Contact Information Childrens Hospital Bldg R Office 513-636-4526 Email danzersc@ucmail.uc.edu Research InterestsMy laboratory examines changes in the structure and function of brain circuitry that drive focal epileptogenesis, with a particular interest in epilepsies driven by gene mutations in the mTOR signaling pathway. The overall goal of our research is to identify common disease-causing mechanisms that are clinically actionable. Peer Reviewed Publications Dusing, Mary; LaSarge, Candi L; White, Angela; Jerow, Lilian G; Gross, Christina; Danzer, Steve C 2023. Neurovascular Development in Pten and Tsc2 Mouse Mutants. eNeuro, 10 2, Kraus, Kimberly L; Nawreen, Nawshaba; Godale, Christin M; Chordia, Arihant P; Packard, Ben; LaSarge, Candi L; Herman, James P; Danzer, Steve C 2023. Hippocampal glucocorticoid receptors modulate status epilepticus severity. Neurobiology of disease, 178 , 106014LaSarge, Candi L; McCoy, Carlie; Namboodiri, Devi V; Hartings, Jed A; Danzer, Steve C; Batie, Matthew R; Skoch, Jesse 2023. Spatial and Temporal Comparisons of Calcium Channel and Intrinsic Signal Imaging During in Vivo Cortical Spreading Depolarizations in Healthy and Hypoxic Brains. Neurocritical care, 39 3, 655-668Kraus, Kimberly L; Chordia, Arihant P; Drake, Austin W; Herman, James P; Danzer, Steve C 2022. Hippocampal interneurons are direct targets for circulating glucocorticoids. The Journal of comparative neurology, 530 12, 2100-2112LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Riccetti, Matthew R; Namboodiri, Devi V; Tiwari, Durgesh; Gross, Christina; Danzer, Steve C 2021. mTOR-driven neural circuit changes initiate an epileptogenic cascade. Progress in neurobiology, 200 , 101974Arafa, Salwa R; LaSarge, Candi L; Pun, Raymund Y K; Khademi, Shadi; Danzer, Steve C 2019. Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth. Experimental neurology, 311 , 125-134LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Santos, Victor R; Danzer, Steve C 2019. Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? Experimental neurology, 321 , 113029Ngwenya, Laura B; Danzer, Steve C 2018. Impact of Traumatic Brain Injury on Neurogenesis. Frontiers in neuroscience, 12 , 1014Hosford, Bethany E; Rowley, Shane; Liska, John P; Danzer, Steve C 2017. Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. Scientific reports, 7 1, 18015Rowley, Shane; Sun, Xiaofei; Lima, Isabel V; Tavenier, Alexandra; de Oliveira, Antonio Carlos Pinheiro; Dey, Sudhansu K; Danzer, Steve C 2017. Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. Epilepsia, 58 12, e162-e166Santos, Victor R; Pun, Raymund Y K; Arafa, Salwa R; LaSarge, Candi L; Rowley, Shane; Khademi, Shadi; Bouley, Tom; Holland, Katherine D; Garcia-Cairasco, Norberto; Danzer, Steve C 2017. PTEN deletion increases hippocampal granule cell excitability in male and female mice. Neurobiology of disease, 108 , 339-351Hosford, Bethany E; Liska, John P; Danzer, Steve C 2016. Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 43, 11013-11023LaSarge, Candi L; Pun, Raymund Y K; Muntifering, Michael B; Danzer, Steve C 2016. Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells. Neurobiology of disease, 96 , 105-114LaSarge, Candi L; Santos, Victor R; Danzer, Steve C 2015. PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiology of disease, 75 , 142-50Hester, Michael S; Danzer, Steve C 2013. Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 21, 8926-36Hofacer, Rylon D; Deng, Meng; Ward, Christopher G; Joseph, Bernadin; Hughes, Elizabeth A; Jiang, Connie; Danzer, Steve C; Loepke, Andreas W 2013. Cell age-specific vulnerability of neurons to anesthetic toxicity. Annals of neurology, 73 6, 695-704Pun, Raymund Y K; Rolle, Isaiah J; Lasarge, Candi L; Hosford, Bethany E; Rosen, Jules M; Uhl, Juli D; Schmeltzer, Sarah N; Faulkner, Christian; Bronson, Stefanie L; Murphy, Brian L; Richards, David A; Holland, Katherine D; Danzer, Steve C 2012. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron, 75 6, 1022-34Murphy, Brian L; Danzer, Steve C 2011. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 8, 2959-64Murphy, Brian L; Pun, Raymund Y K; Yin, Hulian; Faulkner, Christian R; Loepke, Andreas W; Danzer, Steve C 2011. Heterogeneous integration of adult-generated granule cells into the epileptic brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 1, 105-17Walter, Cynthia; Murphy, Brian L; Pun, Raymund Y K; Spieles-Engemann, Anne L; Danzer, Steve C 2007. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 28, 7541-52Danzer SC . , ,
Research InterestsMy laboratory examines changes in the structure and function of brain circuitry that drive focal epileptogenesis, with a particular interest in epilepsies driven by gene mutations in the mTOR signaling pathway. The overall goal of our research is to identify common disease-causing mechanisms that are clinically actionable.
Peer Reviewed Publications Dusing, Mary; LaSarge, Candi L; White, Angela; Jerow, Lilian G; Gross, Christina; Danzer, Steve C 2023. Neurovascular Development in Pten and Tsc2 Mouse Mutants. eNeuro, 10 2, Kraus, Kimberly L; Nawreen, Nawshaba; Godale, Christin M; Chordia, Arihant P; Packard, Ben; LaSarge, Candi L; Herman, James P; Danzer, Steve C 2023. Hippocampal glucocorticoid receptors modulate status epilepticus severity. Neurobiology of disease, 178 , 106014LaSarge, Candi L; McCoy, Carlie; Namboodiri, Devi V; Hartings, Jed A; Danzer, Steve C; Batie, Matthew R; Skoch, Jesse 2023. Spatial and Temporal Comparisons of Calcium Channel and Intrinsic Signal Imaging During in Vivo Cortical Spreading Depolarizations in Healthy and Hypoxic Brains. Neurocritical care, 39 3, 655-668Kraus, Kimberly L; Chordia, Arihant P; Drake, Austin W; Herman, James P; Danzer, Steve C 2022. Hippocampal interneurons are direct targets for circulating glucocorticoids. The Journal of comparative neurology, 530 12, 2100-2112LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Riccetti, Matthew R; Namboodiri, Devi V; Tiwari, Durgesh; Gross, Christina; Danzer, Steve C 2021. mTOR-driven neural circuit changes initiate an epileptogenic cascade. Progress in neurobiology, 200 , 101974Arafa, Salwa R; LaSarge, Candi L; Pun, Raymund Y K; Khademi, Shadi; Danzer, Steve C 2019. Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth. Experimental neurology, 311 , 125-134LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Santos, Victor R; Danzer, Steve C 2019. Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? Experimental neurology, 321 , 113029Ngwenya, Laura B; Danzer, Steve C 2018. Impact of Traumatic Brain Injury on Neurogenesis. Frontiers in neuroscience, 12 , 1014Hosford, Bethany E; Rowley, Shane; Liska, John P; Danzer, Steve C 2017. Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. Scientific reports, 7 1, 18015Rowley, Shane; Sun, Xiaofei; Lima, Isabel V; Tavenier, Alexandra; de Oliveira, Antonio Carlos Pinheiro; Dey, Sudhansu K; Danzer, Steve C 2017. Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. Epilepsia, 58 12, e162-e166Santos, Victor R; Pun, Raymund Y K; Arafa, Salwa R; LaSarge, Candi L; Rowley, Shane; Khademi, Shadi; Bouley, Tom; Holland, Katherine D; Garcia-Cairasco, Norberto; Danzer, Steve C 2017. PTEN deletion increases hippocampal granule cell excitability in male and female mice. Neurobiology of disease, 108 , 339-351Hosford, Bethany E; Liska, John P; Danzer, Steve C 2016. Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 43, 11013-11023LaSarge, Candi L; Pun, Raymund Y K; Muntifering, Michael B; Danzer, Steve C 2016. Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells. Neurobiology of disease, 96 , 105-114LaSarge, Candi L; Santos, Victor R; Danzer, Steve C 2015. PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiology of disease, 75 , 142-50Hester, Michael S; Danzer, Steve C 2013. Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 21, 8926-36Hofacer, Rylon D; Deng, Meng; Ward, Christopher G; Joseph, Bernadin; Hughes, Elizabeth A; Jiang, Connie; Danzer, Steve C; Loepke, Andreas W 2013. Cell age-specific vulnerability of neurons to anesthetic toxicity. Annals of neurology, 73 6, 695-704Pun, Raymund Y K; Rolle, Isaiah J; Lasarge, Candi L; Hosford, Bethany E; Rosen, Jules M; Uhl, Juli D; Schmeltzer, Sarah N; Faulkner, Christian; Bronson, Stefanie L; Murphy, Brian L; Richards, David A; Holland, Katherine D; Danzer, Steve C 2012. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron, 75 6, 1022-34Murphy, Brian L; Danzer, Steve C 2011. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 8, 2959-64Murphy, Brian L; Pun, Raymund Y K; Yin, Hulian; Faulkner, Christian R; Loepke, Andreas W; Danzer, Steve C 2011. Heterogeneous integration of adult-generated granule cells into the epileptic brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 1, 105-17Walter, Cynthia; Murphy, Brian L; Pun, Raymund Y K; Spieles-Engemann, Anne L; Danzer, Steve C 2007. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 28, 7541-52Danzer SC . , ,
Dusing, Mary; LaSarge, Candi L; White, Angela; Jerow, Lilian G; Gross, Christina; Danzer, Steve C 2023. Neurovascular Development in Pten and Tsc2 Mouse Mutants. eNeuro, 10 2, Kraus, Kimberly L; Nawreen, Nawshaba; Godale, Christin M; Chordia, Arihant P; Packard, Ben; LaSarge, Candi L; Herman, James P; Danzer, Steve C 2023. Hippocampal glucocorticoid receptors modulate status epilepticus severity. Neurobiology of disease, 178 , 106014LaSarge, Candi L; McCoy, Carlie; Namboodiri, Devi V; Hartings, Jed A; Danzer, Steve C; Batie, Matthew R; Skoch, Jesse 2023. Spatial and Temporal Comparisons of Calcium Channel and Intrinsic Signal Imaging During in Vivo Cortical Spreading Depolarizations in Healthy and Hypoxic Brains. Neurocritical care, 39 3, 655-668Kraus, Kimberly L; Chordia, Arihant P; Drake, Austin W; Herman, James P; Danzer, Steve C 2022. Hippocampal interneurons are direct targets for circulating glucocorticoids. The Journal of comparative neurology, 530 12, 2100-2112LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Riccetti, Matthew R; Namboodiri, Devi V; Tiwari, Durgesh; Gross, Christina; Danzer, Steve C 2021. mTOR-driven neural circuit changes initiate an epileptogenic cascade. Progress in neurobiology, 200 , 101974Arafa, Salwa R; LaSarge, Candi L; Pun, Raymund Y K; Khademi, Shadi; Danzer, Steve C 2019. Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth. Experimental neurology, 311 , 125-134LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Santos, Victor R; Danzer, Steve C 2019. Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? Experimental neurology, 321 , 113029Ngwenya, Laura B; Danzer, Steve C 2018. Impact of Traumatic Brain Injury on Neurogenesis. Frontiers in neuroscience, 12 , 1014Hosford, Bethany E; Rowley, Shane; Liska, John P; Danzer, Steve C 2017. Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. Scientific reports, 7 1, 18015Rowley, Shane; Sun, Xiaofei; Lima, Isabel V; Tavenier, Alexandra; de Oliveira, Antonio Carlos Pinheiro; Dey, Sudhansu K; Danzer, Steve C 2017. Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. Epilepsia, 58 12, e162-e166Santos, Victor R; Pun, Raymund Y K; Arafa, Salwa R; LaSarge, Candi L; Rowley, Shane; Khademi, Shadi; Bouley, Tom; Holland, Katherine D; Garcia-Cairasco, Norberto; Danzer, Steve C 2017. PTEN deletion increases hippocampal granule cell excitability in male and female mice. Neurobiology of disease, 108 , 339-351Hosford, Bethany E; Liska, John P; Danzer, Steve C 2016. Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 43, 11013-11023LaSarge, Candi L; Pun, Raymund Y K; Muntifering, Michael B; Danzer, Steve C 2016. Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells. Neurobiology of disease, 96 , 105-114LaSarge, Candi L; Santos, Victor R; Danzer, Steve C 2015. PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiology of disease, 75 , 142-50Hester, Michael S; Danzer, Steve C 2013. Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 21, 8926-36Hofacer, Rylon D; Deng, Meng; Ward, Christopher G; Joseph, Bernadin; Hughes, Elizabeth A; Jiang, Connie; Danzer, Steve C; Loepke, Andreas W 2013. Cell age-specific vulnerability of neurons to anesthetic toxicity. Annals of neurology, 73 6, 695-704Pun, Raymund Y K; Rolle, Isaiah J; Lasarge, Candi L; Hosford, Bethany E; Rosen, Jules M; Uhl, Juli D; Schmeltzer, Sarah N; Faulkner, Christian; Bronson, Stefanie L; Murphy, Brian L; Richards, David A; Holland, Katherine D; Danzer, Steve C 2012. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron, 75 6, 1022-34Murphy, Brian L; Danzer, Steve C 2011. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 8, 2959-64Murphy, Brian L; Pun, Raymund Y K; Yin, Hulian; Faulkner, Christian R; Loepke, Andreas W; Danzer, Steve C 2011. Heterogeneous integration of adult-generated granule cells into the epileptic brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 1, 105-17Walter, Cynthia; Murphy, Brian L; Pun, Raymund Y K; Spieles-Engemann, Anne L; Danzer, Steve C 2007. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 28, 7541-52Danzer SC . , ,