Education/CredentialsAssociate Research Scientist: Yale University Postdoctoral Research Associate: Yale University Doctoral Degree: The Ohio State University (Neuroscience; Neuroimmunology)Bachelor's Degree: Saint John's University (Mathematics; Psychology) Contact Information Office 513-558-6870 Email wohlebes@ucmail.uc.edu Peer Reviewed Publications Bollinger, Justin L; Dadosky, David T; Flurer, James K; Rainer, Ivanka L; Woodburn, Samuel C; Wohleb, Eric S 2023. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48 9, 1347-1357Smail, Marissa A; Smith, Brittany L; Shukla, Rammohan; Alganem, Khaled; Eby, Hunter M; Bollinger, Justin L; Parikh, Ria K; Chambers, James B; Reigle, James K; Moloney, Rachel D; Nawreen, Nawshaba; Wohleb, Eric S; Pantazopoulos, Harry; McCullumsmith, Robert E; Herman, James P 2023. Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix. Molecular psychiatry, , Woodburn, Samuel C; Asrat, Helina S; Flurer, James K; Schwierling, Hana C; Bollinger, Justin L; Vollmer, Lauren L; Wohleb, Eric S 2023. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity, 109 , 127-138Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297Koo, Ja Wook; Wohleb, Eric S 2021. How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders. Biological psychiatry, 90 2, 74-84Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. The semantics of microglia activation: neuroinflammation, homeostasis, and stress. Journal of neuroinflammation, 18 1, 258Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy. Neurobiology of stress, 14 , 100312Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S 2020. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , Gerhard, Danielle M; Pothula, Santosh; Liu, Rong-Jian; Wu, Min; Li, Xiao-Yuan; Girgenti, Matthew J; Taylor, Seth R; Duman, Catharine H; Delpire, Eric; Picciotto, Marina; Wohleb, Eric S; Duman, Ronald S 2020. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal of clinical investigation, 130 3, 1336-1349Bollinger, J L; Wohleb, E S 2019. The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences. Neuroscience letters, 711 , 134369Deyama, Satoshi; Bang, Eunyoung; Wohleb, Eric S; Li, Xiao-Yuan; Kato, Taro; Gerhard, Danielle M; Dutheil, Sophie; Dwyer, Jason M; Taylor, Seth R; Picciotto, Marina R; Duman, Ronald S 2019. Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine. The American journal of psychiatry, 176 5, 388-400Girgenti, Matthew J; Wohleb, Eric S; Mehta, Sameet; Ghosal, Sriparna; Fogaca, Manoela V; Duman, Ronald S 2019. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry, 9 1, 292Horchar, Matthew J; Wohleb, Eric S 2019. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress Brain, Behavior, and Immunity, , Franklin, Tina C; Wohleb, Eric S; Zhang, Yi; Fogaça, Manoela; Hare, Brendan; Duman, Ronald S 2018. Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biological psychiatry, 83 1, 50-60Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S 2018. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior Biological Psychiatry, 83 1, 38-49Bath, Kevin G; Russo, Scott J; Pleil, Kristen E; Wohleb, Eric S; Duman, Ronald S; Radley, Jason J 2017. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. Neurobiology of stress, 7 , 137-151Bolyard, Chelsea; Meisen, W Hans; Banasavadi-Siddegowda, Yeshavanth; Hardcastle, Jayson; Yoo, Ji Young; Wohleb, Eric S; Wojton, Jeffrey; Yu, Jun-Ge; Dubin, Samuel; Khosla, Maninder; Xu, Bo; Smith, Jonathan; Alvarez-Breckenridge, Christopher; Pow-Anpongkul, Pete; Pichiorri, Flavia; Zhang, Jianying; Old, Matthew; Zhu, Dan; Van Meir, Erwin G; Godbout, Jonathan P; Caligiuri, Michael A; Yu, Jianhua; Kaur, Balveen 2017. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 7, 1809-1819Wohleb, Eric S; Delpech, Jean-Christophe 2017. Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences. Progress in neuro-psychopharmacology & biological psychiatry, 79 Pt A, 40-48Wohleb, Eric S; Gerhard, Danielle; Thomas, Alex; Duman, Ronald S 2017. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine. Current neuropharmacology, 15 1, 11-20Das, Amitava; Ghatak, Subhadip; Sinha, Mithun; Chaffee, Scott; Ahmed, Noha S; Parinandi, Narasimham L; Wohleb, Eric S; Sheridan, John F; Sen, Chandan K; Roy, Sashwati 2016. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. Journal of immunology (Baltimore, Md. : 1950), 196 12, 5089-100Dutheil, Sophie; Ota, Kristie T; Wohleb, Eric S; Rasmussen, Kurt; Duman, Ronald S 2016. High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41 7, 1874-87Gerhard, Danielle M; Wohleb, Eric S; Duman, Ronald S 2016. Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity. Drug discovery today, 21 3, 454-64Hansen, Christopher N; Norden, Diana M; Faw, Timothy D; Deibert, Rochelle; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P; Basso, D Michele 2016. Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. Experimental neurology, 282 , 86-98McKim, Daniel B; Niraula, Anzela; Tarr, Andrew J; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P 2016. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 9, 2590-604McKim, Daniel B; Patterson, Jenna M; Wohleb, Eric S; Jarrett, Brant L; Reader, Brenda F; Godbout, Jonathan P; Sheridan, John F 2016. Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat. Biological psychiatry, 79 10, 803-813Wohleb, Eric S 2016. Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse" Frontiers in Immunology, 7 , 544Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S 2016. Integrating neuroimmune systems in the neurobiology of depression Nature Reviews Neuroscience, 17 8, 497-511Wohleb, Eric S; Wu, Min; Gerhard, Danielle M; Taylor, Seth R; Picciotto, Marina R; Alreja, Meenakshi; Duman, Ronald S 2016. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine The Journal of Clinical Investigation, 126 7, 2482-94Delpech, Jean-Christophe; Madore, Charlotte; Nadjar, Agnes; Joffre, Corinne; Wohleb, Eric S; Layé, Sophie 2015. Microglia in neuronal plasticity: Influence of stress. Neuropharmacology, 96 Pt A, 19-28Fuchikami, Manabu; Thomas, Alexandra; Liu, Rongjian; Wohleb, Eric S; Land, Benjamin B; DiLeone, Ralph J; Aghajanian, George K; Duman, Ronald S 2015. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America, 112 26, 8106-11Meisen, W Hans; Wohleb, Eric S; Jaime-Ramirez, Alena Cristina; Bolyard, Chelsea; Yoo, Ji Young; Russell, Luke; Hardcastle, Jayson; Dubin, Samuel; Muili, Kamaldeen; Yu, Jianhua; Caligiuri, Michael; Godbout, Jonathan; Kaur, Balveen 2015. The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 14, 3274-85Navarria, Andrea; Wohleb, Eric S; Voleti, Bhavya; Ota, Kristie T; Dutheil, Sophie; Lepack, Ashley E; Dwyer, Jason M; Fuchikami, Manabu; Becker, Astrid; Drago, Filippo; Duman, Ronald S 2015. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors. Neurobiology of disease, 82 , 254-261Reader, B F; Jarrett, B L; McKim, D B; Wohleb, E S; Godbout, J P; Sheridan, J F 2015. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience, 289 , 429-42Sawicki, C M; McKim, D B; Wohleb, E S; Jarrett, B L; Reader, B F; Norden, D M; Godbout, J P; Sheridan, J F 2015. Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience, 302 , 151-64Wohleb, Eric S; McKim, Daniel B; Shea, Daniel T; Powell, Nicole D; Tarr, Andrew J; Sheridan, John F; Godbout, Jonathan P 2014. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biological psychiatry, 75 12, 970-81Wohleb, Eric S; McKim, Daniel B; Sheridan, John F; Godbout, Jonathan P 2014. Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Frontiers in neuroscience, 8 , 447Wohleb, Eric S; Patterson, Jenna M; Sharma, Vikram; Quan, Ning; Godbout, Jonathan P; Sheridan, John F 2014. Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 7, 2583-91Voorhees, Jeffrey L; Tarr, Andrew J; Wohleb, Eric S; Godbout, Jonathan P; Mo, Xiaokui; Sheridan, John F; Eubank, Timothy D; Marsh, Clay B 2013. Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PloS one, 8 3, e58488Wohleb, Eric S; Godbout, Jonathan P 2013. Basic aspects of the immunology of neuroinflammation. Modern trends in pharmacopsychiatry, 28 , 1-19Wohleb, Eric S; Powell, Nicole D; Godbout, Jonathan P; Sheridan, John F 2013. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 34, 13820-33Wohleb, Eric S; Fenn, Ashley M; Pacenta, Ann M; Powell, Nicole D; Sheridan, John F; Godbout, Jonathan P 2012. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology, 37 9, 1491-505Wohleb, Eric S; Hanke, Mark L; Corona, Angela W; Powell, Nicole D; Stiner, La'Tonia M; Bailey, Michael T; Nelson, Randy J; Godbout, Jonathan P; Sheridan, John F 2011. β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 17, 6277-88
Peer Reviewed Publications Bollinger, Justin L; Dadosky, David T; Flurer, James K; Rainer, Ivanka L; Woodburn, Samuel C; Wohleb, Eric S 2023. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48 9, 1347-1357Smail, Marissa A; Smith, Brittany L; Shukla, Rammohan; Alganem, Khaled; Eby, Hunter M; Bollinger, Justin L; Parikh, Ria K; Chambers, James B; Reigle, James K; Moloney, Rachel D; Nawreen, Nawshaba; Wohleb, Eric S; Pantazopoulos, Harry; McCullumsmith, Robert E; Herman, James P 2023. Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix. Molecular psychiatry, , Woodburn, Samuel C; Asrat, Helina S; Flurer, James K; Schwierling, Hana C; Bollinger, Justin L; Vollmer, Lauren L; Wohleb, Eric S 2023. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity, 109 , 127-138Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297Koo, Ja Wook; Wohleb, Eric S 2021. How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders. Biological psychiatry, 90 2, 74-84Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. The semantics of microglia activation: neuroinflammation, homeostasis, and stress. Journal of neuroinflammation, 18 1, 258Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy. Neurobiology of stress, 14 , 100312Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S 2020. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , Gerhard, Danielle M; Pothula, Santosh; Liu, Rong-Jian; Wu, Min; Li, Xiao-Yuan; Girgenti, Matthew J; Taylor, Seth R; Duman, Catharine H; Delpire, Eric; Picciotto, Marina; Wohleb, Eric S; Duman, Ronald S 2020. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal of clinical investigation, 130 3, 1336-1349Bollinger, J L; Wohleb, E S 2019. The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences. Neuroscience letters, 711 , 134369Deyama, Satoshi; Bang, Eunyoung; Wohleb, Eric S; Li, Xiao-Yuan; Kato, Taro; Gerhard, Danielle M; Dutheil, Sophie; Dwyer, Jason M; Taylor, Seth R; Picciotto, Marina R; Duman, Ronald S 2019. Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine. The American journal of psychiatry, 176 5, 388-400Girgenti, Matthew J; Wohleb, Eric S; Mehta, Sameet; Ghosal, Sriparna; Fogaca, Manoela V; Duman, Ronald S 2019. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry, 9 1, 292Horchar, Matthew J; Wohleb, Eric S 2019. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress Brain, Behavior, and Immunity, , Franklin, Tina C; Wohleb, Eric S; Zhang, Yi; Fogaça, Manoela; Hare, Brendan; Duman, Ronald S 2018. Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biological psychiatry, 83 1, 50-60Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S 2018. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior Biological Psychiatry, 83 1, 38-49Bath, Kevin G; Russo, Scott J; Pleil, Kristen E; Wohleb, Eric S; Duman, Ronald S; Radley, Jason J 2017. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. Neurobiology of stress, 7 , 137-151Bolyard, Chelsea; Meisen, W Hans; Banasavadi-Siddegowda, Yeshavanth; Hardcastle, Jayson; Yoo, Ji Young; Wohleb, Eric S; Wojton, Jeffrey; Yu, Jun-Ge; Dubin, Samuel; Khosla, Maninder; Xu, Bo; Smith, Jonathan; Alvarez-Breckenridge, Christopher; Pow-Anpongkul, Pete; Pichiorri, Flavia; Zhang, Jianying; Old, Matthew; Zhu, Dan; Van Meir, Erwin G; Godbout, Jonathan P; Caligiuri, Michael A; Yu, Jianhua; Kaur, Balveen 2017. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 7, 1809-1819Wohleb, Eric S; Delpech, Jean-Christophe 2017. Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences. Progress in neuro-psychopharmacology & biological psychiatry, 79 Pt A, 40-48Wohleb, Eric S; Gerhard, Danielle; Thomas, Alex; Duman, Ronald S 2017. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine. Current neuropharmacology, 15 1, 11-20Das, Amitava; Ghatak, Subhadip; Sinha, Mithun; Chaffee, Scott; Ahmed, Noha S; Parinandi, Narasimham L; Wohleb, Eric S; Sheridan, John F; Sen, Chandan K; Roy, Sashwati 2016. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. Journal of immunology (Baltimore, Md. : 1950), 196 12, 5089-100Dutheil, Sophie; Ota, Kristie T; Wohleb, Eric S; Rasmussen, Kurt; Duman, Ronald S 2016. High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41 7, 1874-87Gerhard, Danielle M; Wohleb, Eric S; Duman, Ronald S 2016. Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity. Drug discovery today, 21 3, 454-64Hansen, Christopher N; Norden, Diana M; Faw, Timothy D; Deibert, Rochelle; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P; Basso, D Michele 2016. Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. Experimental neurology, 282 , 86-98McKim, Daniel B; Niraula, Anzela; Tarr, Andrew J; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P 2016. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 9, 2590-604McKim, Daniel B; Patterson, Jenna M; Wohleb, Eric S; Jarrett, Brant L; Reader, Brenda F; Godbout, Jonathan P; Sheridan, John F 2016. Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat. Biological psychiatry, 79 10, 803-813Wohleb, Eric S 2016. Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse" Frontiers in Immunology, 7 , 544Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S 2016. Integrating neuroimmune systems in the neurobiology of depression Nature Reviews Neuroscience, 17 8, 497-511Wohleb, Eric S; Wu, Min; Gerhard, Danielle M; Taylor, Seth R; Picciotto, Marina R; Alreja, Meenakshi; Duman, Ronald S 2016. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine The Journal of Clinical Investigation, 126 7, 2482-94Delpech, Jean-Christophe; Madore, Charlotte; Nadjar, Agnes; Joffre, Corinne; Wohleb, Eric S; Layé, Sophie 2015. Microglia in neuronal plasticity: Influence of stress. Neuropharmacology, 96 Pt A, 19-28Fuchikami, Manabu; Thomas, Alexandra; Liu, Rongjian; Wohleb, Eric S; Land, Benjamin B; DiLeone, Ralph J; Aghajanian, George K; Duman, Ronald S 2015. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America, 112 26, 8106-11Meisen, W Hans; Wohleb, Eric S; Jaime-Ramirez, Alena Cristina; Bolyard, Chelsea; Yoo, Ji Young; Russell, Luke; Hardcastle, Jayson; Dubin, Samuel; Muili, Kamaldeen; Yu, Jianhua; Caligiuri, Michael; Godbout, Jonathan; Kaur, Balveen 2015. The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 14, 3274-85Navarria, Andrea; Wohleb, Eric S; Voleti, Bhavya; Ota, Kristie T; Dutheil, Sophie; Lepack, Ashley E; Dwyer, Jason M; Fuchikami, Manabu; Becker, Astrid; Drago, Filippo; Duman, Ronald S 2015. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors. Neurobiology of disease, 82 , 254-261Reader, B F; Jarrett, B L; McKim, D B; Wohleb, E S; Godbout, J P; Sheridan, J F 2015. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience, 289 , 429-42Sawicki, C M; McKim, D B; Wohleb, E S; Jarrett, B L; Reader, B F; Norden, D M; Godbout, J P; Sheridan, J F 2015. Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience, 302 , 151-64Wohleb, Eric S; McKim, Daniel B; Shea, Daniel T; Powell, Nicole D; Tarr, Andrew J; Sheridan, John F; Godbout, Jonathan P 2014. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biological psychiatry, 75 12, 970-81Wohleb, Eric S; McKim, Daniel B; Sheridan, John F; Godbout, Jonathan P 2014. Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Frontiers in neuroscience, 8 , 447Wohleb, Eric S; Patterson, Jenna M; Sharma, Vikram; Quan, Ning; Godbout, Jonathan P; Sheridan, John F 2014. Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 7, 2583-91Voorhees, Jeffrey L; Tarr, Andrew J; Wohleb, Eric S; Godbout, Jonathan P; Mo, Xiaokui; Sheridan, John F; Eubank, Timothy D; Marsh, Clay B 2013. Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PloS one, 8 3, e58488Wohleb, Eric S; Godbout, Jonathan P 2013. Basic aspects of the immunology of neuroinflammation. Modern trends in pharmacopsychiatry, 28 , 1-19Wohleb, Eric S; Powell, Nicole D; Godbout, Jonathan P; Sheridan, John F 2013. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 34, 13820-33Wohleb, Eric S; Fenn, Ashley M; Pacenta, Ann M; Powell, Nicole D; Sheridan, John F; Godbout, Jonathan P 2012. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology, 37 9, 1491-505Wohleb, Eric S; Hanke, Mark L; Corona, Angela W; Powell, Nicole D; Stiner, La'Tonia M; Bailey, Michael T; Nelson, Randy J; Godbout, Jonathan P; Sheridan, John F 2011. β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 17, 6277-88
Bollinger, Justin L; Dadosky, David T; Flurer, James K; Rainer, Ivanka L; Woodburn, Samuel C; Wohleb, Eric S 2023. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48 9, 1347-1357Smail, Marissa A; Smith, Brittany L; Shukla, Rammohan; Alganem, Khaled; Eby, Hunter M; Bollinger, Justin L; Parikh, Ria K; Chambers, James B; Reigle, James K; Moloney, Rachel D; Nawreen, Nawshaba; Wohleb, Eric S; Pantazopoulos, Harry; McCullumsmith, Robert E; Herman, James P 2023. Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix. Molecular psychiatry, , Woodburn, Samuel C; Asrat, Helina S; Flurer, James K; Schwierling, Hana C; Bollinger, Justin L; Vollmer, Lauren L; Wohleb, Eric S 2023. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity, 109 , 127-138Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297Koo, Ja Wook; Wohleb, Eric S 2021. How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders. Biological psychiatry, 90 2, 74-84Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. The semantics of microglia activation: neuroinflammation, homeostasis, and stress. Journal of neuroinflammation, 18 1, 258Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy. Neurobiology of stress, 14 , 100312Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S 2020. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , Gerhard, Danielle M; Pothula, Santosh; Liu, Rong-Jian; Wu, Min; Li, Xiao-Yuan; Girgenti, Matthew J; Taylor, Seth R; Duman, Catharine H; Delpire, Eric; Picciotto, Marina; Wohleb, Eric S; Duman, Ronald S 2020. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal of clinical investigation, 130 3, 1336-1349Bollinger, J L; Wohleb, E S 2019. The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences. Neuroscience letters, 711 , 134369Deyama, Satoshi; Bang, Eunyoung; Wohleb, Eric S; Li, Xiao-Yuan; Kato, Taro; Gerhard, Danielle M; Dutheil, Sophie; Dwyer, Jason M; Taylor, Seth R; Picciotto, Marina R; Duman, Ronald S 2019. Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine. The American journal of psychiatry, 176 5, 388-400Girgenti, Matthew J; Wohleb, Eric S; Mehta, Sameet; Ghosal, Sriparna; Fogaca, Manoela V; Duman, Ronald S 2019. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry, 9 1, 292Horchar, Matthew J; Wohleb, Eric S 2019. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress Brain, Behavior, and Immunity, , Franklin, Tina C; Wohleb, Eric S; Zhang, Yi; Fogaça, Manoela; Hare, Brendan; Duman, Ronald S 2018. Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biological psychiatry, 83 1, 50-60Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S 2018. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior Biological Psychiatry, 83 1, 38-49Bath, Kevin G; Russo, Scott J; Pleil, Kristen E; Wohleb, Eric S; Duman, Ronald S; Radley, Jason J 2017. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. 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