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Paul Luethy

Associate Professor of Clinical-Affiliate

Pathology & Laboratory Medicine | College of Medicine

Education/Credentials
  • Fellowship: National Institutes of Health (Clinical and Public Health Microbiology)
  • Ph.D.: University of Texas Southwestern Medical Center (Molecular Microbiology)
  • B.S.: Michigan State University (Biochemistry and Molecular Biology)
Contact Information
Research Interests

My research focuses on evaluating novel microbiology and molecular technologies for diagnosing infectious diseases. These exciting advancements often allow us to provide results faster and more accurately than ever before, which can make a real difference in treatment. I’m passionate about understanding how these technologies affect disease management and enjoy collaborating with multidisciplinary teams to study their impact.

Peer Reviewed Publications

Mendoza, Lydia M; Mathison, Blaine; Rehman, Aliya; Luethy, Paul M 2026. The Brief Case: Tastes of travel-intestinal importation. Journal of clinical microbiology, 64 5, e0165525

Smith, Richard D; Luethy, Paul M; Kristie Johnson, J 2025. Evaluation of Group B Streptococcus culture processing using a commercial flocked swab with and without automated sample processing instrument. Microbiology spectrum, 13 8, e0124925

Smith, Richard D; Luethy, Paul M; Riedel, David J 2025. The Pink Road Less Traveled. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 81 4, 815-817

de Hoog, Sybren; Walsh, Thomas J; Ahmed, Sarah A; Alastruey-Izquierdo, Ana; Alexander, Barbara D; Arendrup, Maiken Cavling; Babady, Esther; Bai, Feng-Yan; Balada-Llasat, Joan-Miquel; Borman, Andrew; Chowdhary, Anuradha; Clark, Andrew; Colgrove, Robert C; Cornely, Oliver A; Dingle, Tanis C; Dufresne, Philippe J; Fuller, Jeff; Gangneux, Jean-Pierre; Gibas, Connie; Glasgow, Heather; Graser, Yvonne; Guillot, Jacques; Groll, Andreas H; Haase, Gerhard; Hanson, Kimberly; Harrington, Amanda; Hawksworth, David L; Hayden, Randall T; Hoenigl, Martin; Hubka, Vit; Johnson, Kristie; Kus, Julianne V; Li, Ruoyu; Meis, Jacques F; Lackner, Michaela; Lanternier, Fanny; Leal, Sixto M; Lee, Francesca; Lockhart, Shawn R; Luethy, Paul; Martin, Isabella; Kwon-Chung, Kyung J; Meyer, Wieland; Nguyen, M Hong; Ostrosky-Zeichner, Luis; Palavecino, Elizabeth; Pancholi, Preeti; Pappas, Peter G; Procop, Gary W; Redhead, Scott A; Rhoads, Daniel D; Riedel, Stefan; Stevens, Bryan; Sullivan, Kaede Ota; Vergidis, Paschalis; Roilides, Emmanuel; Seyedmousavi, Amir; Tao, Lili; Vicente, Vania A; Vitale, Roxana G; Wang, Qi-Ming; Wengenack, Nancy L; Westblade, Lars; Wiederhold, Nathan; White, Lewis; Wojewoda, Christina M; Zhang, Sean X 2024. Reply to Kidd et al., "Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion". Journal of clinical microbiology, 62 4, e0162523

Flores, Hannah; Luethy, Paul; Doub, James B 2024. Discordant Susceptibilities of Enterobacterales to Different Tetracycline Classes. Cureus, 16 12, e74917

Rodino, Kyle G; Luethy, Paul M; Abbott, April N; Bender, Jeffrey M; Eberly, Allison R; Gitman, Melissa; Leber, Amy; Dien Bard, Jennifer 2024. Defining the value of medical microbiology consultation. Journal of clinical microbiology, 62 10, e0035924

de Hoog, Sybren; Walsh, Thomas J; Ahmed, Sarah A; Alastruey-Izquierdo, Ana; Alexander, Barbara D; Arendrup, Maiken Cavling; Babady, Esther; Bai, Feng-Yan; Balada-Llasat, Joan-Miquel; Borman, Andrew; Chowdhary, Anuradha; Clark, Andrew; Colgrove, Robert C; Cornely, Oliver A; Dingle, Tanis C; Dufresne, Philippe J; Fuller, Jeff; Gangneux, Jean-Pierre; Gibas, Connie; Glasgow, Heather; Gräser, Yvonne; Guillot, Jacques; Groll, Andreas H; Haase, Gerhard; Hanson, Kimberly; Harrington, Amanda; Hawksworth, David L; Hayden, Randall T; Hoenigl, Martin; Hubka, Vit; Johnson, Kristie; Kus, Julianne V; Li, Ruoyu; Meis, Jacques F; Lackner, Michaela; Lanternier, Fanny; Leal, Sixto M; Lee, Francesca; Lockhart, Shawn R; Luethy, Paul; Martin, Isabella; Kwon-Chung, Kyung J; Meyer, Wieland; Nguyen, M Hong; Ostrosky-Zeichner, Luis; Palavecino, Elizabeth; Pancholi, Preeti; Pappas, Peter G; Procop, Gary W; Redhead, Scott A; Rhoads, Daniel D; Riedel, Stefan; Stevens, Bryan; Sullivan, Kaede Ota; Vergidis, Paschalis; Roilides, Emmanuel; Seyedmousavi, Amir; Tao, Lili; Vicente, Vania A; Vitale, Roxana G; Wang, Qi-Ming; Wengenack, Nancy L; Westblade, Lars; Wiederhold, Nathan; White, Lewis; Wojewoda, Christina M; Zhang, Sean X 2023. A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC. Journal of clinical microbiology, 61 11, e0087323

Heil, Emily L; Claeys, Kimberly C; Kline, Ellen G; Rogers, Tara M; Squires, Kevin M; Iovleva, Alina; Doi, Yohei; Banoub, Mary; Noval, Mandee M; Luethy, Paul M; Shields, Ryan K 2023. Early initiation of three-drug combinations for the treatment of carbapenem-resistant A. baumannii among COVID-19 patients. The Journal of antimicrobial chemotherapy, 78 4, 1034-1040

Luethy, Paul M 2023. Point-of-Care Testing for the Diagnosis of Fungal Infections: Current Testing Applications and Potential for the Future. Clinics in laboratory medicine, 43 2, 209-220

Putnam, Nicole E; Youn, Jung-Ho; Wallace, Meghan A; Luethy, Paul M; Burnham, Carey-Ann D; Butler-Wu, Susan; Dekker, John P; Lau, Anna F 2023. Comparative Evaluation of Current Biochemical-, Sequencing-, and Proteomic-Based Identification Methods for the Streptococcus bovis Group. Journal of clinical microbiology, 61 4, e0171222

Traver, Edward C; Saharia, Kapil; Luethy, Paul; Amoroso, Anthony 2023. Severe Infective Endocarditis Caused by Bartonella rochalimae. Emerging infectious diseases, 30 2, 394-396

McCarty, Todd P; Luethy, Paul M; Baddley, John W; Pappas, Peter G 2022. Clinical utility of antifungal susceptibility testing. JAC-antimicrobial resistance, 4 3, dlac067

Rice, Kathryn S; Luethy, Paul M 2022. Overprediction of Carbapenemase-Containing Isolates by an Automated AST Instrument's Computer Algorithm. The journal of applied laboratory medicine, 7 6, 1283-1289

Shishido, Akira A; Noe, Myint; Saharia, Kapil; Luethy, Paul 2022. Clinical impact of a metagenomic microbial plasma cell-free DNA next-generation sequencing assay on treatment decisions: a single-center retrospective study. BMC infectious diseases, 22 1, 372

Hardy, Naomi L; Luethy, Paul M 2021. Evaluation of Inappropriate COVID-19 RT-PCR Test Utilization at an Academic Medical Center. The journal of applied laboratory medicine, 6 6, 1484-1491

Harfouch, Omar; Luethy, Paul M; Noval, Mandee; Baghdadi, Jonathan D 2021. Wohlfahrtiimonas chitiniclastica Monomicrobial Bacteremia in a Homeless Man. Emerging infectious diseases, 27 12, 3195-3197

Hauser, Naomi; Kim, Justin J; Luethy, Paul M; Schmalzle, Sarah A; Bork, Jacqueline T 2021. Multicenter retrospective cohort study of the clinical significance of Staphylococcus lugdunensis isolated from a single blood culture set. Diagnostic microbiology and infectious disease, 99 3, 115261

Hauser, Naomi; Luethy, Paul M; Stamatos, Nicholas 2021. Listeria Meningitis: An Inconsistent Organism Causing an Inconsistent Disease. The American journal of medicine, 134 1, e64-e65

Luethy, Paul M; Johnson, J Kristie 2021. Comparison of Three Sample-to-Answer RT-PCR Testing Platforms for the Detection of SARS-CoV-2 RNA in Positive Nasopharyngeal and Nasal Swabs. The journal of applied laboratory medicine, 6 6, 1635-1639

Murphy, Colin; Fontaine, Magali; Luethy, Paul; McGann, Heather; Jackson, Bryon 2021. Blood usage at a large academic center in Maryland in relation to the COVID-19 pandemic in 2020. Transfusion, 61 7, 2075-2081

Patel, Ashka; Emerick, Michele; Cabunoc, Marie K; Williams, Michelle H; Preas, Michael Anne; Schrank, Gregory; Rabinowitz, Ronald; Luethy, Paul; Johnson, J Kristie; Leekha, Surbhi 2021. Rapid Spread and Control of Multidrug-Resistant Gram-Negative Bacteria in COVID-19 Patient Care Units. Emerging infectious diseases, 27 4, 1234-1237

Rebechi, Melanie T; Heil, Emily L; Luethy, Paul M; Schmalzle, Sarah A 2021. Streptococcus pyogenes Infective Endocarditis-Association With Injection Drug Use: Case Series and Review of the Literature. Open forum infectious diseases, 8 6, ofab240

Zhang, Sean X; Babady, N Esther; Hanson, Kimberly E; Harrington, Amanda T; Larkin, Paige M K; Leal, Sixto M; Luethy, Paul M; Martin, Isabella W; Pancholi, Preeti; Procop, Gary W; Riedel, Stefan; Seyedmousavi, Seyedmojtaba; Sullivan, Kaede V; Walsh, Thomas J; Lockhart, Shawn R 2021. Recognition of Diagnostic Gaps for Laboratory Diagnosis of Fungal Diseases: Expert Opinion from the Fungal Diagnostics Laboratories Consortium (FDLC). Journal of clinical microbiology, 59 7, e0178420

Hauser, Naomi; Luethy, Paul M; Rapaka, Rekha R 2020. An Immunocompromised Woman with a Brain Lesion. The American journal of medicine, 133 9, e516-e517

Kim, Justin J; Luethy, Paul M; Stashek, Kristen M; Koka, Rima; Mathur, Poonam 2020. Answer to June 2020 Photo Quiz. Journal of clinical microbiology, 58 6,

Kim, Justin J; Luethy, Paul M; Stashek, Kristen M; Koka, Rima; Mathur, Poonam 2020. Photo Quiz: An Elderly Leukemia Patient with Jaw Pain and Swelling and Subjective Fevers. Journal of clinical microbiology, 58 6,

Jakharia, Niyati; Hossain, Aneesha; Luethy, Paul; Riedel, David J 2019. 48-Year-Old Male With Febrile Neutropenia and Massive Hemolysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69 12, 2193-2194

Luethy, Paul M; Johnson, J Kristie 2019. The Use of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) for the Identification of Pathogens Causing Sepsis. The journal of applied laboratory medicine, 3 4, 675-685

Luethy, Paul M; Murphy, Sean C; Seilie, Annette M; Xie, Yingda L; Lau, Chuen-Yen; Tisdale, John F; Hsieh, Matthew M; Reinhardt, Jessica L; Lau, Anna F; Fahle, Gary A 2018. Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease. Malaria journal, 17 1, 23

Luethy, Paul M; Zelazny, Adrian M 2018. Rapid one-step extraction method for the identification of molds using MALDI-TOF MS. Diagnostic microbiology and infectious disease, 91 2, 130-135

Meisel, Jacquelyn S; Nasko, Daniel J; Brubach, Brian; Cepeda-Espinoza, Victoria; Chopyk, Jessica; Corrada-Bravo, Héctor; Fedarko, Marcus; Ghurye, Jay; Javkar, Kiran; Olson, Nathan D; Shah, Nidhi; Allard, Sarah M; Bazinet, Adam L; Bergman, Nicholas H; Brown, Alexis; Caporaso, J Gregory; Conlan, Sean; DiRuggiero, Jocelyne; Forry, Samuel P; Hasan, Nur A; Kralj, Jason; Luethy, Paul M; Milton, Donald K; Ondov, Brian D; Preheim, Sarah; Ratnayake, Shashikala; Rogers, Stephanie M; Rosovitz, M J; Sakowski, Eric G; Schliebs, Nils Oliver; Sommer, Daniel D; Ternus, Krista L; Uritskiy, Gherman; Zhang, Sean X; Pop, Mihai; Treangen, Todd J 2018. Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018. Microbiome, 6 1, 197

Hesse, Shayla E; Luethy, Paul M; Beigel, John H; Zelazny, Adrian M 2017. Penicillium citrinum: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity. Medical mycology case reports, 17 , 8-10

Luethy, Paul M; Huynh, Steven; Ribardo, Deborah A; Winter, Sebastian E; Parker, Craig T; Hendrixson, David R 2017. Microbiota-Derived Short-Chain Fatty Acids Modulate Expression of Campylobacter jejuni Determinants Required for Commensalism and Virulence. mBio, 8 3,

Luethy, Paul M; Huynh, Steven; Parker, Craig T; Hendrixson, David R 2015. Analysis of the activity and regulon of the two-component regulatory system composed by Cjj81176_1484 and Cjj81176_1483 of Campylobacter jejuni. Journal of bacteriology, 197 9, 1592-605

Zhang, Yang; Luethy, Paul M; Zhou, Ruanbao; Kroos, Lee 2013. Residues in conserved loops of intramembrane metalloprotease SpoIVFB interact with residues near the cleavage site in pro-σK. Journal of bacteriology, 195 21, 4936-46

Lee, Jun-Seok; Son, Bongjun; Viswanathan, Poorna; Luethy, Paul M; Kroos, Lee 2011. Combinatorial regulation of fmgD by MrpC2 and FruA during Myxococcus xanthus development. Journal of bacteriology, 193 7, 1681-9