George G. Smulian, MD

Peer Reviewed Publications

Dade, Jessica; DuBois, Juwen C; Pasula, Rajamouli; Donnell, Anna M; Caruso, Joseph A; Smulian, A George; Deepe, George S 2016. HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo. Medical mycology, 54 8, 865-75

DuBois, Juwen C; Pasula, Rajamouli; Dade, Jessica E; Smulian, A George 2016. Yeast Transcriptome and In Vivo Hypoxia Detection Reveals Histoplasma capsulatum Response to Low Oxygen Tension. Medical mycology, 54 1, 40-58

DuBois, Juwen C; Smulian, A George 2016. Sterol Regulatory Element Binding Protein (Srb1) Is Required for Hypoxic Adaptation and Virulence in the Dimorphic Fungus Histoplasma capsulatum. PloS one, 11 10, e0163849

Newman, Simon L; Smulian, A George 2013. Iron uptake and virulence in Histoplasma capsulatum. Current opinion in microbiology, 16 6, 700-7

Laskowski-Peak, Meggan C; Calvo, Ana M; Rohrssen, Jennifer; Smulian, A George 2012. VEA1 is required for cleistothecial formation and virulence in Histoplasma capsulatum. Fungal genetics and biology : FG & B, 49 10, 838-46

Smulian, A George 2012. Invasive models of histoplasmosis. Methods in molecular biology (Clifton, N.J.), 845 , 519-25

Holodniy, Mark; Brown, Sheldon T; Cameron, D William; Kyriakides, Tassos C; Angus, Brian; Babiker, Abdel; Singer, Joel; Owens, Douglas K; Anis, Aslam; Goodall, Ruth; Hudson, Fleur; Piaseczny, Mirek; Russo, John; Schechter, Martin; Deyton, Lawrence; Darbyshire, Janet 2011. Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA trial. PloS one, 6 3, e14764

Newman, Simon L; Lemen, Wendy; Smulian, Alan G 2011. Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts. Medical mycology : official publication of the International Society for Human and Animal Mycology, 49 4, 356-64

Perkins, Charles; Yanase, Noriko; Smulian, George; Gildea, Lucy; Orekov, Tatyana; Potter, Crystal; Brombacher, Frank; Aronow, Bruce; Wills-Karp, Marsha; Finkelman, Fred D 2011. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. The Journal of experimental medicine, 208 4, 853-67

Rani, Reena; Smulian, Alan G; Greaves, David R; Hogan, Simon P; Herbert, De 2011. TGF-B limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. European journal of immunology, ,

Rani, Reena; Smulian, Alan G; Greaves, David R; Hogan, Simon P; Herbert, De'Broski R 2011. TGF-? limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. European journal of immunology, 41 7, 2000-9

Laskowski, Meggan C; Smulian, Alan G 2010. Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum. BMC microbiology, 10 , 49

Sesterhenn, Thomas M; Slaven, Bradley E; Keely, Scott P; Smulian, A George; Lang, B Franz; Cushion, Melanie T 2010. Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii. Molecular genetics and genomics : MGG, 283 1, 63-72

Deepe, George S; Gibbons, Reta S; Smulian, A George 2008. Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs. Journal of leukocyte biology, 84 3, 669-78

Hilty, Jeremy; Smulian, A George; Newman, Simon L 2008. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis. Molecular microbiology, 70 1, 127-39

Winters, Michael S; Spellman, Daniel S; Chan, Qilin; Gomez, Francisco J; Hernandez, Margarita; Catron, Brittany; Smulian, Alan G; Neubert, Thomas A; Deepe, George S 2008. Histoplasma capsulatum proteome response to decreased iron availability. Proteome science, 6 , 36

Bubnick, Meggan; Smulian, A George 2007. The MAT1 locus of Histoplasma capsulatum is responsive in a mating type-specific manner. Eukaryotic cell, 6 4, 616-21

Cushion, Melanie T; Smulian, A George; Slaven, Bradley E; Sesterhenn, Tom; Arnold, Jonathan; Staben, Chuck; Porollo, Aleksey; Adamczak, Rafal; Meller, Jarek 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS one, 2 5, e423

Smulian, A George; Gibbons, Reta S; Demland, Jeffery A; Spaulding, Deborah T; Deepe, George S 2007. Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum. Eukaryotic cell, 6 11, 2066-71

Cushion, Melanie T; Smulian, A George 2006. Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists. The Journal of eukaryotic microbiology, 53 Suppl 1 , S80-4

Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E; Smulian, A George 2006. Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets. The Journal of eukaryotic microbiology, 53 Suppl 1 , S154-5

Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S89-91

Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S151-3

Keely, Scott P; Renauld, Hubert; Wakefield, Ann E; Cushion, Melanie T; Smulian, A George; Fosker, Nigel; Fraser, Audrey; Harris, David; Murphy, Lee; Price, Claire; Quail, Michael A; Seeger, Kathy; Sharp, Sarah; Tindal, Carolyn J; Warren, Tim; Zuiderwijk, Eduard; Barrell, Barclay G; Stringer, James R; Hall, Neil 2005. Gene arrays at Pneumocystis carinii telomeres. Genetics, 170 4, 1589-600

Parvatiyar, Kislay; Alsabbagh, Eyad M; Ochsner, Urs A; Stegemeyer, Michelle A; Smulian, Alan G; Hwang, Sung Hei; Jackson, Colin R; McDermott, Timothy R; Hassett, Daniel J 2005. Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite. Journal of bacteriology, 187 14, 4853-64

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M 2005. Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, 2 2, 149-55

Wilkinson, Deepti S; Ogden, Stacey K; Stratton, Sabrina A; Piechan, Julie L; Nguyen, Thi T; Smulian, George A; Barton, Michelle Craig 2005. A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Molecular and cellular biology, 25 3, 1200-12

Subauste, Carlos S; Wessendarp, Matthew; Portilllo, Jose-Andres C; Andrade, Rosa M; Hinds, Linda M; Gomez, Francisco J; Smulian, A George; Grubbs, Peter A; Haglund, Lisa A 2004. Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients. The Journal of infectious diseases, 189 1, 61-70

Sesterhenn, Thomas M; Slaven, Bradley E; Smulian, A George; Cushion, Melanie T 2003. Generation of sequencing libraries for the Pneumocystis Genome project. The Journal of eukaryotic microbiology, 50 Suppl , 663-5

Worsham, D Nicole; Basselin, Mireille; Smulian, A George; Beach, David H; Kaneshiro, Edna S 2003. Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. The Journal of eukaryotic microbiology, 50 Suppl , 678-9

Xu, Zheng; Lance, Britton; Vargas, Claudia; Arpinar, Budak; Bhandarkar, Suchendra; Kraemer, Eileen; Kochut, Krys J; Miller, John A; Wagner, Jeff R; Weise, Michael J; Wunderlich, John K; Stringer, James; Smulian, George; Cushion, Melanie T; Arnold, Jonathan 2003. Mapping by sequencing the Pneumocystis genome using the ordering DNA sequences V3 tool. Genetics, 163 4, 1299-313

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D 2002. Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons. The Journal of infectious diseases, 186 5, 644-51

Kaneshiro, Edna S; Rosenfeld, Jill A; Basselin-Eiweida, Mireille; Stringer, James R; Keely, Scott P; Smulian, A George; Giner, José-Luis 2002. The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. Molecular microbiology, 44 4, 989-99

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C 2002. Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma. Developmental neuroscience, 24 2-3, 154-60

Cushion, M T; Smulian, A G 2001. The pneumocystis genome project: update and issues. The Journal of eukaryotic microbiology, Suppl , 182S-183S

Fox, D; Smulian, A G 2001. Plasminogen-binding activity of enolase in the opportunistic pathogen Pneumocystis carinii. Medical mycology : official publication of the International Society for Human and Animal Mycology, 39 6, 495-507

Kaneshiro, E S; Rosenfeld, J A; Basselin, M; Bradshaw, S; Stringer, J R; Smulian, A G; Giner, J L 2001. Pneumocystis carinii erg6 gene: sequencing and expression of recombinant SAM:sterol methyltransferase in heterologous systems. The Journal of eukaryotic microbiology, Suppl , 144S-146S

Keely, S P; Wakefield, A E; Cushion, M T; Smulian, A G; Hall, N; Barrell, B G; Stringer, J R 2001. Detailed structure of Pneumocystis carinii chromosome ends. The Journal of eukaryotic microbiology, Suppl , 118S-120S

Smulian, A G 2001. Pneumocystis carinii: genetic diversity and cell biology. Fungal genetics and biology : FG & B, 34 3, 145-54

Smulian, A G; Sesterhenn, T; Tanaka, R; Cushion, M T 2001. The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes. Genetics, 157 3, 991-1002

Subauste, C S; Wessendarp, M; Smulian, A G; Frame, P T 2001. Role of CD40 ligand signaling in defective type 1 cytokine response in human immunodeficiency virus infection. The Journal of infectious diseases, 183 12, 1722-31

Fox, D; Smulian, A G 2000. Mkp1 of Pneumocystis carinii associates with the yeast transcription factor Rlm1 via a mechanism independent of the activation state. Cellular signalling, 12 6, 381-90

Okuda, M; Horn, H F; Tarapore, P; Tokuyama, Y; Smulian, A G; Chan, P K; Knudsen, E S; Hofmann, I A; Snyder, J D; Bove, K E; Fukasawa, K 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, 103 1, 127-40

Smulian, A G; Sullivan, D W; Theus, S A 2000. Immunization with recombinant Pneumocystis carinii p55 antigen provides partial protection against infection: characterization of epitope recognition associated with immunization. Microbes and infection / Institut Pasteur, 2 2, 127-36

Fox, D; Smulian, A G 1999. Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiae. Molecular microbiology, 34 3, 451-62

Theus, S A; Sawhney, N; Smulian, A G; Walzer, P D 1998. Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. The Journal of infectious diseases, 177 1, 238-41

Theus, S A; Smulian, A G; Steele, P; Linke, M J; Walzer, P D 1998. Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine, 16 11-12, 1149-57

Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R 1997. Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, 65 10, 4365; author reply 4

Perlada, D E; Smulian, A G; Cushion, M T 1997. Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. Journal of clinical microbiology, 35 9, 2342-7

Smulian, A G; Keely, S P; Sunkin, S M; Stringer, J R 1997. Genetic and antigenic variation in Pneumocystis carinii organisms: tools for examining the epidemiology and pathogenesis of infection. The Journal of laboratory and clinical medicine, 130 5, 461-8

Theus, S A; Smulian, A G; Sullivan, D W; Walzer, P D 1997. Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii. Clinical and experimental immunology, 109 2, 255-60

Keely, S P; Baughman, R P; Smulian, A G; Dohn, M N; Stringer, J R 1996. Source of Pneumocystis carinii in recurrent episodes of pneumonia in AIDS patients. AIDS (London, England), 10 8, 881-8

Smulian, A G; Ryan, M; Staben, C; Cushion, M 1996. Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti. Infection and immunity, 64 3, 691-701

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T 1996. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Infection and immunity, 64 1, 290-7

Keely, S P; Stringer, J R; Baughman, R P; Linke, M J; Walzer, P D; Smulian, A G 1995. Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. The Journal of infectious diseases, 172 2, 595-8

Kralovic, S M; Hutchins, M G; Smulian, A G 1995. Pancreatic abscess due to Eikenella corrodens in association with severe ethanolism. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 20 1, 198-9

Linke, M J; Smulian, A G; Stringer, J R; Walzer, P D 1994. Characterization of multiple unique cDNAs encoding the major surface glycoprotein of rat-derived Pneumocystis carinii. Parasitology research, 80 6, 478-86

Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), 8 11, 1555-62

Smulian, A G; Theus, S A 1994. Cellular immune response in Pneumocystis carinii infection. Parasitology today (Personal ed.), 10 6, 229-31

Theus, S A; Sullivan, D W; Walzer, P D; Smulian, A G 1994. Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen. Infection and immunity, 62 8, 3479-84

Smulian, A G; Sullivan, D W; Linke, M J; Halsey, N A; Quinn, T C; MacPhail, A P; Hernandez-Avila, M A; Hong, S T; Walzer, P D 1993. Geographic variation in the humoral response to Pneumocystis carinii. The Journal of infectious diseases, 167 5, 1243-7

Smulian, A G; Theus, S A; Denko, N; Walzer, P D; Stringer, J R 1993. A 55 kDa antigen of Pneumocystis carinii: analysis of the cellular immune response and characterization of the gene. Molecular microbiology, 7 5, 745-53

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D 1992. Isolation and characterization of a recombinant antigen of Pneumocystis carinii. Infection and immunity, 60 3, 907-15

Smulian, A G; Walzer, P D 1992. The biology of Pneumocystis carinii. Critical reviews in microbiology, 18 3, 191-216

Peglow, S L; Smulian, A G; Linke, M J; Pogue, C L; Nurre, S; Crisler, J; Phair, J; Gold, J W; Armstrong, D; Walzer, P D 1990. Serologic responses to Pneumocystis carinii antigens in health and disease. The Journal of infectious diseases, 161 2, 296-306

Levy, H; Feldman, C; Smulian, G 1987. Pulmonary mucormycosis. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 71 4, 265-6

Lewis, M I; Kallenbach, J M; Smulian, G; Bezwoda, W; Zaltzman, M; Derman, D; Zwi, S 1982. Complete remission of thrombotic thrombocytopenic purpura following the use of plasma exchange and dipyridamole. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 62 6, 177-8

Broomall, K R; Morris, R E; Walzer, P D; Smulian, A G . Zymolyase treatment exposes p55 antigen of Pneumocystis carinii. The Journal of eukaryotic microbiology, 45 3, 284-9

Broomall, K; Collins, M; Smulian, A G . Pneumocystis carinii promoter analysis in a heterologous Saccharomyces cerevisiae assay system. The Journal of eukaryotic microbiology, 44 6, 10S-11S

Dohn, M N; Frame, P T; Baughman, R P; Lafon, S W; Smulian, A G; Caldwell, P; Rogers, M D . Open-label efficacy and safety trial of 42 days of 566C80 for Pneumocystis carinii pneumonia in AIDS patients. The Journal of protozoology, 38 6, 220S-221S

Juárez-Figueroa, L A; Hernández-Avila, M; Uribe-Zúñiga, P; Smulian, G . [Prevalence of antibodies to Pneumocystis carinii in subjects with high risk behavior for AIDS]. Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición, 45 3, 229-31

Linke, M J; Smulian, A G; Yoshihara, P; Walzer, P D . Production and characterization of monoclonal antibodies specific for the major surface glycoprotein of Pneumocystis carinii. The Journal of eukaryotic microbiology, 41 5, 99S-100S

Smulian, A G . Identification of potential Pneumocystis carinii autonomous replication sequences for use in the development of a transformation system. The Journal of eukaryotic microbiology, 44 6, 12S

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D . Expression cloning of Pneumocystis carinii antigens. The Journal of protozoology, 38 6, 8S-10S

Stringer, J R; Stringer, S L; Zhang, J; Baughman, R; Smulian, A G; Cushion, M T . Molecular genetic distinction of Pneumocystis carinii from rats and humans. The Journal of eukaryotic microbiology, 40 6, 733-41

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T . Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii. The Journal of eukaryotic microbiology, 41 5, 114S

Zhang, J X; Cushion, M T; Giuntoli, D; Hong, S T; Meade, J C; Smulian, A G; Stringer, S L; Stringer, J J . Analysis of the Pneumocystis carinii genome. The Journal of protozoology, 38 6, 69S

George G. Smulian, MD

Professor

Clinical Interests

Peer Reviewed Publications