Education/CredentialsBA Chemistry: Kalamazoo CollegePhD in Pharmacology: Michigan State University Contact Information Email gudelsga@ucmail.uc.edu Research InterestsNeuropharmacology of amphetamines Peer Reviewed Publications O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695Collins, Sean M; O'Connell, Christopher J; Reeder, Evan L; Norman, Sophia V; Lungani, Kainat; Gopalan, Poornima; Gudelsky, Gary A; Robson, Matthew J 2022. Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance. Frontiers in pharmacology, 13 , 930346Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B 2022. Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. Investigational new drugs, 40 5, 944-952Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Pitzer, Emily M; Sugimoto, Chiho; Regan, Samantha L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V 2022. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Current research in toxicology, 3 , 100093Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B 2019. Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. Cancer chemotherapy and pharmacology, 83 1, 81-89Pitzer, Emily M; Sugimoto, Chiho; Gudelsky, Gary A; Huff Adams, Courtney L; Williams, Michael T; Vorhees, Charles V 2019. Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits. Toxicological sciences : an official journal of the Society of Toxicology, 169 2, 511-523Collins, Stuart A; Huff, Courtney; Chiaia, Nicolas; Gudelsky, Gary A; Yamamoto, Bryan K 2016. 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling. Journal of neurochemistry, 136 5, 1074-84Huff, Courtney L; Morano, Rachel L; Herman, James P; Yamamoto, Bryan K; Gudelsky, Gary A 2016. MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate. Neurotoxicology, 57 , 282-290Collins, Stuart A; Gudelsky, Gary A; Yamamoto, Bryan K 2015. MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors. European journal of pharmacology, 761 , 95-100Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B 2015. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Molecular cancer therapeutics, 14 4, 857-64Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth 2014. Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain. Drug delivery, 21 1, 8-16Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A 2014. Effects of stress and MDMA on hippocampal gene expression. BioMed research international, 2014 , 141396Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A 2013. MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8 1, 58-65Dave, Nimita; Gudelsky, Gary A; Desai, Pankaj B 2013. The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. Cancer chemotherapy and pharmacology, 72 2, 349-57Dave,N; Gudelsky,G; Desai,P 2013. The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma assessed by intracerebral microdialysis Cancer Chemother Pharmacol, 72 2, 349Huff, Courtney; Bhide, Nirmal; Schroering, Allen; Yamamoto, Bryan K; Gudelsky, Gary A 2013. Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake. Brain research bulletin, 91 , 52-7Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M 2013. Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect? Medical hypotheses, 80 3, 252-8Anneken, John H; Gudelsky, Gary A 2012. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology, 63 6, 1022-7Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M 2012. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology, 63 4, 575-81Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2012. Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats. ACS chemical neuroscience, 3 1, 12-21Darvesh, Altaf S; Carroll, Richard T; Geldenhuys, Werner J; Gudelsky, Gary A; Klein, Jochen; Meshul, Charles K; Van der Schyf, Cornelis J 2011. In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery. Expert opinion on drug discovery, 6 2, 109-127Roenker, Nicole L; Gudelsky, Gary; Ahlbrand, Rebecca; Bronson, Stefanie L; Kern, Joseph R; Waterman, Heather; Richtand, Neil M 2011. Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801. Neuroscience letters, 500 3, 167-71Roenker, NL, Gudelsky, GA, Ahlbrand, R, Bronson, SL, Kern,JR, Waterman, H and Richtand, NM 2011. Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801 Neuroscience Letters, 500 , 575-581Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2010. (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia. Synapse (New York, N.Y.), 64 10, 773-85Pachmerhiwala, Rashida; Bhide, Nirmal; Straiko, Megan; Gudelsky, Gary A 2010. Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. European journal of pharmacology, 644 1-3, 67-72Schaefer, T L; Grace, C E; Gudelsky, G A; Vorhees, C V; Williams, M T 2010. Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress (Amsterdam, Netherlands), 13 6, 469-80Yamamoto, Bryan K; Moszczynska, Anna; Gudelsky, Gary A 2010. Amphetamine toxicities: classical and emerging mechanisms. Annals of the New York Academy of Sciences, 1187 , 101-21Bhide, Nirmal S; Lipton, Jack W; Cunningham, Jacobi I; Yamamoto, Bryan K; Gudelsky, Gary A 2009. Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain. Brain research, 1286 , 32-41Apparaju, Sandhya Kiran; Gudelsky, Gary A; Desai, Pankaj B 2008. Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis. Cancer chemotherapy and pharmacology, 61 2, 223-9Gudelsky, GA and Yamamoto, BK 2008. Actions of 3,4methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, Biochemistry and Behavior, 90 , 198-207Gudelsky, Gary A; Yamamoto, Bryan K 2008. Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, biochemistry, and behavior, 90 2, 198-207Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats. Psychopharmacology, 199 4, 637-50Herring, Nicole R; Schaefer, Tori L; Tang, Peter H; Skelton, Matthew R; Lucot, James P; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC neuroscience, 9 2, 49-59Schaefer, TL, Skelton, MR, Herring, NR, Gudelsky, GA, Vorhees, CV, Williams, MT 2008. Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J. Neurochemistry, 104 , 1674-1685Schaefer, Tori L; Skelton, Matthew R; Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. Journal of neurochemistry, 104 6, 1674-85Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology, 55 7, 1121-30Straiko, M M W; Coolen, L M; Zemlan, F P; Gudelsky, G A 2007. The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain. Neuroscience, 144 1, 223-31Straiko, Megan M W; Gudelsky, Gary A; Coolen, Lique M 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats. Behavioral neuroscience, 121 3, 586-93Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA 2007. The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain Neuroscience, 144 , 223-231Straiko, MM, Gudelsky, GA and Coolen, LM 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats Behavioral Neuroscience, 121 3, 58-593Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological psychiatry, 59 12, 1219-26Nair, S G; Gudelsky, G A 2006. Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. Brain research bulletin, 69 4, 382-7Nair, Sunila G; Gudelsky, Gary A 2006. 3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat. Psychopharmacology, 184 2, 182-9Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. Journal of neurochemistry, 98 5, 1369-78Darvesh, A, Yamamoto, BK and Gudelsky, GA. 2005. Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain J. Pharmacol. Exp. Ther, 312 , 694-701Darvesh, Altaf S; Gudelsky, Gary A 2005. Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT Brain research, 1056 2, 168-75Darvesh, Altaf S; Yamamoto, Bryan K; Gudelsky, Gary A 2005. Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. The Journal of pharmacology and experimental therapeutics, 312 2, 694-701Nair, SG and Gudelsky, GA 2005. 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex Synapse, 58 , 229-235Nair, Sunila G; Gudelsky, Gary A 2005. 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. Synapse (New York, N.Y.), 58 4, 229-35Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V 2005. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research, 1039 1-2, 97-107Nair, Sunila G; Gudelsky, Gary A 2004. Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat. Brain research, 1013 2, 168-73Nair, Sunila G; Gudelsky, Gary A 2004. Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat. Synapse (New York, N.Y.), 53 4, 202-7Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T 2004. Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. Synapse (New York, N.Y.), 54 4, 214-22Darvesh, Altaf S; Gudelsky, Gary A 2003. Activation of 5-HT2 receptors induces glycogenolysis in the rat brain. European journal of pharmacology, 464 2-3, 135-40Gudelsky, Gary A; Yamamoto, Bryan K 2003. Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine. Methods in molecular medicine, 79 , 55-73Hui, Anna S; Striet, Justin B; Gudelsky, Gary; Soukhova, Galia K; Gozal, Evelyne; Beitner-Johnson, Dana; Guo, Shang-Z; Sachleben, Leroy R; Haycock, John W; Gozal, David; Czyzyk-Krzeska, Maria F 2003. Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons. Hypertension (Dallas, Tex. : 1979), 42 6, 1130-6Wallace, T L; Vorhees, C V; Zemlan, F P; Gudelsky, G A 2003. Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience, 116 4, 1063-8Williams, Michael T; Blankenmeyer, Tracy L; Schaefer, Tori L; Brown, Carrie A; Gudelsky, Gary A; Vorhees, Charles V 2003. Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood. Brain research. Developmental brain research, 147 1-2, 163-75Darvesh, Altaf S; Shankaran, Mahalakshmi; Gudelsky, Gary A 2002. 3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain. The Journal of pharmacology and experimental therapeutics, 301 1, 138-44Shankaran, M; Yamamoto, B K; Gudelsky, G A 2001. Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT. Synapse (New York, N.Y.), 40 1, 55-64Wallace, T L; Gudelsky, G A; Vorhees, C V 2001. Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine. Psychopharmacology, 153 3, 321-6Wallace, T L; Gudelsky, G A; Vorhees, C V 2001. Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat. Synapse (New York, N.Y.), 39 1, 1-7Wallace, T L; Vorhees, C V; Gudelsky, G A 2001. Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine. Synapse (New York, N.Y.), 40 2, 95-101Burrows, K B; Gudelsky, G; Yamamoto, B K 2000. Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration. European journal of pharmacology, 398 1, 11-8Harold, C; Wallace, T; Friedman, R; Gudelsky, G; Yamamoto, B 2000. Methamphetamine selectively alters brain glutathione. European journal of pharmacology, 400 1, 99-102Shankaran, M; Gudelsky, G A 1999. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology, 147 1, 66-72Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. European journal of pharmacology, 385 2-3, 103-10Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum. Journal of neurochemistry, 72 6, 2516-22Wallace, T L; Gudelsky, G A; Vorhees, C V 1999. Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19 20, 9141-8Shankaran, M; Gudelsky, G A 1998. Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin. Pharmacology, biochemistry, and behavior, 61 4, 361-6Gudelsky, G A 1996. Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin. Journal of neural transmission (Vienna, Austria : 1996), 103 12, 1397-404Gudelsky, G A; Nash, J F 1996. Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. Journal of neurochemistry, 66 1, 243-9Gudelsky, G A; Nwajei, E E; Defife, K; Nash, J F 1992. Effects of amfonelic acid and GBR 12909 on the haloperidol- and clozapine-induced activation of dopamine neurons. Psychopharmacology bulletin, 28 3, 275-9Nash, J F; Meltzer, H Y; Gudelsky, G A 1988. Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, 151 3, 463-9Ackerman, G E; MacDonald, P C; Gudelsky, G; Mendelson, C R; Simpson, E R 1981. Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives. Endocrinology, 109 6, 2084-8 Collins S.M.; O’Connell C.J.; Reeder E.L.; Norman S.V.; Lungani K.; Gopalan P.; Gudelsky G.A.; Robson M.J. 07-15-2022. Altered Serotonin 2A (5-HT<inf>2A</inf>) Receptor Signaling Underlies Mild TBI-Elicited Frontiers in Pharmacology, 13 , Anneken J.; Collins S.; Yamamoto B.; Gudelsky G. 04-15-2016. MDMA and Glutamate: Implications for Hippocampal Neurotoxicity Neuropathology of Drug Addictions and Substance Misuse, 2 , 406-414 Arora P.; Gudelsky G.; Desai P.B. 04-01-2021. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: A PLoS ONE, 16 4 April, Gudelsky G.; Hippius H.; Meltzer H.; Naber D. 03-01-1989. Summary of discussions Psychopharmacology, 99 1 Supplement, Oatman N.; Dasgupta N.; Arora P.; Choi K.; Gawali M.V.; Gupta N.; Parameswaran S.; Salomone J.; Reisz J.A.; Lawler S.; Furnari F.; Brennan C.; Wu J.; Sallans L.; Gudelsky G.; Desai P.; Gebelein B.; Weirauch M.T.; D'Alessandro A.; Komurov K.; Dasgupta B. 02-10-2021. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer Science Advances, 7 7, Darvesh A.; Carroll R.; Geldenhuys W.; Gudelsky G.; Klein J.; Meshul C.; Van Der Schyf C. 02-01-2011. In vivo brain microdialysis: Advances in neuropsychopharmacology and drug discovery Expert Opinion on Drug Discovery, 6 2, 109-127 Schaefer T.; Grace C.; Skelton M.; Graham D.; Gudelsky G.; Vorhees C.; Williams M. 01-18-2012. Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats ACS Chemical Neuroscience, 3 1, 12-21 Pitzer E.M.; Sugimoto C.; Regan S.L.; Gudelsky G.A.; Williams M.T.; Vorhees C.V. 01-01-2022. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats Current Research in Toxicology, 3 , Anneken J.H.; Collins S.A.; Yamamoto B.K.; Gudelsky G.A. 01-01-2016. MDMA and Glutamate: Implications for Hippocampal Neurotoxicity Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects, , 406-414 Yamamoto B.; Moszczynska A.; Gudelsky G. 01-01-2010. Amphetamine toxicities: Classical and emerging mechanisms Annals of the New York Academy of Sciences, 1187 , 101-121 Wallace T.L.; Gudelsky G.A.; Vorhees C.V. 01-01-2001. Effect of chronic olanzapine treatment on striatal synaptic organization Synapse, 39 1, 8-15 Gudelsky G.A.; Nash J.F.; Koenig J.I.; Meltzer H.Y. 01-01-1987. Neuroendocrine effects of typical and atypical antipsychotics in the rat Psychopharmacology Bulletin, 23 3, 483-486 Locatelli V.; Apud J.A.; Gudelsky G.A.; Cocchi D.; Masotto C.; Casanueva F.; Racagni G.; Müller E.E. 01-01-1985. Prolactin in cerebrospinal fluid increases the synthesis and release of hypothalamic ?-aminobutyric Journal of Endocrinology, 106 3, 323-328 Porter J.C.; Dale Nansel D.; Gudelsky G.A.; Reymond M.J.; Pilotte N.S.; Foreman M.M.; Tilders F.J.H. 01-01-1980. Some aspects of hypothalamic and hypophysial secretion in aging rats Peptides, 1 SUPPL. 1, 135-139 Gudelsky G.A.; Porter J.C. 01-01-1979. Prolactin and haloperidol stimulation of hypothalamic secretion of dopamine into pituitary stalk blo Federation Proceedings, 38 3 II, Nansel D.D.; Gudelsky G.A.; Porter J.C. 01-01-1979. Subcellular localization of dopamine in the anterior pituitary gland of the rat: Apparent associatio Federation Proceedings, 38 3 II, Annunziato L.; Gudelsky G.; Moore K. 01-01-1977. The effects of hypothalamic deafferentation on the haloperidol induced activation of tuberoinfundibu Pharmacologist, 19 2, Gudelsky G.; Annunziato L.; Ravitz A. 01-01-1977. Effects of estrogen on serum prolactin levels and dopamine turnover in nigrostriatal and tuberoinfun Federation Proceedings, 36 3, Gudelsky G.; Moore K. 01-01-1976. Differential drug effects on the tuberoinfundibular, mesolimbic and nigrostriatal dopaminergic neuro Pharmacologist, 18 2, Gudelsky G.; Simpkins J.; Mueller G.; Meites J.; Moore K. 01-01-1976. Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH Neuroendocrinology, 22 3, 206-215 Rech R.; Gudelsky G. 01-01-1974. Interactions between Ro4 1284 and d amphetamine (dA) on shuttle box avoidance in rats Pharmacologist, 16 2, . , , . , , Darvesh, Altaf S; Gudelsky, Gary A . The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats. Neurotoxicology and teratology, 26 4, 571-7Grace, Curtis E; Schaefer, Tori L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V . Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology, 32 3, 356-61Grace, Curtis E; Schaefer, Tori L; Herring, Nicole R; Graham, Devon L; Skelton, Matthew R; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V . Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice. Neurotoxicology and teratology, 32 3, 346-55
Peer Reviewed Publications O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695Collins, Sean M; O'Connell, Christopher J; Reeder, Evan L; Norman, Sophia V; Lungani, Kainat; Gopalan, Poornima; Gudelsky, Gary A; Robson, Matthew J 2022. Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance. Frontiers in pharmacology, 13 , 930346Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B 2022. Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. Investigational new drugs, 40 5, 944-952Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Pitzer, Emily M; Sugimoto, Chiho; Regan, Samantha L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V 2022. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Current research in toxicology, 3 , 100093Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B 2019. Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. 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MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors. European journal of pharmacology, 761 , 95-100Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B 2015. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Molecular cancer therapeutics, 14 4, 857-64Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth 2014. Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain. Drug delivery, 21 1, 8-16Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A 2014. Effects of stress and MDMA on hippocampal gene expression. BioMed research international, 2014 , 141396Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A 2013. 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Brain research bulletin, 91 , 52-7Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M 2013. Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect? Medical hypotheses, 80 3, 252-8Anneken, John H; Gudelsky, Gary A 2012. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology, 63 6, 1022-7Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M 2012. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology, 63 4, 575-81Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2012. Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats. 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Behavioral neuroscience, 121 3, 586-93Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA 2007. The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain Neuroscience, 144 , 223-231Straiko, MM, Gudelsky, GA and Coolen, LM 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats Behavioral Neuroscience, 121 3, 58-593Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological psychiatry, 59 12, 1219-26Nair, S G; Gudelsky, G A 2006. Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. Brain research bulletin, 69 4, 382-7Nair, Sunila G; Gudelsky, Gary A 2006. 3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat. Psychopharmacology, 184 2, 182-9Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. Journal of neurochemistry, 98 5, 1369-78Darvesh, A, Yamamoto, BK and Gudelsky, GA. 2005. Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain J. Pharmacol. Exp. Ther, 312 , 694-701Darvesh, Altaf S; Gudelsky, Gary A 2005. 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O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J 2024. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology, 374 , 114695Collins, Sean M; O'Connell, Christopher J; Reeder, Evan L; Norman, Sophia V; Lungani, Kainat; Gopalan, Poornima; Gudelsky, Gary A; Robson, Matthew J 2022. Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance. Frontiers in pharmacology, 13 , 930346Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B 2022. Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. Investigational new drugs, 40 5, 944-952Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Pitzer, Emily M; Sugimoto, Chiho; Regan, Samantha L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V 2022. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Current research in toxicology, 3 , 100093Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B 2019. Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. 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MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors. European journal of pharmacology, 761 , 95-100Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B 2015. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Molecular cancer therapeutics, 14 4, 857-64Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth 2014. Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain. Drug delivery, 21 1, 8-16Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A 2014. Effects of stress and MDMA on hippocampal gene expression. BioMed research international, 2014 , 141396Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A 2013. 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Brain research bulletin, 91 , 52-7Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M 2013. Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect? Medical hypotheses, 80 3, 252-8Anneken, John H; Gudelsky, Gary A 2012. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology, 63 6, 1022-7Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M 2012. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology, 63 4, 575-81Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2012. Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats. 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Behavioral neuroscience, 121 3, 586-93Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA 2007. The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain Neuroscience, 144 , 223-231Straiko, MM, Gudelsky, GA and Coolen, LM 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats Behavioral Neuroscience, 121 3, 58-593Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological psychiatry, 59 12, 1219-26Nair, S G; Gudelsky, G A 2006. Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. 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Methamphetamine selectively alters brain glutathione. European journal of pharmacology, 400 1, 99-102Shankaran, M; Gudelsky, G A 1999. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology, 147 1, 66-72Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. European journal of pharmacology, 385 2-3, 103-10Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum. Journal of neurochemistry, 72 6, 2516-22Wallace, T L; Gudelsky, G A; Vorhees, C V 1999. Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat. 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Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, 151 3, 463-9Ackerman, G E; MacDonald, P C; Gudelsky, G; Mendelson, C R; Simpson, E R 1981. Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives. Endocrinology, 109 6, 2084-8 Collins S.M.; O’Connell C.J.; Reeder E.L.; Norman S.V.; Lungani K.; Gopalan P.; Gudelsky G.A.; Robson M.J. 07-15-2022. Altered Serotonin 2A (5-HT<inf>2A</inf>) Receptor Signaling Underlies Mild TBI-Elicited Frontiers in Pharmacology, 13 , Anneken J.; Collins S.; Yamamoto B.; Gudelsky G. 04-15-2016. MDMA and Glutamate: Implications for Hippocampal Neurotoxicity Neuropathology of Drug Addictions and Substance Misuse, 2 , 406-414 Arora P.; Gudelsky G.; Desai P.B. 04-01-2021. 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