Education/CredentialsDoctoral Degree: Pennsylvania State University (Pathobiology with concentration in Toxicology)Bachelor's Degree: Gettysburg College (Biology )Postdoctoral Fellowship : National Institute of Environmental Health Sciences Contact Information Kettering Lab Complex 250 Office 513-558-1877 Email burns2ki@ucmail.uc.edu Research InterestsThe Burns Laboratory studies endometriosis. Endometriosis occurs when endometrial tissue from the uterus is located outside the uterus and adheres to and invades the pelvic cavity. Endometrial tissue attaches to places in the peritoneal cavity including fallopian tubes, ovaries, peritoneal wall, and bowel. This disease affects the quality of life and reproductive health of 7.7 million women in the U.S. with an estimated cost burden of $110 billion. Symptoms include painful periods, chronic pain, pain... Peer Reviewed Publications Greene, Alexis D; Kendziorski, Jessica A; Buckholz, Jeanette M; Niu, Liang; Xie, Changchun; Pinney, Susan M; Burns, Katherine A 2019. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure. Reproductive toxicology (Elmsford, N.Y.), 84 , 26-31Burns, Katherine A; Thomas, Seddon Y; Hamilton, Katherine J; Young, Steven L; Cook, Donald N; Korach, Kenneth S 2018. Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor ? and IL-6 Cross-Talk. Endocrinology, 159 1, 103-118Jones, Rebecca L; Lang, Stephanie A; Kendziorski, Jessica A; Greene, Alexis D; Burns, Katherine A 2018. Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure. Environmental health perspectives, 126 12, 127004Greene, Alexis D; Lang, Stephanie A; Kendziorski, Jessica A; Sroga-Rios, Julie M; Herzog, Thomas J; Burns, Katherine A 2016. Endometriosis: where are we and where are we going? Reproduction (Cambridge, England), 152 3, R63-78Hinds, Terry D; Burns, Katherine A; Hosick, Peter A; McBeth, Lucien; Nestor-Kalinoski, Andrea; Drummond, Heather A; AlAmodi, Abdulhadi A; Hankins, Michael W; Vanden Heuvel, John P; Stec, David E 2016. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. The Journal of biological chemistry, 291 48, 25179-25191Franasiak, Jason M; Burns, Katherine A; Slayden, Ov; Yuan, Lingwen; Fritz, Marc A; Korach, Kenneth S; Lessey, Bruce A; Young, Steven L 2015. Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.), 22 4, 442-51Burns, Katherine A; Li, Yin; Liu, Liwen; Korach, Kenneth S 2014. Research resource: comparison of gene profiles from wild-type ER? and ER? hinge region mutants. Molecular endocrinology (Baltimore, Md.), 28 8, 1352-61Jayes, Friederike L; Burns, Katherine A; Rodriguez, Karina F; Kissling, Grace E; Korach, Kenneth S 2014. The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biology of reproduction, 90 2, 24Li, Yin; Hamilton, Katherine J; Lai, Anne Y; Burns, Katherine A; Li, Leping; Wade, Paul A; Korach, Kenneth S 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ER? alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environmental health perspectives, 122 3, 262-8Burns, Katherine A; Zorrilla, Leah M; Hamilton, Katherine J; Reed, Casey E; Birnbaum, Linda S; Korach, Kenneth S 2013. A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice. Toxicological sciences : an official journal of the Society of Toxicology, 136 2, 514-26Li, Yin; Luh, Colin J; Burns, Katherine A; Arao, Yukitomo; Jiang, Zhongliang; Teng, Christina T; Tice, Raymond R; Korach, Kenneth S 2013. Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environmental health perspectives, 121 4, 459-66Winuthayanon, Wipawee; Piyachaturawat, Pawinee; Suksamrarn, Apichart; Burns, Katherine A; Arao, Yukitomo; Hewitt, Sylvia C; Pedersen, Lars C; Korach, Kenneth S 2013. The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor ?. Environmental health perspectives, 121 4, 433-9Burns, Katherine A; Korach, Kenneth S 2012. Estrogen receptors and human disease: an update. Archives of toxicology, 86 10, 1491-504Burns, Katherine A; Rodriguez, Karina F; Hewitt, Sylvia C; Janardhan, Kyathanahalli S; Young, Steven L; Korach, Kenneth S 2012. Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology, 153 8, 3960-71Li, Yin; Burns, Katherine A; Arao, Yukitomo; Luh, Colin J; Korach, Kenneth S 2012. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor ? and ? in vitro. Environmental health perspectives, 120 7, 1029-35Burns, Katherine A; Li, Yin; Arao, Yukitomo; Petrovich, Robert M; Korach, Kenneth S 2011. Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. The Journal of biological chemistry, 286 14, 12640-9Rodriguez, Karina F; Couse, John F; Jayes, Friederike L; Hamilton, Katherine J; Burns, Katherine A; Taniguchi, Fuminori; Korach, Kenneth S 2010. Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. Endocrinology, 151 6, 2826-34Burns, Katherine A; Vanden Heuvel, John P 2007. Modulation of PPAR activity via phosphorylation. Biochimica et biophysica acta, 1771 8, 952-60Gray, Joshua P; Burns, Katherine A; Leas, Tara L; Perdew, Gary H; Vanden Heuvel, John P 2005. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry, 44 30, 10313-21Vanden Heuvel, John P; Kreder, Dirk; Belda, Benjamin; Hannon, Daniel B; Nugent, Courtney A; Burns, Katherine A; Taylor, Michael J 2003. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicology and applied pharmacology, 188 3, 185-98
Research InterestsThe Burns Laboratory studies endometriosis. Endometriosis occurs when endometrial tissue from the uterus is located outside the uterus and adheres to and invades the pelvic cavity. Endometrial tissue attaches to places in the peritoneal cavity including fallopian tubes, ovaries, peritoneal wall, and bowel. This disease affects the quality of life and reproductive health of 7.7 million women in the U.S. with an estimated cost burden of $110 billion. Symptoms include painful periods, chronic pain, pain...
Peer Reviewed Publications Greene, Alexis D; Kendziorski, Jessica A; Buckholz, Jeanette M; Niu, Liang; Xie, Changchun; Pinney, Susan M; Burns, Katherine A 2019. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure. Reproductive toxicology (Elmsford, N.Y.), 84 , 26-31Burns, Katherine A; Thomas, Seddon Y; Hamilton, Katherine J; Young, Steven L; Cook, Donald N; Korach, Kenneth S 2018. Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor ? and IL-6 Cross-Talk. Endocrinology, 159 1, 103-118Jones, Rebecca L; Lang, Stephanie A; Kendziorski, Jessica A; Greene, Alexis D; Burns, Katherine A 2018. Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure. Environmental health perspectives, 126 12, 127004Greene, Alexis D; Lang, Stephanie A; Kendziorski, Jessica A; Sroga-Rios, Julie M; Herzog, Thomas J; Burns, Katherine A 2016. Endometriosis: where are we and where are we going? Reproduction (Cambridge, England), 152 3, R63-78Hinds, Terry D; Burns, Katherine A; Hosick, Peter A; McBeth, Lucien; Nestor-Kalinoski, Andrea; Drummond, Heather A; AlAmodi, Abdulhadi A; Hankins, Michael W; Vanden Heuvel, John P; Stec, David E 2016. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. The Journal of biological chemistry, 291 48, 25179-25191Franasiak, Jason M; Burns, Katherine A; Slayden, Ov; Yuan, Lingwen; Fritz, Marc A; Korach, Kenneth S; Lessey, Bruce A; Young, Steven L 2015. Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.), 22 4, 442-51Burns, Katherine A; Li, Yin; Liu, Liwen; Korach, Kenneth S 2014. Research resource: comparison of gene profiles from wild-type ER? and ER? hinge region mutants. Molecular endocrinology (Baltimore, Md.), 28 8, 1352-61Jayes, Friederike L; Burns, Katherine A; Rodriguez, Karina F; Kissling, Grace E; Korach, Kenneth S 2014. The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biology of reproduction, 90 2, 24Li, Yin; Hamilton, Katherine J; Lai, Anne Y; Burns, Katherine A; Li, Leping; Wade, Paul A; Korach, Kenneth S 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ER? alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environmental health perspectives, 122 3, 262-8Burns, Katherine A; Zorrilla, Leah M; Hamilton, Katherine J; Reed, Casey E; Birnbaum, Linda S; Korach, Kenneth S 2013. A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice. Toxicological sciences : an official journal of the Society of Toxicology, 136 2, 514-26Li, Yin; Luh, Colin J; Burns, Katherine A; Arao, Yukitomo; Jiang, Zhongliang; Teng, Christina T; Tice, Raymond R; Korach, Kenneth S 2013. Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environmental health perspectives, 121 4, 459-66Winuthayanon, Wipawee; Piyachaturawat, Pawinee; Suksamrarn, Apichart; Burns, Katherine A; Arao, Yukitomo; Hewitt, Sylvia C; Pedersen, Lars C; Korach, Kenneth S 2013. The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor ?. Environmental health perspectives, 121 4, 433-9Burns, Katherine A; Korach, Kenneth S 2012. Estrogen receptors and human disease: an update. Archives of toxicology, 86 10, 1491-504Burns, Katherine A; Rodriguez, Karina F; Hewitt, Sylvia C; Janardhan, Kyathanahalli S; Young, Steven L; Korach, Kenneth S 2012. Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology, 153 8, 3960-71Li, Yin; Burns, Katherine A; Arao, Yukitomo; Luh, Colin J; Korach, Kenneth S 2012. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor ? and ? in vitro. Environmental health perspectives, 120 7, 1029-35Burns, Katherine A; Li, Yin; Arao, Yukitomo; Petrovich, Robert M; Korach, Kenneth S 2011. Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. The Journal of biological chemistry, 286 14, 12640-9Rodriguez, Karina F; Couse, John F; Jayes, Friederike L; Hamilton, Katherine J; Burns, Katherine A; Taniguchi, Fuminori; Korach, Kenneth S 2010. Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. Endocrinology, 151 6, 2826-34Burns, Katherine A; Vanden Heuvel, John P 2007. Modulation of PPAR activity via phosphorylation. Biochimica et biophysica acta, 1771 8, 952-60Gray, Joshua P; Burns, Katherine A; Leas, Tara L; Perdew, Gary H; Vanden Heuvel, John P 2005. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry, 44 30, 10313-21Vanden Heuvel, John P; Kreder, Dirk; Belda, Benjamin; Hannon, Daniel B; Nugent, Courtney A; Burns, Katherine A; Taylor, Michael J 2003. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicology and applied pharmacology, 188 3, 185-98
Greene, Alexis D; Kendziorski, Jessica A; Buckholz, Jeanette M; Niu, Liang; Xie, Changchun; Pinney, Susan M; Burns, Katherine A 2019. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure. Reproductive toxicology (Elmsford, N.Y.), 84 , 26-31Burns, Katherine A; Thomas, Seddon Y; Hamilton, Katherine J; Young, Steven L; Cook, Donald N; Korach, Kenneth S 2018. Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor ? and IL-6 Cross-Talk. Endocrinology, 159 1, 103-118Jones, Rebecca L; Lang, Stephanie A; Kendziorski, Jessica A; Greene, Alexis D; Burns, Katherine A 2018. Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure. Environmental health perspectives, 126 12, 127004Greene, Alexis D; Lang, Stephanie A; Kendziorski, Jessica A; Sroga-Rios, Julie M; Herzog, Thomas J; Burns, Katherine A 2016. Endometriosis: where are we and where are we going? Reproduction (Cambridge, England), 152 3, R63-78Hinds, Terry D; Burns, Katherine A; Hosick, Peter A; McBeth, Lucien; Nestor-Kalinoski, Andrea; Drummond, Heather A; AlAmodi, Abdulhadi A; Hankins, Michael W; Vanden Heuvel, John P; Stec, David E 2016. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. The Journal of biological chemistry, 291 48, 25179-25191Franasiak, Jason M; Burns, Katherine A; Slayden, Ov; Yuan, Lingwen; Fritz, Marc A; Korach, Kenneth S; Lessey, Bruce A; Young, Steven L 2015. Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.), 22 4, 442-51Burns, Katherine A; Li, Yin; Liu, Liwen; Korach, Kenneth S 2014. Research resource: comparison of gene profiles from wild-type ER? and ER? hinge region mutants. Molecular endocrinology (Baltimore, Md.), 28 8, 1352-61Jayes, Friederike L; Burns, Katherine A; Rodriguez, Karina F; Kissling, Grace E; Korach, Kenneth S 2014. The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biology of reproduction, 90 2, 24Li, Yin; Hamilton, Katherine J; Lai, Anne Y; Burns, Katherine A; Li, Leping; Wade, Paul A; Korach, Kenneth S 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ER? alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environmental health perspectives, 122 3, 262-8Burns, Katherine A; Zorrilla, Leah M; Hamilton, Katherine J; Reed, Casey E; Birnbaum, Linda S; Korach, Kenneth S 2013. A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice. Toxicological sciences : an official journal of the Society of Toxicology, 136 2, 514-26Li, Yin; Luh, Colin J; Burns, Katherine A; Arao, Yukitomo; Jiang, Zhongliang; Teng, Christina T; Tice, Raymond R; Korach, Kenneth S 2013. Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environmental health perspectives, 121 4, 459-66Winuthayanon, Wipawee; Piyachaturawat, Pawinee; Suksamrarn, Apichart; Burns, Katherine A; Arao, Yukitomo; Hewitt, Sylvia C; Pedersen, Lars C; Korach, Kenneth S 2013. The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor ?. Environmental health perspectives, 121 4, 433-9Burns, Katherine A; Korach, Kenneth S 2012. Estrogen receptors and human disease: an update. Archives of toxicology, 86 10, 1491-504Burns, Katherine A; Rodriguez, Karina F; Hewitt, Sylvia C; Janardhan, Kyathanahalli S; Young, Steven L; Korach, Kenneth S 2012. Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology, 153 8, 3960-71Li, Yin; Burns, Katherine A; Arao, Yukitomo; Luh, Colin J; Korach, Kenneth S 2012. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor ? and ? in vitro. Environmental health perspectives, 120 7, 1029-35Burns, Katherine A; Li, Yin; Arao, Yukitomo; Petrovich, Robert M; Korach, Kenneth S 2011. Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. The Journal of biological chemistry, 286 14, 12640-9Rodriguez, Karina F; Couse, John F; Jayes, Friederike L; Hamilton, Katherine J; Burns, Katherine A; Taniguchi, Fuminori; Korach, Kenneth S 2010. Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. Endocrinology, 151 6, 2826-34Burns, Katherine A; Vanden Heuvel, John P 2007. Modulation of PPAR activity via phosphorylation. Biochimica et biophysica acta, 1771 8, 952-60Gray, Joshua P; Burns, Katherine A; Leas, Tara L; Perdew, Gary H; Vanden Heuvel, John P 2005. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry, 44 30, 10313-21Vanden Heuvel, John P; Kreder, Dirk; Belda, Benjamin; Hannon, Daniel B; Nugent, Courtney A; Burns, Katherine A; Taylor, Michael J 2003. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicology and applied pharmacology, 188 3, 185-98