Michael T. Williams, MD

Braun, Amanda A; Amos-Kroohs, Robyn M; Gutierrez, Arnold; Lundgren, Kerstin H; Seroogy, Kim B; Skelton, Matthew R; Vorhees, Charles V; Williams, Michael T 2015. Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning. Neurobiology of learning and memory, 118 , 55-63

Hautman, Emily R; Kokenge, Amanda N; Udobi, Kenea C; Williams, Michael T; Vorhees, Charles V; Skelton, Matthew R 2014. Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits. Journal of inherited metabolic disease, 37 1, 63-8

Williams, Michael T; Skelton, Matthew R; Longacre, Ian D; Huggins, Kimberly N; Maple, Amanda M; Vorhees, Charles V; Brown, Russell W 2014. Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine. Toxicology reports, 1 , 699-706

Graham, Devon L; Amos-Kroohs, Robyn M; Braun, Amanda A; Grace, Curtis E; Schaefer, Tori L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V 2013. Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 16 2, 377-91

Braun, Amanda A; Graham, Devon L; Schaefer, Tori L; Vorhees, Charles V; Williams, Michael T 2012. Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiology of learning and memory, 97 4, 402-8

Chen, Y; Curran, C P; Nebert, D W; Patel, K V; Williams, M T; Vorhees, C V 2012. Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice. Genes, brain, and behavior, 11 3, 269-77

Chen, Ying; Curran, Christine P; Nebert, Daniel W; Patel, Krishna V; Williams, Michael T; Vorhees, Charles V 2012. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicology and teratology, 34 4, 450-7

Vorhees, Charles V; Graham, Devon L; Braun, Amanda A; Schaefer, Tori L; Skelton, Matthew R; Richtand, Neil M; Williams, Michael T 2012. Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC. Synapse (New York, N.Y.), 66 8, 725-37

Braun, Amanda A; Skelton, Matthew R; Vorhees, Charles V; Williams, Michael T 2011. Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents. Pharmacology, biochemistry, and behavior, 97 3, 406-15

Curran, Christine P; Vorhees, Charles V; Williams, Michael T; Genter, Mary Beth; Miller, Marian L; Nebert, Daniel W 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological sciences : an official journal of the Society of Toxicology, 119 1, 189-208

Vorhees, Charles V; Morford, LaRonda R; Graham, Devon L; Skelton, Matthew R; Williams, Michael T 2011. Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug. Behavioral and brain functions : BBF, 7 , 41

Grace, Curtis E; Schaefer, Tori L; Graham, Devon L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V 2010. Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 28 4, 331-42

Schaefer, T L; Grace, C E; Gudelsky, G A; Vorhees, C V; Williams, M T 2010. Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress (Amsterdam, Netherlands), 13 6, 469-80

Vorhees, Charles V; Schaefer, Tori L; Skelton, Matthew R; Grace, Curtis E; Herring, Nicole R; Williams, Michael T 2009. (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. Developmental neuroscience, 31 1-2, 107-20

Vorhees, Charles V; Skelton, Matthew R; Grace, Curtis E; Schaefer, Tori L; Graham, Devon L; Braun, Amanda A; Williams, Michael T 2009. Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 27 3, 289-98

Herring, Nicole R; Schaefer, Tori L; Tang, Peter H; Skelton, Matthew R; Lucot, James P; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC neuroscience, 9 , 49

Pan, Dao; Sciascia, Anthony; Vorhees, Charles V; Williams, Michael T 2008. Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome. Brain research, 1188 , 241-53

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology, 55 7, 1121-30

Sun, Ying; Jia, Li; Williams, Michael T; Zamzow, Matt; Ran, Huimin; Quinn, Brian; Aronow, Bruce J; Vorhees, Charles V; Witte, David P; Grabowski, Gregory A 2008. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. BMC neuroscience, 9 , 76

Sun, Ying; Witte, David P; Ran, Huimin; Zamzow, Matt; Barnes, Sonya; Cheng, Hua; Han, Xianlin; Williams, Michael T; Skelton, Matthew R; Vorhees, Charles V; Grabowski, Gregory A 2008. Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice. Human molecular genetics, 17 15, 2345-56

Lingrel, Jerry B; Williams, Michael T; Vorhees, Charles V; Moseley, Amy E 2007. Na,K-ATPase and the role of alpha isoforms in behavior. Journal of bioenergetics and biomembranes, 39 5-6, 385-9

Moseley, Amy E; Williams, Michael T; Schaefer, Tori L; Bohanan, Cynthia S; Neumann, Jon C; Behbehani, Michael M; Vorhees, Charles V; Lingrel, Jerry B 2007. Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 3, 616-26

Vorhees, Charles V; Schaefer, Tori L; Williams, Michael T 2007. Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution. Synapse (New York, N.Y.), 61 7, 488-99

Williams, Michael T; Herring, Nicole R; Schaefer, Tori L; Skelton, Matthew R; Campbell, Nicholas G; Lipton, Jack W; McCrea, Anne E; Vorhees, Charles V 2007. Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 6, 1404-20

Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological psychiatry, 59 12, 1219-26

Brown, Russell W; Perna, Marla K; Schaefer, Tori L; Williams, Michael T 2006. The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole. Synapse (New York, N.Y.), 59 5, 253-9

Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. Journal of neurochemistry, 98 5, 1369-78

Vorhees, Charles V; Williams, Michael T 2006. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature protocols, 1 2, 848-58

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V 2005. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research, 1039 1-2, 97-107

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T 2004. Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. Synapse (New York, N.Y.), 54 4, 214-22

Williams, Michael T; Brown, Russell W; Vorhees, Charles V 2004. Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex. The European journal of neuroscience, 19 12, 3165-70

Williams, Michael T; Moran, Mary S; Vorhees, Charles V 2003. Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze. Psychopharmacology, 168 3, 329-38

Williams, Michael T; Morford, LaRonda L; Wood, Sandra L; Rock, Stephanie L; McCrea, Anne E; Fukumura, Masao; Wallace, Tanya L; Broening, Harry W; Moran, Mary S; Vorhees, Charles V 2003. Developmental 3,4-methylenedioxymethamphetamine (MDMA) impairs sequential and spatial but not cued learning independent of growth, litter effects or injection stress. Brain research, 968 1, 89-101

Williams, Michael T; Morford, LaRonda L; Wood, Sandra L; Wallace, Tanya L; Fukumura, Masao; Broening, Harry W; Vorhees, Charles V 2003. Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory. Synapse (New York, N.Y.), 48 3, 138-48

Williams, Michael T; Vorhees, Charles V; Boon, Francis; Saber, Andrea J; Cain, Donald P 2002. Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats. Brain research, 958 2, 312-21

Williams, M T; Hennessy, M B; Davis, H N 1995. CRF administered to pregnant rats alters offspring behavior and morphology. Pharmacology, biochemistry, and behavior, 52 1, 161-7

Amos-Kroohs, Robyn M; Bloor, Colin P; Qureshi, Momina A; Vorhees, Charles V; Williams, Michael T . Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801. Toxicology reports, 2 , 1046-1056

Becker, Lora A; Kunkel, Aaron J; Brown, Michelle R; Ball, Erin E; Williams, Michael T . Effects of dietary phytoestrogen exposure during perinatal period. Neurotoxicology and teratology, 27 6, 825-34

Grace, Curtis E; Schaefer, Tori L; Herring, Nicole R; Williams, Michael T; Vorhees, Charles V . Effects of neonatal methamphetamine treatment on adult stress-induced corticosterone release in rats. Neurotoxicology and teratology, 34 1, 136-42

Vorhees, Charles V; Graham, Devon L; Braun, Amanda A; Schaefer, Tori L; Skelton, Matthew R; Richtand, Neil M; Williams, Michael T . Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. Neurotoxicology and teratology, 47 , 54-65

Vorhees, Charles V; Reed, Tracy M; Morford, LaRonda L; Fukumura, Masao; Wood, Sandra L; Brown, Carrie A; Skelton, Matthew R; McCrea, Anne E; Rock, Stephanie L; Williams, Michael T . Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60). Neurotoxicology and teratology, 27 1, 117-34

Williams, M T; Davis, H N; McCrea, A E; Hennessy, M B . Stress during pregnancy alters the offspring hypothalamic, pituitary, adrenal, and testicular response to isolation on the day of weaning. Neurotoxicology and teratology, 21 6, 653-9

Williams, M T; Davis, H N; McCrea, A E; Hennessy, M B . The distribution of radiolabeled corticotropin-releasing factor in pregnant rats: an investigation of placental transfer to the fetuses. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 16 3-4, 229-34

Williams, Michael T; Moran, Mary S; Vorhees, Charles V . Behavioral and growth effects induced by low dose methamphetamine administration during the neonatal period in rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 22 5-6, 273-83