Education/CredentialsMedical Degree: University of Kansas School of MedicineResidency: Brigham and Women's HospitalDoctorate: University of Kansas School of MedicineFellowship: Hematopathology: Brigham and Women's Hospital Contact Information Medical Sciences Building Office 513-558-4500 Email lorsbart@ucmail.uc.edu Peer Reviewed Publications Niss, Omar; Lorsbach, Robert B; Berger, Mikaela; Chonat, Satheesh; McLemore, Morgan; Buchbinder, David; McCavit, Timothy; Shaffer, Linda G; Simpson, Jessica; Schwartz, Jeffrey H; Meznarich, Jessica; Emberesh, Myesa; Seu, Katie G; Zhang, Wenying; Kalfa, Theodosia A 2021. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood cells, molecules & diseases, 87 , 102534Lee, Lynn H; Krupski, Christa; Clark, Jason; Wunderlich, Mark; Lorsbach, Robert B; Grimley, Michael S; Burwinkel, Matthew; Nelson, Adam; Kumar, Ashish R 2020. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood advances, 4 4, 717-727Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A 2020. VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. American journal of human genetics, 107 6, 1149-1156Gurunathan, Arun; Boucher, Alexander A; Mark, Melissa; Prus, Kristina M; O'Brien, Maureen M; Breese, Erin H; Mizukawa, Benjamin E; Absalon, Michael J; Nelson, Adam S; Jordan, Michael B; Grimley, Michael S; Lorsbach, Robert B; Rotz, Seth J; Mathanda, Reema; Kumar, Ashish R 2018. Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 65 12, e27400Cetin, Neslihan; Pandey, Soumya; Lorsbach, Robert B 2015. Immature lymphoid cells are a consistent feature of chylothorax in neonates and infants: cytologic features and flow cytometry aid in its distinction from lymphoblastic leukemia/lymphoma. Diagnostic cytopathology, 43 4, 335-8Cetin, Neslihan; Lorsbach, Robert B 2014. Pan myeloid antigen-negative pediatric acute megakaryoblastic leukemia. Pediatric blood & cancer, 61 11, 2089-91Alapat, Daisy; Coviello-Malle, Jean; Owens, Rebecca; Qu, Pingping; Barlogie, Bart; Shaughnessy, John D; Lorsbach, Robert B 2012. Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma. American journal of clinical pathology, 137 1, 93-100Hsi, Eric D; Lorsbach, Robert B; Fend, Falko; Dogan, Ahmet 2011. Plasmablastic lymphoma and related disorders. American journal of clinical pathology, 136 2, 183-94Lorsbach, Robert B; Hsi, Eric D; Dogan, Ahmet; Fend, Falko 2011. Plasma cell myeloma and related neoplasms. American journal of clinical pathology, 136 2, 168-82Lorsbach, Robert B 2010. Update on the Diagnosis and Classification of the Plasma Cell Neoplasms. Surgical pathology clinics, 3 4, 1061-89Lorsbach, Robert B 2004. Megakaryoblastic disorders in children. American journal of clinical pathology, 122 Suppl , S33-46Lorsbach, Robert B; Moore, Jennifer; Ang, Sonny O; Sun, Weili; Lenny, Noel; Downing, James R 2004. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood, 103 7, 2522-9Lorsbach, R B; Moore, J; Mathew, S; Raimondi, S C; Mukatira, S T; Downing, J R 2003. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia, 17 3, 637-41Lorsbach, Robert B; Shay-Seymore, Dominic; Moore, Jennifer; Banks, Peter M; Hasserjian, Robert P; Sandlund, John T; Behm, Frederick G 2002. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood, 99 6, 1959-64Onciu, Mihaela; Lorsbach, Robert B; Henry, E Charlene; Behm, Frederick G 2002. Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients. American journal of clinical pathology, 118 2, 248-54Greenwald, R J; Boussiotis, V A; Lorsbach, R B; Abbas, A K; Sharpe, A H 2001. CTLA-4 regulates induction of anergy in vivo. Immunity, 14 2, 145-55Lorsbach, R B; Downing, J R 2001. The role of the AML1 transcription factor in leukemogenesis. International journal of hematology, 74 3, 258-65Lorsbach, R B; McNall, R; Mathew, S 2001. Marked bone marrow basophilia in a child with acute myeloid leukemia with a cryptic t(8;21)(q22;q22) chromosomal translocation. Leukemia, 15 11, 1799-801Gao, J J; Filla, M B; Lorsbach, R B; Pace, J L; Crespo, A; Russell, S W; Murphy, W J 2000. Prolonged exposure of mouse macrophages to IFN-beta suppresses transcription of the inducible nitric oxide synthase gene: altered availability of transcription factor Stat1alpha. European journal of immunology, 30 6, 1551-61Lorsbach, R B; Pinkus, G S; Shahsafaei, A; Dorfman, D M 2000. Primary marginal zone lymphoma of the thymus. American journal of clinical pathology, 113 6, 784-91Mathew, S; Lorsbach, R B; Shearer, P; Sandlund, J T; Raimondi, S C 2000. Double minute chromosomes and c-MYC amplification in a child with secondary myelodysplastic syndrome after treatment for acute lymphoblastic leukemia. Leukemia, 14 7, 1314-5Lorsbach, R B; Folkerth, R D; Pinkus, G S 1999. Relapse of acute myelogenous leukemia as a cerebellar myeloblastoma showing megakaryoblastic differentiation. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12 12, 1186-91Oosterwegel, M A; Greenwald, R J; Mandelbrot, D A; Lorsbach, R B; Sharpe, A H 1999. CTLA-4 and T cell activation. Current opinion in immunology, 11 3, 294-300Oosterwegel, M A; Mandelbrot, D A; Boyd, S D; Lorsbach, R B; Jarrett, D Y; Abbas, A K; Sharpe, A H 1999. The role of CTLA-4 in regulating Th2 differentiation. Journal of immunology (Baltimore, Md. : 1950), 163 5, 2634-9Dileepan, K N; Lorsbach, R B; Stechschulte, D J 1993. Mast cell granules inhibit macrophage-mediated lysis of mastocytoma cells (P815) and nitric oxide production. Journal of leukocyte biology, 53 4, 446-53Lorsbach, R B; Murphy, W J; Lowenstein, C J; Snyder, S H; Russell, S W 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. The Journal of biological chemistry, 268 3, 1908-13Lorsbach, R B; Russell, S W 1992. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infection and immunity, 60 5, 2133-5Pinson, D M; LeClaire, R D; Lorsbach, R B; Parmely, M J; Russell, S W 1992. Regulation by transforming growth factor-beta 1 of expression and function of the receptor for IFN-gamma on mouse macrophages. Journal of immunology (Baltimore, Md. : 1950), 149 6, 2028-34
Peer Reviewed Publications Niss, Omar; Lorsbach, Robert B; Berger, Mikaela; Chonat, Satheesh; McLemore, Morgan; Buchbinder, David; McCavit, Timothy; Shaffer, Linda G; Simpson, Jessica; Schwartz, Jeffrey H; Meznarich, Jessica; Emberesh, Myesa; Seu, Katie G; Zhang, Wenying; Kalfa, Theodosia A 2021. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood cells, molecules & diseases, 87 , 102534Lee, Lynn H; Krupski, Christa; Clark, Jason; Wunderlich, Mark; Lorsbach, Robert B; Grimley, Michael S; Burwinkel, Matthew; Nelson, Adam; Kumar, Ashish R 2020. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood advances, 4 4, 717-727Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A 2020. VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. American journal of human genetics, 107 6, 1149-1156Gurunathan, Arun; Boucher, Alexander A; Mark, Melissa; Prus, Kristina M; O'Brien, Maureen M; Breese, Erin H; Mizukawa, Benjamin E; Absalon, Michael J; Nelson, Adam S; Jordan, Michael B; Grimley, Michael S; Lorsbach, Robert B; Rotz, Seth J; Mathanda, Reema; Kumar, Ashish R 2018. Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 65 12, e27400Cetin, Neslihan; Pandey, Soumya; Lorsbach, Robert B 2015. Immature lymphoid cells are a consistent feature of chylothorax in neonates and infants: cytologic features and flow cytometry aid in its distinction from lymphoblastic leukemia/lymphoma. Diagnostic cytopathology, 43 4, 335-8Cetin, Neslihan; Lorsbach, Robert B 2014. Pan myeloid antigen-negative pediatric acute megakaryoblastic leukemia. Pediatric blood & cancer, 61 11, 2089-91Alapat, Daisy; Coviello-Malle, Jean; Owens, Rebecca; Qu, Pingping; Barlogie, Bart; Shaughnessy, John D; Lorsbach, Robert B 2012. Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma. American journal of clinical pathology, 137 1, 93-100Hsi, Eric D; Lorsbach, Robert B; Fend, Falko; Dogan, Ahmet 2011. Plasmablastic lymphoma and related disorders. American journal of clinical pathology, 136 2, 183-94Lorsbach, Robert B; Hsi, Eric D; Dogan, Ahmet; Fend, Falko 2011. Plasma cell myeloma and related neoplasms. American journal of clinical pathology, 136 2, 168-82Lorsbach, Robert B 2010. Update on the Diagnosis and Classification of the Plasma Cell Neoplasms. Surgical pathology clinics, 3 4, 1061-89Lorsbach, Robert B 2004. Megakaryoblastic disorders in children. American journal of clinical pathology, 122 Suppl , S33-46Lorsbach, Robert B; Moore, Jennifer; Ang, Sonny O; Sun, Weili; Lenny, Noel; Downing, James R 2004. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood, 103 7, 2522-9Lorsbach, R B; Moore, J; Mathew, S; Raimondi, S C; Mukatira, S T; Downing, J R 2003. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia, 17 3, 637-41Lorsbach, Robert B; Shay-Seymore, Dominic; Moore, Jennifer; Banks, Peter M; Hasserjian, Robert P; Sandlund, John T; Behm, Frederick G 2002. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood, 99 6, 1959-64Onciu, Mihaela; Lorsbach, Robert B; Henry, E Charlene; Behm, Frederick G 2002. Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients. American journal of clinical pathology, 118 2, 248-54Greenwald, R J; Boussiotis, V A; Lorsbach, R B; Abbas, A K; Sharpe, A H 2001. CTLA-4 regulates induction of anergy in vivo. Immunity, 14 2, 145-55Lorsbach, R B; Downing, J R 2001. The role of the AML1 transcription factor in leukemogenesis. International journal of hematology, 74 3, 258-65Lorsbach, R B; McNall, R; Mathew, S 2001. Marked bone marrow basophilia in a child with acute myeloid leukemia with a cryptic t(8;21)(q22;q22) chromosomal translocation. Leukemia, 15 11, 1799-801Gao, J J; Filla, M B; Lorsbach, R B; Pace, J L; Crespo, A; Russell, S W; Murphy, W J 2000. Prolonged exposure of mouse macrophages to IFN-beta suppresses transcription of the inducible nitric oxide synthase gene: altered availability of transcription factor Stat1alpha. European journal of immunology, 30 6, 1551-61Lorsbach, R B; Pinkus, G S; Shahsafaei, A; Dorfman, D M 2000. Primary marginal zone lymphoma of the thymus. American journal of clinical pathology, 113 6, 784-91Mathew, S; Lorsbach, R B; Shearer, P; Sandlund, J T; Raimondi, S C 2000. Double minute chromosomes and c-MYC amplification in a child with secondary myelodysplastic syndrome after treatment for acute lymphoblastic leukemia. Leukemia, 14 7, 1314-5Lorsbach, R B; Folkerth, R D; Pinkus, G S 1999. Relapse of acute myelogenous leukemia as a cerebellar myeloblastoma showing megakaryoblastic differentiation. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12 12, 1186-91Oosterwegel, M A; Greenwald, R J; Mandelbrot, D A; Lorsbach, R B; Sharpe, A H 1999. CTLA-4 and T cell activation. Current opinion in immunology, 11 3, 294-300Oosterwegel, M A; Mandelbrot, D A; Boyd, S D; Lorsbach, R B; Jarrett, D Y; Abbas, A K; Sharpe, A H 1999. The role of CTLA-4 in regulating Th2 differentiation. Journal of immunology (Baltimore, Md. : 1950), 163 5, 2634-9Dileepan, K N; Lorsbach, R B; Stechschulte, D J 1993. Mast cell granules inhibit macrophage-mediated lysis of mastocytoma cells (P815) and nitric oxide production. Journal of leukocyte biology, 53 4, 446-53Lorsbach, R B; Murphy, W J; Lowenstein, C J; Snyder, S H; Russell, S W 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. The Journal of biological chemistry, 268 3, 1908-13Lorsbach, R B; Russell, S W 1992. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infection and immunity, 60 5, 2133-5Pinson, D M; LeClaire, R D; Lorsbach, R B; Parmely, M J; Russell, S W 1992. Regulation by transforming growth factor-beta 1 of expression and function of the receptor for IFN-gamma on mouse macrophages. Journal of immunology (Baltimore, Md. : 1950), 149 6, 2028-34
Niss, Omar; Lorsbach, Robert B; Berger, Mikaela; Chonat, Satheesh; McLemore, Morgan; Buchbinder, David; McCavit, Timothy; Shaffer, Linda G; Simpson, Jessica; Schwartz, Jeffrey H; Meznarich, Jessica; Emberesh, Myesa; Seu, Katie G; Zhang, Wenying; Kalfa, Theodosia A 2021. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood cells, molecules & diseases, 87 , 102534Lee, Lynn H; Krupski, Christa; Clark, Jason; Wunderlich, Mark; Lorsbach, Robert B; Grimley, Michael S; Burwinkel, Matthew; Nelson, Adam; Kumar, Ashish R 2020. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood advances, 4 4, 717-727Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A 2020. VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. American journal of human genetics, 107 6, 1149-1156Gurunathan, Arun; Boucher, Alexander A; Mark, Melissa; Prus, Kristina M; O'Brien, Maureen M; Breese, Erin H; Mizukawa, Benjamin E; Absalon, Michael J; Nelson, Adam S; Jordan, Michael B; Grimley, Michael S; Lorsbach, Robert B; Rotz, Seth J; Mathanda, Reema; Kumar, Ashish R 2018. Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 65 12, e27400Cetin, Neslihan; Pandey, Soumya; Lorsbach, Robert B 2015. Immature lymphoid cells are a consistent feature of chylothorax in neonates and infants: cytologic features and flow cytometry aid in its distinction from lymphoblastic leukemia/lymphoma. Diagnostic cytopathology, 43 4, 335-8Cetin, Neslihan; Lorsbach, Robert B 2014. Pan myeloid antigen-negative pediatric acute megakaryoblastic leukemia. Pediatric blood & cancer, 61 11, 2089-91Alapat, Daisy; Coviello-Malle, Jean; Owens, Rebecca; Qu, Pingping; Barlogie, Bart; Shaughnessy, John D; Lorsbach, Robert B 2012. Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma. American journal of clinical pathology, 137 1, 93-100Hsi, Eric D; Lorsbach, Robert B; Fend, Falko; Dogan, Ahmet 2011. Plasmablastic lymphoma and related disorders. American journal of clinical pathology, 136 2, 183-94Lorsbach, Robert B; Hsi, Eric D; Dogan, Ahmet; Fend, Falko 2011. Plasma cell myeloma and related neoplasms. American journal of clinical pathology, 136 2, 168-82Lorsbach, Robert B 2010. Update on the Diagnosis and Classification of the Plasma Cell Neoplasms. Surgical pathology clinics, 3 4, 1061-89Lorsbach, Robert B 2004. Megakaryoblastic disorders in children. American journal of clinical pathology, 122 Suppl , S33-46Lorsbach, Robert B; Moore, Jennifer; Ang, Sonny O; Sun, Weili; Lenny, Noel; Downing, James R 2004. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood, 103 7, 2522-9Lorsbach, R B; Moore, J; Mathew, S; Raimondi, S C; Mukatira, S T; Downing, J R 2003. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia, 17 3, 637-41Lorsbach, Robert B; Shay-Seymore, Dominic; Moore, Jennifer; Banks, Peter M; Hasserjian, Robert P; Sandlund, John T; Behm, Frederick G 2002. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood, 99 6, 1959-64Onciu, Mihaela; Lorsbach, Robert B; Henry, E Charlene; Behm, Frederick G 2002. Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients. American journal of clinical pathology, 118 2, 248-54Greenwald, R J; Boussiotis, V A; Lorsbach, R B; Abbas, A K; Sharpe, A H 2001. CTLA-4 regulates induction of anergy in vivo. Immunity, 14 2, 145-55Lorsbach, R B; Downing, J R 2001. The role of the AML1 transcription factor in leukemogenesis. International journal of hematology, 74 3, 258-65Lorsbach, R B; McNall, R; Mathew, S 2001. Marked bone marrow basophilia in a child with acute myeloid leukemia with a cryptic t(8;21)(q22;q22) chromosomal translocation. Leukemia, 15 11, 1799-801Gao, J J; Filla, M B; Lorsbach, R B; Pace, J L; Crespo, A; Russell, S W; Murphy, W J 2000. Prolonged exposure of mouse macrophages to IFN-beta suppresses transcription of the inducible nitric oxide synthase gene: altered availability of transcription factor Stat1alpha. European journal of immunology, 30 6, 1551-61Lorsbach, R B; Pinkus, G S; Shahsafaei, A; Dorfman, D M 2000. Primary marginal zone lymphoma of the thymus. American journal of clinical pathology, 113 6, 784-91Mathew, S; Lorsbach, R B; Shearer, P; Sandlund, J T; Raimondi, S C 2000. Double minute chromosomes and c-MYC amplification in a child with secondary myelodysplastic syndrome after treatment for acute lymphoblastic leukemia. Leukemia, 14 7, 1314-5Lorsbach, R B; Folkerth, R D; Pinkus, G S 1999. Relapse of acute myelogenous leukemia as a cerebellar myeloblastoma showing megakaryoblastic differentiation. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12 12, 1186-91Oosterwegel, M A; Greenwald, R J; Mandelbrot, D A; Lorsbach, R B; Sharpe, A H 1999. CTLA-4 and T cell activation. Current opinion in immunology, 11 3, 294-300Oosterwegel, M A; Mandelbrot, D A; Boyd, S D; Lorsbach, R B; Jarrett, D Y; Abbas, A K; Sharpe, A H 1999. The role of CTLA-4 in regulating Th2 differentiation. Journal of immunology (Baltimore, Md. : 1950), 163 5, 2634-9Dileepan, K N; Lorsbach, R B; Stechschulte, D J 1993. Mast cell granules inhibit macrophage-mediated lysis of mastocytoma cells (P815) and nitric oxide production. Journal of leukocyte biology, 53 4, 446-53Lorsbach, R B; Murphy, W J; Lowenstein, C J; Snyder, S H; Russell, S W 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. The Journal of biological chemistry, 268 3, 1908-13Lorsbach, R B; Russell, S W 1992. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infection and immunity, 60 5, 2133-5Pinson, D M; LeClaire, R D; Lorsbach, R B; Parmely, M J; Russell, S W 1992. Regulation by transforming growth factor-beta 1 of expression and function of the receptor for IFN-gamma on mouse macrophages. Journal of immunology (Baltimore, Md. : 1950), 149 6, 2028-34