Education/CredentialsPostdoc: Memorial Sloan Kettering Cancer Center (Structural Biology; Ion Channel Biochemistry and Biophysics)PhD: University of Science and Technology of China; Institute of Biophysics, Chinese Academy of Sciences (Molecular Biology and Biochemistry; Structural Biology)BS: Anhui University (Chemical Engineering) Contact Information Medical Sciences Building 2251 Office 513-558-7827 Email houxi@ucmail.uc.edu Research InterestsMolecular mechanisms of human diseases; ion channels and channelopathies; cellular signaling; inter-organelle communication; protein-protein interactions; structural dynamics of macromolecular assemblies; cryo-electron microscopy Peer Reviewed Publications Hou, Xiaowei; Outhwaite, Ian R; Pedi, Leanne; Long, Stephen Barstow 2020. Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. eLife, 9 , Hou, Xiaowei; Burstein, Shana R; Long, Stephen Barstow 2018. Structures reveal opening of the store-operated calcium channel Orai. eLife, 7 , Hou, Xiaowei; Pedi, Leanne; Diver, Melinda M; Long, Stephen B 2012. Crystal structure of the calcium release-activated calcium channel Orai. Science (New York, N.Y.), 338 6112, 1308-13Hu, Pu; Sun, Lei; Zhu, Zhi-Qiang; Hou, Xiao-Wei; Wang, Shu; Yu, Shan-Shan; Wang, Hui-Li; Zhang, Ping; Wang, Ming; Niu, Li-Wen; Teng, Mai-Kun; Ruan, Di-Yun 2008. Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents. Proteins, 72 2, 673-83Hou, Xiaowei; Liu, Rujuan; Ross, Stuart; Smart, Eric J; Zhu, Haining; Gong, Weimin 2007. Crystallographic studies of human MitoNEET. The Journal of biological chemistry, 282 46, 33242-33246Hou, Xiaowei; Wang, Yanli; Zhou, Zhongwei; Bao, Shilai; Lin, Yajing; Gong, Weimin 2007. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. Journal of structural biology, 159 3, 523-8
Research InterestsMolecular mechanisms of human diseases; ion channels and channelopathies; cellular signaling; inter-organelle communication; protein-protein interactions; structural dynamics of macromolecular assemblies; cryo-electron microscopy
Peer Reviewed Publications Hou, Xiaowei; Outhwaite, Ian R; Pedi, Leanne; Long, Stephen Barstow 2020. Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. eLife, 9 , Hou, Xiaowei; Burstein, Shana R; Long, Stephen Barstow 2018. Structures reveal opening of the store-operated calcium channel Orai. eLife, 7 , Hou, Xiaowei; Pedi, Leanne; Diver, Melinda M; Long, Stephen B 2012. Crystal structure of the calcium release-activated calcium channel Orai. Science (New York, N.Y.), 338 6112, 1308-13Hu, Pu; Sun, Lei; Zhu, Zhi-Qiang; Hou, Xiao-Wei; Wang, Shu; Yu, Shan-Shan; Wang, Hui-Li; Zhang, Ping; Wang, Ming; Niu, Li-Wen; Teng, Mai-Kun; Ruan, Di-Yun 2008. Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents. Proteins, 72 2, 673-83Hou, Xiaowei; Liu, Rujuan; Ross, Stuart; Smart, Eric J; Zhu, Haining; Gong, Weimin 2007. Crystallographic studies of human MitoNEET. The Journal of biological chemistry, 282 46, 33242-33246Hou, Xiaowei; Wang, Yanli; Zhou, Zhongwei; Bao, Shilai; Lin, Yajing; Gong, Weimin 2007. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. Journal of structural biology, 159 3, 523-8
Hou, Xiaowei; Outhwaite, Ian R; Pedi, Leanne; Long, Stephen Barstow 2020. Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. eLife, 9 , Hou, Xiaowei; Burstein, Shana R; Long, Stephen Barstow 2018. Structures reveal opening of the store-operated calcium channel Orai. eLife, 7 , Hou, Xiaowei; Pedi, Leanne; Diver, Melinda M; Long, Stephen B 2012. Crystal structure of the calcium release-activated calcium channel Orai. Science (New York, N.Y.), 338 6112, 1308-13Hu, Pu; Sun, Lei; Zhu, Zhi-Qiang; Hou, Xiao-Wei; Wang, Shu; Yu, Shan-Shan; Wang, Hui-Li; Zhang, Ping; Wang, Ming; Niu, Li-Wen; Teng, Mai-Kun; Ruan, Di-Yun 2008. Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents. Proteins, 72 2, 673-83Hou, Xiaowei; Liu, Rujuan; Ross, Stuart; Smart, Eric J; Zhu, Haining; Gong, Weimin 2007. Crystallographic studies of human MitoNEET. The Journal of biological chemistry, 282 46, 33242-33246Hou, Xiaowei; Wang, Yanli; Zhou, Zhongwei; Bao, Shilai; Lin, Yajing; Gong, Weimin 2007. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. Journal of structural biology, 159 3, 523-8