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#R33DA048439 Title: PHASE II-Omics analysis of HIV during synthetic opioid exposure Start: 01-01-2022 / End: 01-31-2024 Investigators: Blackard, Jason; Brown, Jennifer; Lyons, Michael; Medvedovic, Mario; Sherman, Kenneth Grant Sponsor: National Institute on Drug Abuse Grant Amount: $616,145.00 (level: Federal)
#R01DA057944 Title: Role of Prelimbic Cortical Endocannabinoid Signaling in Enhanced Cocaine-seeking Behavior Following Combined Repeated Stress and Cocaine Use in Rats Start: 03-01-2024 / End: 01-31-2025 Primary Investigators: Jayme Rose McReynolds Grant Sponsor: National Institute on Drug Abuse Grant Amount: $440,054.00
#20-A0-S2-003671 / UG1DA013035 Title: CTN0100 - Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Phramacotherapy (RDD) Start: 09-01-2020 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John Grant Sponsor: National Institute on Drug Abuse Grant Amount: $22,367.00
#UG1DA013732-00000 Title: The Ohio Valley Node (OVN) of the Clinical Trials Network Start: 09-01-2015 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Investigators: Brown, Jennifer; Lyons, Michael; Montgomery, LaTrice; Burlew, Kathleen Grant Sponsor: National Institute on Drug Abuse Grant Amount: $16,108,823.00
#UG1DA013732-00046 Title: CTN-0150: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD: A pilot randomized trial (TOME trial). (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV; Magee Women’s Hospital/University of Pittsburgh, Pittsburgh, PA; University of Utah, Salt Lake City, UT; Medical University of South Carolina, Charleston, SC; Gateway Community Services, Inc., Jacksonville, FL) Start: 03-01-2023 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $541,250.00
#A00-0322-S010 Title: CTN-0107: Peer Recovery Support: A Bridge to Treatment for Overdose Survivors (Study site: Mercy Health, Youngstown, OH) Start: 03-01-2021 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: Medical University of South Carolina Grant Amount: $94,674.00
#UG1DA013732-00032 Title: CTN-0134: Buprenorphine-Precipitated Withdrawal Hotspots and Correlates: Identifying Regional ‘Hotspots’ and Potential Correlates of Precipitated Withdrawal during Buprenorphine Induction in Fentanyl Users Through Prescriber Survey Responses and Patient Urine Drug Test Results. Start: 03-01-2021 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $265,227.00
#UG1DA013732-00035 Title: CTN Base: The Ohio Valley Node (OVN) joined NIDA’s Clinical Trials Network (CTN) in September of 2000 as one of the CTN’s second wave of awardees and has been funded continuously since then. Funds in the current 5-year award cycle (6/1/2020 - 2/28/2025) support OVN infrastructure, project development, and support to all OVN performance sites. Start: 06-01-2020 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $3,129,564.0
#UG1DA013732-00037 Title: CTN-0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations. (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV) Start: 06-01-2018 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $9,157,440.00
#UG1DA013732-00038 Title: CTN-0114: Drug Repurposing for Cocaine Use Disorder (CUD) Using a Combined Strategy of Artificial Intelligence (AI)-Based Prediction and Retrospective Clinical Corroboration (AI-4-CUD) Start: 09-01-2020 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $1,613,197.00
#UG1DA013732-00039 Title: CTN-0125: Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine (Secondary analysis) Start: 07-01-2021 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $105,781.00
#UG1DA013732-00040 Title: CTN-0129: “The Great Plains Initiative.” Start: 03-01-2021 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $770.042.0
#UG1DA013732-00041 Title: CTN-0138: Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Pro-gram Risk Assessment Tool Start: 03-01-2022 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $806,307.0
#UG1DA013732-00042 Title: CTN-0142: Towards personalized medicine in medication for opioid use disorder (MOUD): Analyses of Veterans Health Administration data to delineate patient characteristics associated with treatment outcomes and successful MOUD discontinuation Start: 03-01-2022 / End: 02-29-2024 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $610,901.00
#60071380 OSU (UM1DA049417 NIH NIDA) Title: Optimizing HEALing in Ohio Communities (OHIO) Start: 04-17-2019 / End: 03-31-2024 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John; Brown, Jennifer PhD; Lyons, Michael MD; McMullan, Jason Grant Sponsor: National Institute on Drug Abuse Grant Amount: $15,781,558.00
#R13AI071925 Title: HIV and Liver Disease Conference Start: 04-12-2021 / End: 03-31-2024 Primary Investigators: Kenneth E. Sherman Investigators: Sherman, Kenneth Grant Sponsor: National Institute of Allergy and Infectious Diseases Grant Amount: $30,000.00 (level: Federal)
#312397 / R01DA051895 Title: Role of Siglec-1 in HIV Interactions with Microglia and Astrocytes Start: 07-15-2020 / End: 04-30-2025 Primary Investigators: Jason T. Blackard Investigators: Blackard, Jason Grant Sponsor: National Institute on Drug Abuse Grant Amount: $10,964.00 (level: Federal)
#K23DA058053 Title: A Unique, Co-designed Family-based Therapy for Marginalized Women with Opioid Use Disorder and Justice-Involvement Start: 06-15-2023 / End: 05-01-2028 Primary Investigators: Aaron William Murnan Investigators: Aaron Murnan; Melinda Butsch Kovacic; Jennifer Brown; Sarah Manchak; Christine Wilder Grant Sponsor: National Institute on Drug Abuse Grant Amount: $1,000,000 (level: National)
#pending / NU38OT000306 Title: ED Based Substance Use Navigation - Advancing the Evidence Start: 10-01-2023 / End: 06-30-2024 Primary Investigators: Caroline Elizabeth Freiermuth Investigators: Freiermuth, Caroline; Ryan, Richard Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $99,851.58 (level: Federal)
#K01DA054339 Title: Circuit-Selective Astroglial Plasticity During Opioid Relapse Start: 08-01-2023 / End: 07-31-2024 Primary Investigators: Anna Katherine Kruyer Investigators: Kruyer, Anna Grant Sponsor: National Institute on Drug Abuse Grant Amount: $179,096.00 (level: Federal)
#U01DA050330 Title: IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody Start: 09-15-2019 / End: 07-31-2024 Primary Investigators: Andrew B Norman Investigators: Amlal, Hassane; Crutchfield, Christopher; Kirley, Terence; Norman, Andrew; Rubinstein, Jack; Webster, Rose; Wetzel, Hanna Grant Sponsor: National Institute on Drug Abuse (level: Federal)
#K01Da054339 Title: Circuit-Selective Astroglial Plasticity During Opioid Relapse Start: 08-01-2022 / End: 07-31-2027 Primary Investigators: Anna Katherine Kruyer Investigators: Anna Kruyer Grant Sponsor: National Institute on Drug Abuse Grant Amount: $964,010.00 (level: National)
#R01AA030486 Title: Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination Start: 09-10-2022 / End: 07-31-2027 Investigators: ; Blackard, Jason; Brown, Jennifer; Robertson, Jaime; Welge, Jeffrey; Yan, Bingfang Grant Sponsor: National Institute on Alcohol Abuse and Alcoholism Grant Amount: $721,672.00 (level: Federal)
#UG3DA059409 Title: Improving Buprenorphine Retention with Transcutaneous Auricular Neurostimulation for Patients with Co-occurring Posttraumatic Stress Disorder and Opioid Use Disorder Start: 09-01-2023 / End: 08-31-2024 Primary Investigators: Joel Gregory Sprunger Investigators: Welge, Jeffrey; Winhusen, T Grant Sponsor: National Institute on Drug Abuse Grant Amount: $582205.00
#315660 / H79TI084035 Title: FY 2021 Screening, Brief Intervention and Referral to Treatment (SBIRT) Start: 09-30-2021 / End: 09-29-2026 Primary Investigators: Shauna P Acquavita Investigators: Acquavita, Shauna Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $33,878.00 (level: Federal)
#H79TI085997 Title: Alternatives to opioids for pain in the Emergency Department: Implementing Integrative Health approaches and expanding local nerve block initiatives Start: 09-30-2023 / End: 09-29-2026 Primary Investigators: Caroline Elizabeth Freiermuth Investigators: Freiermuth, Caroline; Ryan, Richard Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $478,958.00
#R00AA028265 Title: Identifying how alcohol-evoked changes in neural firing affect systems level computations during decision-making Start: 01-01-2024 / End: 12-31-2024 Primary Investigators: Nick Morgan Timme Investigators: Timme, Nicholas Grant Sponsor: National Institute on Alcohol Abuse and Alcoholism (level: Federal)
#T98HP33422 Title: SAFE T 2019 - Opioid Workforce Expansion Program (OWEP) Start: 2019-09-01 / End: 2023-12-31 Primary Investigators: Brubaker, Michael Investigators: Acquavita, Shauna Grant Sponsor: Health Resources and Services Administration Grant Amount: $1,332,484.78 (level: Federal)
#H79TI080732 Title: ASPIRE: Accelerating Substance use and Psychiatric screening among Individuals at-risk or HIV-infected and facilitated Referral via the Emergency Department Start: 2018-09-30 / End: 2023-09-29 Primary Investigators: Sprunger, Joel PhD Investigators: Brown, Jennifer PhD; Sprunger, Joel PhD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $2,447,305.00 (level: Federal)
#5K23DA042130-01A1 Title: Twitter-Based Intervention for Young Adult African American Blunt Smokers Start: 2017-08-15 / End: 2023-07-31 Primary Investigators: Montgomery, LaTrice PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $726,280.00 (level: Federal)
#R01DA044248 Title: EMPOWER: Evaluating the ability to reduce Morphine equivalent dose for chronic Pain patients receiving Opioid-therapy through a Web-based E-Health self-management program: a Randomized multi-site Clin Start: 2017-09-01 / End: 2023-06-30 Primary Investigators: Winhusen, T. John PHD Investigators: Elder, Nancy MD; Regan, Saundra PHD; Welge, Jeffrey PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $2,550,410.50 (level: Federal)
#U01DA048525 Title: First-In-Human Study of a Humanized Anti-Cocaine Monoclonal Antibody Start: 2019-07-01 / End: 2023-04-30 Primary Investigators: Norman, Andrew PhD Investigators: Geracioti, Thomas MD; Kirley, Terry PhD; Nelson, Erik MD; Ridgway, William MD; Webster, Rose ; Welge, Jeffrey PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $8,474,481.00 (level: Federal)
#03140014IN0223 Title: UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23) Start: 2021-09-30 / End: 2023-03-31 Primary Investigators: Freiermuth, Caroline MD Investigators: Jarrell, Kelli MD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $93,250.00 (level: Federal)
#Services Agreement / ISR 117-10246 Title: An evaluation of vertical transmission of hepatitis C virus (HCV) and natural history of chronic HCV in pregnant women with subsequent treatment post-partum Start: 2019-08-01 / End: 2023-01-01 Primary Investigators: Blackard, Jason PhD Grant Sponsor: Gilead Sciences, Inc. Grant Amount: $75,855.00 (level: Industry)
#AGO Contract #12545 Title: Identifying genetic markers associated with opioid use disorder Start: 2020-03-01 / End: 2022-12-31 Primary Investigators: Freiermuth, Caroline MD Investigators: Brown, Jennifer PhD Grant Sponsor: Ohio Attorney General Grant Amount: $2,787,805.00 (level: Ohio, State of)
#R21DA049253 Title: DAT18-09 Maternal opioid exposure and executive function evaluation in the mouse Start: 2019-09-01 / End: 2022-08-31 Primary Investigators: Reyes, Teresa PHD Investigators: Wohleb, Eric PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $441,375.00 (level: Federal)
#NY UM1DA049417 Title: NIDA CTN-0112: Optimal Policies to Improve Methadone Maintenance Adherence Long term (OPTIMMAL Study) Start: 2021-08-01 / End: 2022-07-31 Primary Investigators: Winhusen, T. John PHD Investigators: Wilder, Christine Grant Sponsor: National Institute on Drug Abuse Grant Amount: $134,468.00 (level: Federal)
#800005519-01UG/U01DA040381 Title: Cohort Studies of HIV/AIDS and Substance Abuse in Miami Start: 2015-09-15 / End: 2022-05-31 Primary Investigators: Sherman, Kenneth MD,PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $805,035.00 (level: Federal)
#1802163 / DA143396 Title: Immune correlates of long-term success with DAA therapy in HCV/HIV infected people who inject drugs Start: 2018-02-01 / End: 2022-05-31 Primary Investigators: Sherman, Kenneth MD,PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $58,535.00 (level: Federal)
#K01DA045295 Title: Recruitment of endocannabinoid signaling in the ventral tegmental area and stressinduced escalation of cocaine intake Start: 2020-05-01 / End: 2022-04-30 Primary Investigators: McReynolds, Jayme Grant Sponsor: National Institute on Drug Abuse Grant Amount: $228,716.49 (level: Federal)