Davidson, W Sean; Thompson, Thomas B 2007. The structure of apolipoprotein A-I in high density lipoproteins. The Journal of biological chemistry, 282 31, 22249-53Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology, 148 6, 2681-9Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean 2007. The structure of apolipoprotein A-II in discoidal high density lipoproteins. The Journal of biological chemistry, 282 13, 9713-21Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean 2007. Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. The Journal of biological chemistry, 282 39, 28385-94Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C 2007. ABCA1-induced cell surface binding sites for ApoA-I. Arteriosclerosis, thrombosis, and vascular biology, 27 7, 1603-9Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin 2006. The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins. Journal of lipid research, 47 2, 440-9Ghering, Amy B; Davidson, W Sean 2006. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. Journal of lipid research, 47 12, 2781-8Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7Davidson, W Sean; Silva, R A Gangani D 2005. Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Current opinion in lipidology, 16 3, 295-300Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y 2005. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. The Journal of biological chemistry, 280 46, 38592-8Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean 2005. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. The Journal of biological chemistry, 280 46, 38576-82Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean 2005. A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading. Biochemistry, 44 8, 2759-69Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean 2005. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins. Biochemistry, 44 24, 8600-7Davidson, W Sean 2004. 5th Annual International Conference on HDL Cholesterol: metabolic pathways and drug developments. Expert opinion on therapeutic targets, 8 4, 359-66Maiorano, J Nicholas; Jandacek, Ronald J; Horace, Erica M; Davidson, W Sean 2004. Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size. Biochemistry, 43 37, 11717-26Narayanaswami, Vasanthy; Maiorano, J Nicholas; Dhanasekaran, Padmaja; Ryan, Robert O; Phillips, Michael C; Lund-Katz, Sissel; Davidson, W Sean 2004. Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. The Journal of biological chemistry, 279 14, 14273-9Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean 2004. Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry, 43 33, 10719-29Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J 2004. Apolipoprotein A-IV inhibits experimental colitis. The Journal of clinical investigation, 114 2, 260-9Davidson, W Sean; Hilliard, George M 2003. The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study. The Journal of biological chemistry, 278 29, 27199-207Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A 2003. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. Journal of lipid research, 44 10, 1909-18Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2003. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. The Journal of biological chemistry, 278 41, 40121-7Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean 2002. The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1. The Journal of biological chemistry, 277 42, 39477-84Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S 2002. Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. The Journal of biological chemistry, 277 12, 9645-54Panagotopulos, S E; Horace, E M; Maiorano, J N; Davidson, W S 2001. Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins. The Journal of biological chemistry, 276 46, 42965-70Safi, W; Maiorano, J N; Davidson, W S 2001. A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I. Journal of lipid research, 42 5, 864-72Maiorano, J N; Davidson, W S 2000. The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins. The Journal of biological chemistry, 275 23, 17374-80Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A 1999. Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry, 38 43, 14387-95Woods, M O; Young, T L; Parfrey, P S; Hefferton, D; Green, J S; Davidson, W S 1999. Genetic heterogeneity of Bardet-Biedl syndrome in a distinct Canadian population: evidence for a fifth locus. Genomics, 55 1, 2-9Davidson, W S; Jonas, A; Clayton, D F; George, J M 1998. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. The Journal of biological chemistry, 273 16, 9443-9Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1998. Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. Journal of lipid research, 39 10, 1918-28Davidson, W S; Hazlett, T; Mantulin, W W; Jonas, A 1996. The role of apolipoprotein AI domains in lipid binding. Proceedings of the National Academy of Sciences of the United States of America, 93 24, 13605-10Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C 1996. Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. The Journal of biological chemistry, 271 39, 23792-8Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S 1996. Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles. Lipids, 31 11, 1107-13McGuire, K A; Davidson, W S; Jonas, A 1996. High yield overexpression and characterization of human recombinant proapolipoprotein A-I. Journal of lipid research, 37 7, 1519-28Bruce, C; Davidson, W S; Kussie, P; Lund-Katz, S; Phillips, M C; Ghosh, R; Tall, A R 1995. Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins. The Journal of biological chemistry, 270 19, 11532-42Davidson, W S; Gillotte, K L; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 11, 5882-90Davidson, W S; Rodrigueza, W V; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C 1995. Effects of acceptor particle size on the efflux of cellular free cholesterol. The Journal of biological chemistry, 270 29, 17106-113Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1995. Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability. The Journal of biological chemistry, 270 45, 26910-7Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C 1994. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. The Journal of biological chemistry, 269 37, 22975-82Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C 1994. The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. The Journal of biological chemistry, 269 12, 8959-65McLean, L R; Hagaman, K A; Davidson, W S 1993. Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids. Lipids, 28 6, 505-9Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C 1993. Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles. The Journal of biological chemistry, 268 31, 23250-7McLean, L R; Hagaman, K A; Owen, T J; Payne, M H; Davidson, W S; Krstenansky, J L 1991. Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine. Biochimica et biophysica acta, 1086 1, 106-14Davidson, W Sean; Shah, Amy S . High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes. Methodist DeBakey cardiovascular journal, 15 1, 55-61Mythreye, Karthikeyan; Satterwhite, Lisa L; Davidson, W Sean; Goldschmidt-Clermont, Pascal J . ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. Biochimica et biophysica acta, 1781 11-12, 703-9Shah, Amy S; Davidson, W Sean; Gao, Zhiqian; Dolan, Lawrence M; Kimball, Thomas R; Urbina, Elaine M . Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes. Journal of clinical lipidology, 10 3, 610-8Swertfeger, Debi K; Rebholz, Sandra; Li, Hailong; Shah, Amy S; Davidson, William Sean; Lu, Long J . Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins. Journal of clinical lipidology, 12 6, 1539-1548Toth, Peter P; Barter, Philip J; Rosenson, Robert S; Boden, William E; Chapman, M John; Cuchel, Marina; D'Agostino, Ralph B; Davidson, Michael H; Davidson, W Sean; Heinecke, Jay W; Karas, Richard H; Kontush, Anatol; Krauss, Ronald M; Miller, Michael; Rader, Daniel J . High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of clinical lipidology, 7 5, 484-525