Nancy L. Sawtell, PhD

Doll, Jessica R; Hoebe, Kasper; Thompson, Richard L; Sawtell, Nancy M 2020. Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. PLoS pathogens, 16 3, e1008296

Sawtell, Nancy M; Thompson, Richard L 2020. Alphaherpesvirus Latency and Reactivation with a Focus on Herpes Simplex Virus. Current issues in molecular biology, 41 , 267-356

Sawtell, Nancy M; Thompson, Richard L 2020. HSV Mutant Generation and Dual Detection Methods for Gaining Insight into Latent/Lytic Cycles In Vivo. Methods in molecular biology (Clifton, N.J.), 2060 , 219-239

Doll, Jessica R; Thompson, Richard L; Sawtell, Nancy M 2019. Infectious Herpes Simplex Virus in the Brain Stem Is Correlated with Reactivation in the Trigeminal Ganglia. Journal of virology, 93 8,

Thompson, Richard L; Sawtell, Nancy M 2019. Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo. Frontiers in microbiology, 10 , 1624

Doll, Jessica R; Sawtell, Nancy M 2017. Analysis of Herpes Simplex Virus Reactivation in Explant Reveals a Method-Dependent Difference in Measured Timing of Reactivation. Journal of virology, 91 16,

Pandey, Utsav; Renner, Daniel W; Thompson, Richard L; Szpara, Moriah L; Sawtell, Nancy M 2017. Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes. Scientific reports, 7 1, 13666

Sawtell, Nancy M; Thompson, Richard L 2016. De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia. PLoS pathogens, 12 9, e1005877

Sawtell, Nancy M; Thompson, Richard L 2016. Herpes simplex virus and the lexicon of latency and reactivation: a call for defining terms and building an integrated collective framework. F1000Research, 5 ,

Sawtell, Nancy M; Thompson, Richard L 2014. Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo. Methods in molecular biology (Clifton, N.J.), 1144 , 129-47

Thompson, Richard L; Williams, Robert W; Kotb, Malak; Sawtell, Nancy M 2014. A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. PloS one, 9 3, e92342

Catez, Frédéric; Picard, Christel; Held, Kathrin; Gross, Sylvain; Rousseau, Antoine; Theil, Diethilde; Sawtell, Nancy; Labetoulle, Marc; Lomonte, Patrick 2012. HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons. PLoS pathogens, 8 8, e1002852

Divanovic, Senad; Sawtell, Nancy M; Trompette, Aurelien; Warning, Jamie I; Dias, Alexandra; Cooper, Andrea M; Yap, George S; Arditi, Moshe; Shimada, Kenichi; Duhadaway, James B; Prendergast, George C; Basaraba, Randall J; Mellor, Andrew L; Munn, David H; Aliberti, Julio; Karp, Christopher L 2012. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. The Journal of infectious diseases, 205 1, 152-61

Sawtell, Nancy M; Triezenberg, Steven J; Thompson, Richard L 2011. VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo. Journal of neurovirology, 17 6, 546-51

Thompson, Richard L; Sawtell, Nancy M 2011. The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections. Journal of neurovirology, 17 6, 552-8

Farley, Nicholas; Bernstein, David I; Bravo, Fernando J; Earwood, Julie; Sawtell, Nancy; Cardin, Rhonda D 2010. Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. Antiviral research, 86 2, 188-95

Thompson, Richard L; Sawtell, Nancy M 2010. Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency. Future medicinal chemistry, 2 7, 1099-105

Thompson, Richard L; Preston, Chris M; Sawtell, Nancy M 2009. De novo synthesis of VP16 coordinates the exit from HSV latency in vivo. PLoS pathogens, 5 3, e1000352

Currier, Mark A; Gillespie, Rebecca A; Sawtell, Nancy M; Mahller, Yonatan Y; Stroup, Greg; Collins, Margaret H; Kambara, Hirokazu; Chiocca, E Antonio; Cripe, Timothy P 2008. Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide. Molecular therapy : the journal of the American Society of Gene Therapy, 16 5, 879-85

Sawtell, N M; Thompson, R L; Haas, R L 2006. Herpes simplex virus DNA synthesis is not a decisive regulatory event in the initiation of lytic viral protein expression in neurons in vivo during primary infection or reactivation from latency. Journal of virology, 80 1, 38-50

Thompson, R L; Sawtell, N M 2006. Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo. Journal of virology, 80 22, 10919-30

Sawtell, Nancy M 2005. Detection and quantification of the rare latently infected cell undergoing herpes simplex virus transcriptional activation in the nervous system in vivo. Methods in molecular biology (Clifton, N.J.), 292 , 57-72

Sawtell, N M; Thompson, R L 2004. Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences. Journal of virology, 78 14, 7784-94

Sawtell, N M 2003. Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation. Journal of virology, 77 7, 4127-38

Thompson, R L; Shieh, May T; Sawtell, N M 2003. Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo. Journal of virology, 77 22, 12319-30

Sawtell, N M 2002. Preparation of single cells from solid tissues for analysis by PCR. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], Chapter 25 , Unit 25A.2

Sawtell, N M; Thompson, R L; Stanberry, L R; Bernstein, D I 2001. Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo. The Journal of infectious diseases, 184 8, 964-71

Thompson, R L; Sawtell, N M 2001. Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. Journal of virology, 75 14, 6660-75

Thompson, R L; Sawtell, N M 2000. HSV latency-associated transcript and neuronal apoptosis. Science (New York, N.Y.), 289 5485, 1651

Thompson, R L; Sawtell, N M 2000. Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency. Journal of virology, 74 2, 965-74

Efstathiou, S; Field, H J; Griffiths, P D; Kern, E R; Sacks, S L; Sawtell, N M; Stanberry, L R 1999. Herpes simplex virus latency and nucleoside analogues. Antiviral research, 41 3, 85-100

Sawtell, N M; Bernstein, D I; Stanberry, L R 1999. A temporal analysis of acyclovir inhibition of induced herpes simplex virus type 1 In vivo reactivation in the mouse trigeminal ganglia. The Journal of infectious diseases, 180 3, 821-3

Sawtell, N M 1998. The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia. Journal of virology, 72 8, 6888-92

Sawtell, N M; Poon, D K; Tansky, C S; Thompson, R L 1998. The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. Journal of virology, 72 7, 5343-50

Sawtell, N M 1997. Comprehensive quantification of herpes simplex virus latency at the single-cell level. Journal of virology, 71 7, 5423-31

Thompson, R L; Sawtell, N M 1997. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. Journal of virology, 71 7, 5432-40

Perng, G C; Chokephaibulkit, K; Thompson, R L; Sawtell, N M; Slanina, S M; Ghiasi, H; Nesburn, A B; Wechsler, S L 1996. The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. Journal of virology, 70 1, 282-91

Perng, G C; Thompson, R L; Sawtell, N M; Taylor, W E; Slanina, S M; Ghiasi, H; Kaiwar, R; Nesburn, A B; Wechsler, S L 1995. An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. Journal of virology, 69 5, 3033-41

Bolovan, C A; Sawtell, N M; Thompson, R L 1994. ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. Journal of virology, 68 1, 48-55

Pyles, R B; Sawtell, N M; Thompson, R L 1992. Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. Journal of virology, 66 11, 6706-13

Sawtell, N M; Thompson, R L 1992. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. Journal of virology, 66 4, 2157-69

Sawtell, N M; Thompson, R L 1992. Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. Journal of virology, 66 4, 2150-6

Rudnicki, M A; Sawtell, N M; Reuhl, K R; Berg, R; Craig, J C; Jardine, K; Lessard, J L; McBurney, M W 1990. Smooth muscle actin expression during P19 embryonal carcinoma differentiation in cell culture. Journal of cellular physiology, 142 1, 89-98

Sawtell, N M; Hartman, A L; Lessard, J L 1990. Conserved tissue-restricted expression of HUC 1-1 actin phenotype among eumetazoan organisms. The Journal of experimental zoology, 256 1, 54-62

Hartman, A L; Sawtell, N M; Lessard, J L 1989. Expression of actin isoforms in developing rat intestinal epithelium. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 37 8, 1225-33

Sawtell, N M; Lessard, J L 1989. Cellular distribution of smooth muscle actins during mammalian embryogenesis: expression of the alpha-vascular but not the gamma-enteric isoform in differentiating striated myocytes. The Journal of cell biology, 109 6 Pt 1, 2929-37

Sawtell, N M; Hartman, A L; Lessard, J L 1988. Unique isoactins in the brush border of rat intestinal epithelial cells. Cell motility and the cytoskeleton, 11 4, 318-25

Sawtell, N M; Hartman, A L; Weiss, M A; Pesce, A J; Michael, J G 1988. C3 dependent, C5 independent immune complex glomerulopathy in the mouse. Laboratory investigation; a journal of technical methods and pathology, 58 3, 287-93

Sawtell, N M; Weiss, M A; Pesce, A J; Michael, J G 1987. An immune complex glomerulopathy associated with glomerular capillary thrombosis in the laboratory mouse. A highly reproducible accelerated model utilizing cationized antigen. Laboratory investigation; a journal of technical methods and pathology, 56 3, 256-63

Sawtell, N M; DiPersio, L; Michael, J G; Pesce, A J; Weiss, M A 1984. Expression of normal and tumor-associated antigens in human breast carcinoma. Laboratory investigation; a journal of technical methods and pathology, 51 2, 225-32